Browse > Article
http://dx.doi.org/10.5487/TR.2010.26.3.185

Fatty Acid Composition of Adipose Tissues in Obese Mice and SD Rats Fed with Isaria sinclairii Powder  

Ahn, Mi-Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Seo, Yun-Jung (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Ji, Sang-Deok (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Han, Jea-Woong (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Hwang, Jae-Sam (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Yun, Eun-Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Publication Information
Toxicological Research / v.26, no.3, 2010 , pp. 185-192 More about this Journal
Abstract
Isaria sinclairii (Cicada Dongchunghacho) was studied as a potential crude natural food in powdered form. The role of tissue fatty acids in relation to the anti-obesity effects of I. sinclairii (IS) was examined by feeding the powder to SD rats ad libitum at 0, 1.25, 2.5, 5 and 10% (calculated about 8 g/kg) of the feed for a period of 3 months and 6 months. The fatty acid composition profile as indicated GC-MS, showed significantly slight dose-dependent increases in the levels of unsaturated fatty acids, particularly, arachidonic acid (C20: 4n6), oleic acid, linoleic acid, eicosadienoic acid, eicosapentaenoic acid (EPA) (C20: 5) concentration in the the ad libitum IS-fed groups compared to the control group in SD abdominal fat over 6 month period. Over viewing of the SD and Ob mice treated Isaria sinclairii powder; there were increases in the single (mono) unsaturated fatty acids ratio but decreases in polyunsaturated fatty acid. In IS-fed groups in proportion to the treatment period, this Dongchunghacho also induced an increase in the level of same result of unsaturated fatty acid in C57BL/6 obese (ob/ob) mice over a 6-month period treatment compared to those given 10% dry mulberry leaf powder (ML) or silkworm powder mixed with the standard diet.
Keywords
Anti-diabetic effect; Isaria sinclairii; Obese mice; 6 months treatment;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Slawik, M. and Vidal-Puig, A.J. (2006). Lipotoxicity, overnutrition and energy metabolism in aging. Ageing Res. Rev., 5, 144-164.   DOI   ScienceOn
2 Tsuduki, T., Nakamura, Y., Honma, T., Nakagawa, K., Kimura, T.,Ikeda, I. and Miyazawa, T. (2009). Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the $\beta$-oxidation system in rat liver. J. Agri. Food. Chem., 57, 11024-11029.   DOI   ScienceOn
3 Ueda, H., Takahara, S., Itoh, S., Nomi, H., Shibahara, N. and Katsuoka,Y. (2005). Preoperative administration of FTY720 prolonged renal allograft survival. Transpl. Immunol., 14, 1-8.   DOI   ScienceOn
4 Vong, T., Benhaddou-Andaloussi, A., Brault, A., Harbilas D., Martineau,L.C., Vallerand, D., Ramassamy, C., Matar, C. andHaddad, P.S. (2009). Antiobesity and antidiabetic effects ofbiotransformed blueberry juice in KKA mice. Int. J. Obesity,33, 1166-1173.   DOI   ScienceOn
5 Liu, L.K., Chou, F.P., Chen, Y.C., Chayau, C.C., Ho, H.H. andWang, C.J. (2009). Effects of mulberry (Morus alba L.) extractson lipid homeostasis in vitro and in vivo. J. Agri. Food Chem.,57, 7605-7611.   DOI   ScienceOn
6 Neve, B.P., Fruchart, J.C. and Staels, B. (2000). Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis. Biochem. Pharmacol., 60, 1245-1250.   DOI   ScienceOn
7 Madsen, L., Petersen, R.K. and Kristiansen, K. (2005). Regulation of adipocyte differentiation and function by polyunsaturated fatty acids. Biochim Biophys Acta, 1740, 266-286.   DOI   ScienceOn
8 Mellor, H.R., Platt, F.M., Dwek, R.A. and Butters, T.D. (2003).Membrane disruption and cytotoxicity of hydrophobic N-alkylatediminosugars is independent of the inhibition of protein andlipid glycosylation. Biochem. J., 374, 307-314.   DOI   ScienceOn
9 Nevab, M., Berliner, J.A., Watson, A.D., Hama, S.Y., Terito, M.C., Lusis, A.J., Shih, D.M., Van Lenten, B.J., Frank, J.S., Demer, L.L., Edwards, P.A. and Fogelman, A.M. (1996). The Yin and Yang oxidation in the development of the fatty streak. Arteriosclerosis, Thromb. Vas. Biol., 16, 831-842.
