• Psychiatry investigation
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• v.15 no.12
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• pp.1130-1134
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• 2018

Objective Trichotillomania is a relatively common illness whose neurobiology is poorly understood. One treatment for adult trichotillomania, n-acetyl cysteine (NAC), has antioxidative properties, as well as effects on central glutamatergic transmission. Preclinical models suggest that excessive oxidative stress may be involved in its pathophysiology. Methods Adults with trichotillomania provided a blood sample for analysis of compounds that may be influenced by oxidative stress [glutathione, angiotensin II, ferritin, iron, glucose, insulin and insulin growth factor 1 (IGF1), and hepcidin]. Participants were examined on symptom severity, disability, and impulsivity. The number of participants with out-of-reference range oxidative stress measures were compared against the null distribution. Correlations between oxidative stress markers and clinical measures were examined. Results Of 14 participants (mean age 31.2 years; 92.9% female), 35.7% (n=5) had total glutathione levels below the reference range (p=0.041). Other oxidative stress measures did not have significant proportions outside the reference ranges. Lower levels of glutathione correlated significantly with higher motor impulsiveness (Barratt Impulsiveness Scale sub-score) (r=0.97, p=0.001). Conclusion A third of patients with trichotillomania had low levels of glutathione, and lower levels of glutathione correlated significantly with higher motor impulsiveness. Because NAC is a precursor for cysteine, and cysteine is a rate limiting step for glutathione production, these results may shed light on the mechanisms through which NAC can have beneficial effects for impulsive symptoms. Confirmation of these results requires a suitable larger follow-up study, including an internal normative control group.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.32 no.3
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• pp.93-98
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• 2021

Electroencephalography (EEG) measures neural activation due to various cognitive processes. EEG and event-related potentials (ERPs) are widely used in studies investigating psychopathology and neural substrates of psychiatric diseases in children and adolescents. The present study aimed to review recent ERP studies in child and adolescent psychiatry. ERPs are non-invasive methods for studying synaptic functions in the brain. ERP might be a candidate biomarker in child-adolescent psychiatry, considering its ability to reflect cognitive and behavioral functions in humans. For the EEG study of psychiatric diseases in children and adolescents, several ERP components have been used, such as mismatch negativity, P300, error-related negativity (ERN), and reward positivity (RewP). Regarding executive functions and inhibition in patients with attention-deficit/hyperactivity disorder (ADHD), P300 latency, and ERN were significantly different in patients with ADHD compared to those in the healthy population. ERN showed meaningful changes in patients with anxiety disorders, such as generalized anxiety disorder, separation anxiety disorder, and obsessive-compulsive disorder. Patients with depression showed significantly attenuated RewP compared to the healthy population, which was related to the symptoms of anhedonia.

• Journal of mucopolysaccharidosis and rare diseases
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• v.5 no.1
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• pp.29-33
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• 2021

Prader-Willi Syndrome (PWS) is a neurodevelopmental genomic imprinting disorder involving a lack of gene expression from the paternal chromosome 15q11-q13 region. This is typically due to paternal 15q11-q13 deletions (in approximately 60% of cases), maternal uniparental disomy 15, or when both 15s are from the mother (about 35% of cases). An imprinting center controls the expression of imprinted genes in the chromosome 15q11-q13 region. PWS is a neurodevelopmental disorder characterized by mental retardation and distinct physical, behavioral, and psychiatric features. Characteristic behavioral disturbances in PWS include excessive interest in food, skin picking, difficulty with a change in routine, temper tantrums, obsessive and compulsive behaviors, and mood fluctuations. Individuals with PWS typically have intellectual disabilities (borderline to mild/moderate mental retardation) and exhibit a higher overall level of behavior disturbances compared to individuals with similar intellectual disabilities. This condition severely limits social adaptations and quality of life. Different factors have been linked to the intensity and form of these behavioral disturbances, but there is no consensus regarding the cause. Consequently, there is still controversy surrounding management strategies and there is a need for new data. PWS is a multisystem disorder. Family members, caregivers, physicians, dieticians, and speech-language pathologists all play an important role in the management and treatment of symptoms in an individual with PWS. Here we analyze behavioral problems in children and adults with PWS by age and review appropriate management and treatment strategies for these symptoms.

