• Title/Summary/Keyword: Normal Aging

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Development of FURA Code and Application for Load Follow Operation (FURA 코드 개발과 부하 추종 운전에 대한 적용)

  • Park, Young-Seob;Lee, Byong-Whi
    • Nuclear Engineering and Technology
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    • v.20 no.2
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    • pp.88-104
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    • 1988
  • The FUel Rod Analysis(FURA) code is developed using two-dimensional finite element methods for axisymmetric and plane stress analysis of fuel rod. It predicts the thermal and mechanical behavior of fuel rod during normal and load follow operations. To evaluate the exact temperature distribution and the inner gas pressure, the radial deformation of pellet and clad, the fission gas release are considered over the full-length of fuel rod. The thermal element equation is derived using Galerkin's techniques. The displacement element equation is derived using the principle of virtual works. The mechanical analysis can accommodate various components of strain: elastic, plastic, creep and thermal strain as well as strain due to swelling, relocation and densification. The 4-node quadratic isoparametric elements are adopted, and the geometric model is confined to a half-pellet-height region with the assumption that pellet-pellet interaction is symmetrical. The pellet cracking and crack healing, pellet-cladding interaction are modelled. The Newton-Raphson iteration with an implicit algorithm is applied to perform the analysis of non-linear material behavior accurately and stably. The pellet and cladding model has been compared with both analytical solutions and experimental results. The observed and predicted results are in good agreement. The general behavior of fuel rod is calculated by axisymmetric system and the cladding behavior against radial crack is used by plane stress system. The sensitivity of strain aging of PWR fuel cladding tube due to load following is evaluated in terms of linear power, load cycle frequency and amplitude.

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Effect of Resistant Starch on Body Weight and Defecation in Loperamide-induced Constipated Rats (저항전분 투여가 loperamide 유도 변비 쥐의 체중변화와 배변상태에 미치는 영향)

  • Sin, Hyun-Ju;Kim, Kwang-Ok;Kim, Young-Ah;Lee, Hye-Sung
    • Korean Journal of Food Science and Technology
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    • v.42 no.6
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    • pp.743-749
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    • 2010
  • The present study was conducted to evaluate the effects of resistant starches (RS2, RS3) on weight change and defecation states in rats with constipation induced by loperamide. Sixty male Sprague-Dawley rats were divided into the following six groups: normal control-5% cellulose (NC), constipated-5% cellulose (CC), constipated-5% pectin (CP), constipated-5% RS2 (CR2), constipated-8% RS2 (CR2-H) and constipated-5% RS3 (CR3). The animals were fed AIN76-based experimental diets for 5 weeks. Supplementation of RS2 and RS3 resulted in significantly lower feed efficiency ratios and body weight gain as compared to cellulose supplemented group. Large intestine length was significantly longer in the resistant starch and cellulose groups than in the pectin group. Relative fecal weight to feed intake was significantly higher in the RS3 resistant starch group than in the pectin group, and the appearance of feces was similar to that of the cellulose group. Supplementation of RS3 or cellulose significantly shortened gastrointestinal transit time in the constipated rats as compared to pectin. The results of the present study demonstrated that resistant starch supplementation, especially RS3, may help in depress body weight gain and alleviate constipation through an increase of fecal weight and shortening gastrointestinal transit time in constipated animals.

Improvement of High-fat Diet-induced Obesity by Xanthigen in C57BL/6N Mice (잔티젠(Xanthigen)에 의한 고지방식이로 유도된 비만 개선 효과)

