Browse > Article
http://dx.doi.org/10.4163/jnh.2014.47.3.157

Effect of stabilized rice bran-added high sucrose diet on glucose control in C57BL/6 mice  

Lee, Seung-Min (Department of Food and Nutrition, Chonnam National University)
Shin, Mal-Shick (Department of Food and Nutrition, Chonnam National University)
Heo, Young-Ran (Department of Food and Nutrition, Chonnam National University)
Publication Information
Journal of Nutrition and Health / v.47, no.3, 2014 , pp. 157-166 More about this Journal
Abstract
Purpose: Rice bran is a byproduct of the hulling of rice and contains a variety of bioactive components. Various studies have reported on the antioxidative, anticancer, immune-enhancing, and hypocholesterolemic effects of rice bran. However, few studies about the physiological activity of stabilized rice bran supplement on dietary intake of sugars is limited. The aim of this study was to investigate the effect of stabilized rice bran supplement on blood glucose in C57BL/6 mice fed a high sucrose diet. Methods: Animals were randomly divided into three groups respectively, and were fed a normal diet (ND group), a high sucrose diet (HSD group) or a high sucrose diet containing 20% stabilized rice bran (HSD-SRB group) for 12 weeks. Results: In the oral glucose tolerance test (OGTT), after seven weeks of feeding on the experimental diets, a significantly lower result was observed for HSD-SRB than for HSD at 30 and 60 minutes after oral administration in glucose solution (2 g/kg body weight). The incremental area under the curve (IAUC) of HSD-SRB was significantly lower than that of HSD. After 12 weeks, fasting blood glucose level of HSD-SRB was significantly lower than that of HSD. No significant difference in the serum insulin level was observed between HSD and HSD-SRB. However, HOMA-IR was significantly decreased in HSD-SRB compared to HSD. In addition, HOMA ${\beta}$-cell was significantly increased in HSD-SRB compared to HSD. Triglyceride in liver of HSD-SRB was significantly lower than that of HSD. Conclusion: Feeding diets containing 20% rice bran improved insulin resistance and insulin secretion by decreasing triglyceride in liver. Thus, rice bran has a positive effect on glycemic control. In addition, the results are expected to be utilized as a basis for human study and development of food products with added rice bran.
Keywords
rice bran; high sucrose diet; insulin resistance; blood glucose.;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Laaksonen DE, Toppinen LK, Juntunen KS, Autio K, Liukkonen KH, Poutanen KS, Niskanen L, Mykkanen HM. Dietary carbohydrate modification enhances insulin secretion in persons with the metabolic syndrome. Am J Clin Nutr 2005; 82(6): 1218-1227.
2 Moynihan P. The interrelationship between diet and oral health. Proc Nutr Soc 2005; 64(4): 571-580.   DOI
3 Lombardo YB, Drago S, Chicco A, Fainstein-Day P, Gutman R, Gagliardino JJ, Gomez Dumm CL. Long-term administration of a sucrose-rich diet to normal rats: relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreas. Metabolism 1996; 45(12): 1527-1532.   DOI   ScienceOn
4 Saunders RM. The properties of rice bran as a foodstuff. Cereal Foods World 1990; 35(7): 632, 634-636.
5 Oliveira LS, Santos DA, Barbosa-da-Silva S, Mandarim-de-Lacerda CA, Aguila MB. The inflammatory profile and liver damage of a sucrose-rich diet in mice. J Nutr Biochem 2014; 25(2): 193-200.   DOI
6 Nguyen S, Choi HK, Lustig RH, Hsu CY. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr 2009; 154(6): 807-813.   DOI
7 James J, Kerr D. Prevention of childhood obesity by reducing soft drinks. Int J Obes (Lond) 2005; 29 Suppl 2: S54-S57.   DOI
8 Ha TY, Ko SN, Lee SM, Kim HR, Chung SH, Kim SR, Yoon HH, Kim IH. Changes in nutraceutical lipid components of rice at different degrees of milling. Eur J Lipid Sci Technol 2006; 108(3): 175-181.   DOI   ScienceOn
9 Ishitani A, inventor; Kokai Tokkyo Koho, assignee. Oryzanol antioxidant for food. Japan Kokai Tokkyo Koho JP 80, 50, 094. 1980. (C.A.-93:112560).
10 Torsdottir I, Alpsten M, Holm G, Sandberg AS, Tolli J. A small dose of soluble alginate-fiber affects postprandial glycemia and gastric emptying in humans with diabetes. J Nutr 1991; 121(6): 795-799.   DOI
11 Pastors JG, Blaisdell PW, Balm TK, Asplin CM, Pohl SL. Psyllium fiber reduces rise in postprandial glucose and insulin concentrations in patients with non-insulin-dependent diabetes. Am J Clin Nutr 1991; 53(6): 1431-1435.   DOI
12 Lee HS. Choi MS, Lee YK, Park SH, Kim YJ. A study on the development of high-fiber supplements for the diabetic patients: effect of seaweed supplementation on the lipid and glucose metabolism in streptozotocin-induced diabetic rats. Korean J Nutr 1996; 29(3): 296-306.
