• Title/Summary/Keyword: Nonlinear regression model

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Characteristics of Individual Growth Curve by Porcine LEPR-derived Microsatellite Polymorphisms (돼지의 Leptin receptor 유전자내 초위성체 다형성에 따른 개체별 성장곡선 특성)

  • Cho, Y.M.;Choi, B.H.;Kim, T.H.;Lee, J.W.;Cheong, I.C.
    • Journal of Animal Science and Technology
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    • v.45 no.6
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    • pp.885-890
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    • 2003
  • This study was conducted to estimate the growth curve parameters of 253 heads of F2 population produced by inter-crossing F1 from Korean Native boars and Landrace sows, and to estimate the effects of Leptin receptor gene(LEPR) on their growth characteristics. Growth curve parameters were estimated from nonlinear regression using Gompertz model individually. Average mature weight and average maturing rate estimated were 179.69${\pm}$4.40kg and 0.3103${\pm}$0.0043, respectively. The effect of sex was insignificant for all the parameters estimated from Gempertz model(p〉.05), and the effect of calving group was significant for mature weight and maximum growth rate at inflection point (p〈.05). The effect of LEPR genotype were significant for all the growth curve parameters(p〈.05). According from the results of the least squares means of growth curve parameters by LEPR genotypes, mature weight and point of inflection were highest in genotype AA in which the maturing rate was the lowest, and were lowest in genotype DD in which maturing rate was the highest, reversely.

Prediction and analysis of acute fish toxicity of pesticides to the rainbow trout using 2D-QSAR (2D-QSAR방법을 이용한 농약류의 무지개 송어 급성 어독성 분석 및 예측)

  • Song, In-Sik;Cha, Ji-Young;Lee, Sung-Kwang
    • Analytical Science and Technology
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    • v.24 no.6
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    • pp.544-555
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    • 2011
  • The acute toxicity in the rainbow trout (Oncorhynchus mykiss) was analyzed and predicted using quantitative structure-activity relationships (QSAR). The aquatic toxicity, 96h $LC_{50}$ (median lethal concentration) of 275 organic pesticides, was obtained from EU-funded project DEMETRA. Prediction models were derived from 558 2D molecular descriptors, calculated in PreADMET. The linear (multiple linear regression) and nonlinear (support vector machine and artificial neural network) learning methods were optimized by taking into account the statistical parameters between the experimental and predicted p$LC_{50}$. After preprocessing, population based forward selection were used to select the best subsets of descriptors in the learning methods including 5-fold cross-validation procedure. The support vector machine model was used as the best model ($R^2_{CV}$=0.677, RMSECV=0.887, MSECV=0.674) and also correctly classified 87% for the training set according to EU regulation criteria. The MLR model could describe the structural characteristics of toxic chemicals and interaction with lipid membrane of fish. All the developed models were validated by 5 fold cross-validation and Y-scrambling test.

Stiffness Reduction Factor for Post-Tensioned Flat Plate Slabs under Lateral Loads (횡하중하의 포스트 텐션 플랫 플레이트 해석을 위한 강성감소계수)

  • Park, Young-Mi;Park, Jin-Ah;Han, Sang-Whan
    • Journal of the Korea Concrete Institute
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    • v.21 no.5
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    • pp.661-668
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    • 2009
  • Effective beam width model(EBWM) has been used for analysis of post-tensioned(PT) flat plate slab frames under lateral loads. The accuracy of this model in predicting lateral drifts and unbalanced moments strongly depends on the estimated effective stiffness of PT flat plate slabs. As moments on the slab due to lateral loads increases, cracks occur which leads to stiffness reduction in slabs. For analyzing PT flat plate slab structure under lateral loads with good precision, reduction in slab stiffness has to be accurately estimated for EBWM. For this purpose, this study collected test results of PT flat plate system conducted by former researches. And this study reduced the width of slab so that the stiffness of the EBWM converged into the lateral stiffness of each test specimens by trial and error. By conducting nonlinear regression analysis using the stiffness ratio of the reduced width of slab to the effective width of EBWM with respect to the level of slab moments, an equation for calculating stiffness reduction factor for slab is proposed. For verifying the accuracy of the proposed equation, this study compared with the test result of the PT flat plate frame. It is shown that the EBWM with the proposed equation predicts the actual stiffness of the PT specimen which varied according to the level of applied moment.

