• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.127-138
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• 2023

Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer's disease (AD). In this study, structure-based virtual screening was performed to search database for compounds targeting GSK-3β from Enamine's screening collection. Of the top-ranked compounds, 7 primary hits underwent a luminescent kinase assay and a cell assay using human neuroblastoma SH-SY5Y cells expressing Tau repeat domain (Tau_RD) with pro-aggregant mutation ΔK280. In the kinase assay for these 7 compounds, residual GSK-3β activities ranged from 36.1% to 90.0% were detected at the IC₅₀ of SB-216763. In the cell assay, only compounds VB-030 and VB-037 reduced Tau aggregation in SH-SY5Y cells expressing ΔK280 Tau_RD-DsRed folding reporter. In SH-SY5Y cells expressing ΔK280 Tau_RD, neither VB-030 nor VB-037 increased expression of GSK-3α Ser21 or GSK-3β Ser9. Among extracellular signal-regulated kinase (ERK), AKT serine/threonine kinase 1 (AKT), mitogen-activated protein kinase 14 (P38) and mitogenactivated protein kinase 8 (JNK) which modulate Tau phosphorylation, VB-037 attenuated active phosphorylation of P38 Thr180/ Tyr182, whereas VB-030 had no effect on the phosphorylation status of ERK, AKT, P38 or JNK. However, both VB-030 and VB-037 reduced endogenous Tau phosphorylation at Ser202, Thr231, Ser396 and Ser404 in neuronally differentiated SH-SY5Y expressing ΔK280 Tau_RD. In addition, VB-030 and VB-037 further improved neuronal survival and/or neurite length and branch in mouse hippocampal primary culture under Tau cytotoxicity. Overall, through inhibiting GSK-3β kinase activity and/or p-P38 (Thr180/Tyr182), both compounds may serve as promising candidates to reduce Tau aggregation/cytotoxicity for AD treatment.

• Journal of Korean Physical Therapy Science
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• v.2 no.1
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• pp.367-373
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• 1995

The purpose of this studied was the comparison with shoulder girdle muscles of isokinetic evaluation in the spinal cord injury group, and adults normal group. Data was collected from 20 cases spinal cord injury from January 10. 1994 to February 10, 1995 in a Chungnam University hospital and adults normal group to 20 cases. The results were as follows; 1. Low speeds peak torque was higher spinal cord group than normal group shoulder girdle muscles of flexor, extensor, external rotator showed statistically significant in spinal cord injury group(p<0.05). Against normal groups shoulder girdle muscles of internal rotator showed statistically significant in normal group(p<0.05). 2. High speeds peak torque was higher spinal cord group than normal group shoulder girdle muscles of flexor, extensor, showed statistically significant in spinal cord injury group(p<0.05). 3. High speeds total work was higher spinal cord group than normal group shoulder girdle muscles of flexor, extensor, external rotator showed statistically significant in spinal cord injury group(p<0.05).(p<0.01). Against normal group shoulder girdle muscles of internal rotator showed statistically significant in normal group(p<0.05).

• Honam Mathematical Journal
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• v.26 no.4
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• pp.559-587
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• 2004

We study some properties of intuitionistic fuzzy normal subgroups of a group. In particular, we obtain two characterizations of intuitionistic fuzzy normal subgroups. Moreover, we introduce the concept of an intuitionistic fuzzy coset and obtain several results which are analogous of some basic theorems of group theory.

• Journal of applied mathematics & informatics
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• v.35 no.1_2
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• pp.83-93
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• 2017

The Cayley graph ${\Gamma}=Cay(G,S)$ is called normal edge-transitive if $N_A(R(G))$ acts transitively on the set of edges of ${\Gamma}$, where $A=Aut({\Gamma})$ and R(G) is the regular subgroup of A. In this paper, we determine all hexavalent normal edge-transitive Cayley graphs on groups of order pqr, where p > q > r > 2 are prime numbers.

• Journal of the Korean Mathematical Society
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• v.36 no.4
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• pp.663-677
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• 1999

This work is concerned mainly with the variational problem on an immersion x:M $\rightarrow$} $E^4$ . A new approach is introduced depends on the normal variation in any arbitrary normal direction in the normal bundle. The results of this work are considered as a continuation and an extension to that obtained in [1], [2] and [3], [4] respectively. The methods adapted here are based on Cartan's methods of moving frames and the calculus of variations.