13 Mittendorfer B, Sidossis LS. Mechanism for the increase in plasma triacylglycerol concentrations after consumption of shortterm, high-carbohydrate diets. Am J Clin Nutr 2001; 73(5): 892-899.
14 Swanson JE, Laine DC, Thomas W, Bantle JP. Metabolic effects of dietary fructose in healthy subjects. Am J Clin Nutr 1992; 55 (4): 851-856.   DOI
15 Sidossis LS, Stuart CA, Shulman GI, Lopaschuk GD, Wolfe RR. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J Clin Invest 1996; 98 (10): 2244-2250.   DOI   ScienceOn
16 Shindo N, Fujisawa T, Sugimoto K, Nojima K, Oze-Fukai A, Yoshikawa Y, Wang X, Yasuda O, Ikegami H, Rakugi H. Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model. J Hepatol 2010; 52(6): 903-912.   DOI
17 Aguila MB, Fernandes-Santos C, Pinheiro-Mulder AR, Faria TS, Mandarim-De-Lacerda CA. Hepatic insulin resistance and nonalcoholic fatty liver disease. In: Moliere J, Gauthier L, editors. Insulin resistance: symptoms, causes, and treatment. Hauppauge (NY): Nova Science; 2010. p.1-44.
18 Ausman LM, Rong N, Nicolosi RJ. Hypocholesterolemic effect of physically refined rice bran oil: studies of cholesterol metabolism and early atherosclerosis in hypercholesterolemic hamsters. J Nutr Biochem 2005; 16(9): 521-529.   DOI
19 Sievenpiper JL, de Souza RJ, Mirrahimi A, Yu ME, Carleton AJ, Beyene J, Chiavaroli L, Di Buono M, Jenkins AL, Leiter LA, Wolever TM, Kendall CW, Jenkins DJ. Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis. Ann Intern Med 2012; 156(4): 291-304.   DOI   ScienceOn
20 Ha TY, Lee SH, Lee HY. The effect of various rice bran extracts on the lipid contents of serum and liver in rat fed with high fat diet. Korean J Food Sci Technol 1997; 29(1): 178-182.
21 Anderson JW, Jones AE, Riddell-Mason S. Ten different dietary fibers have significantly different effects on serum and liver lipids of cholesterol-fed rats. J Nutr 1994; 124(1): 78-83.
22 Yu JR. Effect of rice bran protein on lipid metabolism in rats fed high fat diet [dissertation]. Yongin: Yongin University; 2013.
23 Borkan GA, Hults DE, Gerzof SG, Robbins AH, Silbert CK. Age changes in body composition revealed by computed tomography. J Gerontol 1983; 38(6): 673-677.   DOI   ScienceOn
24 Gutman RA, Basilico MZ, Bernal CA, Chicco A, Lombardo YB. Long-term hypertriglyceridemia and glucose intolerance in rats fed chronically an isocaloric sucrose-rich diet. Metabolism 1987; 36(11): 1013-1020.   DOI
25 Wang Y, Lam KS, Yau MH, Xu A. Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J 2008; 409(3): 623-633.   DOI   ScienceOn
26 Kamari Y, Grossman E, Oron-Herman M, Peleg E, Shabtay Z, Shamiss A, Sharabi Y. Metabolic stress with a high carbohydrate diet increases adiponectin levels. Horm Metab Res 2007; 39(5): 384-388.   DOI   ScienceOn
27 Tan HY, Rand JS, Morton JM, Fleeman LM, Armstrong PJ, Coradini M, Ishioka K, Verkest KR, Richards AA, Rawlings JM, Rose FJ, Whitehead JP. Adiponectin profiles are affected by chronic and acute changes in carbohydrate intake in healthy cats. Gen Comp Endocrinol 2011; 172(3): 468-474.   DOI
28 Fuente-Martin E, Garcia-Caceres C, Granado M, Sanchez-Garrido MA, Tena-Sempere M, Frago LM, Argente J, Chowen JA. Early postnatal overnutrition increases adipose tissue accrual in response to a sucrose-enriched diet. Am J Physiol Endocrinol Metab 2012; 302(12): E1586-E1598.   DOI
29 Carvalho CR, Bueno AA, Mattos AM, Biz C, de Oliveira C, Pisani LP, Ribeiro EB, do Nascimento CM, Oyama LM. Fructose alters adiponectin, haptoglobin and angiotensinogen gene expression in 3T3-L1 adipocytes. Nutr Res 2010; 30(9): 644-649.   DOI
30 Siddiqui S, Rashid Khan M, Siddiqui WA. Comparative hypoglycemic and nephroprotective effects of tocotrienol rich fraction (TRF) from palm oil and rice bran oil against hyperglycemia induced nephropathy in type 1 diabetic rats. Chem Biol Interact 2010; 188(3): 651-658.   DOI   ScienceOn
31 Bharti SK, Kumar A, Sharma NK, Prakash O, Jaiswal SK, Krishnan S, Gupta AK, Kumar A. Tocopherol from seeds of Cucurbita pepo against diabetes: validation by in vivo experiments supported by computational docking. J Formos Med Assoc 2013; 112 (11): 676-690.   DOI
32 Kim SM. Effects of rice bran and phytic acid supplementation on glucose and lipid metabolism in high-fat diet-fed C57BL/6 mice [dissertation]. Daegu: Kyungpook National University; 2010.
