• Human Ecology Research
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• 제52권6호
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• pp.639-649
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• 2014

The main purpose of this study was to find the relationship between the delinquency-onset time in the source and the continuity of delinquency. In order to achieve this objective, we divided 350 first-year high school students into three groups early-onset type, late-onset type, and non-delinquent adolescents on the basis of the delinquency onset. The results of this study were as follow: (1) for the boys, the early-onset type shows a higher continuity of delinquency than both the late-onset type and the general adolescents. On the other hand, for the girls, the early-onset type shows a higher continuity of delinquency than the late-onset type, but there was no difference in the persistence duration between the late-onset type and the non-delinquent adolescents. (2) For the boys, the examination reveals that the early-onset type has a higher degree of sensation seeking and impulsivity than the general adolescents. In addition, the early-onset type shows a higher degree of sensation seeking than the late-onset type, whereas the two show no difference in impulsivity. For the girls, sensation seeking did not show any difference depending on the delinquency onset. However, more impulsivity appeared in the early-onset type than in the late-onset type or the non-delinquent adolescents. (3) The relative priorities of variables determining the group to which the students belong on the basis of the delinquency onset are in the order of sensation seeking and juvenile impulsivity. Therefore, this study, suggests that the early-onset type requires a different kind of intervention than the late-onset type.

• 생물정신의학
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• 제20권4호
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• pp.179-186
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• 2013

Objectives This study is designed to compare the clinical characteristics of patients with early onset schizophrenia to those of adult onset schizophrenia patients in first episode. Methods Authors reviewed medical records of 16 early-onset schizophrenia patients and 22 adult-onset schizophrenia patients who had been admitted in the psychiatric ward and diagnosed as schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders, fourth Edition (DSM-IV) at Eulji University Hospital during 2004-2008. Socio-demographic data and clinical characteristics such as duration between onset and active phase, number of significant positive and negative symptoms, positive and negative symptom scores of Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression-Severity (CGI-S) scores, duration from onset to admission, duration of admission, and equivalent dose of antipsychotics were reviewed. These clinical characteristics of early-onset group were compared to those of adult-onset group. Correlation between age of onset and other clinical characteristics was also analyzed. Results Early-onset group showed more insidious onset pattern and had longer duration of hospitalization than adult-onset group. Early onset group also exhibited more negative symptoms, higher negative symptom scores, and higher CGI-S scores than adult-onset group after treatment. However, there were no significant differences in family history of psychosis, positive symptom frequency at discharge and equivalent dose of antipsychotics between two groups. Conclusions This study revealed that patients with early-onset schizophrenia exhibited more insidious onset, more negative symptoms, and more severe symptoms than those with adult-onset schizophrenia after treatment.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권2호
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• pp.219-230
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• 2005

목적 : 소아, 청소년기 발병 정신분열병은 성인기 발병 정신분열병보다 전구증상을 동반하여 점진적으로 발생하고 심각한 인지기능저하와 신경해부학적 결손을 보여주는 예후가 안좋은 질환으로 알려져왔다. 금번 연구의 목적은 13세를 기준으로 소아, 청소년기 발병 정신분열병을 두 그룹으로 나누어 인구학적 자료, 임상적 특징, 발달학적 지연, 심리학적 특성을 비교하여 소아-청소년기 발병 정신분열병에 대한 이해를 높이고자 하였다. 방법 : 17명의 소아기발병 정신분열병(매우이른 발병) 입원 환아와 16명의 청소년기발병 정신분열병(이른 발병) 입원 환아의 의무기록을 조사하였다. 두 그룹의 기록에서 성별, 연령, 정신과적 과거력, 전구증상 및 기간, 아형, 공존질환, 발달력상 지연, 처방약물 및 용량, 치료반응, 지능지수와 로샤검사를 평가하였다. 결과 : 소아기발병(매우 이른발병)과 청소년기 발병(이른 발병) 정신분열병의 평균 입원 연령은 12.69세$({\pm}2.34)$와 15.13세$({\pm}1.04)$였다. 소아기발병(매우 이른발병)과 청소년기 발병(이른 발병) 정신분열병의 평균 발병 연령은 10.79세 $({\pm}1.95)$와 14.46$({\pm}0.82)$세 였다. 소아기발병 (매우 이른발병)과 청소년기 발병 (이른 발병)의 평균 전구기간은 15.94개월$({\pm}12.33)$과 8.06$({\pm}6.10)$ 개월이었다. 소아기발병 (매우 이른 발병)과 청소년기 발병 (이른 발병)의 관해에까지 이르는데 걸리는 시간은 50.58$({\pm}24.67)$일과 30.06(18.04) 일이었다. 소아기발병 (매우 이른 발병) 그룹에서 관해에까지 이르는 기간이 길수록 일찍 발병 하였다. 두 그룹에서 전체지능, 언어성지능, 동작성 지능은 평균수준이었다. 결론 : 소아기발병(매우 이른 발병)과 청소년기 발병(이른 발병) 정신분열병은 이전의 연구결과와 마찬가지로 전구증상과 함께 전구기간이 존재하고 발달력상 지연이 있을 수 있으며 입원 당시 명백한 정신병적 증상이 존재한다는 점에서는 비슷하지만 청소년기 발병(이른 발병) 그룹에 비해 소아기발병(매우 이른발병) 그룹은 전구기간이 더 짧았으며 발병연령이 늦을수록 관해에 이르는 기간이 짧은 것으로 나타났다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제14권1호
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• pp.1-25
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• 2011