10 Park, C.G., Park, G.B., Kim, Y.S., Kim, S.J., Min, D.B. and Ha,Y.L. (2006). Production of silkworm with conjuagated linoleicacid (CLA) incopotared into their lipids by dietary CLA. Agri.Food Chem., 54, 6572-6577.   DOI   ScienceOn
11 Pico, C., Sanchez, J., Oliver, P. and Palou, A. (2002). Leptin production by the stomach is up-regulation in obese (fa/fa) Zucker rats. Obes. Res., 10, 932-938.   DOI
12 Prowlowska, A.M., Oleszek, W. and Braca, A. (2008). Qualiquantitative analyses of flavonoids of Morus nigra L. andMorus alba L. (Moraceae) Fruits. J. Agric. Food Chem., 56, 3377-3380.   DOI   ScienceOn
13 Riley, R.T., Voss, K.A., Norred, W.P., Bacon, C.W., Meredith, F.I.and Sharma, R.P. (1999). Serine palmitoyltransferase inhibition reverses anti-proliferative effects of ceramide synthase inhibiton in cultured renal cells and suppresses free sphingoid base accumulation in kidney of BALBc mice. Environ. Toxicol. Pharmacol., 7, 109-115.   DOI   ScienceOn
14 Hall, J.E., Crook, E.D., Jones D.W., Wofford, M.R. and Dubbert,P.M. (2002). Mechanisms of obesity-associated cardiovascularand renal disease. Am. J. Med. Sci., 324, 127-137.   DOI   ScienceOn
15 Chiba, K.A. (2009). New therapeutic approach for autoimmune diseases by the spingosine 1-phosphate receptor modulator, fingolimod (FTY720). Jpn. J. Clin. Immunol., 32, 92-101.   DOI   ScienceOn
16 Furuya, T., Hirotani, M. and Matsuzuwa, M. (1983). N6-(2- hydroxyethyl) adenosine, a biologically active compound from cultured mycelia of cordyceps and Isaria species. Pytochemistry,22, 2509-2512.   DOI   ScienceOn
17 Grasa, M.M., Cabot, C., Esteve, M., Yubero, P., Masanes, R.M.,Blay, M.T., Vila, R., Lopez-Marti, J., .Fernandez-Lopez, J.A.,Remesar, X. and Alemany, M. (2001). Daily oral oleoyl-estronegavage induced a dose-dependent loss of fat in Wistar rats,Obes. Res., 9, 202-209.   DOI
18 He, M.L., Mir, P.S., Okine, E.K. and Napadajlo, H. (2009). Effect of conjugated linoleic acids from beef or industrial hydrogenation on growth and adipose tissue characteristics of rats. Nutr. Metab., 6, 19-32.   DOI   ScienceOn
19 Jee, S.H., Sull, J.W., Park, J., Lee, S.Y., Ohrr, H., Gualler, E. and Samet, J.M. (2006). Body-mass index and mortality in Korean men and women. New Engl. J. Med., 355, 779-787.   DOI   ScienceOn
20 Jequier, E. (2002). Leptin signaling, adiposity, and energy balance. Ann. NY Acad. Sci., 967, 379-388.
21 Kim, M.J. and Kim, H.K. (2009). Perilla leaf extract ameliorates obesity and dyslipidemia induced by high-fat diet. Phytotherapy Research, 23, 1685-1690.   DOI   ScienceOn
22 Ji, S.D., Nam, S.H., Jung, I.Y., Cho, S.Y., Song, B.K., Lee, H.S. and Choi, Y.S. (2001). The characteristics and nutrient content of entomopathogenic fungus, Isaria sinclairii. in Sericulture and Entomology Research. National Institute of Agricultural Science & Entomolgy, RDA, Suwon, pp. 177-183.
