Medical Lasers

Korean Society for Laser Medicine and Surgery (대한의학레이저학회)
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Optical Imaging Technology for Real-time Tumor Monitoring

  • Shin, Yoo-kyoung (Department of Biomedical Science, College of Medicine, Dankook University) ;
  • Eom, Joo Beom (Department of Biomedical Science, College of Medicine, Dankook University)
  • Received : 2021.07.20
  • Accepted : 2021.08.11
  • Published : 2021.09.30
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Abstract

Optical imaging modalities with properties of real-time, non-invasive, in vivo, and high resolution for image-guided surgery have been widely studied. In this review, we introduce two optical imaging systems, that could be the core of image-guided surgery and introduce the system configuration, implementation, and operation methods. First, we introduce the optical coherence tomography (OCT) system implemented by our research group. This system is implemented based on a swept-source, and the system has an axial resolution of 11 ㎛ and a lateral resolution of 22 ㎛. Second, we introduce a fluorescence imaging system. The fluorescence imaging system was implemented based on the absorption and fluorescence wavelength of indocyanine green (ICG), with a light-emitting diode (LED) light source. To confirm the performance of the two imaging systems, human malignant melanoma cells were injected into BALB/c nude mice to create a xenograft model and using this, OCT images of cancer and pathological slide images were compared. In addition, in a mouse model, an intravenous injection of indocyanine green was used with a fluorescence imaging system to detect real-time images moving along blood vessels and to detect sentinel lymph nodes, which could be very important for cancer staging. Finally, polarization-sensitive OCT to find the boundaries of cancer in real-time and real-time image-guided surgery using a developed contrast agent and fluorescence imaging system were introduced.

Keywords

Acknowledgement

This work was supported by the Korea Medical Device Development Fund (KMDF) grant funded by the Korea government (KMDF_PR_20200901_0024). All experiments with mice were performed in the animal facility at Dankook University according to the guidelines of the Dankook University Institutional Animal Care & Use Committee.

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