• Biomolecules & Therapeutics
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• v.14 no.4
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• pp.253-258
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• 2006

LDD175(4-choloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-l-carboxylic acid) is one of benzofuroindole derivatives that act as a potent $BK_{Ca}$ channel openers. In the process of testing LDD175 as a new drug candidate, an acute toxicity study was carried out in mice. The mice were administered LDD175 intraperitoneally at dose of 0.2, 1, 10, 50, 100, 200, 400, 800mg/kg and orally at dose of 10, 100, 400, 800mg/kg body weight. After administering LDD175, the vital organs such as the liver, kidney and spleen were carefully observed for any significant pathological features or differences from the norm over a l4-day period. LDD175 did not induce any short-term toxicity at doses less than 100mg/kg. A $LD_{50}$ of LDD175 was 2493mg/kg in male mice and 4908mg/kg in female mice. Weight reduction was observed at a dose of 800mg/kg in male, and 400 and 800mg/kg in female. The kidney weight decreased in females after an intraperitoneal injection of LDD175 high dose(>400mg/kg, i.p.), and the spleen weight increased in the male(800mg/kg, i.p.) and female(400mg/kg, i.p.) mice. Inspite of the change in organ weights, there were neither histopathological changes nor any gross morphological abnormalities detected in any organ. LDD175 did not produce significant changes in the general behavior at doses of <200mg/kg, but decreased locomotor activity was observed at an intraperitoneal dose of 400mg/kg. Its effects on the locomotor activity and activity on the rotarod were tested and compared with the effects of diazepam 5mg/kg. The decrement in the locomotor activity and the activity on the rotarod induced by LDD175 was less serious than it by diazepam.

• Journal of the Korea Computer Industry Society
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• v.6 no.3
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• pp.477-493
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• 2005

The cause of the eating disordered diet, which is a main topic of this study, has not been identified clearly, however, has been affected by an emphasis of western norm of a beauty - being tall and skinny - since the eighties. Another reason would be his/her lack of self-confidence and willingness to resolve his/her unsatisfied mental problem. There are two different of eating disordered diets; anorexia nervosa, bulimia nervosa. firstly, a patient of anorexia nervosa which is characterized by the loss in weight, tends to either deny meals, due to his/her desire to be skinny and a fear of gaining the weight. Secondly, a patient of bulimia nervosa eats much more food than an ordinary person does in around two hours and then removes them by doing vomiting with drugs. obesity is defined as overweight by $20\%$ and more than normal weight. In this case, body mass index(BMI) defined by the ratio of the weight(kg) to the height(m') is used. BMI = Weight(kg) / Height(m) In this paper, a list of questioneire for an adolescent to self-diagnosis the possibility of his/her eating disorder diet is identified and then a multi-media system which incorporates the list is designed and implemented with ASP language as a server language on a local host.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.3
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• pp.59-66
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• 2016

This paper presents an empirical evaluation on dimensionality reduction strategies by which dissimilarity-based classifications (DBC) can be implemented efficiently. In DBC, classification is not based on feature measurements of individual objects (a set of attributes), but rather on a suitable dissimilarity measure among the individual objects (pair-wise object comparisons). One problem of DBC is the high dimensionality of the dissimilarity space when a lots of objects are treated. To address this issue, two kinds of solutions have been proposed in the literature: prototype selection (PS)-based methods and dimension reduction (DR)-based methods. In this paper, instead of utilizing the PS-based or DR-based methods, a way of performing DBC in Eigen spaces (ES) is considered and empirically compared. In ES-based DBC, classifications are performed as follows: first, a set of principal eigenvectors is extracted from the training data set using a principal component analysis; second, an Eigen space is expanded using a subset of the extracted and selected Eigen vectors; third, after measuring distances among the projected objects in the Eigen space using $l_p$-norms as the dissimilarity, classification is performed. The experimental results, which are obtained using the nearest neighbor rule with artificial and real-life benchmark data sets, demonstrate that when the dimensionality of the Eigen spaces has been selected appropriately, compared to the PS-based and DR-based methods, the performance of the ES-based DBC can be improved in terms of the classification accuracy.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.12
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• pp.2293-2300
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• 2008

In ad-hoc sensor network, AODV routing information is disclosed to other nodes because AODV protocol doesn't have any security mechanisms. The problem of AODV is that an attacker can falsify the routing information in RREQ packet. If an attacker broadcasts the falsified packet, other nodes will update routing table based on the falsified one so that the path passing through the attacker itself can be considered as a shortest path. In this paper, we design the routing-information-spoofing attack such as falsifying source sequence number and hop count fields in RREQ packet. And we suggest an efficient scheme for detecting the attackers and isolating those nodes from the network without extra security modules. The proposed scheme doesn't employ cryptographic algorithm and authentication to reduce network overhead. We used NS-2 simulation to evaluate the network performance. And we analyzed the simulation results on three cases such as an existing normal AODV, AODV under the attack and proposed AODV. Simulation results using NS2 show that the AODV using proposed scheme can protect the routing-information-spoofing attack and the total n umber of received packets for destination node is almost same as the existing norm at AODV.