  • Choi, Kyeong-Mi;Lee, Youn-Sun;Kim, Wonkyun;Choi, Yung-Hyun;Kwak, Youn-Gil;Jung, Jae-Chul;Lee, Jeongrai;Yoo, Hwan-Soo
    • Journal of Life Science
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    • v.22 no.12
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    • pp.1697-1703
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    • 2012
  • Obesity is a risk factor for numerous metabolic diseases. Recently, naturally occurring compounds that may improve obesity have received increasing attention. Xanthigen is a mixture of fucoxanthin and punicic acid derived from brown seaweed and pomegranate seed, respectively, which have been traditionally used for lipid-lowering effects in humans. In this study, we investigated whether Xanthigen attenuates high-fat diet-induced obesity in C57BL/6N mice. The mice were fed on a normal diet (ND), high-fat diet (HFD), HFD plus 1% Xanthigen or HFD plus 1% green tea extract (GTE) for 11 weeks. Food efficiency ratio (FER) and body weight were significantly reduced in mice fed HFD plus Xanthigen compared to HFD-fed mice. Consistent with the results in body weight change, Xanthigen also significantly decreased the weights of epididymal adipose tissue, retroperitoneal adipose tissue, and liver in HFD plus 1% Xanthigen-fed mice. The serum level of low-density lipoprotein (LDL)-cholesterol was significantly decreased in HFD plus Xanthigen-fed mice compared to HFD-fed mice. These results suggest that Xanthigen may be useful in the development of a functional health food for anti-obesity.

Sanguinarine Increases Sensitivity of Human Gastric Adenocarcinoma Cells to TRAIL-mediated Apoptosis by Inducing DR5 Expression and ROS Generation (AGS 인체 위암세포에서 DR5의 발현 및 ROS 생성의 증가를 통한 sanguinarine과 TRAIL 혼합처리의 apoptosis 유도 활성 촉진)

  • Lee, Taek Ju;Im, Yong Gyun;Choi, Woo Young;Choi, Sung Hyun;Hwang, Won Deok;Choi, Yung Hyun
    • Journal of Life Science
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    • v.24 no.9
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    • pp.927-934
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    • 2014
  • Sanguinarine, a benzophenanthridine alkaloid originally derived from the root of Sanguinaria canadensis, has been shown to possess antimicrobial, antioxidant, and anti-cancer properties. Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to induce apoptosis in cancer cells, but not most normal cells and has shown efficacy in a phase 2 clinical trial, development of resistance to TRAIL by tumor cells is a major roadblock. Our previous study indicated that treatment with TRAIL in combination with subtoxic concentrations of sanguinarine sensitized TRAIL-mediated apoptosis in TRAIL-resistant human gastric carcinoma AGS cells; however, the detailed mechanisms are not fully understood. In this study, we show that sanguinarine sensitizes AGS cells to TRAIL-mediated apoptosis as detected by MTT assay, agarose gel electrophoresis, chromatin condensation and flow cytometry analysis. Combined treatment with sanguinarine and TRAIL effectively induced expression of death receptor (DR) 5 but did not affect expression of DR4 and mitogen activated protein kinases signaling molecules. Moreover, the combined treatment with sanguinarine and TRAIL increased the generation of reactive oxygen species (ROS); however, N-acetylcysteine, ROS scavenger, significantly recovered growth inhibition induced by the combined treatment. Taken together, our results indicate that sanguinarine can potentiate TRAIL-mediated apoptosis through upregulation of DR5 expression and ROS generation.

Awareness, Treatment, and Control Rates of Hypertension and Related Factors of Awareness among Middle Aged Adult and Elderly in Chuncheon : Hallym Aging Study(HAS) (춘천지역 중년과 노인의 고혈압 인지율, 치료율, 조절률 및 인지율 관련 요인: 한림노년연구(HAS))

