• 대한한의학방제학회지
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• 제31권4호
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• pp.373-388
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• 2023

Objectives : This study aimed to provide basic data for research by investigating non-clinical experimental studies on herbal medicines and its compounds for precocious puberty. Methods : A search was conducted for all literature until October 2023 using combinations of keywords such as precocious puberty, puberty, and chinese medicine in three databases (Pubmed, OASIS, and ScienceON). Results : 1. In animal experiments, studies were mainly conducted using a model that induced precocious puberty by subcutaneously administering danazol to SD rats on the 5th day after birth, and in cell experiments, precocious puberty was induced by treating GT1-7 cells with kisspeptin 10 or estradiol. 2. Anemarrhenae Rhizoma, Phellodendri Cortex, and Prunellae Spica were mainly used as herbal medicine to evaluate their efficacy on precocious puberty in non-clinical experiments. 3. Macroscopic observation, hematological analysis, histological analysis, and genetic analysis were performed as methods to analyze the experimental results. Conclusions : In this study, the effects of herbal medicine on precocious puberty and non-clinical research methods were confirmed. Based on the results of this study, it is expected that non-clinical effectiveness and mechanism research on materials that are clinically effective in Traditional Korean Medicine will be revitalized.

• 한국환경농학회지
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• 제34권4호
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• pp.274-281
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• 2015

영산강과 섬진강의 지천을 중심으로 총 22개 지점에서 4회에 걸쳐 농약(aldicarb, carbaryl, carbofuran, chlorpyrifos, 2,4-D, MCPA, methomyl, metolachlor, molinate)의 실태조사를 수행하였다. 하천수 시료에서 농약을 추출하기 위해 Oasis HLB 카트리지를 사용하였고 LC/ MS/MS를 이용하여 분석하였다. 시험법은 matrix-matched 내부표준검량곡선과 방법검출한계, 정량한계, 정확도, 정밀도, 회수율 등으로 정도관리를 수행하였다. 각 화합물의 방법검출한계는 모든 화합물이 국립환경과학원에서 제안하는 GV/10을 만족하였다. 모든 화합물의 상관계수(r²)는 0.9965- 0.9999로써 직선성이 매우 높았고 정확도와 정밀도는 각각 89.4-113.6%와 3.1-14.0%로써 매우 양호함을 알 수 있었으며 평균 회수율은 90.8-106.2%로 매우 우수하였다. Aldicarb를 제외한 모든 성분이 검출되었고, 특히 carbofuran과 metolachlor의 검출농도와 빈도가 높았는데 이들의 광범위한 적용 범위에 따른 많은 사용량에 기인한 것으로 판단되었다. 2,4-D와 MCPA는 1(5월), 2차(7월) 시료에서만 검출되었는데 이는 두 농약의 사용 적기와 일치하였다. Methomyl과 molinate는 사용 금지된 농약이었으나 일부 지역에서 검출되었고 이는 두 농약이 불법적으로 사용되었거나 과거에 사용되어 수계로 유입, 저질에 흡착된 일부분이 지금까지 용출되어 검출되었을 것으로 판단되었다. 영산강 및 섬진강 수계의 많은 하천수 시료에서 농약이 검출되었고 그 원인이 영농활동 중 농약의 사용이라고 단정할 수 없으나, 영산강과 섬진강 수계 인근의 주된 산업활동이 농업활동이고 농약의 주된 사용이 영농활동에 이루어지며 검출된 농약이 농작물에 대한 약제의 사용 시기와 부합하는 것을 미루어 보아 영산강과 섬진강 유역 농경지에서 사용된 농약이 수계로 유입되어 비점오염원으로 작용하는 것으로 판단되었다. 따라서 수생태계 보존을 위하여 농약에 대한 수질기준 설정이 절실히 요구되었고, 이를 위해 보다 많은 실태조사 결과의 축적과 꾸준한 연구 수행이 필요한 것으로 판단되었다.

