• 대한의용생체공학회:의공학회지
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• 제20권2호
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• pp.213-220
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• 1999

본 연구는 쥐의 뇌, 심장, 간, 근육 및 근육부위의 종양조직과 인간의 뇌 조직과 뇌 종양 조직의 광학적 흡수계수를 500nm~900nm 범위의 파장에서 측정하고 비교분석하였다. 광학적 흡수계수는 물질마다 가지고 있는 고유한 성질을 나타내므로 생체조직의 광학계수를 측정하면, 생체 조직의 고유한 특성을 나타낼 수 있다. Spectrograph monometer와 PDA를 이용하여, 동결절편으로 제작한 시편에 대하여 실험하였다. 실험결과, 쥐 조직과 인체의 뇌 조직의 흡수계수는 정상적인 일반 조직과 종양 조직에서 차이가 분명하게 있음을 알 수 있었다. 정상 뇌 조직의 흡수계수는 파장이 변화함에 따라 0.1~0.2$cm^{-1}$사이의 비교적 균일한 값을 보이는데 반하여, 뇌종양 조직의 흡수계수는 파장에 따라서 크게는 약 0.4~0.5$cm^{-1}$정도의 변화가 있다. 본 실험 결과들은 다양한 조직에서의 광학계수 중에서 흡수계수를 측정함으로써, 생체조직의 흡수계수의 변화를 감지하여 질병진단의 지표로 삼을 수 있다.

• 전자공학회논문지SC
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• 제46권4호
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• pp.70-76
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• 2009

본 연구에서는 자동차 사고나 뇌졸중 둥에 의해 경추 이하의 마비나 손, 발 등의 움직임이 자유롭지 못한 사람들의 컴퓨터 사용을 돕고자 손이나 발을 이용하지 않고 머리의 움직임과 눈의 깜박임만으로 컴퓨터 마우스 제어가 가능한 장치를 제안하였다. 마우스의 위치는 각속도 센서를 이용하여 머리의 움직임으로 추정하고, 눈 깜빡임에 의한 클릭과 더블 클릭은 광센서의 시야를 방해하지 않는 위치에 장착하여 커 클위치와 이벤트를 검출하였다. 제안한 마우스의 공간 이동 능력과 이벤트 검출을 비교한 실험에서는 좌우, 상하 이동은 기존 마우스와 비교하여 속도 면에서는 큰 차이는 없었으나, 정확도가 조금 떨어지는 이유로 인하여 정확한 위치로 이동시키는데 소요시간이 3$\sim$4배 정도 더 필요하였다. 데드 존을 갖는 비선형 상대 좌표계 방식을 이용하여 주기적으로 적분 에러를 제거해야 하는 문제를 해결하였고, 이동 거리와 속도를 함께 고려하여 직관적인 마우스 포인터 제어가 가능하도록 하였다. 주변광의 영향을 최소화하도록 광원 제어 회로를 설계하여 외부 광원의 변화에도 마우스 이벤트 검출이 영향을 받지 않았다.

• 약학회지
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• 제48권3호
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• pp.177-181
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• 2004

Non-invasive blood glucose measurement from mouse tail was performed by near-infrared (NIR) spectroscopy. Three groups; normal, type I diabetes (insulin dependent diabetes mellitus, IDDM), type II diabetes (non-insulin dependent diabetes mellitus, NIDDM) group, were studied over a 10 weeks period with the collection of near-infrared (NIR) spectra. Spectral variations from long-term measurement (10 weeks) from dramatic and nonlinear changes in the optical properties of the live tissue sample were compensated by chemometrics techniques such as principle component analysis (PCA) and partial least squares (PLS) regression. The effect from mouse body temperature changes on NIR spectral data was also considered. This study showed that the compensation of variations from long-term measurement and temperature changes improved calibration accuracy of non-invasive blood glucose measurement.

• Journal of the Optical Society of Korea
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• 제10권1호
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• pp.42-47
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• 2006

M-mode imaging of the in vivo murine myocardium using optical coherence tomography (OCT) is described. Application of conventional techniques (e.g. MRI, Ultrasound imaging) for imaging the murine myocardium is problematic because the wall thickness is less than 1.5 mm (20 g mouse), and the heart rate can be as high as six hundred beats per minute. To acquire a real-time image of the murine myocardium, OCT can provide sufficient spatial resolution ($10{\mu}m$) and imaging speed (1000 A-scans/s). Strong light scattering by blood in the heart causes significant light attenuation, which makes delineation of the endocardium-chamber boundary problematic. To measure the thickness change of the myocardium during one heart beat cycle, a myocardium edge detection algorithm is developed and demonstrated.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 심포지엄 논문집 정보 및 제어부문
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• pp.145-146
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• 2007

This paper presents the sensitivity analysis of the leasst qsuares velocity estimation of an omnidirectional mobile robot using a regular polygonal array of optical mice. First, the velocity kinematics from a mobile robot to an array of optical mice is derived as an overdetermined linear system. Then, for a given set of optical mouse readings, the least squares velocity estimation of a mobile robot is obtained as the simple average. Finally, the sensitivity analysis of the proposed least squares velocity estimation to imprecise installation is made.