Inflammatory bowel disease (IBD) develops during childhood or adolescence in approximately 25% of patients with IBD. Recent studies on pediatric IBD have revealed that early-onset IBD has distinct phenotype differences compared to adult onset IBD. Pediatric early-onset IBD differs in many aspects including disease type, location of the lesions, disease behavior, gender preponderance and genetically attributable risks. This review examines the currently published data on the clinical, epidemiological and genetic differences between early-onset and adult-onset IBD. And finally, therapeutic considerations in the management of pediatric-onset IBD are also discussed.

• 대한불안의학회지
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• 제7권1호
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• pp.34-39
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• 2011

Objectives : An early age at onset of obsessive compulsive symptoms in family studies has been strongly associated with a more familial form of obsessive compulsive disorder (OCD). Further, many reports have suggested that early- and late- onset OCD represent separate subtypes of the disorder. The aim of this study was to investigate the associations between the glutamate receptor, the ionotropic, n-methyl-d-aspartate (NMDA) subunit 2B gene (GRIN2B) polymorphisms, and onset of OCD in the Korean population. Methods : We recruited 109 OCD patients and classified them into early- (age of onset <18 years) and late-onset groups (age of onset${\geq}$18). Genomic DNA was extracted from their blood after which the genotypes and allelic frequencies of the two GRIN2B polymorphisms (5072T/G and 5988T/C) were compared in the two groups. We also compared genetic data between child- (age of onset${\leq}$15) and adult-onset groups (age of onset${\geq}$19) using the same protocol. Results : There were no significant differences between the early- and late-onset groups with respect to genotype. Moreover, we could not find any differences in genotype frequencies between child and adult-onset groups. Conclusions : Our study suggested that GRIN2B polymorphisms (5072T/G and 5988T/C) do not affect the onset of OCD in Koreans. However, this finding has resulted from a preliminary study and thus, further study is required.

• 대한불안의학회지
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• 제10권2호
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• pp.108-114
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• 2014

Objective : The correlation between age of onset and symptoms/severity of panic disorder has not yet been determined. The aim of this research is to determine the different clinical features of panic disorder according to the age of onset. Methods : Patients diagnosed with panic disorder were placed into two groups according to onset of age. The subjects were checked for 13 different panic symptoms presented in the DSM-IV. The investigation was also executed by severity, the anxiety sensitivity index, the scale for depression and anxiety. Results : The early onset group had significantly higher frequencies than the late onset group in the areas of "choking feeling" and "derealization or paresthesia". It was found that only "choking feeling" was statically significant as a risk factor of early onset panic disorder. Among the objective anxiety scale, the subscale of psychological anxiety was higher in the early onset group compared to the late onset group. Conclusion : "Choking feeling" was the only panic symptom that showed a significant difference in accordance with onset age. Earlier onset patients tend to experience a more frequent "choking feeling," which is related to respiratory symptoms. This could mean that earlier onset patients are more likely to have higher psychological anxiety.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1767-1770
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• 2012

