• Journal of Oriental Neuropsychiatry
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• v.3 no.2
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• pp.87-96
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• 1992

In order to see the variation of human nature, M.M.P.I. was carried on 2, April 1992 (the last day of the second lunar month) and 15, June 1992 (the fifteenth day of the fifth lunar month). These experiments took male and female students who were in Won kwang University as subjects (108 students on 2, April, 105 students on 15, June). The results of it suggested the followings. 1) Every students' average of T-grades on each measure were in a normal scope. 2) There were no significant differences in comparison between the fifteenth day and the last day of the month. 3) On every measure except L, Mf, Si, the female students showed higher grade in the fifteenth day than the last day of the month. But there was no significant difference in male students. Both male and female students didn't show the significant one. 4) On the fifteenth day of the month, the female students showed higher T-grade then male did on every measure except Mf, Ma, Si. There was a significant difference on D, Pd, Mf(P<0.05) measure. 5) On the last day of the month, male students showed higher T-grade then female did on every measure except L, K, Hy, Pt. There was a significant difference on L(P<0.001), K(P<0.01). 6) On experiments about female students, there was no symptom of neurosis and psychosis on the last day of the month. But three of sixteen students(18.7%) showed symptom of neurosis, one of thirteen(6%) showed symptom of psychosis on the fifteenth day of the month. On experiments about male students, eleven of ninety-two(11.9%), four of ninety-two(4.3%) showed symptom of neurosis and psychosis respectively on the fifteenth day of the month. Ten of ninety-two(10.8%), six of ninety-two(6.5%) showed symptom of neurosis and psychosis respectively on the last day of the month. As the results of the above, human nature changes to some extend according to lunar cycle. And there are many changes in female than male. But it is difficult to generalize this fact by limited subject and only one experiments. So the controlled studies are needed on the basis of this result and have to take many person as a subject.

• Parasites, Hosts and Diseases
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• v.36 no.1
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• pp.7-14
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• 1998

In order to understand the action mechanism of polyhexamethylene biguanide (PHMB) to the cyst of Accnthcnloebc on the morphological basis, the cysts of four corneal isolates of Acanthanoebc were treated with minimal cysticidal concentration (MCC) of PHMB and their ultrastructural changes were examined by transmission electron microscopy. The most striking change of cysts treated with PHMB compared with normal cysts was the shrinkage of intracystic amoebae, which resulted in the separation of the plasma membrane of intracystic amoeba from endocystic wall. Subplasmalemmal lipid droplets became irregularly shaped . In severely damaged cysts, cytoplasm was aggregated and organelles were severely deformed. Cytoplasmic materials were leaked out through the damaged plasma membrane. Most cysts showed aggregation of nuclear chromatin material. Number of mitochondrial cristae was also reduced. Ecto- and endo-cystic walls were relatively well tolerated. Findings in the present study revealed that PHMB affected mainly on plasma membrane, but lesser on organellar membrane of intracystic amoeba. It seemed likely that PHMB might kill cystic forms of Accnthamoebc by similar mechanism in which this environmental biocide can damage the cell wall of Escherichia coli by binding with acidic phospholipids.

• Korean Journal of Acupuncture
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• v.37 no.1
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• pp.14-23
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• 2020

Objectives : We investigated the efficacy and safety of miniscalpel acupuncture (MA) treatment combined with non-steroidal anti-inflammatory drugs (NSAIDs) for chronic neck pain (CNP) in an assessor-blinded randomized controlled pilot trial to establish a basis for larger-scale randomized controlled studies on this subject. Methods : Participants (n=36) were recruited and randomly allocated to the MA group, NSAIDs and combined treatment group. The MA group received MA three times over three weeks. The NSAIDs group was administered orally with zaltoprofen 80mg t.i.d. over three weeks. The combined treatment group received MA and zaltoprofen in the same manner as MA and NSAIDs groups. The primary outcome was pain as assessed by a visual analogue scale (VAS) and the secondary outcomes were assessed using the Neck Disability index (NDI), EuroQol 5-dimension questionnaire (EQ-5D), and Patients' Global Impression of Change scale (PGIC). Assessments were made at week 0 (baseline), 1, 2, 3 (primary end point) during treatment and at week 7 (4 weeks after the end of treatment). Results : 35 participants completed the study. No serious adverse event occurred and blood test results were within normal limits. The improvement of VAS and NDI was significantly greater in combined and MA group than that in NSAIDs group (p<0.017). The combined group showed better outcomes in EQ-5D at visit 2 and 5, in PGIC at visit 4 than the NSAIDs group (p<0.017). No significant differences were found between combined and MA group. Conclusions : Our results suggest that both combined and MA group can be more effective in improving pain control than NSAIDs group. A large-scale clinical study is warranted to further clarify these findings.