  • Jeong, Jin-Young;Choi, Yong-Jun;Jang, Soong-Nang;Hong, Kyung-Soon;Choi, Young-Ho;Choi, Moon-Ki;Kim, Dong-Hyun
    • Journal of Preventive Medicine and Public Health
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    • v.40 no.4
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    • pp.305-312
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    • 2007
  • Objectives : To estimate the awareness, treatment and control rate, as well as to identify the awareness-related factors for hypertension. Methods : The study participants were 482 adults (men 206, women 276), aged 45 or over, diagnosed with hypertension and living in Chuncheon. The awareness rate was defined as the proportion of persons among those with hypertension who had previously been diagnosed by a physician. The treatment rate was defined as the proportion of persons who had used anti-hypertensive medication, among those who were aware of their hypertension. The control rate was defined as the proportion of persons who kept blood pressure normal, among those who had been treated for their hypertension. Multivariable logistic regression analysis was carried out for the awareness-related factors using SAS VER 8.1. Results : The awareness, treatment, and control rate were 55,8% (53.4% for men; 57.6% for women), 89.6% (87,2% for men; 91.2% for women), and 34.4% (28.1 % for men; 38.6% for women), respectively. The awareness-related factors included a family history of hypertension (odds ratio[OR], 5.63; 95% confidence interval[95% CI]=1.53-20.72), smoking([Ex; OR 0.38, 95% CI= 0.15-0.96)], [Current; OR 0.28, 95% CI=0.10-0.80]), and alcohol intake ([Ex; OR 3.22, 95% CI 1.03-10.09],[Current; OR 3.36, 95% CI=1.30-8.71]) for men, and education(OR 2.23, 95% CI=1.10-4.53), body mass index(OR 2.72, 95% CI=1.13-6.53), and self-rated health(OR 2.38, 95% CI=1.07-5.30) for women. Conclusions : The awareness rate of hypertension among the middle aged and elderly in Chuncheon was 55.8%. The related factors of awareness were gender specific. Further studies are needed to elucidate the putative reasons for these gender differences.

A Study on Urinary Incontinence of Elderly Communities (지역사회 거주 노인의 요실금에 관한 연구)

  • Ju, Young-Hee;Kim, Jung-Soon
    • Research in Community and Public Health Nursing
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    • v.11 no.2
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    • pp.441-452
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    • 2000
  • The purpose of this study was to identify the prevalence of urinary incontinence and its relating factors elderly communities. Subjects of this survey consisted of 877 elderly women and men in one Kun. Korea, who were over 60 years old. The design for this study was descriptive: the subjects were interviewed by well trained investigators from July 9. 1999 to July 20. 1999. During that survey period, the subjects were interviewed with a structured questionnaire. The data were analyzed by frequency, percentage, $X^2-test$. T-test using an SAS program. The results of the study were the following: 1. The prevalence rate of urinary incontinence was 20.1 %. of the total. The types of urinary incontinence were mixed incontinence 44.3%. stress incontinence 38.1%. and urge type incontinence 17.6%. 2. The relating factors of urinary incontinence were as follows: 1) 33.5% of UI(urinary incontinence) subjects reported urine loss once a month. twice or three times a week 23.3%. one or two times a day 17.0% 2) 38.1% of elderly reported only 1 to 2 drops. 1 t-spoon 36.9%. 1 T-spoon 15.9% 3) The volume of urine loss registered by changing underwear was 63.1 %. no necessity of changing underwear was 22.1 %. or using some type of pads was 13.1%. 4) 62.5% of UI subjects never discussed their UI problem with other people. 73.9% of the total had never experienced any treatment for their UI problem. The reasons for not receiving medical cure were their typical conception about urinary incontinence taking UI as a normal part of aging 76.2% and due to their bad financial situation 9.2%. 3. Women had more prevalence of UI than men (p=0.01), and it was found that the worse the subjective health state. the higher the prevalence of UI (p=0.001). However. there was no statistical difference in daily frequency of UI (p>0.05). The more nocturnal incontinence (p=0.001), the more intermittent stream experience (p = 0.01), the more retention experience (p = 0.01), and the more incomplete the emptying experience (p=0.001), the higher the prevalence of UI. 4. UI groups had lower ADL scores than non UI groups(p=0.01). The level of depression in the group of urinary incontinence was significantly higher than that of non incontinence group (p=0.0001). As shown above, the elderly people suffering from UI haven't been treated properly: their subjective health state and their ADL competence was lower, and their depression level was higher than non UI groups. Therefore, the development of a proper urinary incontinence management program are required so that they can lead more healthy lives. Also continual case studies for the elderly people with UI are necessary.