23 Ahn, M.Y., Han, J.W., Jee, S.D., Hwang, J.S., Hwang, S.J., Hong,Y.N. and Kim, S.N. (2007b). A Thirteen-week oral dose subchronictoxicity study of Isaria sinclairii in Rats. J. Toxicol.Pub. Health, 23, 363-371.   과학기술학회마을   DOI   ScienceOn
24 Ahn, M.Y., Jee, S.D., Kim, J.Y., Han, J.W., Lee, Y.K., Lee, Y.W.,Ryu, K.S., Lee, B.M., Jung, N.J. and Kim S.N. (2004). Thirteenweek repeated oral toxicity study of Paecilomyces sinclairii in Sprague-Dawely rats. J. Toxico.Pub. Health 20, 339-348.   과학기술학회마을
25 Ahn, M.Y., Jung, Y.S., Jee, S.D., Kim, C.S., Lee, S.H., Moon, C.H., Cho, S.I., Lee, B.M. and Ryu, K.S. (2007a). Antihypertensive effect of the Dongchunhacho, Isaria sinclairii, in the spontaneously hypertensive rats. Arch.Pharm. Res., 30, 493-501.   과학기술학회마을   DOI   ScienceOn
26 Ahn, M.Y., Kim, J.Y., Han, J.W., Jee, S.D., Hwang, J.S., Cho, S.I. and Yun, E.Y. (2007). Isaria sinclairii extract reduces body weight and ameliorates metabolic abnormalities, Int. J. Indust.Entomol., 14, 121-126.   과학기술학회마을
27 Asano, N., Yamashita, T., Yasuda, K., Ikeda, K., Kizu, H.,Kameda, Y., Kato, A., Nash, R.J., Lee, H.S. and Ryu, K.S.(2001). Polyhydroxylated alkaloids isolated from mulberrytrees (Morus alba L.) and silk worms (Bombyx mori L.). J.Agric. Food Chem., 49, 4208-4213.   DOI   ScienceOn
28 Chen, F.J., Nakashima, N. and Kimura, M. (1995). Hypoglycemic activity and mechanisms of extracts from mulberry leaves (Folium Mori) and Cortex Mori Radicis in streptozotocininduced diabetic mice. Yakugaku Zasshi, 115, 476-482.   DOI
29 Chen, Q. and Reimer, R.A. (2009). Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro. Nutrition, 25, 340-349.   DOI   ScienceOn
30 Cui, Z., Ahn, M.Y., Lee, Y.B. and Ryu, K.S. (2002). Bombycidaein Materia Medica from insects. Shinilbooks, Seoul, pp. 137-151.
31 Ahn, M.Y., Heo J.E., Ryu, J.H. and Jeong, H.K. (2008). Antioxi-dant activity of N-hydroxyethyl adenosine from Isaria sinclairii. Int. J. Indusr. Entomol., 17, 197-200.   과학기술학회마을
32 Ahn, M.Y., Jee, S.D., Lee, B.M., Yeon, J.H., Park, K.K., Hwang, J.S. and Yu, E.Y. (2010). Anti-diabetic effect and gene expression profiling in obese mice treated with Isaria sinclairii over a 6-month period. J. Toxicol. Environ. Health Part A, Nov. in print.
33 Ahn, M.Y., Jee, S.D. and Lee, B.M. (2007b). Antiobesity effects of an Isaria sinclairii by repeated oral treatment in obese Zucker rats over a 4-month period. J. Toxicol. Environ. Health Part A, 70, 1395-401.   DOI   ScienceOn
34 Ahn, M.Y., Jee, S.D. and Lee, B.M. (2007c). Antiobesity effects of an Isaria sinclairii by repeated oral treatment in obese Zucker rats over a 4-month period. J. Toxicol. Environ. Health Part A, 70, 1395-401.   DOI   ScienceOn