• International Journal of Air-Conditioning and Refrigeration
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• v.11 no.2
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• pp.51-60
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• 2003

In the nuclear power plant, emergency core coolant system (ECCS) is furnished at reactor coolant system (RCS) in order to cool down high temperature water in case of emergency. However, in this coolant system, thermal stratification phenomenon can occur due to coolant leaking in the check valve. The thermal stratification produces excessive thermal stresses at the pipe wall so as to yield thermal fatigue crack (TFC) accident. In the present study, effects of turbulence penetration on the thermal stratification into T-branches with square cross-section in the modeled ECCS are analysed numerically. Standard k-$\varepsilon$ model is employed to calculate the Reynolds stresses in momentum equations. Results show that the length and strength of thermal stratification are primarily affected by the leak flow rate of coolant and the Reynolds number of duct. Turbulence penetration into the T-branch of ECCS shows two counteracting effects on the thermal stratification. Heat transport by turbulence penetration from main duct to leaking flow region may enhance thermal stratification while the turbulent diffusion may weaken it.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.1116-1120
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• 2004

In the nuclear power plant, there are several cylindrical vessels such as reactor vessel, pressuriser and so on. The vessels are usually constructed by welding large rolled plates, forged sections or nozzle pipes together. In order to assure the integrity of the vessel, these welds should be periodically inspected using sensors such as ultrasonic transducer or visual cameras. This inspection is usually conducted under water to minimize exposure to the radioactively contaminated vessel walls. The inspections have been performed by using a conventional inspection machine with a big structural sturdy column, however, it is so huge and heavy that maintenance and handling of the machine are extremely difficult. It requires much effort to transport the system to the site and also requires continuous use of the utility's polar crane to move the manipulator into the building and then onto the vessel. Setup beside the vessel requires a large volume of work preparation area and several shifts to complete. In order to resolve these problems, we have developed an underwater mobile robot guided by the laser pointer, and performed a series of experiments both in the mockup and in the real reactor vessel. This paper introduces our robotic inspection system and the laser guidance of the mobile robot as well as the results of the functional test.

• Journal of Advanced Marine Engineering and Technology
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• v.8 no.1
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• pp.85-99
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• 1984

The stability of the two-phase flow in a heated channel is of great importance in the design and operation of the boilers and light water nuclear reactors, because it can cause flow oscillations and lead to a violation of thermal limits with resultant overheating of the channels and cladding. This paper presents a systematic evaluation to the variation effects of the basic four (4) dimensionless parameters in a homogeneous equilibrium model. The flow stability is examined on the ground of static characteristic curves. The complicated transfer function of flow dynamics which gives consideration to the transport lag of density wave is derived, and the transient flow stability is analysed by applying the Nyquist stability criterion in control engineering. The analysis results summed up as follows 1. The coolant flow becomes stable in large friction number and specific flow, while it is unstabale in small friction number and flow. 2. Large phase-change number and Froude number destabilize the two-phase flow, but small numbers stabilize it. The effect to variation of phase-change number is more dominant compared with Froude number. 3. The dynamic analysis is required to hold the sufficient safety of heated channels since only static results does not keep it. The special attention could be payed in the design and operation of heat engines, because the unstaable region exists within the stable boundary at small and middle phase-change number and Froude number.

• BMB Reports
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• v.36 no.1
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• pp.110-119
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• 2003

The acetylation state of histone is reversibly regulated by histone acetyltransferase (HAT) and deacetylase (HDAC). An imbalance of this reaction leads to an aberrant behavior of the cells in morphology, cell cycle, differentiation, and carcinogenesis. Recently, these key enzymes in the gene expression were cloned. They revealed a broad use of this modification, not only in histone, but also other proteins that involved transcription, nuclear transport, and cytoskeleton. These results suggest that HAT/HDAC takes charge of multiple-functions in the cell, not just the gene expression. HDAC is especially known to play an important role in carcinogenesis. The enzyme has been considered a target molecule for cancer therapy. The inhibition of HDAC activity by a specific inhibitor induces growth arrest, differentiation, and apoptosis of transformed or several cancer cells. Some of these inhibitors are in a clinical trial at phase I or phase II. The discovery and development of specific HDAC inhibitors are helpful for cancer therapy, and decipher the molecular mode of action for HDAC.

• Membrane Journal
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• v.18 no.2
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• pp.124-131
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• 2008

The biodegradable hyaluronic acid membranes cross-linked with lactide using the crosslinking agent, 1,3-butadiene diepoxide (BD), were prepared as a potential biocompatible material for tissue engineering. The degree of lactide and BD reaction of the crosslinked membrane was determined by the analysis of nuclear magnetic resonance spectroscopy 6% of growth inhibition was observed in case of high BD concentration but the value is low enough not to affect cell growth. As the crosslinking reaction temperature increased, elongation increased and swelling ratio decreased. The rate of degradation was found to increase with the crosslinking temperature. The drug release experiment showed that the transport of drug through the membrane decreased with the crosslinking temperature.