Effects of Temperature on the Development and Reproduction of Matsumuraeses phaseoli (Lepidoptera: Tortricidae) (팥나방(Matsumuraeses phaseoli)의 발육과 생식에 미치는 온도의 영향)

  • Jeong Joon, Ahn;Eun Young, Kim;Bo Yoon, Seo;Jin Kyo, Jung
    • Korean journal of applied entomology
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    • v.61 no.3
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    • pp.461-473
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    • 2022
  • Matsumuraeses phaseoli is one of important pests in soybean crops, especially adzuki beans. We investigated the effects of temperature on development of each life stage, adult longevity and fecundity of M. phaseoli for understanding the biological characteristics of M. phaseoli at ten constant temperatures of 7, 10, 13, 16, 19, 22, 25, 28, 31, and 34℃. Eggs hatched successfully at all temperature subjected except 7℃ and 34℃. The developmental period of each life stage and adult longevity of M. phaseoli decreased as temperature increased. Lower and higher threshold temperature (TL and TH) were calculated by the Lobry-Rosso-Flandrois (LRF) and Sharpe-Schoolfield-Ikemoto (SSI) models. The lower developmental threshold (LDT) and thermal constant (K) from egg hatching to adult emergence of M. phaseoli were estimated by linear regression as 9.04℃ and 422.97DD, respectively. TL and TH from egg hatching to adult emergence using SSI model were 20.0℃ and 32.3℃. Thermal windows, i.e., the range in temperature between the minimum and maximum rate of development, of M. phaseoli was 12.3℃. We constructed the adult oviposition model of M. phaseoli using adult survivorship and fecundity. Temperature-dependent development models and adult oviposition models will be helpful to understand the population dynamics of M. falcana and to establish the strategy of integrated pest management in soybean fields.

Domain-Specific Terminology Mapping Methodology Using Supervised Autoencoders (지도학습 오토인코더를 이용한 전문어의 범용어 공간 매핑 방법론)

  • Byung Ho Yoon;Junwoo Kim;Namgyu Kim
    • Information Systems Review
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    • v.25 no.1
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    • pp.93-110
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    • 2023
  • Recently, attempts have been made to convert unstructured text into vectors and to analyze vast amounts of natural language for various purposes. In particular, the demand for analyzing texts in specialized domains is rapidly increasing. Therefore, studies are being conducted to analyze specialized and general-purpose documents simultaneously. To analyze specific terms with general terms, it is necessary to align the embedding space of the specific terms with the embedding space of the general terms. So far, attempts have been made to align the embedding of specific terms into the embedding space of general terms through a transformation matrix or mapping function. However, the linear transformation based on the transformation matrix showed a limitation in that it only works well in a local range. To overcome this limitation, various types of nonlinear vector alignment methods have been recently proposed. We propose a vector alignment model that matches the embedding space of specific terms to the embedding space of general terms through end-to-end learning that simultaneously learns the autoencoder and regression model. As a result of experiments with R&D documents in the "Healthcare" field, we confirmed the proposed methodology showed superior performance in terms of accuracy compared to the traditional model.

Development of a Predictive Model Describing the Growth of Listeria Monocytogenes in Fresh Cut Vegetable (샐러드용 신선 채소에서의 Listerio monocytogenes 성장예측모델 개발)