Background: The Asia Pacific consensus for colorectal cancer (CRC) recommends that screening programs should begin by the age of 50. However, there have been reports about increasing incidence of CRC at a younger age (i.e. early-onset CRC). Little is known about the features of early-onset CRC in the Vietnamese population. Aim: To describe the clinical, endoscopic and pathological characteristics of early-onset CRC in Vietnamese. Method: A prospective, cross-sectional study was conducted at the University Medical Center from March 2009 to March 2011. All patients with definite pathological diagnosis of CRC were recruited. The early-onset CRC group were analyzed in comparison with the late-onset (i.e. ${\geq}$ 50-year-old) CRC group. Results: The rate of early-onset CRC was 28% (112/400) with a male-to-female ratio of 1.3. Some 22.3% (25/112) of the patients only experienced abdominal pain and/or change in bowel habit without alarming symptoms, 42.9% (48/112) considering their symptoms intermittent. The rate of familial history of CRC in early-onset group was significantly higher that of the late-onset group (21.4% versus 7.6%, p<0.001). The distribution of CRC lesions in rectum, distal and proximal colon were 51.8% (58/112), 26.8% (30/112) and 21.4% (24/112), respectively; which was not different from that in the late-onset group (${\chi}2$, p = 0.29). The rates for poorly differentiated tumors were also not significantly different between the two groups: 12.4% (14/112) versus 8.3% (24/288) (${\chi}2$, p = 0.25). Conclusion: A high proportion of CRC in Viet Nam appear at an earlier age than that recommended for screening by the Asia Pacific consensus. Family history was a risk factor of early-onset CRC. Diagnosis of early-onset CRC needs more attention because of the lack of alarming symptoms and their intermittent patterns as described by the patients.

• 생물치료정신의학
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• 제24권3호
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• pp.202-208
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• 2018

Objectives : The purpose of this study was to investigate the differences in forensic demographic characteristics, interpersonal problems and personality disorder between early and late onset criminal patients with schizophrenia. Methods : The participants included 187 inpatients with schizophrenia who had committed crimes. They filled out the Korean Inventory of Interpersonal Problem Personality Disorder Scales and Psychopathic Personality Inventory-Revised. They were divided into early onset group and late onset group according to onset age of schizophrenia at 26 years old(under 26 versus 26 and older) and forensic demographic characteristics, interpersonal problem and personality disorders including psychopathy were compared between two groups. Results : There were no differences in gender, education years and family history between the two groups. Early onset group was associated with lower age, earlier onset of age and earlier age at the time of the crime. Duration from onset to diagnosis was not different between the two groups. Duration from onset to crime and after diagnosis to crime was shorter in late onset group. There were no differences between the two groups in the interpersonal problems, personality disorder and psychopathic personality evaluation. Conclusion : These results suggested that there may be forensic demographic differences related to crime between early and later onset schizophrenia. Psychiatrists should consider the age at onset of schizophrenia when assessing the risk of violence in patients with schizophrenia. In the future. it will be needed other study of age classification such as admixture analysis.

• 대한추나의학회지
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• 제5권1호
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• pp.151-161
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• 2004

Objectives : To investigate and compare the curvature of the cervical spine of the patients with whiplash and insidious onset neck pain. Method : Clinical study carried out in 33 insidious onset neck pain outpatients and 34 whiplash onset neck pain inpatients in Conmaul Oriental Hospital. Cervical spine curvature was measured using five measuring Methods. Type of cervical spine curvature was analyzed by Jochumsen method. Ishihara Index. T-test was used to compare the cervical spine angle of the two groups. Results : The prevalence of 'straight' and 'kyphotic' cervical spines was 46.5% in the insidious onset cases and 26.47% in the whiplash onset cases. In Jackson's angle, Jochumsen method, Ishihara Index, and Park's method, angle of the Cervical spine curvature was significantly lower in the insidious onset cases. (P<0.01) Conclusion : The results suggest that the cervical spine of neck pain patients is 'straight' and 'kyphotic' and more significant in insidious onset cases.

• 대한한방부인과학회지
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• 제24권3호
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• pp.116-126
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• 2011

Objectives: To identify the difference of autonomic nervous system activity in women with overactive bladder between women with pre-menopausal onset and post-menopausal onset. Methods: Total of 46 women with overactive bladder participated in this study. Patients were categorized in two groups, patients with pre-menopausal onset(n=31) and post-menopausal onset(n=15). We measured and compared parameters of Heart Rate Variability of patients. The results were analysed using SPSS for windows 12.0. Results: On frequency domain analysis, the patients with post-menopausal onset had significantly decreased mean value of Total Power, High Frequence, Low Frequence, compared with the patients with post-menopausal onset. Conclusion: Decreased Total Power of patients with post-menopausal onset indicated that they may have had decreased activity of autonomic nervous system. Also, the patients with pre-menopausal onset had relatively increased sympathetic activity than the patients with post-menopausal onset.