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http://dx.doi.org/10.12989/anr.2022.13.3.217

Geometry effect in the drug delivery for therapy with nanomedicines based on the conditions of the sport  

Zhu, Lemei (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations)
Zou, Xuemin (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations)
Li, Xi (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations)
Zhang, Yuan (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations)
Liu, Juan (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations)
Xiang, Yuhan (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations)
Publication Information
Advances in nano research / v.13, no.3, 2022 , pp. 217-231 More about this Journal
Abstract
This study investigates the geometrical impact on the nanomedicine drug delivery via nanodevices. A nanomotor made of the nanotube carrying the drug as the motor blade is considered in the blood flow. Physical activities change the blood flow, and sports training enhances the blood flow and plays a significant role in the stability of drug delivery devices. This paper studies the impact of geometrical parameters on the nanomotors carrying the nanomedicine. The effect of physical exercise on the dynamic response regarding the stability of drug delivery devices is discussed in detail.
Keywords
drug delivery; dynamic analysis; geometric impact; sport effect;
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Times Cited By KSCI : 13  (Citation Analysis)
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89 Luo, G., Zhang, H., Yuan, Q., Li, J. and Wang, F.Y. (2022), "ESTNet: Embedded Spatial-Temporal Network for Modeling Traffic Flow Dynamics", IEEE T. Intell. Transp. Syst., 1-12. https://doi.org/10.1109/TITS.2022.3167019.   DOI
90 Ma, H., Gao, X.L. and Reddy, J. (2008), "A microstructuredependent Timoshenko beam model based on a modified couple stress theory", J. Mech. Phys. Solids, 56(12), 3379-3391. https://doi.org/10.1016/j.jmps.2008.09.007.   DOI
91 Mirjavadi, S.S., Afshari, B.M., Shafiei, N., Hamouda, A., Kazemi, M. and Structures, C. (2017a), "Thermal vibration of twodimensional functionally graded (2D-FG) porous Timoshenko nanobeams", Steel Compos. Struct., 25(4), 415-426. https://doi.org/10.12989/scs.2017.25.4.415.   DOI
92 Najaafi, N., Jamali, M., Habibi, M., Sadeghi, S., Jung, D.w. and Nabipour, N. (2020), "Dynamic instability responses of the substructure living biological cells in the cytoplasm environment using stress-strain size-dependent theory", J. Biomol. Struct. Dyn., 1-12. https://doi.org/10.1080/07391102.2020.1751297.   DOI
93 Moradi, Z., Davoudi, M., Ebrahimi, F. and Ehyaei, A.F. (2021), "Intelligent wave dispersion control of an inhomogeneous micro-shell using a proportional-derivative smart controller", Wave. Random Complex Med., 1-24. https://doi.org/10.1080/17455030.2021.1926572.   DOI
94 Murmu, T. and Pradhan, S. (2009), "Thermo-mechanical vibration of a single-walled carbon nanotube embedded in an elastic medium based on nonlocal elasticity theory", Comput. Mater. Sci., 46(4), 854-859. https://doi.org/10.1016/j.commatsci.2009.04.019.   DOI
95 Naderi, A., Behdad, S., Fakher, M. and Hosseini-Hashemi, S. (2020), "Vibration analysis of mass nanosensors with considering the axial-flexural coupling based on the two-phase local/nonlocal elasticity", Mech. Syst. Signal Pr., 145, 106931. https://doi.org/10.1016/j.ymssp.2020.106931.   DOI
96 Ansari, R., Torabi, J. and Faghih Shojaei, M. (2018), "An efficient numerical method for analyzing the thermal effects on the vibration of embedded single-walled carbon nanotubes based on the nonlocal shell model", Mech. Adv. Mater. Struct., 25(6), 500-511. https://doi.org/10.1080/15376494.2017.1285457.   DOI
97 Obireddy, S.R. and Lai, W.F. (2021a), "Multi-component hydrogel beads incorporated with reduced graphene oxide for phresponsive and controlled co-delivery of multiple agents", Pharmaceutics, 13(3). https://doi.org/10.3390/pharmaceutics13030313.   DOI
98 Ghadiri, M. and Shafiei, N. (2016b), "Vibration analysis of a nano-turbine blade based on Eringen nonlocal elasticity applying the differential quadrature method", J. Vib. Control, 23(19), 3247-3265. https://doi.org/10.1177/1077546315627723.   DOI
99 Habibi, M., Mohammadgholiha, M. and Safarpour, H. (2019b), "Wave propagation characteristics of the electrically GNPreinforced nanocomposite cylindrical shell", J. Brazil. Soc. Mech. Sci. Eng., 41(5), 221. https://doi.org/10.1007/s40430-019-1715-x.   DOI
100 Ebrahimi, F., Hajilak, Z.E., Habibi, M. and Safarpour, H. (2019b), "Buckling and vibration characteristics of a carbon nanotubereinforced spinning cantilever cylindrical 3D shell conveying viscous fluid flow and carrying spring-mass systems under various temperature distributions", Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 233(13), 4590-4605. https://doi.org/10.1177/0954406219832323.   DOI
101 Ghadiri, M., Shafiei, N., Salekdeh, S.H., Mottaghi, P. and Mirzaie, T. (2016d), "Investigation of the dental implant geometry effect on stress distribution at dental implant-bone interface", J. Brazil. Soc. Mech. Sci. Eng., 38(2), 335-343. https://doi.org/10.1007/s40430-015-0472-8.   DOI
102 Ghadiri, M., Shafiei, N. and Alavi, H. (2017c), "Vibration analysis of a rotating nanoplate using nonlocal elasticity theory", J. Solid Mech., 9(2), 319-337.
