• Journal of applied mathematics & informatics
• /
• v.28 no.5_6
• /
• pp.1203-1216
• /
• 2010

The homotopy analysis method (HAM) has been applied to develop an analytic solution for the coupled radiation-convection dissipative non-gray gas flow in a non-Darcy porous medium. Results are presented for the surface shear and temperature profiles are presented to illustrate the effect of various parameters appearing in the analytical formulation. The accuracy and convergence of the method is also discussed.

• Structural Engineering and Mechanics
• /
• v.60 no.3
• /
• pp.529-545
• /
• 2016

In this article, the generalized coupled non-Fickian diffusion-thermoelasticity analysis is carried out using an analytical method. The transient behaviors of field variables, including mass concentration, temperature and displacement are studied in a strip, which is subjected to shock loading. The governing equations are derived using generalized coupled non-Fickian diffusion-thermoelasticity theory, which is based on Lord-Shulman theory of coupled thermoelasticity. The governing equations are transferred to the frequency domain using Laplace transform technique and then the field variables are obtained in analytical forms using the presented method. The field variables are eventually determined in time domain by employing the Talbot technique. The dynamic behaviors of mass concentration, temperature and displacement are studied in details. It is concluded that the presented analytical method has a high capability for simulating the wave propagation with finite speed in mass concentration field as well as for tracking thermoelastic waves. Furthermore, the obtained results are more realistic than that of others.

• Proceedings of the KIEE Conference
• /
• 2000.07e
• /
• pp.52-55
• /
• 2000

In this paper, the coupled and the non-coupled vibration mode AE sensor for GIS were simulated by finite element analysis and manufactured, and characterized. The maximum sensitivity was 64.3 dB when the resonant frequency of the coupled vibration mode AE sensor was 166 kHz and the maximum sensitivity was 58.9 dB when the resonant frequency of the non-coupled mode AE sensor was 265 kHz. The coupled vibration mode AE sensor responded higher than the non-coupled vibration mode AE sensor at the partial discharge detection in GIS.

• Journal of Microbiology and Biotechnology
• /
• v.27 no.11
• /
• pp.1961-1970
• /
• 2017

Lespedeza cuneata G. Don is a traditional herb that has been associated with multiple biological activities. In this study, we investigated the antioxidative/antiaging activities and performed an active component analysis of the non-fermented and fermented (using Lactobacillus pentosus) extracts of Lespedeza cuneata G. Don. The antioxidative activities of the fermented extract were higher than those of non-fermented extracts. The elastase inhibitory activity, inhibitory effects on UV-induced MMP-1 expression, and ability to promote type I procollagen synthesis were investigated in Hs68 human fibroblasts cells. These tests also revealed that the fermented extract had increased antiaging activities compared with the non-fermented extract. A component analysis of the ethyl acetate fractions of non-fermented and fermented extracts was performed using TLC, HPLC, and LC/ESI-MS/MS to observe changes in the components before and after fermentation. Six components that were different before and after fermentation were investigated. It was thought that kaempferol and quercetin were converted from kaempferol glucosides and quercetin glucosides, respectively, via bioconversion with the fermentation strain. These results indicate that the fermented extract of L. cuneata G. Don has potential for use as a natural cosmetic material with antioxidative and antiaging effects.

• Biomolecules & Therapeutics
• /
• v.26 no.2
• /
• pp.101-108
• /
• 2018

G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are the most commonly used therapeutic target. It has been suggested that GPCRs undergo massive genetic variations such as genetic polymorphisms and DNA insertions or deletions. Among these genetic variations, non-synonymous natural variations change the amino acid sequence and could thus alter GPCR functions such as expression, localization, signaling, and ligand binding, which may be involved in disease development and altered responses to GPCR-targeting drugs. Despite the clinical importance of GPCRs, studies on the genotype-phenotype relationship of GPCR natural variants have been limited to a few GPCRs such as b-adrenergic receptors and opioid receptors. Comprehensive understanding of non-synonymous natural variations within GPCRs would help to predict the unknown genotype-phenotype relationship and yet-to-be-discovered natural variants. Here, we analyzed the non-synonymous natural variants of all non-olfactory GPCRs available from a public database, UniProt. The results suggest that non-synonymous natural variations occur extensively within the GPCR superfamily especially in the N-terminus and transmembrane domains. Within the transmembrane domains, natural variations observed more frequently in the conserved residues, which leads to disruption of the receptor function. Our analysis also suggests that only few non-synonymous natural variations have been studied in efforts to link the variations with functional consequences.

