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Association between the GRIN2B Gene and Age of Onset in Obsessive-Compulsive Disorder  

Hwang, Syung-Shick (Pyeongnae Psychiatric Hospital)
Roh, Dae-Young (Department of Psychiatry, Yonsei University College of Medicine)
Kim, Chan-Hyung (Department of Psychiatry, Yonsei University College of Medicine)
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Anxiety and mood / v.7, no.1, 2011 , pp. 34-39 More about this Journal
Abstract
Objectives : An early age at onset of obsessive compulsive symptoms in family studies has been strongly associated with a more familial form of obsessive compulsive disorder (OCD). Further, many reports have suggested that early- and late- onset OCD represent separate subtypes of the disorder. The aim of this study was to investigate the associations between the glutamate receptor, the ionotropic, n-methyl-d-aspartate (NMDA) subunit 2B gene (GRIN2B) polymorphisms, and onset of OCD in the Korean population. Methods : We recruited 109 OCD patients and classified them into early- (age of onset <18 years) and late-onset groups (age of onset${\geq}$18). Genomic DNA was extracted from their blood after which the genotypes and allelic frequencies of the two GRIN2B polymorphisms (5072T/G and 5988T/C) were compared in the two groups. We also compared genetic data between child- (age of onset${\leq}$15) and adult-onset groups (age of onset${\geq}$19) using the same protocol. Results : There were no significant differences between the early- and late-onset groups with respect to genotype. Moreover, we could not find any differences in genotype frequencies between child and adult-onset groups. Conclusions : Our study suggested that GRIN2B polymorphisms (5072T/G and 5988T/C) do not affect the onset of OCD in Koreans. However, this finding has resulted from a preliminary study and thus, further study is required.
Keywords
Obsessive-compulsive disorder; GRIN2B gene; Age of onset;
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