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Exercise With a Novel Digital Device Increased Serum Anti-influenza Antibody Titers After Influenza Vaccination

  • Jun-Pyo Choi (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Ghazal Ayoub (S-Alpha Therapeutics, Inc.) ;
  • Jarang Ham (S-Alpha Therapeutics, Inc.) ;
  • Youngmin Huh (S-Alpha Therapeutics, Inc.) ;
  • Seung Eun Choi (S-Alpha Therapeutics, Inc.) ;
  • Yu-Kyoung Hwang (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Ji Yun Noh (Division of Infectious Diseases, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine) ;
  • Sae-Hoon Kim (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Joon Young Song (Division of Infectious Diseases, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine) ;
  • Eu Suk Kim (Division of Infectious Diseases, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Yoon-Seok Chang (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
  • Received : 2022.09.04
  • Accepted : 2022.12.28
  • Published : 2023.04.30
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Abstract

It has been reported that some exercise could enhance the anti-viral antibody titers after vaccination including influenza and coronavirus disease 2019 vaccines. We developed SAT-008, a novel digital device, consists of physical activities and activities related to the autonomic nervous system. We assessed the feasibility of SAT-008 to boost host immunity after an influenza vaccination by a randomized, open-label, and controlled study on adults administered influenza vaccines in the previous year. Among 32 participants, the SAT-008 showed a significant increase in the anti-influenza antibody titers assessed by hemagglutination-inhibition test against antigen subtype B Yamagata lineage after 4 wk of vaccination and subtype B Victoria lineage after 12 wk (p<0.05). There was no difference in the antibody titers against subtype "A." The SAT-008 also showed significant increase in the plasma cytokine levels of IL-10, IL-1β, and IL-6 at weeks 4 and 12 after the vaccination (p<0.05). A new approach using the digital device may boost host immunity against virus via vaccine adjuvant-like effects.

Keywords

Acknowledgement

This work was supported by a grant (06-2020-0297) from Seoul National University Bundang Hospital (SNUBH) Research fund. We appreciate Prof. Shimon Sakakuchi (Osaka University, Japan) for his kind advice and support.

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