• Journal of Korean Philosophical Society
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• v.116
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• pp.281-312
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• 2010

Der vorliegende Beitrag problematisiert die Zeichen einer Zeit, in der nach der 'Wende des Sprachparadigmas' alle Prozesse einer Posttranszendenz, die in der heutigen philosophischen Problemsituation versucht werden, $bel{\ddot{a}}chelt$ werden, der Relativismus, Partikularismus und Skeptizismus $verst{\ddot{a}}rkt$ wird, und als Resultat die Kritik, Ablehnung und das Desinteresse an der Ideologie der Vernunft und Wahrheit sich verbreitet. Ich werde daher umgekehrt gerade an diesem Punkt ansetzen und ${\ddot{u}}ber$ die Notwendigkeit und Dringlichkeit der Rehabilitierung der "$Realit{\ddot{a}}t$ einer moralischen Vernunft" nachdenken. Zweck dieses Beitrags ist es, in Zusammenhang mit der Rehabilitierung der $Realit{\ddot{a}}t$ einer moralischen Vernunft, aufzuzeigen, welche theoretische Erkenntnis bzw.moralische Erkenntnis wahr ist, d.h., dass ein 'bewiesenes', da 'objektiv gerechtfertigtes' Argument existiert. $Daf{\ddot{u}}r$ werde ich als erstes auf das Problem der Relativistischen und Skeptizistischen Anhaltspunkte philosophisch eingehen(2), zur ${\ddot{U}}berwindung$ dieser Anhaltspunkte eine Rechtfertigung der rationelen und moralischen $Begr{\ddot{u}}ndung$ versuchen(3). In Folge soll betrachtet werden, dass die Rechtfertigung der rational moralischen $Begr{\ddot{u}}ndung$ mit dem Problem der $Letztbegr{\ddot{u}}ndung$ in enger Verbindung steht(4), und nachdem darauf hingewiesen wird, dass dies durch eine Konfrontation mit der Fallibilismus These zu erkenntnistheoretisch objektiver $G{\ddot{u}}ltigkeit$ gelangt(5), werde ich den Beitrag $abschlie{\ss}en$(6).

• Journal of Korean Philosophical Society
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• v.142
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• pp.241-263
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• 2017

The purpose of this paper is to investigate Toegye's simhak in relation to spiritualism. In general, we call Chu Hsi's learning "lihak" (the learning of principle) while Wang Yangming's learning is described as "simhak" (the learning of mind). However, we sometimes call Toegye's learning "simhak" in spite of his respect for Chu Hsi's philosophy of li. Toegye's simhak is different from Wang Yangming's. Nonetheless, Toegye too, highlighted the existential meaning of truth. Toegye regarded simgyung (the book of mind) as one of the most important classics for self-cultivation. As is well known, Toegye's main concern was concentration on mind and heart cultivation. Toegye understood li as a spiritual being, which can actualize itself. The goal of simhak is to become a sage. For a sage, there is no contradiction between moral norm and human desire. To become a sage, Toegye developed the theory and practice of mind cultivation. Toegye's simhak has some common characteristics with Louis Lavelle's philosophy of spiritualism. Both Toegye and Louis Lavelle lay great emphasis on self reflection and spiritual life. In particular, Toegye developed the concrete method of mind cultivation. In the 21st century, human beings are confronted with spiritual crisis in many aspects. Toegye's simhak can be advanced as useful wisdom to keep one's mind in a peaceful and harmonious state.

• Korean Journal of Legislative Studies
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• v.23 no.2
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• pp.67-108
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• 2017

How well citizens are represented by their representatives holds critical importance in representative democracy. While previous studies of ideological congruence have largely focused on Western established democracies, there was not as much attention paid to young democracies including, South Korea. This article investigates ideological congruence in South Korea based on multiple survey data sources collected from 2002 to 2016. When it comes to unidimensional Left-Right ideology, the distance between citizens and governments, unlike its citizen-assembly counterpart, has widened since 2000 sending a negative signal to the norm of representative democracy. As to multidimensional issue positions, however, it turns out that ideological congruence in South Korea has varied along issues such as aids to North Korea and Welfare spending. These results provide both citizens and parties with some important implications. For citizens, they are required to distinguish which party or candidate is more representative of the issue they value the most beyond a simple Left-Right line; for parties, they are required to deal with how to represent their supporters as well as today's increasing independents by strengthening their organizational capacity and providing effective party programs.

