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http://dx.doi.org/10.5352/JLS.2012.22.12.1697

Improvement of High-fat Diet-induced Obesity by Xanthigen in C57BL/6N Mice  

Choi, Kyeong-Mi (College of Pharmacy, Chungbuk National University)
Lee, Youn-Sun (College of Pharmacy, Chungbuk National University)
Kim, Wonkyun (College of Pharmacy, Chungbuk National University)
Choi, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Department of Biomaterial Control, Anti-Aging Research Center and Blue-Bio Industry RIC, Dong-Eui University)
Kwak, Youn-Gil (Rexgene Biotech Co., Ltd.)
Jung, Jae-Chul (Rexgene Biotech Co., Ltd.)
Lee, Jeongrai (Rexgene Biotech Co., Ltd.)
Yoo, Hwan-Soo (College of Pharmacy, Chungbuk National University)
Publication Information
Journal of Life Science / v.22, no.12, 2012 , pp. 1697-1703 More about this Journal
Abstract
Obesity is a risk factor for numerous metabolic diseases. Recently, naturally occurring compounds that may improve obesity have received increasing attention. Xanthigen is a mixture of fucoxanthin and punicic acid derived from brown seaweed and pomegranate seed, respectively, which have been traditionally used for lipid-lowering effects in humans. In this study, we investigated whether Xanthigen attenuates high-fat diet-induced obesity in C57BL/6N mice. The mice were fed on a normal diet (ND), high-fat diet (HFD), HFD plus 1% Xanthigen or HFD plus 1% green tea extract (GTE) for 11 weeks. Food efficiency ratio (FER) and body weight were significantly reduced in mice fed HFD plus Xanthigen compared to HFD-fed mice. Consistent with the results in body weight change, Xanthigen also significantly decreased the weights of epididymal adipose tissue, retroperitoneal adipose tissue, and liver in HFD plus 1% Xanthigen-fed mice. The serum level of low-density lipoprotein (LDL)-cholesterol was significantly decreased in HFD plus Xanthigen-fed mice compared to HFD-fed mice. These results suggest that Xanthigen may be useful in the development of a functional health food for anti-obesity.
Keywords
Xanthigen; C57BL/6N mice; obesity; adipose tissue; LDL-cholesterol;
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