• Restorative Dentistry and Endodontics
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• 제25권3호
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• pp.435-445
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• 2000

The purpose of this study was to compare the leakage of four different obturation techniques in conjunction with immediate apical barrier of ${\beta}$-tricalcium phosphate(TCP) in teeth with open apex. Eighty single-rooted human premolar teeth were prepared and sectioned horizontally, so maximum diameter in apex was 4mm. Apical defects that were similar to open apex, were created with #1/2 round bur and SF104R bur. The apical foramen were opened to a size 80 file extended 3mm beyond the apex. The teeth were placed into the oasis block soaked saline to simulate periapical tissue often associated with pulpless teeth and received apical barriers consisting of TCP followed by obturation using lateral condensation technique, vertical condensation technique, continuous wave technique and thermoplasticized gutta-percha injection technique. Two unobturated teeth served as positive and negative controls. Teeth were immersed in resorcinol-formaldehyde resin for S days at $4^{\circ}C$, and the resin was allowed to polymerize completely for 4 days at room temperature. Teeth were then sectioned horizontally at 1.5mm(level 1), 2.5mm(level 2) and 3.5mm(level 3) from the apex, and examined under a stereomicroscope at ${\times}40$ magnification. The photographs were taken at ${\times}40$ magnification of the filling in each level and scanned. The leakage length in tooth/resin interface was measured at each of the three levels. Each ratio of leakage was obtained by calculating the ratio of the leakage length of canal wall infiltrated with resin to the total length of the canal and was analyzed statistically(One-way ANOVA and Scheffe test). The result were as follows : 1. At the level 1, there was the least leakage in the thermoplasticized gutta-percha injection technique group(group 4), but there was statistically significant(p<0.05). 2. At the level 2, there was the least leakage in the thermoplasticized gutta-percha injection technique group(group 4), and the most leakage in the continuous wave technique group(group 3). There was statistically significant difference between the thermoplasticized gutta-percha injection technique group and the continuous wave technique group(p<0.05). 3. At the level 3, there was the least leakage in the thermoplasticized gutta-percha injection technique group(group 4), but there were no statistically significant differences between other groups(p>0.05). These results suggest that thermoplasticized gutta-percha injection technique which had 1mm apical gutta-percha matrix after the formation of TCP apical barrier, can demonstrate favorable apical sealing.

• 한방재활의학과학회지
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• 제27권3호
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• pp.61-70
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• 2017

Objectives The purpose of this review is to analyse the trend in papers related with Korean Medicine Treatment after musculoskeletal disorder surgery. Methods We reviewed Korean Medicine papers by searching Korean web databases 'Korea Traditional Knowledge Portal', 'Scientific and Technological Information Integration Service (NDSL)', 'Academic Research Information Service (RISS)', 'Korea Medical Informati on Portal (OASIS)'. We classified the papers by the year of publishment, the title of journals, the type of study, surgery region, chief complain after surgery, main treatment, periods after surgery, assessment for outcomes. Results 1. Korean Medicine treatment after musculoskeletal disorder surgery has received more attention than in the past and there are attempts to do various studies besides the case reports. 2. 41 research papers were divided in to 3 original articles, 3 review articles, 35 case reports. But almost presented a low level of evidence. 3. Pain was the most common symptom after the musculoskeletal disorder surgery. Pain should be the primary goal of Korean rehabilitation treatment after musculoskeletal disorder surgery. 4. Assessment tools for outcome were concentrated in questionnaries, VAS and NRS. In order to evaluate better, it is necessary to evaluate the overall condition of the patient such as the quality of life evaluation and patient satisfaction. Conclusions In this study, we expect that the development and clinical application of Korean rehabilitation treatment program after musculoskeletal disorder surgery will be actively pursued.

