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Application of Hyaluronic Acid Membrane Cross-linked with 1,3-Butadiene Diepoxide  

Cheong, Seong-Ihl (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Han, Gwang-Seon (Department of Chemical Engineering and Nano-Bio Technology, Hannam University)
Bae, Jung-Eun (Department of Biological Sciences, Hannam University)
Kim, In-Seop (Department of Biological Sciences, Hannam University)
Publication Information
Membrane Journal / v.18, no.2, 2008 , pp. 124-131 More about this Journal
Abstract
The biodegradable hyaluronic acid membranes cross-linked with lactide using the crosslinking agent, 1,3-butadiene diepoxide (BD), were prepared as a potential biocompatible material for tissue engineering. The degree of lactide and BD reaction of the crosslinked membrane was determined by the analysis of nuclear magnetic resonance spectroscopy 6% of growth inhibition was observed in case of high BD concentration but the value is low enough not to affect cell growth. As the crosslinking reaction temperature increased, elongation increased and swelling ratio decreased. The rate of degradation was found to increase with the crosslinking temperature. The drug release experiment showed that the transport of drug through the membrane decreased with the crosslinking temperature.
Keywords
hyaluronic acid; crosslinking; swelling; degradation; drug delivery;
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Times Cited By KSCI : 6  (Citation Analysis)
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