• Korea journal of population studies
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• v.11 no.1
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• pp.14-31
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• 1988

The national family planning program in Korea, which was instituted as an integral part of the nation's economic development plans since 1962, has contributed greatly to a reduction in the fertility and population growth rate. The total fertility rate dipped from 6.0 births per women in 1960 to 2.0 in 1985, and the population growth rate rom 2.84 percent per year to 1.25 percent during the same period, while the contraceptive practice rate for the 15-44 married women increased from 9 percent in 1965 to 70 percent in 1985. Study findings indicate that the fertility reduction in the past 26 years is largely attributed to the virgorous implementation of the national family planning program, rising age at marriage, wide-spread use of induced abortion, and the changes in attitude regarding the value of children that came into being in the wake of the rapid socio-economic development over the period. Among the strengths of the national family planning program are the following : 1) a pluralistic system of program manageent with active participation of various government and voluntary organizations, 2) utilization of a large corps of family planning field workers to conduct face-to-face communication and motivation activities, 3) use of private physicians with government support to provide contraceptive services, 4) a systematic program management system including program planning of traget allocation, evaluation, and supervision with a broad MIS and award system, 5) numerous incentive and disincentive schemes for stimulating the small family norm and contraceptive use, and 6) strong commitments to the family planning program by political leaders. The new demographic targets during the Sixth Five-Year Economic and Social Development plan period(1987-91) have been set for a further reduction in the population growth rate to 1.0 percent by 1993, assuming that the TFR will decline to 1.75 level in 1995. This target is, however, not easy to achieve due to anticipated unfavorable factors like the strong boy preference, high discontinuation rates of reversible contraceptive methods, fertility termination-oriented contraceptive use, a plateau level of contraceptive practice rate that has mostly accounted for a sterilization, shortened length of birth intervals, and the changing patterns of contraceptive mix. The recent changes in contraceptive and fertility behaviors clearly indicate that the past quantity-oriented management system of the national program should be redirected toward a quality-oriented approach. Particularly, program efforts should be expanded to recruit new contraceptive users in the 20s of younger age groups, both for birth spacing and controlling their fertility since the women aged 20 to 29 account for more than 80 percent of the total annual births in recent years. In addition, the current contraceptive fee system of the national family planning program should be gradually shifted from free contraceptive services to a acceptor's charge system, and the provision of contraceptive services through the medical insurance system, which will cover the entire population by 1989, should be accelerated as a means of integration of family planning program with other health programs.

• Journal of Christian Education in Korea
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• v.67
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• pp.377-414
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• 2021

Since Schwab mentioned the Fourth Industrial Revolution at the World Economic Forum Annual Meeting 2016, discussions have been ongoing about it and the future society. The Fourth Industrial Revolution exceeds the development of technology and influences society, culture, and lifestyle. Moreover, in the face of the COVID-19 crisis, society continues to experience and realize the era of the Fourth Industrial Revolution. Although we hope that this era will surely improve human life, we are also concerned about human alienation and social and economic polarization that may emerge as a consequence. How, then, does Christianity contribute to the public space and set the direction for education in this day and age? This study focused on the role of Christianity and the direction of education during the Fourth Industrial Revolution. First, I examine problems in terms of the inner and outer aspects of individuals and communities that may occur during the Fourth Industrial Revolution through the perspectives of Mitchell, a psychologist, Bellah, a sociologist, McGrath, a theologian, and Bostrom, a philosopher. Through their theories, we can view the lives of individuals in the real, virtual, and transcendental worlds of this era. I find that Christianity can provide a transcendent norm in this world, give meaning to life, and change people and the world. Therefore, I suggest the creation and expression of symbols as a direction for education. For this form of education, I recommend five steps, namely, observing, entering, discovering, participating, and making symbols. In this manner, people can represent the kingdom of God in the real world.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.4
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• pp.71-84
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• 2021

As part of the recent economic revitalization measures, the national level of encouragement for young people's entrepreneurship continues, and investment in young people's entrepreneurship and support from young people are increasing. Entrepreneurship intention is a direct factor leading to entrepreneurship, and many studies have studied the individual characteristics of entrepreneurs that influence entrepreneurial intention. In the same context, the purpose of this study was to investigate the entrepreneur's passion as a factor affecting entrepreneurial intention, divided into harmony passion and obsessive passion. In addition, the pass to need for achievement, emotion, and subjective norms, which are the individual characteristics of entrepreneurs that influence passion, were verified. To this end, an online survey was conducted for prospective entrepreneurs in universities, and data of 203 persons were collected and structural equations were analyzed. As a result of the analysis, it was found that the need for achievement and positive emotions of preliminary entrepreneurs had a positive (+) effect on the passion for harmony, while the negative emotions and subjective norms were not significant for the passion for harmony. The need for achievement had a negative (-) effect on the obsessive passion, and the positive and negative emotions had a positive (+) effect on the obsessive passion, but the subjective norm was not significant on the obsessive passion. It was confirmed that harmony passion and obsessive passion showed positive (+) effect on entrepreneurial intention. It also confirmed whether harmonious passion and obsessive passion have a mediating effect between need for achievement, positive emotion, negative emotion, and entrepreneurial intention. As a result, it has a mediating effect between need for achievement, positive emotion and entrepreneurial intention, especially need for achievement has a complete mediating effect. Obsessive passion was also confirmed to have a mediating effect in the relationship between positive emotions and intention to start a business.