• 한국전문물리치료학회지
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• 제19권3호
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• pp.72-80
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• 2012

The purpose of the present study was to investigate the effects of familiar exercise and novel exercise on motor function after intracerebral hemorrhage (ICH) in rats. The rats were subjected to a unilateral striatal ICH via collagenase infusion. The rats were randomly divided into the following three groups: the CON (control group; rested one week post-ICH), the FE (familiar exercise group; familiar exercise was performed two weeks after one-week post-ICH period), and NE (novel exercise group; novel exercise was performed two weeks after one-week post-ICH period). We measured neurological behavior using a ladder rung walking test and a beam walking test; we measured the level of nerve growth factor (NGF) using immunohistochemistry and western blot analysis. We performed a one-way ANOVA test to analyze the scores obtained from the neurological behavior tests and the differences of NGF protein levels among the three groups. In the present study, the FE group and the NE group showed significant improvement during the neurological behavior tests and in their expression of NGF protein level, as compared to the CON group. Especially, NE group more increase than FE group in neurological behavior tests, the expression of NGF on motor cortex. In conclusion, these results suggest that, after ICH, familiar exercise and novel exercise enhance motor function and, novel exercise is more effective than familiar exercise.

• The Korean Journal of Physiology and Pharmacology
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• 제25권1호
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• pp.1-14
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• 2021

Cardiovascular disease (CVD) accounts for approximately 30% of all deaths worldwide and its prevalence is constantly increasing despite advancements in medical treatments. Cardiac remodeling and dysfunction are independent risk factors for CVD. Recent studies have demonstrated that cardiac structure and function are genetically influenced, suggesting that understanding the genetic basis for cardiac structure and function could provide new insights into developing novel therapeutic targets for CVD. Regular exercise has long been considered a robust nontherapeutic method of treating or preventing CVD. However, recent studies also indicate that there is inter-individual variation in response to exercise. Nevertheless, the genetic basis for cardiac structure and function as well as their responses to exercise training have yet to be fully elucidated. Therefore, this review summarizes accumulated evidence supporting the genetic contribution to these traits, including findings from population-based studies and unbiased large genomic-scale studies in humans.

• Advances in nano research
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• 제13권3호
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• pp.217-231
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• 2022

This study investigates the geometrical impact on the nanomedicine drug delivery via nanodevices. A nanomotor made of the nanotube carrying the drug as the motor blade is considered in the blood flow. Physical activities change the blood flow, and sports training enhances the blood flow and plays a significant role in the stability of drug delivery devices. This paper studies the impact of geometrical parameters on the nanomotors carrying the nanomedicine. The effect of physical exercise on the dynamic response regarding the stability of drug delivery devices is discussed in detail.

• The Korean Journal of Physiology and Pharmacology
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• 제28권1호
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• pp.31-38
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• 2024

As in type 1 diabetes, the loss of pancreatic β-cells leads to insulin deficiency and the subsequent development of hyperglycemia. Exercise has been proposed as a viable remedy for hyperglycemia. Lithium, which has been used as a treatment for bipolar disorder, has also been shown to improve glucose homeostasis under the conditions of obesity and type 2 diabetes by enhancing the effects of exercise on the skeletal muscles. In this study, we demonstrated that unlike in obesity and type 2 diabetic conditions, under the condition of insulin-deficient type 1 diabetes, lithium administration attenuated pancreatic a-cell mass without altering insulin-secreting β-cell mass, implying a selective impact on glucagon production. Additionally, we also documented that lithium downregulated the hepatic gluconeogenic program by decreasing G6Pase protein levels and upregulating AMPK activity. These findings suggest that lithium's effect on glucose metabolism in type 1 diabetes is mediated through a different mechanism than those associated with exercise-induced metabolic changes in the muscle. Therefore, our research presents the novel therapeutic potential of lithium in the treatment of type 1 diabetes, which can be utilized along with insulin and independently of exercise.

• 대한수의학회지
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• 제55권4호
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• pp.247-252
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• 2015

Exercise is one of the most common stressors in horses. Although various physiological parameters such as cortisol respond to exercise, there is no reliable parameter for the measurement of exercise-induced stress in sport horses. This study was performed to discover a new biomarker with high sensitivity for exercise-induced stress. The expression of fos mRNA was increased more than 10-fold in horse blood samples collected after an hour of exercise, as compared with before the exercise. The plasma cortisol levels were also increased after the exercise, but only by about two-fold. The fos mRNA levels were well-correlated with plasma cortisol concentrations. These findings suggest that fos mRNA expression in blood may be useful for the measurement of exercise-induced stress in horses.