• Korean journal of food and cookery science
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• v.13 no.2
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• pp.192-203
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• 1997

The purpose of this study is to investigate the difference of dietary habits between normal and handicapped children. This study was performed with 166 normal children and 154 handicapped children in Incheon area. There was very significant differences of dietary habits between normal and handicapped children, but there was no significant difference in disable type.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.10 no.1
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• pp.82-88
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• 2010

In this paper we continue the study of intuitionistic fuzzy groups by introducing the notion of intuitionistic fuzzy normal subgroup based on intuitionistic fuzzy space as a generalization of fuzzy normal subgroup.

• Structural Engineering and Mechanics
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• v.76 no.2
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• pp.153-162
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• 2020

Aiming at the mechanical and structural characteristics of the contact zone composite rock, the shear tests and numerical studies were carried out. The effects of the differences in mechanical properties of different materials and the normal stress on shear properties of contact zone composite samples were analyzed from a macro-meso level. The results show that the composite samples have high shear strength, and the interface of different materials has strong adhesion. The differences in mechanical properties of materials weakens the shear strength and increase the shear brittleness of the sample, while normal stress will inhibit these effect. Under low/high normal stress, the sample show two failure modes, at the meso-damage level: elastic-shearing-frictional sliding and elastic-extrusion wear. This is mainly controlled by the contact and friction state of the material after damage. The secondary failure of undulating structure under normal-shear stress is the nature of extrusion wear, which is positively correlated to the normal stress and the degree of difference in mechanical properties of different materials. The increase of the mechanical difference of the sample will enhance the shear brittleness under lower normal stress and the shear interaction under higher normal stress.

• The Journal of Korean Physical Therapy
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• v.11 no.1
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• pp.129-136
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• 1999

The purpode of this study was to determine the EMG characteristies of 7 subjects with hemiplegic gait receiving therapeautic exercise after stroke. The akin electrode and gait analysis system were used. The normal gait of 6 health volunteers was analysised. The results were following. 1. Gluteus maximus, the extensor of hip joint had high level of activity compared to normal, and had two peak in late stance phase and early Swing phase. 2. Medial hamstring, the flexor of knee joint had low level of activity compared to normal, and had continuous low amplitude pattern. 3. Vastus lateralis, the extensor of knee joint had high level of activity compared to normal, and had not continuous high amplitude. From early stance phase and mid stance phase, activity had high level but after swing phase. similar to normal. 4. Gastrocnemius, plantar flexor of ankle joint had low level of activity compared to normal and had continuous low amplitude. 5. Tibialis anterior, dorsiflexor of ankle joint had similar muscle activity to normal and had continuous low amplitude.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.18 no.3
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• pp.738-754
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• 2024

Side-channel analysis (SCA) is a cryptanalytic technique that exploits physical leakages, such as power consumption or electromagnetic emanations, from cryptographic devices to extract secret keys used in cryptographic algorithms. Recent studies have shown that training SCA models with semi-supervised learning can effectively overcome the problem of few labeled power traces. However, the process of training SCA models using semi-supervised learning generates many pseudo-labels. The performance of the SCA model can be reduced by some of these pseudo-labels. To solve this issue, we propose the HWFilter method to improve semi-supervised SCA. This method uses a Hamming Weight Pseudo-label Filter (HWPF) to filter the pseudo-labels generated by the semi-supervised SCA model, which enhances the model's performance. Furthermore, we introduce a normal distribution method for constructing the HWPF. In the normal distribution method, the Hamming weights (HWs) of power traces can be obtained from the normal distribution of power points. These HWs are filtered and combined into a HWPF. The HWFilter was tested using the ASCADv1 database and the AES_HD dataset. The experimental results demonstrate that the HWFilter method can significantly enhance the performance of semi-supervised SCA models. In the ASCADv1 database, the model with HWFilter requires only 33 power traces to recover the key. In the AES_HD dataset, the model with HWFilter outperforms the current best semi-supervised SCA model by 12%.