• The Journal of Pediatrics of Korean Medicine
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• v.21 no.1
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• pp.211-226
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• 2007

Objectives : These experimental studies were designed to investigate the effects of Bangpoongtongsungsankamibang on the weight and the lipid metabolism of the obese rats induced by 2% cholesterol diet. They were designed to change values in the serum and leptin levels in the rats. Materials and Methods : The serum and leptin levels were measured for a period of 8 weeks for obese SD rats induced by 2% cholesterol diet. Results : The body weight showed a tendency to decreased significantly in sample (p<0.05). The Total cholesterol and Triglyceride level significantly decreased in sample (p<0.05). The HDL Cholesterol levels significantly increased in sample (p<0.05). The LDH levels did not show a significant change in sample. The ALP levels significantly decreased in sample (p<0.05). The SGOT and SGPT level did not show a significant change in sample. The Leptin levels significantly decreased in sample (p<0.05). The average size of the epididymal fat cell significantly decreased in sample (p<0.05).

• The Journal of Korean Medicine
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• v.26 no.1 s.61
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• pp.148-160
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• 2005

Objective: We investigated the effects of deer antler extract (DAE) on the expression of the weight, leptin, and serum levels (lipid metabolism) of the obese SD rats induced by a $2\%$ cholesterol diet in vivo. Methods: In vivo, the weight, leptin and serum levels were measured after a period of 7 weeks for obese SD rats induced by a $2\%$ cholesterol diet and treated with DAE of three concentrations (0.938 g/kg/5ml, 1.875 g/kg/5ml, 3.75 g/kg/5ml). Results: 1. Body weight didn't change significantly. 2. Leptin levels significantly decreased (p<0.05). 3. Total cholesterol, triglyceride, LDH, sGOT & sGPT levels significantly decreased in the sample (p<0.05). 4. The HDL cholesterol levels significantly increased in the sample (p<0.05). 5. The average size of the epididymal fat cells significantly decreased as the concentration of deer antler extract increased (p<0.05). Conclusion: Deer antler effects inhibition of obese rats.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.2
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• pp.1-13
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• 2001

Objective : These experimental studies were designed to investigate the effects of Sargassum extract and Polygoni multiflori radix extract on the weight and the lipid metabolism of the obese rats induced by 1% cholesterol diet. They were designed to detect changes in the serum and leptin levels in the infant rats. Methods : The serum and leptin levels were measured for a period of 8 weeks for obese SD rats induced by 1% cholesterol diet. Result : 1. The body weight showed a tendency to decrease in samples I & II(P>0.05). 2. The average size of the epididymal fat cell significantly decreased in sample II(p<0.05), and showed a tendency to decrease in sample I(P>0.05). 3. The leptin levels significantly decreased in samples I & II(P<0.05). 4. The total cholesterol levels significantly decreased in samples I & II(P<0.05). 5. The triglyceride levels significantly decreased in sample I & II(P<0.05). 6. The glucose levels significantly decreased in sample I & II(P<0.05).

• Food Science and Biotechnology
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• v.15 no.1
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• pp.158-161
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• 2006

This study was designed to determine possible weight loss effects of Hangbisan, an oriental medicine, on Sprague-Dawley (SD) rats. SD rats that were fed a high-fat diet for 6 weeks to induce obesity and subsequently fed with a basic diet containing 10%(w/w) Hangbisan or 10%(w/w) cellulose for 8 weeks. The Hangbisan fed rats demonstrated a significantly (p<0.05) reduced weight gain compared to the cellulose fed rats as well as a reduced level of plasma cholesterol and triglycerides and an increased level of (HDL)-cholesterol. These results suggest that dietary Hangbisan has an anti-obesity effect in the high-fat diet-induced obesity (DIG) rat and therefore a potential use as an anti-obesity agent in the application of oriental medicine compounds.

• Toxicological Research
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• v.26 no.3
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• pp.185-192
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• 2010

Isaria sinclairii (Cicada Dongchunghacho) was studied as a potential crude natural food in powdered form. The role of tissue fatty acids in relation to the anti-obesity effects of I. sinclairii (IS) was examined by feeding the powder to SD rats ad libitum at 0, 1.25, 2.5, 5 and 10% (calculated about 8 g/kg) of the feed for a period of 3 months and 6 months. The fatty acid composition profile as indicated GC-MS, showed significantly slight dose-dependent increases in the levels of unsaturated fatty acids, particularly, arachidonic acid (C20: 4n6), oleic acid, linoleic acid, eicosadienoic acid, eicosapentaenoic acid (EPA) (C20: 5) concentration in the the ad libitum IS-fed groups compared to the control group in SD abdominal fat over 6 month period. Over viewing of the SD and Ob mice treated Isaria sinclairii powder; there were increases in the single (mono) unsaturated fatty acids ratio but decreases in polyunsaturated fatty acid. In IS-fed groups in proportion to the treatment period, this Dongchunghacho also induced an increase in the level of same result of unsaturated fatty acid in C57BL/6 obese (ob/ob) mice over a 6-month period treatment compared to those given 10% dry mulberry leaf powder (ML) or silkworm powder mixed with the standard diet.