103 Ghazanfari, A., Soleimani, S.S., Keshavarzzadeh, M., Habibi, M., Assempuor, A. and Hashemi, R. (2020), "Prediction of FLD for sheet metal by considering through-thickness shear stresses", Mech. Based Des. Struct., 48(6), 755-772. https://doi.org/10.1080/15397734.2019.1662310.   DOI
104 Safarpour, H., Hajilak, Z.E. and Habibi, M. (2019a), "A sizedependent exact theory for thermal buckling, free and forced vibration analysis of temperature dependent FG multilayer GPLRC composite nanostructures restring on elastic foundation", Int. J. Mech. Mater. Des., 15(3), 569-583. https://doi.org/10.1007/s10999-018-9431-8.   DOI
105 Oyarhossein, M.A., Alizadeh, A.a., Habibi, M., Makkiabadi, M., Daman, M., Safarpour, H. and Jung, D.W. (2020), "Dynamic response of the nonlocal strain-stress gradient in laminated polymer composites microtubes", Sci. Rep., 10(1), 1-19. https://doi.org/10.1038/s41598-020-61855-w.   DOI
106 Pourjabari, A., Hajilak, Z.E., Mohammadi, A., Habibi, M. and Safarpour, H. (2019), "Effect of porosity on free and forced vibration characteristics of the GPL reinforcement composite nanostructures", Comput. Math. Appl., 77(10), 2608-2626. https://doi.org/10.1016/j.camwa.2018.12.041.   DOI
107 Safarpour, H., Ghanizadeh, S.A. and Habibi, M. (2018), "Wave propagation characteristics of a cylindrical laminated composite nanoshell in thermal environment based on the nonlocal strain gradient theory", Eur. Phys. J. Plus, 133(12), 532. https://doi.org/10.1140/epjp/i2018-12385-2.   DOI
108 Safarpour, M., Ebrahimi, F., Habibi, M. and Safarpour, H. (2020), "On the nonlinear dynamics of a multi-scale hybrid nanocomposite disk", Eng. Comput., 1-20. https://doi.org/10.1007/s00366-020-00949-5.   DOI
109 Shafiei, N., Kazemi, M. and Ghadiri, M. (2016a), "Comparison of modeling of the rotating tapered axially functionally graded Timoshenko and Euler-Bernoulli microbeams", Physica E, 83, 74-87. https://doi.org/10.1016/j.physe.2016.04.011.   DOI
110 Shafiei, N., Kazemi, M. and Ghadiri, M. (2016c), "Nonlinear vibration of axially functionally graded tapered microbeams", Int. J. Eng. Sci., 102, 12-26. https://doi.org/10.1016/j.ijengsci.2016.02.007.   DOI
111 Habibi, M., Safarpour, M. and Safarpour, H. (2020), "Vibrational characteristics of a FG-GPLRC viscoelastic thick annular plate using fourth-order Runge-Kutta and GDQ methods", Mech. Based Des. Struct., 1-22. https://doi.org/10.1080/15397734.2020.1779086.   DOI
112 Habibi, M., Mohammadi, A., Safarpour, H. and Ghadiri, M. (2019c), "Effect of porosity on buckling and vibrational characteristics of the imperfect GPLRC composite nanoshell", Mech. Based Des. Struct., 1-30. https://doi.org/10.1080/15397734.2019.1701490.   DOI
113 Habibi, M., Mohammadi, A., Safarpour, H., Shavalipour, A. and Ghadiri, M. (2019d), "Wave propagation analysis of the laminated cylindrical nanoshell coupled with a piezoelectric actuator", Mech. Based Des. Struct., 1-19. https://doi.org/10.1080/15397734.2019.1697932.   DOI
114 Habibi, M., Taghdir, A. and Safarpour, H. (2019e), "Stability analysis of an electrically cylindrical nanoshell reinforced with graphene nanoplatelets", Compos. Part B Eng., 175, 107125. https://doi.org/10.1016/j.compositesb.2019.107125.   DOI
115 Habibi, M., Darabi, R., Sa, J.C.d. and Reis, A. (2021a), "An innovation in finite element simulation via crystal plasticity assessment of grain morphology effect on sheet metal formability", Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications. 235(8), 1937-1951. https://doi.org/10.1177/14644207211024686.   DOI
116 Habibi, M., Mohammadi, A., Safarpour, H. and Ghadiri, M. (2021b), "Effect of porosity on buckling and vibrational characteristics of the imperfect GPLRC composite nanoshell", Mech. Based Des. Struct., 49(6), 811-840. https://doi.org/10.1080/15397734.2019.1701490.   DOI
