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http://dx.doi.org/10.5187/JAST.2003.45.6.885

Characteristics of Individual Growth Curve by Porcine LEPR-derived Microsatellite Polymorphisms  

Cho, Y.M. (National Livestock Research Institute, RDA.)
Choi, B.H. (National Livestock Research Institute, RDA.)
Kim, T.H. (National Livestock Research Institute, RDA.)
Lee, J.W. (National Livestock Research Institute, RDA.)
Cheong, I.C. (National Livestock Research Institute, RDA.)
Publication Information
Journal of Animal Science and Technology / v.45, no.6, 2003 , pp. 885-890 More about this Journal
Abstract
This study was conducted to estimate the growth curve parameters of 253 heads of F2 population produced by inter-crossing F1 from Korean Native boars and Landrace sows, and to estimate the effects of Leptin receptor gene(LEPR) on their growth characteristics. Growth curve parameters were estimated from nonlinear regression using Gompertz model individually. Average mature weight and average maturing rate estimated were 179.69${\pm}$4.40kg and 0.3103${\pm}$0.0043, respectively. The effect of sex was insignificant for all the parameters estimated from Gempertz model(p〉.05), and the effect of calving group was significant for mature weight and maximum growth rate at inflection point (p〈.05). The effect of LEPR genotype were significant for all the growth curve parameters(p〈.05). According from the results of the least squares means of growth curve parameters by LEPR genotypes, mature weight and point of inflection were highest in genotype AA in which the maturing rate was the lowest, and were lowest in genotype DD in which maturing rate was the highest, reversely.
Keywords
Leptin receptor; Growth Curve Parameter; Gompertz Model;
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1 Baratta, M., Saleri, R., Mainardi, G. L., Valle, D., Giustina, A. and Tamanini, C. 2002. Leptin regulates GH gene expression and secretion and nitric oxide production in pig pituitary cells. Endocrinology 143:551-557.
2 Barb, C. R., Yan, X., Azain M. J., Kraeling, R. R., Rampacek, G. B. and Ramsay, T. G. 1998. Recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine. Domest. Anim. Endocrinol 15:77-86.   DOI   ScienceOn
3 Brown, J. E., Fitzhugh, Jr., H. A. and Cartwright, T. C. 1976. A comparison of nonlinear models for describing weight-age relationship in cattle. J. Anim. Sci. 42:810.
4 Chen, G., Koyama, K., Yuan, X. Lee, Y., Zhou, Y. T., O'Doherty, R., Newgard, C. B. and Unger, R. H. 1996. Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proceedings of the National Academy of Science, USA. 93:14795-14799.   DOI   ScienceOn
5 Reichart, U., Renner-Muller, I., Hoflich, A., Oliver J., Muller, Wolfgang, M. F., Wolf, E., Muller, M., Brem, G. and Aigner, B. 2000. Contrasting Obesity Phenotypes Uncovered by Partial Leptin Receptor Gene Deletion in Transgenic Mice. Biochemical and Biophysical Research Communications. 269:502-507.
6 Roh, S. G., Nie, G. Y., Loneragan, K., Gertler, A.and Chen, C. 2001. Direct modification of somatotrope function by long-term leptin treatment of primary cultured ovine pituitary cells. Endocrinology 142:5167-5171.
7 SAS. 2000. SAS/STAT User's guide. SAS institute Inc., Cary, NC., USA.
8 Winsor, C. R. 1932. The Gompertz curve as a growth curve. Proc. Natl. Acad. Sci. 18:1.
9 Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J. M. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.   DOI   ScienceOn
10 이일주. 2001. 돼지의 검정 종료 체중과 측정 모드에 따른 경제 형질의 유전 모수 및 성장 곡선 모수의 추정. 서울대학교 박사학위논문.
11 조용민, 윤호백, 이영창, 서강석, 김시동, 박영일. 2001. 개체별 성장곡선 모수를 이용한 재래돼지와 랜드레이스종의 성장 특성에 관한 연구. 한국동물자원과학회지 43(6):817-822.
12 Clement, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J, Lacorte, J. M., Basdevant, A., Bougnes, P., Lebouc, Y., Froguel, P. and Guy-Grand, B. 1998. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392:398-401.
13 Emnett, R., Moeller, S., Irvin, K., Rothschild, M., Plastow, G. and Goodwin, R. 2000. An Investigation into the genetic controls of pork quality. NSIF Proceedings.
14 Lin, J., Barb, C. R., Kraeling, R. R. and Rampaek, G. B. 2003. Growth hormone releasing factor decreases long form leptin receptor expression in porcine anterior pituitary cells. Domestic Animal Endocrinology 24:95-101.   DOI   ScienceOn
15 Ramsay, G., Yan, X. and Morrison, C. 1998. The Obesity Gene in Swine: Sequence and Expression of Porcine Leptin. J. Anim. Sci. 76:484-490.