• Molecules and Cells
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• v.38 no.12
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• pp.1044-1053
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• 2015

This study first investigated the effects of corn gluten hydrolysate (CGH) (1.5 g/day) administration for 7 days on appetite-responsive genes in lean Sprague-Dawley (SD) rats. In a second set of experiments, the metabolic changes occurring at multiple time points over 8 weeks in response to CGH (35.33% wt/wt) were observed in high-fat (HF, 60% of energy as fat) diet-fed SD rats. In lean rats, the hypothalamus neuropeptide-Y and proopiomelanocortin mRNA levels of the CGH group were significantly changed in response to CGH administration. In the second part of the study, CGH treatment was found to reduce body weight and perirenal and epididymal fat weight. CGH also prevented an increase in food intake at 2 weeks and lowered plasma leptin and insulin levels in comparison with the HF group. This reduction in the plasma and hepatic lipid levels was followed by improved insulin resistance, and the beneficial metabolic effects of CGH were also partly related to increases in plasma adiponectin levels. The Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR), an index of insulin resistance, was markedly improved in the HF-CGH group compared with the HF group at 6 weeks. According to the microarray results, adipose tissue mRNA expression related to G-protein coupled receptor protein signaling pathway and sensory perception was significantly improved after 8 weeks of CGH administration. In conclusion, the present findings suggest that dietary CGH may be effective for improving hyperglycemia, dyslipidemia and insulin resistance in diet-induced obese rats as well as appetite control in lean rats.

• Food Science and Preservation
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• v.20 no.1
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• pp.1-6
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• 2013

In this study, the effect of Curcuma longa L. on obesity and insulin resistance was investigated in animals fed a moderate high fat diet. The animals used in this study were normal weight Spargue-Dawley (SD) rats and type 2 diabetic obese db/db mice. Accumulation of abdominal adipose tissue and weight gain were inhibited in the animals fed the C. longa extract. C. longa decreased fasting insulin and HOMA-IR in the SD rats, and effectively decreased blood glucose and hemoglobin A1c in db/db mice. C. longa decreased serum free fatty acid (FFA) level in the SD rats. FFA in db/db mice fed C. longa tended to decrease. C. longa significantly decreased serum triglyceride level. Our results collectively represent that C. longa prevented fat accumulation and insulin resistance in both normal weight SD rats and type 2 diabetic obese db/db mice fed a moderate high fat diet.

• The Journal of Korean Medicine
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• v.27 no.3 s.67
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• pp.1-13
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• 2006

The purpose of this study was to investigate the anti-obesity effects of crude saponin (CS) in Korean red ginseng (KRG) on rats fed a high fat (HF) diet. Methods: Male Sprague-Dawley (SD) rats were divided into a normal diet group and a high-fat (HF) diet group. The HF diet group became obese from being fed a HF diet over five weeks. The normal diet group were fed a normal diet. Each CS group of the normal diet group and HF diet group was administered CS (200 mg/kg, i.p.) for three weeks, the control group of both types was administered normal saline (1ml/kg, i.p.) instead of CS. Each group had 5 rats. Results: After administration of CS, the body weight, food consumption, adipose tissues, and expression of appetite peptides such as leptin and neuropeptide-Y (NPY) were investigated in the HF diet group as well as the normal diet group. Administration of CS reduced body weight, food intake, and fat content in the HF and normal diet groups. After CS administration, NPY expression and leptin were lower in the HF diet group. Conclusions: Our results suggest that CS may be useful in the treatment of obesity, especially of type qixu (氣虛).

• Food Science and Biotechnology
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• v.15 no.1
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• pp.70-76
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• 2006

Anti-obesity effect of biocellulose and diet formulation containing it was evaluated using obese rats. Thirty male Sprague-Dawlely (SD) rats were randomly assigned to high-fat diet group (CON), high-fat diet group containing 5% biocellulose (BIO), and high-fat diet group containing 5% dietary formulation (DF). After 10 weeks, body weight gains of BIO and DF groups were reduced by 15.1 and 6%, respectively, as compared with CON group. Epididymus, parirenal, and visceral fat pads of BIO and DF groups were lower than those of CON group. Weight of interscapular brown adipose tissues increased slightly in BIO group and significantly in DF group. Size of adipocyte in rats decreased in BIO and DF groups. Results indicate biocellulose-containing diet has anti-obesity effect by reducing body weight gain and white adipocytes depots in rats fed high-fat diet.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.130.3-131
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• 2003

The biological effects of NADPH-dependent isocitrate dehydrogenase (IDPc) inhibitor. DA-11004, was examined in obese zucker rats or streptozotocin-induced diabetic SD rats. Diabetes was induced by injection of streptozotocin (50mg/kg) dissolved in citrate buffer (pH 4.8) into the tail vein and induction of diabetes was confirmed by the measurement of the tail blood glucose level at 48h. DA-11004 (30mg/kg, po) was injected for successive 7days and significantly reduced the plasma glucose in streptozotocin-induced diabetic rats (P<0.05). (omitted)