117 Ebrahimi, F., Supeni, E.E.B., Habibi, M. and Safarpour, H. (2020b), "Frequency characteristics of a GPL-reinforced composite microdisk coupled with a piezoelectric layer", Eur. Phys. J. Plus, 135(2), 144. https://doi.org/10.1140/epjp/s13360-020-00217-x.   DOI
118 Ebrahimi, F. and Shafiei, N. (2016), "Application of Eringen's nonlocal elasticity theory for vibration analysis of rotating functionally graded nanobeams", Smart Struct. Syst., 17(5), 837-857. https://doi.org/10.12989/sss.2016.17.5.837.   DOI
119 Ebrahimi, F. and Shafiei, N. (2017), "Influence of initial shear stress on the vibration behavior of single-layered graphene sheets embedded in an elastic medium based on Reddy's higherorder shear deformation plate theory", Mech. Adv. Mater. Struct., 24(9), 761-772. https://doi.org/10.1080/15376494.2016.1196781.   DOI
120 Ebrahimi, F., Shafiei, N., Kazemi, M. and Mousavi Abdollahi, S.M. (2017), "Thermo-mechanical vibration analysis of rotating nonlocal nanoplates applying generalized differential quadrature method", Mech. Adv. Mater. Struct., 24(15), 1257-1273. https://doi.org/10.1080/15376494.2016.1227499.   DOI
121 Ehyaei, J., Akbarshahi, A. and Shafiei, N. (2017), "Influence of porosity and axial preload on vibration behavior of rotating FG nanobeam", Adv. Nano Res., 5(2), 141-169. https://doi.org/10.12989/anr.2017.5.2.141.   DOI
122 Shafiei, N. and Kazemi, M. (2017b), "Nonlinear buckling of functionally graded nano-/micro-scaled porous beams", Compos. Struct., 178, 483-492. https://doi.org/10.1016/j.compstruct.2017.07.045.   DOI
123 Habibi, M., Hashemi, R., Sadeghi, E., Fazaeli, A., Ghazanfari, A. and Lashini, H. (2016), "Enhancing the mechanical properties and formability of low carbon steel with dual-phase microstructures", J. Mater. Eng. Perform., 25(2), 382-389. https://doi.org/10.1007/s11665-016-1882-1.   DOI
124 Huang, X., Zhang, Y., Moradi, Z. and Shafiei, N. (2021b), "Computer simulation via a couple of homotopy perturbation methods and the generalized differential quadrature method for nonlinear vibration of functionally graded non-uniform microtube", Eng. Comput., 1-18. https://doi.org/10.1007/s00366-021-01395-7.   DOI
125 Jiao, J., Ghoreishi, S.M., Moradi, Z. and Oslub, K. (2021), "Coupled particle swarm optimization method with genetic algorithm for the static-dynamic performance of the magnetoelectro- elastic nanosystem", Eng. Comput., 38(3), 2499-2513. https://doi.org/10.1007/s00366-021-01391-x.   DOI
126 Shafiei, N., Mousavi, A. and Ghadiri, M. (2016g), "Vibration behavior of a rotating non-uniform FG microbeam based on the modified couple stress theory and GDQEM", Compos. Struct., 149, 157-169. https://doi.org/10.1016/j.compstruct.2016.04.024.   DOI
127 Shafiei, N. and Kazemi, M. (2017a), "Buckling analysis on the bidimensional functionally graded porous tapered nano-/microscale beams", Aerosp. Sci. Technol., 66, 1-11. https://doi.org/10.1016/j.ast.2017.02.019.   DOI
128 Shafiei, N., Ghadiri, M., Makvandi, H. and Hosseini, S.A. (2017a), "Vibration analysis of Nano-Rotor's Blade applying Eringen nonlocal elasticity and generalized differential quadrature method", Appl. Math. Modell., 43, 191-206. https://doi.org/10.1016/j.apm.2016.10.061.   DOI
129 Shafiei, N., Kazemi, M. and Fatahi, L. (2017b), "Transverse vibration of rotary tapered microbeam based on modified couple stress theory and generalized differential quadrature element method", Mech. Adv. Mater. Struct., 24(3), 240-252. https://doi.org/10.1080/15376494.2015.1128025.   DOI
130 Shafiei, N., Mirjavadi, S.S., Afshari, B.M., Rabby, S. and Hamouda, A.M.S. (2017c), "Nonlinear thermal buckling of axially functionally graded micro and nanobeams", Compos. Struct., 168, 428-439. https://doi.org/10.1016/j.compstruct.2017.02.048.   DOI