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Meta-Analysis of Correlation Between Subjective and Objective Cognitive-Linguistic Tests : Focused on Normal Aging, MCI, and Dementia (메타분석을 통한 주·객관적 인지-언어 평가 간 상관성 연구 : 정상 노년층, MCI, 치매 환자를 중심으로)

  • Lee, Mi-Sook
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.11
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    • pp.7414-7423
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    • 2015
  • Subjective cognitive-linguistic complaints in older adults contribute to the diagnostic and prognostic investigation of MCI or dementia. However, the utility of subjective test for predicting cognitive-linguistic decline is controversial. Few domestic studies have included the correlation between subjective and objective tests systematically. The current study analyzed 26 studies published since 2000, and the effect sizes of their correlation coefficients between two tests were computed. The results of qualitative analysis indicated that the number of subjects ranged from 26 to 657. Subjective tests included the self-report 75.4% and the informant-report 24.6%. In objective tests, memory comprised the largest proportion, followed by global cognition, and language, etc. As a result of meta-analysis, self-report test had the predictive value for dementia, and informant-report test contributed to discriminate among 3 groups. In the elderly group, self-report test was correlated with reasoning, and informant-report test with memory and language. In MCIs, self-report test predicted several abilities including language, and informant-report test signaled the future decline of domains like global cognition. Two types of subjective tests in dementia also represented memory, language, and global cognition accurately. This study provides evidence-based information to support relationships between subjective and objective tests for cognitive-linguistic ability in 3 groups.

Estimation of Long-term Aging Compressive Strength Through Non-Destructive Testing of Concrete Structure Using Mineral Admixtures (혼화재를 사용한 콘크리트 구조체의 비파괴 시험에 의한 장기재령 압축강도 추정)

  • Kim, Jeong-Sup;Shin, Yong-Seok;Lee, Chang-Hyun;Lee, Seung-Jung;Kim, Kwang-Seok
    • Journal of the Korea Institute of Building Construction
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    • v.11 no.5
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    • pp.426-434
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    • 2011
  • Recently, the use of mineral admixtures in concrete has been studied in many laboratories, and been applied in the field. But the non-destructive testing equation proposed in Japan for normal strength concrete has been used to determine compressive strength, because there has been a lack of systematic research on the compressive strength of concrete using mineral admixtures. For this reason, it is essential to suggest a non-destructive testing equation to estimate the compressive strength of concrete using mineral admixtures. Therefore, this study made a cylindrical specimen and core tube specimen of concrete using a mineral admixture, and suggested a strength estimation of long-term age (4 years) through non-destructive and destructive tests. The results of the research are as follows. Comparing error rates between conventional suggested equations and this estimated equation shows some differences by age, but the error rate of this study was reduced to 0.3 %~115.0 % compared to conventional equations by re-bound hammering, 0.2 %~22.8 % by the ultrasound velocity method and 0.5 %~102.3 % by complex method. Accordingly, it is judged to be suitable for assessing the compressive strength of concretes using mineral admixtures.

Adaptation of Feedlot Cattle to a High-energy Ration by Intraruminal Transplantation of Adapted Ruminal Fluid (제1위내용액 이식에 의한 비육우의 농후사료 적응법에 관한 연구)

