Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Review of non-clinical experimental studies on precocious puberty using herbal medicine

한약을 이용한 성조숙증에 대한 비임상 연구 보고 고찰

  • Hyo-Eun Son (Department of Herbology, College of Korean Medicine, Woosuk University) ;
  • Young-Sik Kim (Department of Herbology, College of Korean Medicine, Woosuk University) ;
  • YongBin Kim (Department of Herbology, College of Korean Medicine, Woosuk University) ;
  • SeonTae Na (Department of Fomula Science, College of Korean Medicine, Woosuk University) ;
  • HongJun Kim (Department of Fomula Science, College of Korean Medicine, Woosuk University)
  • 손효은 (우석대학교 한의과대학 본초학교실) ;
  • 김영식 (우석대학교 한의과대학 본초학교실) ;
  • 김용빈 (우석대학교 한의과대학 본초학교실) ;
  • 나선태 (우석대학교 한의과대학 방제학교실) ;
  • 김홍준 (우석대학교 한의과대학 방제학교실)
  • Received : 2023.10.25
  • Accepted : 2023.11.12
  • Published : 2023.11.30
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Abstract

Objectives : This study aimed to provide basic data for research by investigating non-clinical experimental studies on herbal medicines and its compounds for precocious puberty. Methods : A search was conducted for all literature until October 2023 using combinations of keywords such as precocious puberty, puberty, and chinese medicine in three databases (Pubmed, OASIS, and ScienceON). Results : 1. In animal experiments, studies were mainly conducted using a model that induced precocious puberty by subcutaneously administering danazol to SD rats on the 5th day after birth, and in cell experiments, precocious puberty was induced by treating GT1-7 cells with kisspeptin 10 or estradiol. 2. Anemarrhenae Rhizoma, Phellodendri Cortex, and Prunellae Spica were mainly used as herbal medicine to evaluate their efficacy on precocious puberty in non-clinical experiments. 3. Macroscopic observation, hematological analysis, histological analysis, and genetic analysis were performed as methods to analyze the experimental results. Conclusions : In this study, the effects of herbal medicine on precocious puberty and non-clinical research methods were confirmed. Based on the results of this study, it is expected that non-clinical effectiveness and mechanism research on materials that are clinically effective in Traditional Korean Medicine will be revitalized.

Keywords

Acknowledgement

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술연구개발사업 지원에 의하여 이루어진 것임(과제고유번호: HF22C0109).

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