131 Yu, X., Maalla, A. and Moradi, Z. (2022), "Electroelastic highorder computational continuum strategy for critical voltage and frequency of piezoelectric NEMS via modified multi-physical couple stress theory", Mech. Syst. Signal Pr., 165, 108373. https://doi.org/10.1016/j.ymssp.2021.108373.   DOI
132 Ghadiri, M. and Shafiei, N. (2016c), "Vibration analysis of rotating functionally graded Timoshenko microbeam based on modified couple stress theory under different temperature distributions", Acta Astronaut., 121, 221-240. https://doi.org/10.1016/j.actaastro.2016.01.003.   DOI
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134 Lori, E.S., Ebrahimi, F., Supeni, E.E.B., Habibi, M. and Safarpour, H. (2020), "The critical voltage of a GPL-reinforced composite microdisk covered with piezoelectric layer", Eng. Comput., 1-20. https://doi.org/10.1007/s00366-020-01004-z.   DOI
135 Lai, W.F., Gui, D., Wong, M., Doring, A., Rogach, A.L., He, T. and Wong, W.T. (2021), "A self-indicating cellulose-based gel with tunable performance for bioactive agent delivery", J. Drug Deliv. Sci. Technol., 63, 102428. https://doi.org/10.1016/j.jddst.2021.102428.   DOI
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138 Mirjavadi, S.S., Rabby, S., Shafiei, N., Afshari, B.M. and Kazemi, M. (2017d), "On size-dependent free vibration and thermal buckling of axially functionally graded nanobeams in thermal environment", Appl. Phys. A, 123(5), 315. https://doi.org/10.1007/s00339-017-0918-1.   DOI
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140 Naderi, A., Fakher, M. and Hosseini-Hashemi, S. (2021), "On the local/nonlocal piezoelectric nanobeams: Vibration, buckling, and energy harvesting", Mech. Syst. Signal Pr., 151, 107432. https://doi.org/10.1016/j.ymssp.2020.107432.   DOI
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144 Li, J., Tang, F. and Habibi, M. (2020a), "Bi-directional thermal buckling and resonance frequency characteristics of a GNPreinforced composite nanostructure", Eng. Comput., 1-22. https://doi.org/10.1007/s00366-020-01110-y.   DOI
145 Li, Y., Li, S., Guo, K., Fang, X. and Habibi, M. (2020b), "On the modeling of bending responses of graphene-reinforced higher order annular plate via two-dimensional continuum mechanics approach", Eng. Comput., 1-22. https://doi.org/10.1007/s00366-020-01166-w.   DOI
146 Liu, Z., Su, S., Xi, D. and Habibi, M. (2020a), "Vibrational responses of a MHC viscoelastic thick annular plate in thermal environment using GDQ method", Mech. Based Des. Struct., 1-26. https://doi.org/10.1080/15397734.2020.1784201.   DOI
147 Liu, Z., Wu, X., Yu, M. and Habibi, M. (2020b), "Large-amplitude dynamical behavior of multilayer graphene platelets reinforced nanocomposite annular plate under thermo-mechanical loadings", Mech. Based Des. Struct., 1-25. https://doi.org/10.1080/15397734.2020.1815544.   DOI
148 Liu, H., Shen, S., Oslub, K., Habibi, M. and Safarpour, H. (2021a), "Amplitude motion and frequency simulation of a composite viscoelastic microsystem within modified couple stress elasticity", Eng. Comput., 1-15. https://doi.org/10.1007/s00366-021-01316-8.   DOI
149 Al-Furjan, M., Moghadam, S.A., Dehini, R., Shan, L., Habibi, M. and Safarpour, H. (2020e), "Vibration control of a smart shell reinforced by graphene nanoplatelets under external load: Seminumerical and finite element modeling", Thin Wall. Struct., 107242. https://doi.org/10.1016/j.tws.2020.107242.   DOI
150 Al-Furjan, M., Fereidouni, M., Habibi, M., Abd Ali, R., Ni, J. and Safarpour, M. (2020b), "Influence of in-plane loading on the vibrations of the fully symmetric mechanical systems via dynamic simulation and generalized differential quadrature framework", Eng. Comput., 1-23. https://doi.org/10.1007/s00366-020-01177-7.   DOI
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