• Journal of Life Science
• /
• v.33 no.3
• /
• pp.295-303
• /
• 2023

Immune and metabolic systems are important factors in maintaining homeostasis. Immune response and metabolic regulation are highly associated, so, when the normal metabolism is disturbed, the immune response changed followed the metabolic diseases occur. Likewise, obesity is highly related to immune response. Obesity, which is caused by an imbalance in energy metabolism, is associated with metabolic diseases, such as insulin resistance, type 2 diabetes, fatty liver diseases, atherosclerosis and hypertension. As known, obesity is characterized in chronic low-grade inflammation. In obesity, the microenvironment of immune cells became inflammatory by the unique activation phenotypes of immune cells such as macrophage, natural killer cell, T cell. Also, the immune cells interact each other in cellular or cytokine mechanisms, which intensify the obesity-induced inflammatory response. This phenomenon suggests the possibility of regulating the activation of immune cells as a pharmacological therapeutic strategy for obesity in addition to the common pharmacological treatment of obesity which is aimed at inhibiting enzymes such as pancreatic lipase and α-amylase or inhibiting differentiation of preadipocytes. In this review, we summarize the activation phenotypes of macrophage, natural killer cell and T cell, and their aspects in obesity. We also summarize the pharmacological substances that alleviates obesity by regulating the activation of immune cells.

• Korean Journal of Community Nutrition
• /
• v.12 no.3
• /
• pp.361-371
• /
• 2007

The purpose of this study was to assess the daily steps, physical activities and activity coefficient of the elementary school children in the rural area. Body weight, height and daily steps were measured and one-day activity diaries were collected by interviewing children. The average age of the subjects was $9.96{\pm}1.02$ years. Average height, weight, obesity index, body fat and muscle of subjects were $136.2{\pm}8.9cm,\;35.2{\pm}8.5kg,\;99.6{\pm}18.8%,\;22.9{\pm}8.5%\;and\;35.8{\pm}6.0%$, respectively. The average daily steps of the subjects was 17,584 and daily steps (19,314) of 3rd grade students was significantly higher than that (15,712) of 5th grade children. But there was no significant difference in daily steps and activity coefficients between boys and girls. Daily steps (23,347) of exercise group showed the significantly higher than that (16,144) of non-exercise group. Gender and grade of subjects did not have significant influence on activity coefficients, but there was a significant difference in activity coefficient on weekdays between the exercise group ($1.82{\pm}0.30$) and non-exercise group ($1.50{\pm}0.21$). Analysis of variance revealed stronger associations between daily steps and body fat (%) than between daily steps and BMI. Daily steps showed significant negative correlation with body fat (%) measured using two methods r=-0.321 and r=-0.365, respectively. Activity coefficient was significantly correlated (r=0.436) with daily steps, thus increasing daily steps cm prevent and treat childhood obesity by increasing the energy expenditure. The higher activity coefficients (weekday 1.56, weekend 1.53) of the subjects was caused by the fact that rural students spent more time outside and enjoyed stronger activities than urban students. The results of this study can be used to estimate energy requirements for Korean children based on exercise levels and living areas.

• Journal of the Korean Applied Science and Technology
• /
• v.37 no.5
• /
• pp.1378-1389
• /
• 2020

The purpose of this study was to develop a integrated obesity management program and measure the effects of the program on obesity, life style, dietary self-efficacy and exercise self-efficacy among obese elementary school children. The integrated obesity management program was provided for the experimental group of 4~6th grade elementary school students for 8 weeks. The program included obesity related health educations based on behavior modification and self-efficacy once a week, exercise classes three times a week. Method: There were 30 children with obesity in the experimental and 28 in the control groups. The collected data were analyzed by the 𝑥²-test, independent t-test and repeated measure ANOVA. Results: After 8weeks of participation in the program, the experimental group showed significantly lower body mass index (p<.01), percent body fat(p<.05) and obesity index(p<.01), significantly higher life style (p<.05)), dietary self-efficacy(p<.001), exercise self-efficacy(p<.05) than those in the control group. Conclusion: This study provides evidence that integrated obesity management program is effective nursing intervention for managing child obesity.