  • Cho, Joon-Il;Lee, Soon-Ho;Lim, Ji-Su;Kwak, Hyo-Sun;Hwang, In-Gyun
    • Journal of Food Hygiene and Safety
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    • v.26 no.1
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    • pp.25-30
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    • 2011
  • In this study, predictive mathematical models were developed to predict the kinetics of Listeria monocytogenes growth in the mixed fresh-cut vegetables, which is the most popular ready-to-eat food in the world, as a function of temperature (4, 10, 20 and $30^{\circ}C$). At the specified storage temperatures, the primary growth curve fit well ($r^2$=0.916~0.981) with a Gompertz and Baranyi equation to determine the specific growth rate (SGR). The Polynomial model for natural logarithm transformation of the SGR as a function of temperature was obtained by nonlinear regression (Prism, version 4.0, GraphPad Software). As the storage temperature decreased from $30^{\circ}C$ to $4^{\circ}C$, the SGR decreased, respectively. Polynomial model was identified as appropriate secondary model for SGR on the basis of most statistical indices such as mean square error (MSE=0.002718 by Gompertz, 0.055186 by Baranyi), bias factor (Bf=1.050084 by Gompertz, 1.931472 by Baranyi) and accuracy factor (Af=1.160767 by Gompertz, 2.137181 by Baranyi). Results indicate L. monocytogenes growth was affected by temperature mainly, and equation was developed by Gompertz model (-0.1606+$0.0574^*Temp$+$0.0009^*Temp^*Temp$) was more effective than equation was developed by Baranyi model (0.3502-$0.0496^*Temp$+$0.0022^*Temp^*Temp$) for specific growth rate prediction of L.monocytogenes in the mixed fresh-cut vegetables.

Pharmacokinetics of Haloperidol (III) -The Pharmacokinetics of Haloperidol after single oral and intravenous doses in schizophrenic patients- (Haloperidol의 약물속도론적 연구 (III) -정신분열증 환자에 있어서 Haloperidol의 일회 주사 및 경구투여시의 Pharmacokinetics-)

  • Park, Kyoung-Ho;Lee, Min-Hwa;Lee, Myung-Gull;Kwon, Jun-Soo;Park, Won-Myung;Park, Jin-Seng
    • YAKHAK HOEJI
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    • v.34 no.6
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    • pp.375-383
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    • 1990
  • The pharmacokinetics of haloperidol were determined after single oral and intravenous doses in 13 male schizophrenic patients. Plasma concentrations of haloperidol(HP) and reduced haloperidol(RH) were measured by high performance liquid chromatography. Plasma concentration data obtained were analyzed by obth model dependent (one-or two exponential decay models using nonlinear regression) and model independent (AUC and first moment curve) approaches. The two methods were found to be in close results. After intravenous injections of HP in 8 patients (10 mg/man), the mean central and peripheral volume of distributions were $2.85\;{\pm}\;1.70$ and $8.09\;{\pm}\;2.10\;l/kg$, respectively, and mean steady state volume of distribution was $11.87\;{\pm}\;3.21\;l/kg$. Mean clearance, MRT and elimination half life were $12.39\;{\pm}\;3.25\;ml/min/kg$, $925.10\;{\pm}\;166.79\;min$ and $676.35\;{\pm}\;126.45\;min$, respectively. After oral administrations of HP in 5 patients, mean peak time and peak concentration were $217.63\;{\pm}\;61.60\;min$ and $9.77\;{\pm}\;2.92\;ng/ml$, respectively. Mean MRT and elimination half life were $1112.23\;{\pm}\;131.73\;min$ and $724.02\;{\pm}\;120.03\;min$, respectively, and these parameters were not significantly different from those of intravenous injection of HP. Absolute bioavailability of HP oral product was found to be about 44%. The profiles of plasma RH concentration-time curves after oral or intravenous doses of HP were similar. Also it was found that the elimination rate of RH was solwer than that of HP by comparing the slopes of plasma concentration-time curves of HP and RH.

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The Effect of Trade Credit on Corporate Profitability according to the degree of Corporate Market Share (기업의 시장점유율에 따른 신용거래와 기업수익성간 연관성)

  • Yi, Kayoun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.6
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    • pp.207-214
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    • 2021
  • This study aims to analyze the effect of the level of accounts receivable on firm profitability. It is possible to find the optimal level of accounts receivable that maximizes profitability. In this study, 6,632 samples were selected from manufacturing companies listed on the Korean Stock Exchange from 2001 to 2018. We used the fixed effect panel model to analyze the model equation. There is a positive (+) relationship between the profitability of a company, the Return on Assets (ROA), and accounts receivable (AR). Also, this relationship has a nonlinear relationship or a reverse-U shape. There is an optimal level of accounts receivables, which results in profitability increase up to a certain extent, but subsequently, profitability decreases when accounts receivables exceed this level. In the case of monopoly companies with a higher-than-average market share, the coefficient between accounts receivable and firm profitability is greater than that for competitors with a lower market share than average. It supports the hypothesis that Titman (1984) suggested, that trade credit is important for enhancing corporate profitability. It is confirmed that accounts receivables play an important role in enhancing firm profitability and it is necessary to understand this well from the corporate standpoint.