• Journal of Life Science
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• v.18 no.4
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• pp.447-453
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• 2008

Zinc is an essential trace element in Human Being. Highly zinc containing yeast strain isolated from the tropical fruit, rambutan and the zinc concentration in this yeast strain was 306 ppm (30.6 mg%)per dry matter basis. This strain was found to be a rounded type, normal size, and multi-polar budding. Phylogenetic analysis using the ITS1-5.85 rDNA sequences from isolated strain is most similar to yeast Saccharomyces cerevisiae at the level of nucleotide sequence identity at 99%. This strain was produced alcohol by about 12% using fully colonized koji-rice with Aspergillus oryzae. In conclusion, the isolated strain was found to be closely related to the S. cerevisiae based on its morphological and physiological properties, and alcohol fermentation. The phylogenetic analysis of strain FF-10 using ITS 5.8S rDNA sequence data also supported the closely related to the S. cerevisiae. Accordingly, the isolated yeast was named as S. cerevisiae FF-10. Further studies on the best culture conditions for zinc production from zinc-enriched S. cerevisiae FF-10 are under investigation.

• Molecules and Cells
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• v.40 no.2
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• pp.109-116
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• 2017

Soybean agglutinin (SBA) is an anti-nutritional factor of soybean, affecting cell proliferation and inducing cytotoxicity. Integrins are transmembrane receptors, mediating a variety of cell biological processes. This research aims to study the effects of SBA on cell proliferation and cell cycle progression of the intestinal epithelial cell line from piglets (IPEC-J2), to identify the integrin subunits especially expressed in IPEC-J2s, and to analyze the functions of these integrins on IPEC-J2 cell cycle progression and SBA-induced IPEC-J2 cell cycle alteration. The results showed that SBA lowered cell proliferation rate as the cell cycle progression from G0/G1 to S phase (P < 0.05) was inhibited. Moreover, SBA lowered mRNA expression of cell cycle-related gene CDK4, Cyclin E and Cyclin D1 (P < 0.05). We successfully identified integrins ${\alpha}2$, ${\alpha}3$, ${\alpha}6$, ${\beta}1$, and ${\beta}4$ in IPEC-J2s. These five subunits were crucial to maintain normal cell proliferation and cell cycle progression in IPEC-J2s. Restrain of either these five subunits by their inhibitors, lowered cell proliferation rate, and arrested the cells at G0/G1 phase of cell cycle (P < 0.05). Further analysis indicated that integrin ${\alpha}2$, ${\alpha}6$, and ${\beta}1$ were involved in the blocking of G0/G1 phase induced by SBA. In conclusion, these results suggested that SBA lowered the IPEC-J2 cell proliferation rate through the perturbation of cell cycle progression. Furthermore, integrins were important for IPEC-J2 cell cycle progression, and they were involved in the process of SBA-induced cell cycle progression alteration, which provide a basis for further revealing SBA anti-proliferation and anti-nutritional mechanism.

• Journal of Nutrition and Health
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• v.47 no.3
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• pp.157-166
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• 2014

Purpose: Rice bran is a byproduct of the hulling of rice and contains a variety of bioactive components. Various studies have reported on the antioxidative, anticancer, immune-enhancing, and hypocholesterolemic effects of rice bran. However, few studies about the physiological activity of stabilized rice bran supplement on dietary intake of sugars is limited. The aim of this study was to investigate the effect of stabilized rice bran supplement on blood glucose in C57BL/6 mice fed a high sucrose diet. Methods: Animals were randomly divided into three groups respectively, and were fed a normal diet (ND group), a high sucrose diet (HSD group) or a high sucrose diet containing 20% stabilized rice bran (HSD-SRB group) for 12 weeks. Results: In the oral glucose tolerance test (OGTT), after seven weeks of feeding on the experimental diets, a significantly lower result was observed for HSD-SRB than for HSD at 30 and 60 minutes after oral administration in glucose solution (2 g/kg body weight). The incremental area under the curve (IAUC) of HSD-SRB was significantly lower than that of HSD. After 12 weeks, fasting blood glucose level of HSD-SRB was significantly lower than that of HSD. No significant difference in the serum insulin level was observed between HSD and HSD-SRB. However, HOMA-IR was significantly decreased in HSD-SRB compared to HSD. In addition, HOMA ${\beta}$-cell was significantly increased in HSD-SRB compared to HSD. Triglyceride in liver of HSD-SRB was significantly lower than that of HSD. Conclusion: Feeding diets containing 20% rice bran improved insulin resistance and insulin secretion by decreasing triglyceride in liver. Thus, rice bran has a positive effect on glycemic control. In addition, the results are expected to be utilized as a basis for human study and development of food products with added rice bran.