• Child Health Nursing Research
• /
• v.15 no.1
• /
• pp.61-70
• /
• 2009

Purpose: The purpose of this study was to identify the Health Promotion Life Profile of normal-weight and obese children, and factors related to obesity in elementary school children, and provide basic data for the development an obesity management program for these children. Method: The survey participants were 878 fourth to sixth grade elementary school children in Gwangju. $x^2$-test, t-test, ANOVA and multiple logistic regression with the SPSS program were used to analyze the collected data. Results: The Health Promotion Life Profile showed significant differences between normal-weight and obese groups according to food habits (t=3.305, p= .001) and exercise habits (t=-4.065, p=< .001). The Health Promotion Life Profile of obese children was also significantly different according to interest in weight control (F=3.044, p= .050), regular breakfast (F=3.699, p= .014), regular meals (F=6.868, p= .002). The multiple logistic regression analysis, showed that factors in obesity were significantly different according to gender, interest in weight control, fast eating, overeating and predilection for some food. Conclusion: The results of this study suggest that items on Health Promotion Life Profile such as food habits and exercise habits should be included in education programs to prevent obesity in elementary school children.

• Journal of Korean Public Health Nursing
• /
• v.18 no.2
• /
• pp.299-311
• /
• 2004

Purpose: Somatotype drawing developed by Sorensen et al.(1983) has been evaluated as a simple instrument of obesity level without real somatic measuring as height and weight. This study was designed to validate somatotype drawings for obesity assessment by bioelectrical impedance body component analysis. Method: At first questionnaire of somatotype drawing was done. Subjects were measured body component by bioelectrical impedance analysis as weight, BMI(body mass index), WHR(waist-hip ratio), body water, protein mass, mineral mass, body fat mass, skeletal muscle mass, soft lean mass, fat free mass and percent body fat. We evaluated correlations between these data and somatotype drawings and tried to grouping of somatotype drawings with the means of major body component value. Result: The data were collected from 205 college women whose height and weight were $161.2\pm4.8,\;55\pm8.3$. Spearman's correlation coefficients of somatotype drawing were 0.74 with BMI, 0.68 with weight 0.69 with body fat mass, 0.65 with WHR. 0.64 with percent body fat after adiusted age. The grade of somatotype drawings were grouped as 1-2, 3-4, 5-6. 7-9 by BMI, body fat mass, weight, 1, 2-4, 5-6, 7-9 by WHR and 1-2, 3-4, 5-9 by percent body fat(ANOVA and Duncan's method). Conclusion: So quick instrument using somatotype drawings were useful tools for evaluation of obesity level and is applicable to screen degree of body fat in self-administered questionnaire survey.

• The Korean Journal of Community Living Science
• /
• v.18 no.4
• /
• pp.629-638
• /
• 2007

The aim of this study was to provide fundamental data by degree of obesity which was necessary to nutritional education for the formation of right eating and dietary guideline by researching food habits of children. In order to achieve this purpose, a survey was conducted on 3, 4, 5, 6th grade of students from 4 schools in S and G city in Jeolla-Namdo. The results was as follows. There were 384(44.4%) students were normal weight, 193(22.3) were overweight, and 287(33.2) were low weight by obesity indices. Comparing the student's subjective health condition among the degree of obesity, 40.4% of overweight recognized they were healthy, 30.1% recognized ordinary, and 57.1% of lean recognized they were healthy, 34.5% recognized ordinary. It was turned out that most students who were overweight and lean recognized healthy and normal. Family was reported to be the most impact factor on student's diet habits, and then Multimedia such as TV seemed to have a effect on overweight and lean students, but nutrition teachers had a direct influence on normal weight students. The most thing which eating habits for a reform was unbalanced diet. The students in this research have breakfast everyday and regularly. Regarding dietary attitudes, overweight group enjoyed eating healthy food more than normal and low body weight group did, and tried to eat what they have never eaten before. In conclusion, it's necessary for elementary school students that increase the control ability of self perceived health condition with education for good eating habit and grasp their condition themselves through the nutrition education in school.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.10
• /
• pp.4161-4168
• /
• 2015