Estimation and Validation of the Leaf Areas of Five June-bearing Strawberry (Fragaria × ananassa) Cultivars using Non-destructive Methods (일계성 딸기 5품종의 비파괴적 방법을 사용한 엽면적 추정 및 검증)

  • Jo, Jung Su;Sim, Ha Seon;Jung, Soo Bin;Moon, Yu Hyun;Jo, Won Jun;Woo, Ui Jeong;Kim, Sung Kyeom
    • Journal of Bio-Environment Control
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    • v.31 no.2
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    • pp.98-103
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    • 2022
  • Non-destructive estimation of leaf area is a more efficient and convenient method than leaf excision. Thus, several models predicting leaf area have been developed for various horticultural crops. However, there are limited studies on estimating the leaf area of strawberry plants. In this study, we predicted the leaf areas via nonlinear regression analysis using the leaf lengths and widths of three-compound leaves in five domestic strawberry cultivars ('Arihyang', 'Jukhyang', 'Keumsil', 'Maehyang', and 'Seollhyang'). The coefficient of determination (R2) between the actual and estimated leaf areas varied from 0.923 to 0.973. The R2 value varied for each cultivar; thus, leaf area estimation models must be developed for each cultivar. The leaf areas of the three cultivars 'Jukhyang', 'Seolhyang', and 'Maehyang' could be non-destructively predicted using the model developed in this study, as they had R2 values over 0.96. The cultivars 'Arihyang' and 'Geumsil' had slightly low R2 values, 0.938 and 0.923, respectively. The leaf area estimation model for each cultivar was coded in Python and is provided in this manuscript. The estimation models developed in this study could be used extensively in other strawberry-related studies.

Effects of Temperature on the Development and Fecundity of Maruca vitrata (Lepidoptera: Crambidae) (콩명나방(Maruca vitrata) (나비목: 포충나방과) 발육과 산란에 미치는 온도의 영향)

  • Jeong Joon, Ahn;Eun Young, Kim;Bo Yoon, Seo;Jin Kyo, Jung;Si-Woo, Lee
    • Korean journal of applied entomology
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    • v.61 no.4
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    • pp.563-575
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    • 2022
  • Maruca vitrata is one of important pests in leguminous crops, especially red bean. We investigated the effects of temperature on development of each life stage, adult longevity and fecundity of M. vitrata for understanding the biological characteristics of the insect species at eight constant temperatures of 13, 16, 19, 22, 25, 28, 31, and 34℃. Eggs hatched successfully at all temperature subjected and larvae successfully developed to the adult stage from 16℃ to 31℃. The developmental period of egg decreased up to 31℃ and after then increased. The developmental period of larva and pupa, and adult longevity of M. vitrata decreased with increasing temperature. Lower and higher threshold temperature (TL and TH) were calculated by the Lobry-Rosso-Flandrois (LRF) and Sharpe-Schoolfield-Ikemoto (SSI) models. The lower developmental threshold (LDT) and thermal constant (K) from egg hatching to adult emergence of M. vitrata were estimated by linear regression as 12.8℃ and 280.8DD, respectively. TL and TH from egg hatching to adult emergence using SSI model were 14.2℃ and 31.9℃. Thermal windows, i.e., the range in temperature between the minimum and maximum rate of development, of M. vitrata was 17.7℃. In addition, we constructed the oviposition models of adult, using the investigated adult traits including survival, longevity, oviposition period and fecundity. Temperature-dependent development models and adult oviposition models will be helpful to understand the population dynamics of M vitrata and to establish the strategy of integrated pest management in legume crops.