• Structural Engineering and Mechanics
• /
• v.86 no.1
• /
• pp.49-68
• /
• 2023

This study investigates the static and dynamic structural analysis of symmetrical and asymmetrical coupled shear walls using the continuous and modified transfer matrix methods by idealizing the coupled shear wall as a three-field CTB-type replacement beam. The coupled shear wall is modeled as a continuous structure consisting of the parallel coupling of a Timoshenko beam in tension (with axial extensibility in the shear walls) and a shear beam (replacing the beam coupling effect between the shear walls). The variational method using the Hamilton principle is used to obtain the coupled differential equations and the boundary conditions associated with the model. Using the continuous method, closed-form analytical solutions to the differential equation for the coupled shear wall with uniform properties along the height are derived and a numerical solution using the modified transfer matrix is proposed to overcome the difficulty of coupled shear walls with non-uniform properties along height. The computational advantage of the modified transfer matrix method compared to the classical method is shown. The results of the numerical examples and the parametric analysis show that the proposed analytical and numerical model and method is accurate, reliable and involves reduced processing time for generalized static and dynamic structural analysis of coupled shear walls at a preliminary stage and can used as a verification method in the final stage of the project.

• Computers and Concrete
• /
• v.20 no.3
• /
• pp.257-262
• /
• 2017

This study aims to develop a signal processing scheme to accurately predict the thickness of concrete slab using air-coupled impact-echo. Air-coupled impact-echo has been applied to concrete non-destructive tests (NDT); however, it is often difficult to obtain thickness mode frequency due to noise components. Furthermore, apparent velocity in concrete is a usually unknown parameter in the field and the thickness of the concrete slab often cannot be accurately measured. This study proposes a signal processing scheme using guided wave analysis, wherein dispersion curves are drawn in both frequency-wave number (f-k) and phase velocity-frequency ($V_{cp}-f$) domains. The theoretical and experimental results demonstrate that thickness mode frequency and apparent velocity in concrete are clearly obtained from the f-k and $V_{cp}-f$ domains, respectively. The proposed method has great potential with regard to the application of air-coupled impact-echo in the field.

• Interaction and multiscale mechanics
• /
• v.5 no.3
• /
• pp.169-185
• /
• 2012

The concrete bridge is likely to produce fatigue cracks during long period of service due to the moving vehicular loads and the degeneration of materials. This paper deals with the time-frequency analysis of a coupled bridge-vehicle system. The bridge is modeled as an Euler beam with breathing cracks. The vehicle is represented by a two-axle vehicle model. The equation of motion of the coupled bridge-vehicle system is established using the finite element method, and the Newmark direct integration method is adopted to calculate the dynamic responses of the system. The effect of breathing cracks on the dynamic responses of the bridge is investigated. The time-frequency characteristics of the responses are analyzed using both the Hilbert-Huang transform and wavelet transform. The results of time-frequency analysis indicate that complicated non-linear and non-stationary features will appear due to the breathing effect of the cracks.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.27 no.7
• /
• pp.963-972
• /
• 2003

Performance characteristics of the planar-type solid oxide fuel cell (SOFC) are investigated by the analysis of flow fields coupled with heat and mass transfer phenomena in anode and cathode channels. For these purposes, performance analysis of the SOFC is conducted based on electrochemical reaction phenomena in electrodes and electrolyte coupled with flow fields in anode and cathode channels. In the present study, the isothermal model adopted in the previous paper prepared by the same authors is extended to the non-isothermal model by solving energy equation additionally with momentum and mass transfer equations using CFD technique. It is found that the difference between isothermal and non-isothermal models come from non-uniform temperature distribution along anode and cathode electrodes by solving energy equation in non-isothermal model. Non-uniform temperature distribution in non-isothermal model contributes to the increase of average temperature of the fuel cell and influences its performance characteristics.

• International Journal of Precision Engineering and Manufacturing
• /
• v.4 no.1
• /
• pp.15-22
• /
• 2003

Beams are often subject to bending-torsion coupled vibration due to mass coupling and/or stiffness coupling. This paper proposes a dynamic analysis method using the exact dynamic element for bending-torsion coupled vibration of general plane beam structures with joints. The exact dynamic element matrix for a bending-torsion coupled beam is derived, and the detailed procedure of using the exact dynamic element matrix is also presented. Three examples are provided for validating and illustrating the proposed method. The numerical study proves the proposed method to be useful for dynamic analysis of bending-torsion coupled beam structures with joints.