• Journal of Yeungnam Medical Science
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• v.6 no.1
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• pp.87-98
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• 1989

Clinical estimation of bladder and rectal doses from high dose rate intracavitary irradiation in carcinoma of the cervix uteri has been initiated on a routine basis in an effort to obtain the optimum radiotherapeutic dose. Simulation films with contrast media are used to image the bladder and rectum, and dose rates are estimated at various interesting points with the aid of treatment planning computer, NEC Therac-2300. Fifty-three patients have been reviewed in order to ascertain the correlation between radiation dose at interesting points in the bladder and rectum and the dose at Point A and B. The dose ratio between doses at Point A 'and interesting points is an important clinical factor in evaluating the treatment planning. This also serves as documentation of the dose to normal structures within the treatment volume. Authors conclude that obtained data are within acceptable ranges and routine simulation films of the bladder and rectum after administration of contrast media with dose calculations at interesting points provide important information for optimizing radiotherapy planning in the treatment of cervical carcinoma without increased time and effort or patient's discomfort.

• FLOWER RESEARCH JOURNAL
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• v.18 no.2
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• pp.136-141
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• 2010

In order to analyze the horticultural-therapy program, which was carried out targeting the mentally disabled, relevant 559 copies of 'Confirmation Note of horticultural activity' submitted for to be used the use in license examination to Korean Horticultural Therapy and Wellbeing Association were used as a tool. It contains 64 horticultural therapists for level 1 and 524 horticultural therapists for level 2 from May in 2000 to February in 2008. With the aim of examining difference depending on people covered by the program, license kind and horticultural therapy activity period in horticulture therapists, ${\chi}^2$ test was conducted on the basis of frequency in each. Data was analyzed by using SPSS (Statistical Package for the Social Science) Win 13.0 program, which was carried out targeting the mentally disabled, the 'art and craft activity' was the largest with 46.0%. In terms of 'growing activity', the 'normal growing' showed the highest ratio with 74.7%. In the 'art and craft activity', the 'flower decoration' showed the highest ratio with 37.5%. In the result of 'Cooking activity', the activity related to 'tea' was the largest ratio with 33.6%. As a result of 'learning activity', 'orientation' was the largest ratio with 47.6%. In the 'outdoor activity', 'excursion' was the largest ratio with 36.7%.

• Journal of the Korean Society of Radiology
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• v.15 no.5
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• pp.723-730
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• 2021

This study tries to compare dose distribution between arc radiation therapy and Tomotherapy, which are main radiation therapy modalities. The subjects of this study are lung cancer patients. For planning target volume (PTV), a dose of 60.0 Gy was set as a basis. The PTVmean of Arc was 61.04 Gy, and that of Tomotherapy was 58.50 Gy. The total lung capacities of Arc and Tomotherapy were 3.0 Gy and 4.24 Gy, respectively. The mean heart doses of Arc and Tomotherapy were 0.13 and 0.34, respectively; the mean trachea dose of Arc and Tomotherapy were 1.35 and 2.58, respectively; the mean esophagus dose of Arc and Tomotherapy were 0.41 and 0.86, respectively; the mean spinal cord dose of Arc and Tomotherapy were 3.65 and 4.68, respectively. With regard to the appropriateness of therapeutic effect in DHV, both modalities seemed appropriate. Tomotherapy protected normal tissues better than Arc radiation therapy. In Tomotherapy, patients need to have treatment long in a limited space. If such a point is overcome, Tomotherapy is better. Otherwise, Arc radiation therapy can be applied. This study was conducted with treatment planning images. Therefore, the results of this study are different from actual treatment results. If more research is conducted to overcome the limitation, the effects of radiation therapy are expected to increase further.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.16 no.4
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• pp.441-454
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• 2018

Since the permanent shutdown of Kori Unit 1 in 2017, a full-scale decommissioning project for a commercial nuclear reactor has been approaching. It is estimated that about 160,000 t of low-activity concrete waste will be produced from decommissioning of one unit of this commercial nuclear power reactor. Accordingly, it is necessary to review whether the effectiveness of the current regulatory framework for clearance waste (i.e. waste stream that meets activity concentration guidelines or dose criteria for clearance set forth in NSSC Notice No. 2017-65) can be maintained for the clearance of a bulk amount of concrete waste. In this regard, the IAEA SRS No. 44, which was used as a basis for revision of the Korean clearance regulations, is thoroughly analyzed and the radiological effects from four different clearance scenarios, along with input values and parameters derived from industrial practices in Korea, were evaluated. Though it is shown that the maximum annual dose from most recycling scenarios will be less than the clearance dose criterion for the normal scenario (i.e. an order of magnitude of $0.01mSv{\cdot}y^{-1}$), the radiation dose, estimated with conservative assumptions for the banking scenario, may exceed the above clearance dose criteria. Therefore, for safe and sustainable clearance of the bulk amount of concrete waste, it is required to diversify the concrete waste processors, perform more detailed site-specific assessment, and apply limiting conditions to the banking scenario.