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http://dx.doi.org/10.3807/JOSK.2016.20.1.088

Laser Speckle Contrast Imaging for Measuring Cerebral Blood Flow Changes Caused by Electrical Sensory Stimulation  

Cho, Ahra (School of Mechatronics, Gwangju Institute of Science and Technology)
Yeon, Chanmi (Department of Medical System Engineering, Gwangju Institute of Science and Technology)
Kim, Donghyeon (School of Information and Communications, Gwangju Institute of Science and Technology)
Chung, Euiheon (School of Mechatronics, Gwangju Institute of Science and Technology)
Publication Information
Journal of the Optical Society of Korea / v.20, no.1, 2016 , pp. 88-93 More about this Journal
Abstract
Recently laser speckle contrast (LSC) imaging has become a widely used optical method for in vivo assessment of blood flow in the animal brain. LSC imaging is useful for monitoring brain hemodynamics with relatively high spatio-temporal resolution. A speckle contrast imaging system has been implemented with electrical sensory stimulation apparatus. LSC imaging is combined with optical intrinsic signal imaging in order to measure changes in cerebral blood flow as well as neural activity in response to electrical sensory stimulation applied to the hindlimb region of the mouse brain. We found that blood flow and oxygen consumption are correlated and both sides of hindlimb activation regions are symmetrically located. This apparatus could be used to monitor spatial or temporal responses of cerebral blood flow in animal disease models such as ischemic stroke or cortical spreading depression.
Keywords
Laser speckle contrast imaging; Cerebral blood flow; Functional activation; Brain imaging;
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