• Biomedical Science Letters
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• v.26 no.2
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• pp.109-113
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• 2020

Dangyuja (Citrus maxima (Burm.) Merr.) is a native fruit of great economic importance in Jeju island in Korea. To provide experimental evidence for the antioxidant and anti-inflammation properties on extraction ethanol concentration of Dangyuja, 2 cultivars, including 30-year-old and 120-year-old were evaluated. 30-year-old Dangyuja 50%, 70% ethanol extracts had the highest polyphenol and flavonoid content, and the strongest 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity. To investigate the anti-inflammatory activity of Dangyuja ethanol extracts, we used BV-2 microglia cells and induced inflammation using lipopolysaccharide (LPS). Then, we measured levels of inflammatory mediators as nitric oxide (NO). Among the 6 extracts, 30-year-old Dangyuja 50% ethanol extracts show the highest anti-inflammatory activity. The results suggest that 30-year-old Dangyuja 50% ethanol extracts provides significant health benefits and may be used for developing new functional materials.

• Journal of Veterinary Clinics
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• v.35 no.6
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• pp.282-285
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• 2018

A 7 years old, male, Afghan hound (case 1) and a 10 years old, castrated male, Pekingese (case 2) were referred with dyspnea. In case 1, thoracic radiographs showed moderate amount of pleural effusion and lobar sign in the left cranial lung lobe. Following computed tomographic (CT) examination, lung lobe torsion in left cranial lung lobe was diagnosed. In case 2, thoracic radiographs showed increased cranial lobar opacity but there was no evidence of pleural effusion. CT examination revealed an abrupt ending bronchus in the left cranial lung lobe. Based on the imaging diagnosis, left cranial lung lobectomy was performed in both cases. Case 1 showed increased lobar opacity and pleural effusion, while case 2 just showed less concrete evidence of lung lobe torsion on thoracic radiographs and marked severe chronic suppurative pneumonia was histopathologically confirmed. In conclusion, CT could be an important modality when atypical lung disease is suspicious.

• Journal of Korea Entertainment Industry Association
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• v.13 no.7
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• pp.285-294
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• 2019

The purpose of this study is to assess construct validity and verify the concept of the Happiness-enhancing Activities and Positive Practices Inventory(HAPPI) developed by Henricksen & Stephens(2013), for Korean old adults who participating physical activities with measuring happiness-related propensity. In this study, the research model was confirmed by evidenced based on the content validity, EFA, construct validity of the latent structure analysis with CFA, reliability as internal consistency. Using self-reported questionnaire conducted among 370 participants who physical activities. Total of 344 data were selected. As a result, internal consistency α was acceptable. Evidence-based on convergent and discriminant of the CFA as GFI=.925, CFI .962, TLI .953, and RMSEA .062 appeared significantly. Model goodness-of-fit, C.R. ratio(Critical ratio: estimates/SE) and Squared Multiple Correlations(SMC), and average variance extracted(AVE) was verified with the hypothesis of the model. Therefore, HAPPI validity evidence for the model fit was confirmed. In conclusion, the HAPPI 4 factors and 16 items(Other-focused, Personal recreation and interests, Achievement, Self-Concordant Work, Spiritual and thought-related) has reliable evidence to apply for Korean old adults and applicable assessment of happiness.

• Imaging Science in Dentistry
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• v.32 no.1
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• pp.49-53
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• 2002

Orofacial pain can be caused by intracranial disorders or can be musculoskeletal, vascular, internal derangemental, and neurologic in origin. The neurologic pain is derived from structural and functional disorders of nerve, and the trigeminal neuralgia is the typical manifestation. Trigeminal neuralgia is known from centuries ago, and is one of the most common pains in human. We present our experience with three patients who have trigeminal neuralgia. The first case is a 50-year-old female who had no specific evidence radiographically. Second is a 50-year-old male with microvascular compression on right trigeminal nerve. The third case is a 60-year-old female who had a neoplasm in cerebellopontine angle with associated mass effect.

• KDI Journal of Economic Policy
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• v.35 no.4
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• pp.1-29
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• 2013

This paper examines the effect of trade liberalization or globalization, more broadly, on plants' growth as well as on "bi-polarization". To do so, we reviewed the possible theoretical mechanisms put forward by recent heterogeneous firm trade theories, and provided available micro-evidence from existing empirical studies on Korean manufacturing sector. Above all, the empirical evidence provided in this paper strongly suggests that globalization promoted growth of Korean manufacturing plants. Specifically, evidence suggests that exporting not only increases within-plant productivity but also promotes introduction of new products and dropping of old products. However, the empirical evidence also suggest that globalization has some downsides: widening productivity differences across plants and rising wage inequality between skilled and unskilled workers. Specifically, trade liberalization widens the initial productivity differences among plants through learning from export market participation as well as through interactions between exporting and R&D, both of which increase plants' productivity. We also show that there is only a small group of large and productive "superstar" plants engaged in both R&D and exporting activity, which can fully utilize the potential benefits from globalization. Finally, we also show evidence that trade liberalization interacts with innovation to increase the skilled-unskilled wage inequality.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.32 no.1
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• pp.44-52
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• 2014