Colorectal cancer (CRC) is a worldwide health problem, being the third most commonly detected cancer in males and the second in females. Rising CRC incidence trends are mainly regarded as a part of the rapid 'Westernization' of life-style and are associated with calorically excessive high-fat/low-fibre diet, consumption of refined products, lack of physical activity, and obesity. Most recent epidemiological and clinical investigations have consistently evidenced a significant relationship between obesity-driven inflammation in particular steps of colorectal cancer development, including initiation, promotion, progression, and metastasis. Inflammation in obesity occurs by several mechanisms. Roles of imbalanced metabolism (MetS), distinct immune cells, cytokines, and other immune mediators have been suggested in the inflammatory processes. Critical mechanisms are accounted to proinflammatory cytokines (e.g. IL-1, IL-6, IL-8) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$). These molecules are secreted by macrophages and are considered as major agents in the transition between acute and chronic inflammation and inflammation-related CRC. The second factor promoting the CRC development in obese individuals is altered adipokine concentrations (leptin and adiponectin). The role of leptin and adiponectin in cancer cell proliferation, invasion, and metastasis is attributable to the activation of several signal transduction pathways (JAK/STAT, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3 kinase (PI3K), mTOR, and 5'AMPK signaling pathways) and multiple dysregulation (COX-2 downregulation, mRNA expression).

• Journal of Digital Convergence
• /
• v.14 no.4
• /
• pp.479-486
• /
• 2016

The purpose of this study was to investigate effects of 12-week physical activity intervention on obesity and metabolic syndrome risk factors and smartphone game time in children. A total of 27 children(fifth grade elementary school students) participated in this study. The subjects were divided to exercise group(n=16) and control group(n=11), and participants in exercise group performed running and jump rope(60min/day; 3days/week; 50~70% of THR) during 12-week. We analyzed measurement data using two-way ANOVA. As results, obesity indices except body weight and metabolic syndrome risk factor decreased significantly in exercise group compare with control group. And VO2max increased and smartphone game time decreased significantly in exercise group compare with control group. In conclusion, we suggest that 12-week exercise intervention in children has positive effects on obesity and metabolic syndrome and improve negative lifestyle such as smartphone game.

• Journal of Digital Convergence
• /
• v.18 no.3
• /
• pp.93-98
• /
• 2020

The subjects of this study were 10th grade students and 10 non-disabled students. For statistical programs, data were processed using SPSS Windows 25.0, and the statistical method used in the study was to calculate the mean and standard deviation of physical fitness factors and body mass index to determine the health and obesity of students with intellectual disabilities and non-disabled students. In addition, this study was conducted using the independent sample t-test to identify the differences in health fitness and obesity between intellectually and non-disabled students. The statistical significance level of the study was set at p <.05, and the results of the study showed that there were statistically significant differences in cardiopulmonary endurance, flexibility, muscle strength, muscle endurance, and responsiveness between middle and high school students with intellectual disabilities and non-disabled students. In the case of obesity, intellectually and non-disabled students were significantly different.

• Journal of Korean Academy of Nursing
• /
• v.40 no.6
• /
• pp.775-784
• /
• 2010

Purpose: The study was conducted to describe body shapes of school age children using the degree of obesity index (DOI) and body mass index obesity index classified by the Ministry of Education, Science and Technology (M-BOI) and Seoul Metropolitan Office of Education (S-BOI). Methods: In this cross sectional descriptive study health screening data for school children collected in 2007 was used. Results: Data were analyzed for 2,193 4th-6th grade boys (52%) and girls who attended 4 schools in rural areas. DOI determined that only 44.3% of students had average weight. This proportion was much lower than the results of other methods (74.3-77.6%). All three methods defined girls (51.3-61.8%) as skinnier than boys. Skinny and average body shaped children classified by DOI and obese children classified by S-BOI were heavier and taller and presented higher degrees of obesity (DO) and BMI scores than by other methods. M-BOI and S-BOI presented statistically significant positive correlations with weight, height, DO and BMI, while DOI was not correlated with height. Conclusion: BMI based body shape classifications provide a more rigorous classification of body shape which are favorable for school health professionals with limited resources and policy makers for internationally comparable references.