• 한국지능시스템학회논문지
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• 제24권6호
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• pp.615-621
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• 2014

중독 문제가 사회문제가 되고 있으며 이를 해결하고자하는 사회적 노력이 계속되고 있다. 이러한 노력 중의 하나로 중독에 대한 수학적 모델링과 이 모델링을 이용하여 거동해석을 수행하며 이 결과를 가지고 중독이전과 중독이후의 상태를 판정하는 연구를 중독 이전의 상태에서 중독 상태로 진행하는 단계의 관찰을 통한 연구를 진행하는 것이 필요하다. 이러한 필요성에 따라 본 연구에서는 운동에 대한 중독 방정식을 전개하기 위하여 Spring-Damper-Mass 시스템과 등가적으로 구성할 수 있는 새로운 2차계로 구성한 운동에 대한 운동 중독 방정식 모델을 제안하고 이 중독 방정식에서의 거동을 분석한다.

• 비교문화연구
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• 제21권
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• pp.31-52
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• 2010

Even though Chilean writer Roberto $Bola{\tilde{n}}o^{\prime}s$ novel Amulet was inspired by a historical account, it significantly rewrites the story as well as redefines the people who witnessed the history. This novel focuses on the Uruguayan poet Auxilio Lacouture, the self-anointed "mother of Mexican Poetry". She is trapped in a bathroom at the UNAM in Mexico City for thirteen days while the army storms the campus for the repression of the student movement, which was decreed by the sinister Díaz Ordaz and culminated in the holocaust of Tlatelolco. In the space isolated from the outside world, Auxilio attempts to reconstruct the past and to describe the future through an illogical exercise of times. In the meantime, her temporal recollections finally approach the definition of a generation whose historical experience is crucially marked by the key year of 1968, when the novel is set. The only one who remained on the campus, she defends the university's autonomy only by reading and writing poetry. The novel ends in a scene densely imbued with allegorical imagination, by which the author endeavors to justify her generation, more concretely, "the peoples without history", as defined by bohemian poets. The protagonist represents, in some sense, an allegory of the innocence and truth of the history. Her existence per se manifestly demonstrates the power of literature because the literature within this novel in short becomes the most resilient amulet resisting the political violence in an era of increasing madness.

• IMMUNE NETWORK
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• 제23권2호
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• pp.18.1-18.15
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• 2023

It has been reported that some exercise could enhance the anti-viral antibody titers after vaccination including influenza and coronavirus disease 2019 vaccines. We developed SAT-008, a novel digital device, consists of physical activities and activities related to the autonomic nervous system. We assessed the feasibility of SAT-008 to boost host immunity after an influenza vaccination by a randomized, open-label, and controlled study on adults administered influenza vaccines in the previous year. Among 32 participants, the SAT-008 showed a significant increase in the anti-influenza antibody titers assessed by hemagglutination-inhibition test against antigen subtype B Yamagata lineage after 4 wk of vaccination and subtype B Victoria lineage after 12 wk (p<0.05). There was no difference in the antibody titers against subtype "A." The SAT-008 also showed significant increase in the plasma cytokine levels of IL-10, IL-1β, and IL-6 at weeks 4 and 12 after the vaccination (p<0.05). A new approach using the digital device may boost host immunity against virus via vaccine adjuvant-like effects.

• 한국운동역학회지
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• 제23권2호
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• pp.179-187
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• 2013

This case study was conducted to determine the effects of water exercise on the foot pressure distribution (FPD) of persons who have a hemiplegia. A 43-year old female with hemiplegia acquired at the age of 3 years was selected from a local disability program. A 12-week water exercise program (60 min. per session and twice a week) focusing on gait training was developed and implemented as the intervention of this study. A recent product of the Pedar-X (Novel, Germany) was used to measure the FPD of hemiplegic gait before and after the intervention. Variables considered in this study included the average pressure (AP), contact area (CA), maximum pressure (MP), ground reaction force (GRF), and center of pressure (COP). The data collected were analyzed via the descriptive statistics and qualitative analyses on the graphical presentations of the FPD. Results revealed that the AP and CA of the hemiplegic foot was considerably increased before and after the intervention. Similar results were also found in the MP and GRF. Additionally, the graphical route of the COP related to hemiplegic foot was changed in a positive way after the intervention. It can be concluded that water exercise may be beneficial to restore hemiplegic gait. Limitations related to measurement and generalizability are further discussed.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제12권sup1호
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• pp.118-126
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• 2009

The incidence of childhood obesity has increased dramatically. Childhood obesity is an increasing health problem because of its strong associations with chronic health problems in children and adults. These health problems significantly contribute to the development of common chronic diseases in later life, including hypertension, type2 diabetes, hyperinsulinemia, coronary heart disease, and other psychological disorders. So it is an important issue to prevent and treat obesity during childhood and adolescent. Diet and exercise are the cornerstones of treatment for obesity and related complications. For obese children, some clinical trials have shown improvement with diet, exercise, and /or behavioral interventions. Promising interventions for high-risk individuals, such as bariatric surgery and novel pharmacological agents, also require rigorous assessment with attention to long-term patient important outcomes. There are various pharmacological approaches to the treatment of obesity in the adolescent population some of which have FDA approval. In the article we discuss pharmacological approaches to guide the treatment of obesity in the pediatric population, including risks of treatment, monitoring of potential side effects.