The purpose of this study is to investigate the tendency of the research on the traditional scenery architecture based on the old literature for the last 10 years and to suggest direction of the research on the traditional scenery through utilization of the old literature. For the tendency analysis of the research on the traditional scenery, I investigated and analyzed researches published in the Journal of the Korean Institute of Traditional Landscape Architecture between 2002 and 2012, and reviewed the utilization of the old literature about research on the traditional scenery. The number of the research papers through the old literature was two or three a year by 2009, but has increased to more than eight from 2010. The utilization tendency of the old literature was mostly to use the Korean translations or to use a collection of an individual's works after partially translating. As some of the researches were carried out only through translations even when they used the original, historical evidence on the translation of the original was insufficient. I can suggest the direction of the research on the traditional scenery by the results as follows: it is necessary to present both translation and the original and to specify the source of translation, for the efficient understanding and verification of the original. Professional translation of landscape architecture and scenery also seems to be necessary for the records of the current state. For the analysis of the old literature, as the analysis of the traditional scenery both through poetry and records facilitates assumption of the location of landscape by the abundant data, it seems to be necessary to approach research, using poetry and prose complementarily, after preparing foundation of research based on the records.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.2137-2139
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• 2013

Breast cancer is the most common cancer among females, worldwide, accounting for 22.9% of all cancers (excluding non-melanoma skin cancer) in females. Mammography is a sensitive (77-95%) and specific (94-97%) screening method for breast cancer. Previously, females between the 40-50 years old were recommended to have mammograms every one to two years. However, based on current evidence, in 2009, USPSTF recommended that the decision to start regular, biennial screening mammography for females younger than 50 years should be an individual decision and take patient context into account, including the patient's values regarding specific benefits and harms. This decision was based on findings regarding radiation exposure, false-positive and false-negative rates, over-diagnosis, and pain and psychological responses. The goal of this paper is to focus on evidence for updating the U.S. Preventive Services Task Force (USPSTF) recommendation against routine mammography for females between 40-49 years of age.

• CELLMED
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• v.2 no.2
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• pp.18.1-18.16
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• 2012

An oncology-specific database called OncoRx (http://bit.ly/cancerRx) was previously set up in cyberspace to aid clinicians in identifying interactions of anticancer drugs (ACDs) and chemotherapy regimens with traditional Chinese medicines (TCMs) and complementary and alternative medicines (CAMs). Since then, users have requested the drug-CAM interactions (DCIs) of 5 specific CAMs (cranberry, melatonin, co-enzyme Q10, huachansu, reishi mushroom) to be updated in the database. Pharmacokinetic properties (metabolism, enzyme induction/inhibition, elimination), TCM properties and DCIs of each CAM were collated with 117 ACDs using 9 hardcopy compendia and online databases as resources. Additionally, individual ACDs and CAMs were used as keywords for PubMed searches in combination with the terms 'anticancer drugs', 'drug interactions', 'herb-drug/drug-herb interactions', 'pharmacokinetic interactions' and 'pharmacodynamic interactions'. DCI parameters consisted of interaction effects, evidence summaries, proposed management plans and alternative non-interacting CAMs, together with relevant citations and update dates of the DCIs. OncoRx is also used as a case to introduce the "Four Pharmaco-cybernetic Maxims" of quality, quantity, relationship and manner to developers of digital healthcare tools. Its role in Hayne's "5S" hierarchy of research evidence is also presented. OncoRx is meant to complement existing DCI resources for clinicians and alternative medicine practitioners as an additional drug information resource that provides evidence-based DCI information for ACD-CAM interactions.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.27.3-27.3
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• 2021

Supernova (SN) cosmology is based on the assumption that the width-luminosity relation (WLR) in the type Ia SN luminosity standardization would not vary with progenitor age. Unlike this expectation, recent age datings of stellar populations in host galaxies have shown significant correlations between progenitor age and Hubble residual (HR). It was not clear, however, how this correlation arises from the SN luminosity standardization process, and how this would impact the cosmological result. Here we show that this correlation originates from a strong progenitor age dependence of the WLR and color-luminosity relation (CLR), in the sense that SNe from younger progenitors are fainter each at given light-curve parameters x1 and c. This is reminiscent of Baade's discovery of two Cepheid period-luminosity relations, and, as such, causes a serious systematic bias with redshift in SN cosmology. We illustrate that the differences between the high-z and low-z SNe in the WLR and CLR, and in HR after the standardization, are fully comparable to those between the correspondingly young and old SNe at intermediate redshift, indicating that the observed dimming of SNe with redshift is most likely an artifact of over-correction in the luminosity standardization. When this systematic bias with redshift is properly taken into account, there is no evidence left for an accelerating universe, and the SN data now support a decelerating cosmic expansion. Since the SN cosmology has long been considered as the most direct evidence for an accelerating universe with dark energy, this finding poses a serious question to one of the cornerstones of the concordance model.

• Journal of Gastric Cancer
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• v.11 no.3
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• pp.180-184
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• 2011

Letrozole is a drug used in the treatment of postmenopausal women with breast and ovarian tumours. There is no evidence in the literature indicating its use in treating gastric cancer. We present a 68 year old lady admitted from the emergency department with weight loss, malaise and anaemia. Investigations confirmed the presence of two different primary tumours in the left breast and the stomach. Following that this patient with oestrogen receptor positive breast cancer and oestrogen receptor negative gastric cancer was treated with letrozole for her breast cancer followed by a gastric resection. Independent histology by two pathologists pre-operatively diagnosed gastric adenocarcinoma. Post-operatively, independent analysis of the resected stomach, omentum and lymph nodes revealed no evidence of gastric cancer. Therefore we conclude that there is a possibility of letrozole having an effect on gastric cancer. Further studies are needed.