  • 이현범;탁연빈;성은주;김기석;이영주;정재석;장종식;권오덕
    • Journal of Veterinary Clinics
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    • v.15 no.1
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    • pp.62-74
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    • 1998
  • In feedlot cattle the abrupt change of diet from roughage to a large quantity of grain for the purpose to improve production often results in increased occurrence of rumen acidosis or acute carbohydrate encouragement enterotoxemia, bloats diarrhea liver abscess and laminitis or robot disease. The common management practice to control these problem is to increase the amount of concentrates in the diet in a stepwise manner until the animals are adapted to a high-grain ration. However this practice requires at least about 3 weeks adaptation period and specially prepared adaptation rations which contain various amount of concentrates. Present experiment was undertaken in order to findout the more simple and rapid adaptation method of cattle to a high grain ration. Nineteen Korean calves aging from four to six month were fed artifical hay (Youngchoun Chuk-Hyup, Korea) which contains 10% of concentrates or alfalfa and rye grass hays for two months and randomly alloted to three experimental groups and two control groups. The experimental group-1 was inoculated by stomach tube for two days with li500 ml/day of ruminal fluid fished from Korean beef cattle that had been previously adapted to a high-energy ration. The experimental group-2 was inoculated by trocalization for two days with the same ruminal fluid. The experimental group-3 was inoculated by trocalization with 1,500 ml/day of bacterial culture which contained 2$\times $10$^{9}$/m1 of Gram-negative bacteria derived from adapted luminal fluid. The two control groups were treated with normal saline solution by the same methods. All animals were fed high-energy ration that contained 80% of grain ad libitum for 30-74 days beginning on the third of the treatment. The effect of the inoculation on the adaptation was observed clinicopathologically with the following results; All of the experimental calves inoculated with the ruminal fluid or Gram-negative bacterial culture derived from adapted cattle did not show any signs of rumen acidosis or other related diseases, while most of the control calves did show diarrhea and bloat and a calf laminitis. The average daily weight gain and feed efficiency of experimental calves were slightly improved compared with control calves. Following the feeding of high-grain rational the pH of the ruminal fluid was lowered in both the experimental and control groups. However severe acidosis with the pH of below 5.0 was observed in only a control group-2. The protozoal number in ruminal fluid was markedly decreased during the high-grain feeding in both the experimental and control calves. However the decrease was mere severe in control calves compared with the experimental calves. The activation of the protozoa were completely disappeared within nine hours at the refrigerator temperature (4"C). No significant differences in heamatological and blood chemical values between the experimental and control calves were recognized. However in one control calf which showed clinically laminitis marked elevations of serum glutamic oxaloacetate transaminase and lactic dehydrogenase activities and a decrease of serum glucose level were observed. From these results it would be concluded the intraruminal transplantation of unadapted calves with the adapted ruminal fluid from cattle previously adapted to a high-energy ration prevents disease problem associated with high-grain feeding and improve weight gain and feed efficiency.ency.

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Evaluation of the Relevance of Nutritional Status and Dietary Inflammation Index to Blood Glucose Levels in Middle-aged Women: in terms of 2013-2018's Korean National Health and Nutrition Survey Data (중년 여성의 혈당수준에 따른 영양상태 및 식이염증지수의 융합적 관련성 평가: 2013-2018 국민건강영양조사 자료 이용)

  • Park, Pil-Sook;Kityo, Anthony;Park, Mi-Yeon
    • Journal of the Korea Convergence Society
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    • v.12 no.7
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    • pp.69-82
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    • 2021
  • This study targeted 4,572 middle-aged women to examine the relationship between nutritional status and dietary inflammatory index according to blood glucose level using data from the Korean National Health and Nutrition Examination Survey (KNHANES). Data were analyzed using complex survey chi-square, General Linear Model and logisitc regression in SPSS Win 25.0 program. Women with high blood glucose (normal blood sugar→diabetes) had high rates of obesity and blood TG/HDL-cholesterol ratio. On the other hand, the Mean Adequacy Ratio (10 nutrients) and the intake of anti-inflammatory foods: beans, seeds, mushrooms, and fruits, were lower in the diabetic category. When we analysed the association between blood glucose and the Dietary Inflammatory Index, the risk of pre-diabetes and diabetes was significantly higher in the most pro-inflammatory diet category (Q5) compared to the most anti-inflammatory diet category (Q1). These findings suggest that nutritional education emphasizing the intake of various foods should be effectively conducted effectively in order to improve blood glucose among middle-aged women.