• International journal of advanced smart convergence
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• v.10 no.2
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• pp.123-129
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• 2021

The purpose of this study is to analyze the relationship between dance passion, self-management, and dance immersion. Specifically, passion for dance was subdivided into obsessive-compulsive passion and harmonious passion, and these were selected as exogenous variables. In addition, it is intended to provide theoretical and educational implications by analyzing the structural equation model composed of endogenous variables of self-management and dance immersion. The subjects of this study were college students majoring in dance, and the final 206 students were selected as effective samples by the convenient sampling method. For data processing, frequency analysis and reliability analysis were performed using SPSS 23. In addition, AMOS 21 was used for confirmatory factor analysis, correlation analysis, and structural equation model analysis. As a result of the study, first, it was found that both compulsive passion and harmonious passion have a positive effect on self-management. Second, self-management was found to have a positive effect on dance immersion. Third, it was found that compulsive passion had a positive effect on dance commitment, but harmonious passion did not have a statistically significant effect on dance commitment.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.33 no.4
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• pp.91-98
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• 2022

Objectives: Comprehensive behavioral intervention for tics (CBIT) is effective in children with chronic tic disorders. This study aimed to assess the effect of group-based CBIT (group-CBIT) on tic severity and comorbid symptoms. We compared the efficacy of group CBIT with that of a control. Methods: Thirty children with chronic tic disorder or Tourette's disorder were enrolled in this study. Eighteen were assigned to the group-CBIT for eight sessions, and 12 were assigned to the control group. Tics and comorbid symptoms were assessed pre- and post-intervention using the Yale Global Tic Severity Scale (YGTSS), Premonitory Urge for Tics Scale, attention-deficit hyperactivity disorder Rating Scale-IV, Children's Yale-Brown Obsessive-Compulsive Scale, and the Korean-Children Behavioral Checklist. We compared the pre- and post-intervention results of each group and determined the difference in the pre- and post-intervention results between intervention and the control group. Results: The YGTSS motor and vocal tic interference, global impairment, and global severity scores decreased in the intervention group only. Group CBIT was superior in reducing the motor tic interference, impairment score, and global severity score to the control group. Conclusion: The group-CBIT showed an improvement in tic symptoms, especially in reducing the level of interference and impairment of tics.

• Journal of Digital Convergence
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• v.12 no.4
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• pp.409-418
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• 2014

The purpose of this study is to verify the causal relationship between the smartphone addiction proneness, mental health, and impulsiveness of high school students in Korea. 804 first and second year high school students participated in the survey that included the Smartphone addiction scale, Korean Brief Mental Diagnosis Exam - the highest 25% of total score (Addictive SmartPhone Use Group : ASPUG 213 persons), the lowest 25% of total score(Non-Addictive SmartPhone Use Group : NASPUG 204 persons), BIS-II Impulsiveness Scale and additional questions asking for demographical characteristics. The outcomes of this study were as follows. First, sex, grade of high school, academic accomplishment, student's satisfaction with school life, monthly allowance, the level of parental respect, having a opposite sex friend were related to smartphone addiction and impulsiveness. Second, ASPUG had worse mental health and impulsiveness than NASPUG, and the difference was statistically significant. Third, Students showed higher levels of mental health 9 subareas - anxiety, depression, phobic anxiety, Somatization, obsessive compulsive, interpersonal sensitivity, hostility, Paranoid ideation, Psychosis as their smartphone use increased.