33 Park TS, Lee SY, Kim HJ, Kim KT, Kim YJ, Jeong I, Do WN, Lee HJ. Extracts of adlay, barley and rice bran have antioxidant activity and modulate fatty acid metabolism in adipocytes. Korean J Food Nutr 2009; 22(3): 456-462.
34 Justo ML, Candiracci M, Dantas AP, de Sotomayor MA, Parrado J, Vila E, Herrera MD, Rodriguez-Rodriguez R. Rice bran enzymatic extract restores endothelial function and vascular contractility in obese rats by reducing vascular inflammation and oxidative stress. J Nutr Biochem 2013; 24(8): 1453-1461.   DOI
35 Kim YH, Kang CS, Lee YS. Quantification of tocopherol and tocotrienol content in rice bran by near infrated reflectance spectroscopy. Korean J Crop Sci 2004; 49(3): 211-215.
36 Kim WJ. Quality and antioxidative activity of Garaedduk prepared with stabilized rice bran and rice flours by semi-dry milling [dissertation]. Gwangju: Chonnam National University; 2013.
37 Jang KH. Effect of rice bran on the confectionery and bakery quality [dissertation]. Kyeongsan: Yeungnam University; 2010.
38 Jin HJ, Lee SS. Effect of rice bran dietary fiber level on serum lipid concentration, bowel function, and mineral absorption in rats. Korean J Food Nutr 2011; 24(4): 622-629.   DOI   ScienceOn
39 Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and ${\beta}$-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28(7): 412-419.   DOI   ScienceOn
40 Lo S, Russell JC, Taylor AW. Determination of glycogen in small tissue samples. J Appl Physiol 1970; 28(2): 234-236.   DOI
41 Yang M, Wang C, Chen H. Green, oolong and black tea extracts modulate lipid metabolism in hyperlipidemia rats fed high-sucrose diet. J Nutr Biochem 2001; 12(1): 14-20.   DOI   ScienceOn
42 Kanazawa M, Xue CY, Kageyama H, Suzuki E, Ito R, Namba Y, Osaka T, Kimura S, Inoue S. Effects of a high-sucrose diet on body weight, plasma triglycerides, and stress tolerance. Nutr Rev 2003; 61(5 Pt 2): S27-S33.   DOI
43 Kim SR, Ahn JY, Lee HY, Ha TY. Various properties and phenolic acid contents of rices and rice brans with different milling fractions. Korean J Food Sci Technol 2004; 36(6): 930-936.
44 Kuhlow D, Zarse K, Voigt A, Schulz TJ, Petzke KJ, Schomburg L, Pfeiffer AF, Ristow M. Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice. Eur J Nutr 2010; 49(7): 417-427.   DOI
45 Fraulob JC, Ogg-Diamantino R, Fernandes-Santos C, Aguila MB, Mandarim-de-Lacerda CA. A mouse model of metabolic syndrome: insulin resistance, fatty liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 mice fed a high fat diet. J Clin Biochem Nutr 2010; 46(3): 212-223.   DOI   ScienceOn
46 Newman RK, Betschart AA, Newman CW, Hofer PJ. Effect of full-fat or defatted rice bran on serum cholesterol. Plant Foods Hum Nutr 1992; 42(1): 37-43.   DOI
47 Gross MD. Effect of sucrose on hyperkinetic children. Pediatrics 1984; 74(5): 876-878.
48 Choi HI, Ye EJ, Kim SJ, Bae MJ, Yee ST, Park EJ, Park EM. Anticancer (in vitro) and antiallergy effects of rice bran extracts. J Korean Soc Food Sci Nutr 2006; 35(10): 1297-1303.   DOI
49 Madero M, Arriaga JC, Jalal D, Rivard C, McFann K, Perez-Mendez O, Vazquez A, Ruiz A, Lanaspa MA, Jimenez CR, Johnson RJ, Lozada LG. The effect of two energy-restricted diets, a lowfructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial. Metabolism 2011; 60(11): 1551-1559.   DOI   ScienceOn