• 한국식품위생안전성학회지
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• 제23권4호
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• pp.319-323
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• 2008

식육 중 플로르페니콜을 분석하기 위하여 시료를 ethyl acetate로 추출 농축한 후 이 농축액을 acetonitrile과 n-hexane을 가하여 분획하고, acetonitrile층을 분리하여 농축하였다. 이를 Oasis HLB cartridge로 정제하고 $C_{18}$ 컬럼을 이용한 HPLC-FLD로 분석하였다. 분석법은 표준물질 $0.05{\sim}1.0\;mg/kg$의 농도범위에서 직선성($r^2=0.9997$)을 나타냈으며, 검출한계는 0.012 mg/kg, 정량한계는 0.039 mg/kg이었다. 또한 회수율은 쇠고기에서 $87.6{\sim}92.3%$, 돼지고기에서 $85.6{\sim}93.3%$, 닭고기에서 $92.9{\sim}95.6%$이었으며, 상대표준편차(RSD)는 쇠고기, 돼지고기, 닭고기에서 각각 $1.1{\sim}4.8%$, $1.1{\sim}3.4%$, $1.0{\sim}5.3%$이었다. 본 연구에서 확립된 분석방법으로 유통 중인 식육(쇠고기, 돼지고기, 닭고기) 150건을 전국 지역(서울, 부산, 대구, 대전, 광주)별로 수거하여 플로르페니콜의 잔류 실태를 조사한 결과, 돼지고기 1건에서 0.040 mg/kg이 검출되었으며, 돼지고기 2건, 쇠고기 1건, 닭고기 2건에서는 검출되었으나 정량한계 미만의 수준이었다. 이들 결과로부터 우리나라에서 유통 중인 조사한 식육 150건의 플로르페니콜 잔류량은 모두 국제기준에 적합한 것으로 조사되었다.

• Korean Journal of Acupuncture
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• 제40권3호
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• pp.79-89
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• 2023

Objectives : The purpose of this study is to investigate various application methods of focused ultrasound and apply them to clinical use in Korean medicine. Methods : Search was performed using the search engines of electronic databases, including PubMed, ScienceDirect, Cumulative Index to Nursing and Allied Health Literature (CINAHL), ScienceON, Oriental Medicine Advanced Searching Integrated System (OASIS), China National Knowledge Infrastructure (CNKI), Wanfang Data, Japan Science Technology Information Aggregator, Electronic (J-STAGE) and Citation Information by NII (CiNii), from inception to July 2023 without language limitation. Inclusion criteria were clinical studies including randomized controlled trials (RCTs), and animal experimental studies related with focused ultrasound treatments for acupoints or meridian sinews. Results : Total 17 papers, 7 for RCT, 6 for in vivo animal studies, and other experimental studies, were finally selected. Indications used in studies were shoulder pain, back pain, chronic back pain, and degenerative knee arthritis. In experimental studies, studies on animal models of hypoxic ischemic brain damage and hyperlipidemia were also conducted. As for the acupoints, LR3, LI4, and ST36 were used in clinical studies and, in animal experimental studies, GV20, KI1, and ST36 were used. As for the dose, 4 studies below 3 W/cm² and 3 studies in the range of 0.625 to 5 W/cm² in clinical studies, and all studies did not exceed 5 W/cm². In animal experimental studies, 0.5 W/cm², 2 W/cm², 7.5 WW/cm², 15 W/cm², 10~20 W/cm² were used. In all three studies describing the penetration depth during irradiation, it was less than 1 cm. Conclusions : We suggest that focused ultrasound is an appropriate treatment tool for stimulating the acupoints to transfer heat energy. Future studies with rigorous and well-designed RCTs for various diseases will be required to ascertain the focused ultrasound stimulate acupoints or meridian sinews.

• 한국산림과학회지
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• 제90권1호
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• pp.90-104
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• 2001