• Journal of Korean Academy of Nursing
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• v.39 no.4
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• pp.602-612
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• 2009

Purpose: The purpose of this study was to identify type of anger expression and mental health in middle aged women. Methods: From August to October 2005, survey data were collected by using the State Trait Anger Expression Inventory and Symptom Check List-90-Revision (SCL). Participants (1,442) were classified into four types of anger expression by K-mean cluster analysis. For collecting interview data for content analysis, 18 participants (4-5 participants from each type of anger expression) were recruited. The interview data were collected between March and September 2006. Results: The average score of the state anger of middle-aged women was 11.95, and that of the trait anger was 18.75. The average anger expression scores were 12.72 for Anger-In, 13.45 for Anger-Out, and 18.51 for Anger-Control. The average SCL scores were 45.03 for somatization, 42.23 for obsessive-compulsiveness, 42.44 for interpersonal sensitivity, 42.45 for depression, 42.40 for anxiety, 42.62 for hostility, 44.44 for phobic anxiety, 43.65 for paranoid ideation, and 43.08 for psychoticism. The anger expression types identified in this study were 1) anger-out in secret, 2) anger-control with a patience, 3) anger-out with suppression, and 4) low anger expression type. The psychosomatic symptom scores were the highest in type III (anger-out with suppression), and the lowest in type IV (low anger expression type). Conclusion: This study can be helpful in assisting middle aged women to control their anger effectively and may contribute to the improvement of their mental health.

• Korean Parent-Child Health Journal
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• v.12 no.1
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• pp.25-36
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• 2009

Purpose: The purpose of this study was to explore the patterns of internet usage among 5th and 6th grade elementary students, and analyze the correlation between the internet obsessive disorder and parent-child attachment. Method: A total of 303 elementary students in Seoul, Suwon, Ulsan, and Kwangjoo area participated in this study, and responded to self-administrated questionnaires. Results: With regard to the internet addiction, 2.7% of participants were classified as being in a high risk group, and 5.3% were classified as a potential risk group with boys at greater risk than girls, and 6th graders showing higher internet addiction scores than 5th graders. There were significant negative correlations between internet addiction and father-child attachment (r=-.122, p=.040), and mother-child attachment (r=-.154, p=.009). Conclusion: To prevent internet addiction in elementary school students, promoting parent-child interaction needs to be emphasized. More studies for finding affecting variables on internet addiction would be necessary, and different preventive approaches according to gender and grade should be introduced.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.16 no.1
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• pp.124-131
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• 2005

Childhood and adolescent onset-bipolar disorders have higher rate of comorbidity with anxiety disorders as well as attention deficit hyperactivity disorder and conduct disorder. Obsessive compulsive disorder, social phobia, panic disorder, and separational anxiety disorder are common comorbid anxiety disorders with bipolar disorders in child and adolescent. Prospective and reliable data on temporal and causal relationship between the onset of bipolar disorders and the onset of comorbid anxiety disorders are still in debate. The authors report 2 adolescent cases with antidepressant induced-manic episodes with preceding anxiety symptoms. The authors suggest careful prescription of antidepressants for anxiety disorders, even for those who do not have definite past history or family history of bipolar disorders. Further comprehensive and prospective studies are requested for the temporal relationship and pharmacological guideline for comorbid bipolar disorders and anxiety disorder in child and adolescent.

• Journal of the Korea Convergence Society
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• v.7 no.1
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• pp.31-36
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• 2016

Recently with the wide spread smart devices and the flexible forms of work such as working from home due to changes in work practices, people are getting various information easily. Many women with a baby get to be interested in foods, health, and growth of their baby and the new task of raising a baby comes with a new burden added to taking care of their family and can develop into obsessive compulsive disorder to be a great mother. So many mothers suffer from child-rearing stress. Also, as the balance of work and life in mobile environment emerged as an important issue, the need for integrated information management applications that give infant care assistance to new mothers was increased. This study analyzed preferences on infant care information apps and developed prototype apps for infant care information management that can provide integrated customized infant care information that is actually needed.