• Journal of the Korean Magnetic Resonance Society
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• v.24 no.3
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• pp.91-95
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• 2020

Transthyretin (TTR) is an abundant protein in blood plasma and cerebrospinal fluid (CSF), working as a homo-tetrameric complex to transport thyroxine (T₄) and a holo-retinol binding protein. TTR is well-known for its amyloidogenic property; several types of systemic amyloidosis diseases are caused by aggregation of either wild-type TTR or its variants, for which more than 100 mutations were reported to increase the amyloidogenicity of TTR. The rate-limiting step of TTR aggregation is the dissociation of a monomeric subunit from a tetrameric complex. A wide range of biochemical and biophysical techniques have been employed to elucidate the TTR aggregation processes, among which nuclear magnetic resonance (NMR) spectroscopy contributed much to characterize the structural and functional features of TTR during its aggregation processes. The present review focuses on discussing the recent advances of our understanding to the amyloidosis mechanism of TTR and to the structural features of its monomeric aggregation-prone state in solution. We expect that the present review provides novel insights to appreciate the molecular basis of TTR amyloidosis and to develop novel therapeutic strategies to treat diverse TTR-related diseases.

• Journal of computational fluids engineering
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• v.10 no.4 s.31
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• pp.12-17
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• 2005

A computational study of evaluation of current turbulence models is performed for a better prediction of thermal stratification in an upper plenum of a liquid metal reactor. The turbulence models tested in the present study are the two-layer model, the shear stress transport (SST) model, the v2-f model and the elliptic blending mode(EBM). The performances of the turbulence models are evaluated by applying them to the thermal stratification experiment conducted at JNC (Japan Nuclear Corporation). The algebraic flux model is used for treating the turbulent heat flux for the two-layer model and the SST model, and there exist little differences between the two turbulence models in predicting the temporal variation of temperature. The v2-f model and the elliptic blending model better predict the steep gradient of temperature at the interface of thermal stratification, and the v2-f model and elliptic blending model predict properly the oscillation of the ensemble-averaged temperature. In general the overall performance of the elliptic blending model is better than the v2-f model in the prediction of the amplitude and frequency of the temperature oscillation.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1585-1589
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• 2007

The HANARO, a 30 MW multi-purpose research reactor in Korea, will be equipped with a neutron guide system, in order to transport cold neutrons from the neutron source to the neutron scattering instruments in the neutron guide hall near the reactor building. The neutron guide system of HANARO consists of the in-pile plug assembly with in-pile guides, the primary shutter with in-shutter guides, the neutron guides in the guide shielding room with dedicated secondary shutters, and the neutron guides connected to the instruments in the neutron guide hall. The functions of the in-pile plug assembly are to shield the reactor environment from a nuclear radiation and to support the neutron guides and maintain them precisely oriented. The primary shutter is a mechanical device to be installed just after the in-pile plug assembly, which stops neutron flux on demand. This paper describes the mechanical design of the in-pile plug assembly and the primary shutter for the neutron guide system at HANARO. The design of the guide shielding assembly for the primary shutter and the neutron guides is also presented.

• Ocean Science Journal
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• v.43 no.1
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• pp.39-48
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• 2008

Tritium ($^3H$ or T) has been produced mostly by atmospheric nuclear weapon tests, and entered the ocean in the form of water (HTO). As tritium exists as water itself, it has been regarded as an ideal tool to study the transport of water masses. In April 2001 we collected water samples in the western Japan Basin (WJB) for tritium and helium measurement. The timely sampling provided direct evidence of the bottom water formation, resulting in the drastic increase in tritium concentration from 0.3 TU in 2000 to 0.67 TU in 2001. Considering that the new bottom waters were found mostly in the WJB, it implies that maximum 1% of the whole bottom layer below 2600 m should be replaced with the surface water during the severely cold winter 2000 2001. $^3H-^3He$ age, showing the elapsed time since the water left from the surface, can be used to calculate oxygen utilization rate by dividing AOU by the age. Under the condition of 90% oxygen saturation in the surface water, the integration of OUR in the water column below 200 m yields net oxygen consumption of 12 mol $(O_2)m^{-2}yr^{-1}$, which corresponds to the export production of $99\;g\;C\;m^{-2}yr^{-1}$. This estimate is comparable to a previous estimate based on satellite data and implies that the ratio of export to primary production(f-ratio) is as high as 0.5 in the WJB.

• Proceedings of the KIEE Conference
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• 2008.10c
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• pp.218-220
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• 2008

Urban air quality, including carbon-dioxide emissions, and national energy security are related issues affecting the rail industry and transportation sector as a whole. They are related by the fact that (in the United States) 97-98% of the energy for the transport sector is based on oil, and more than 60% is imported. A fuelcell locomotive combines the environmental advantages of a catenary-electric locomotive with the higher overall energy efficiency and lower infrastructure costs of a diesel-electric. Catenaryelectric locomotives, when viewed as only one component of a distributed machine that includes an electricity-generating plant and transmission lines, are the least energy-efficient locomotive type. The natural fuel for a fuelcell is hydrogen, which can be produced from many renewable energies and nuclear energy, and thus a hydrogen-fuelcell locomotive will not depend on imported oil for its energy supply. This paper proposes a base models of Hybrid fuel cell/IPT railway vehicle power system, the necessary of this research.