이 연구는 지난 3년간 북경임업대학교와 공동연구과제로 중국의 사막화방지 및 방사기술개발을 위한 연구의 일환으로 사막화현황 및 녹화기술수준조사 및 평가를 위하여 수행되었으며, 특히 본고에서는 중국의 황막사지에 대한 녹화기술을 분석하고자 하였다. 사막화지역 식생분포의 일반적인 특징은 부분적으로 집중된 식생분포, 즉 사막의 저지대 또는 분지의 낮은 곳의 사구에 있는 사막식물, 염수호 주변의 내염성식물, 담수 염수호와 하천연안의 포플러 및 위성류의 군생, 사력퇴적지(고비)의 사퇴식생, 하천선상지의 초생지 및 오아시스(녹주(綠洲))숲 등이다. 일반적으로 사막화지역에는 중국식물명(中國植物名)으로 정류(檉柳)(홍류(紅柳))(Tamarix chinensis Lour.), 사사(梭梭)(Haloxylon ammodendron Bunge.), 사괴조(沙拐棗)(Calligonum Spp.), 호루(胡楊)(Populus euphratica Oliver.), 사조(沙棗)(Elaeagnus angustifolia L.), 유(楡)백유(白楡)(Ulmus pumila L.), 류류(柳類)(Salix spp.), 암황시(岩黃蓍)(Hedysarum spp.), 금계아(錦鷄兒)(Caragana spp.), 문관과(文冠果)(Xanthoceras sorbifolia Bunge.), 백자(白刺)(Nitraria tangutorum Bobr.), 호기자(胡技子)(Lespedeza bicolor), 낙타자(駱駝刺)(Alhagi sparsifolia Shap.), 자산감(刺山柑)(Capparis spinosa L.), 사호(沙蒿)(Artemisia arenaria DC.) 등이 널리 분포하며, 이와 같은 사막화지역 자생식물에 관한 연구가 더욱 필요한 상황에 있다. 풍식지역에서는 합리적인 경작체계(지역계획, 방풍림체계 및 오아시스보호체계, 관개수로네트워크설치, 광대한 농지관리기술 등), 식물자원의 합리적 이용기술(연료림, 약용식물, 방목, 초지관리 등), 수자원이용(유역계획 및 관리, 수로건설, 절수관개기법 등), 방풍림조성, 인구증가의 조절, 농용림 연료목 사료증산기술 등에 관해서, 그리고 수식지역에서는 합리적인 토지이용기술, 식생이용기술, 공학적기술, 농작물보호기술 개발 등에 관한 시험연구사업이 중점적으로 추진되고 있다. 또한, 사막화지역에서의 염성토양 알카리토양개량을 위한 수리적(관개, 배수, 세탈, 수도재배 등), 농업적(토지정리, 경작, 시비, 파종, 윤작, 혼작, 객토 등), 생물적(내염성 작물 및 녹비의 재배, 조림 등) 방법 등에 관한 시험연구도 활발하게 추진되고 있으며, 이와 같은 사막화지역의 녹화사업에 국제적인 협력을 절실하게 요망하고 있다.

• 정보처리학회논문지D
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• 제14D권3호
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• pp.319-328
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• 2007

웹 서비스의 활용 범위가 커지고 실제적인 구현사례가 늘어감에 따라, 웹 서비스 품질모델을 현실적으로 적용할 수 있는 방법에 대한 중요성이 커지고 있다. 웹 서비스 품질을 일관성있게 유지하기 위해서는 웹 서비스 품질보증에 대한 방안이 연구되어야만 한다. 웹 서비스 보증이란 웹 서비스의 품질수준을 일정수준이상으로 유지하기 위한 행위들의 총체를 의미하며, 이를 위해 웹 서비스 품질보증자란 새로운 개념의 관계자가 국제기구에서 웹 서비스 표준으로 새롭게 제시되었다. 웹 서비스 품질보증자는 웹 서비스 사용자들의 품질요구사항을 수렴하여, 웹 서비스 제공자가 일정 품질수준이상의 웹 서비스를 제공할 수 있도록 감시한다. 웹 서비스 제공자와 사용자 그리고, 품질보증자는 웹 서비스 수준을 관리하기 위해 서비스 수준을 측정하여 그 결과에 따라 페널티와 인센티브를 부여하는 SLA(Service Level Agreement) 방식을 적용할 수 있다. 하지만, SLA에서는 서비스 사용자와 제공자가 같은 서비스 항목에 대해 일대일로 대응한다는 전제를 가지고 있어서, 다수사용자와 공공성, 그리고 제3자 관리와 같은 웹 서비스 프레임워크에는 적합하지 않은 점들이 존재한다. 따라서, 웹 서비스에 SLA를 적용하기 위해서는 웹 서비스의 이러한 특성들을 반영한 새로운 보증기법이 필요하다. 본 논문에서는 품질 기대수준을 표현하기 위해 웹 서비스 품질 위탁보증수준이라는 새로운 개념을 제시하고자 한다. 이는 각 사용자의 각 품질항목별 품질기대수준의 최대치라 할 수 있으며, 웹 서비스 품질관계자에게 일관성있는 품질 뷰를 제공한다. 본 논문에서는 이를 이용해 각 품질관계자가 보다 쉽게 일정 수준이상의 품질수준을 유지할 수 있는 방안에 대해 제시하고자 한다.