• Medical Lasers
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• 제10권3호
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• pp.123-131
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• 2021

Optical imaging modalities with properties of real-time, non-invasive, in vivo, and high resolution for image-guided surgery have been widely studied. In this review, we introduce two optical imaging systems, that could be the core of image-guided surgery and introduce the system configuration, implementation, and operation methods. First, we introduce the optical coherence tomography (OCT) system implemented by our research group. This system is implemented based on a swept-source, and the system has an axial resolution of 11 ㎛ and a lateral resolution of 22 ㎛. Second, we introduce a fluorescence imaging system. The fluorescence imaging system was implemented based on the absorption and fluorescence wavelength of indocyanine green (ICG), with a light-emitting diode (LED) light source. To confirm the performance of the two imaging systems, human malignant melanoma cells were injected into BALB/c nude mice to create a xenograft model and using this, OCT images of cancer and pathological slide images were compared. In addition, in a mouse model, an intravenous injection of indocyanine green was used with a fluorescence imaging system to detect real-time images moving along blood vessels and to detect sentinel lymph nodes, which could be very important for cancer staging. Finally, polarization-sensitive OCT to find the boundaries of cancer in real-time and real-time image-guided surgery using a developed contrast agent and fluorescence imaging system were introduced.

• Journal of the Optical Society of Korea
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• 제20권1호
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• pp.88-93
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• 2016

Recently laser speckle contrast (LSC) imaging has become a widely used optical method for in vivo assessment of blood flow in the animal brain. LSC imaging is useful for monitoring brain hemodynamics with relatively high spatio-temporal resolution. A speckle contrast imaging system has been implemented with electrical sensory stimulation apparatus. LSC imaging is combined with optical intrinsic signal imaging in order to measure changes in cerebral blood flow as well as neural activity in response to electrical sensory stimulation applied to the hindlimb region of the mouse brain. We found that blood flow and oxygen consumption are correlated and both sides of hindlimb activation regions are symmetrically located. This apparatus could be used to monitor spatial or temporal responses of cerebral blood flow in animal disease models such as ischemic stroke or cortical spreading depression.

• Journal of the Optical Society of Korea
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• 제17권1호
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• pp.91-96
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• 2013

We report a method for optical monitoring of tumors in an animal model using optical coherence tomography (OCT). In a spectral domain OCT system, a superluminescent diode light source with a full width of 66 nm at half maximum and peak wavelength of 950 nm was used to take images having an axial resolution of 6.8 ${\mu}m$. Cancer cells of PC-3 were cultured and inoculated into the hypodermis of auricle tissues in BALB/c nude mice. We observed tumor formation and growth at the injection region of cancer cells in vivo and obtained the images of tumor mass center and sparse circumferences. On the $5^{th}$ day from an inoculation of cancer cells, histological images of the tumor region using cross-sectional slicing and dye staining of specimens were taken in order to confirm the correlation with the high resolution OCT images. The OCT image of tumor mass compared with normal tissues was analyzed using its A-scan data so as to obtain a tissue attenuation rate which increases according to tumor growth.

• 대한기계학회논문집A
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• 제35권12호
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• pp.1619-1625
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• 2011

본 논문의 목적은 3 차원 사출성형 해석을 통하여 컴퓨터 마우스 제작용 이중사출성형 금형의 공정조건을 결정하는 것이다. 적합한 사출성형 공정조건을 선정하기 위하여 사출 시간, 최대 사출압력 및 보압 시간이 사출성형 특성과 제품 품질에 미치는 영향을 정량적으로 고찰하였다. 사출성형 해석 결과로부터 제품의 수축과 휨 변형을 최소화 할 수 있는 최적 사출성형 공정조건을 예측하였다. 최종적으로 사출성형 실험을 수행하여 이종재료로 구성된 컴퓨터 마우스 제품을 제작하였다. 이 결과로부터 선정한 사출성형 공정조건을 적용할 경우 적절한 이종 재료로 구성된 컴퓨터 마우스가 제작될 수 있음을 알 수 있었다.

• 대한본초학회지
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• 제34권1호
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• pp.1-11
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• 2019

Objective : An allergy to peanuts is a major cause of fatal food-induced anaphylaxis, with food allergies becoming an increasingly important health research issue. Food allergy as clinical entity has been recongnized for many years, although there is yet no general concord as to the incidence of this symptom.1) Methods : This study was undertaken to verify the effect of seeds of Canavalia gladiata (Jacq.) DC. extract (CGE) on the inhibition of allergic reactions using a cholera toxin and peanut extract-immunized food allergy mouse model. We determine whether the changes in rectal temperature were related to energy consumption owing to heat production in the body. Mast cell distribution and degranulation in the dermis and epidermis were observed with an optical microscope. Subsequently, Ara h1 levels in serum and interleukin (IL)-4, IL-10, and $IFN-{\gamma}$ levels in cultured supernatants of splenocytes were measured. Results : CGE treatment significantly attenuated the secretion of the Ara h1 antibody in serum and splenocytes. Ara h 1 was undetected in the cholera toxin and peanut extract-immunized food allergy mouse model. Improvement in ear tissue inflammation symptoms was the CGE experimental group. In the control group and peanut extract control group, the expression of mast cells was higher, whereas that in the CGE experimental group was significantly lower. Conclusion : CGE causes suppression in a food allergy mouse model via the inhibition of Ara h1 secretion, and might be useful for developing functional health foods.