• 척추신경추나의학회지
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• 제8권2호
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• pp.67-78
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• 2013

Objectives : The present study examines the domestic trend of Osteoporosis studies in Korea. Method : We reviewed oriental medicine papers published in last ten years (2003-2012). Korean literature search was used for domestic Internet search portal. 'Naver specialized information retrieval', 'Korea Traditional Knowledge Portal', 'Korea Medical Information Portal (OASIS)',' Scientific and Technological Information Integration Services (NDSL)',' Academic Research Information Service (RISS)'as the primary destination of the search were. Since 2003 until 2012, the thesis o'f osteoporosis'and found 92 papers with the search term '(golwi)' to the search terms found in 3 papers Korean medical target of on going research trends in osteoporosis about investigated. Results : 1. We researched 95 papers in 15 journals and patterns of study were as follows : experimental studies were 79(83%), clinical studies were 12(13%), reviewed studies were 3(3%) and etc. were 1(1%). 2. The experimental studies(79) were divided into papers on efficiency testing of herbal medications(67) and herbal acupuncture(12). 3. The clinical studies(12) showed that research has been carried out in the fields of follow up surveys for the herbal medication efficiency testing, basic research, case report, the relativity of osteoporosis to age and sex, and the perception about osteoporosis and korean medicine treatment. 4. The reviewed studies showed that research has been carried out in the fields of osteoporosis about acient literature and domestic studies about herbal medication of osteoporosis. Conclusion : Reviewing the domestic trend of Osteoporosis studies and examining the strong and weak points of those treatments are essential for the future studies. It is anticipated that this review benefits the future in-depth study on the treatments for osteoporosis in Korean medicine.

• 한방안이비인후피부과학회지
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• 제32권3호
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• pp.116-135
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• 2019

Objectives : The purpose of this study is to analyze how purpura and vasculitis have been treated with Korean medicine and potentially to present with future direction of research and treatment. Methods : We searched clinical studies from the Korean databases including Oriental medicine Advanced Searching Integrated System(OASIS), Korean Traditional Knowledge Portal(KTKP), National Discovery for Science Leader(NDSL), Research Information Sharing Service(RISS), using keywords related to "Purpura" and "Vasculitis" from January 2000 to May 2019. Results : A total of 20 studies were selected for analysis. More than half of the patients provided with detailed information were under 19 year-olds, and upper respiratory infection, stress and fatigue, seasonal factor were among the most frequently stated as predisposing factors. Among many treatment modalities, herbal medicine was the most frequently used, followed by acupuncture and herbal acupuncture. 23 basic herbal medicine formulas were retrieved from 20 articles, most frequently used being Guibi-tang(歸脾湯加味), Samul-tang(四物湯加味) and Yukmijihwang-tang(六味地黃湯加味). In total, 122 Korean medicine herbs were used, most frequently used herbs being Glycyrrhizae Radix et Rhizoma(甘草), Angelicae Gigantis Radix(當歸), Poria Sclerotium(茯?) and Paeoniae Radix(芍藥). By its category, herbs were mostly classified into Tonyfying and replenishing medicinal(補益藥), Heat-clearing medicinal(淸熱藥) and Exterior-releasing medicinal(解表藥). Patients with total treatment period of 3 months or under were 2/3 of all cases provided with detailed information. Follow up periods were short in general with only 6 cases of over 6 months. The primary motive of patients to receive Korean medicine treatments was unresponsiveness or adverse effects of western medication. Conclusion : Through this literature review, we could find out tendencies of Korean medicine treatments of purpura and vasculitis up to date and some points that may have clinical significance.