• IMMUNE NETWORK
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• v.1 no.2
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• pp.162-169
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• 2001

Background: Nitric oxide (NO), a cytotoxic molecule is produced in various tissues including tumor cells during interleukin-2 (IL-2) therapy . Lymphokine-activated killer (LAK) cells are induced during IL-2 therapy, and have cytotoxic activity against tumor cells. The current study investigated the effects of NO synthesized in target cells or exposure of target cells to NO on the sensitivity of target cells to LAK cell cytotoxicity. Methods: Cytotoxicity was measured using 4 h chromium release assays. LAK cells which were induced by a 4 day incubation of BALB/c mouse splenocytes with IL-2 (6,000 IU/mL) were employed as effector cells. RD-995 skin tumor cells originated from a C3H/HeN mouse were employed as target cells. NO synthesis in target cells was induced by a 24 h incubation of RD-995 cells with $IFN{\gamma}$ (25 U/mL), TNF (50 U/mL) and IL-1 (20 U/mL). S-nitrosyl acetylpenicillamine (SNAP), an NO donor, was used to expose target cells to NO. $N^G$-monomethyl-L-arginine (MLA) and carboxy-PTIO were added during cytotoxicity assays to inhibit NO synthesis, and to scavenge NO produced by target cells, respectively. Results: Sensitivity of NO-producing RD-995 cells to LAK cell cytotoxicity was decreased by addition of MLA and carboxy-PTIO during cytotoxicity assays. However, the two reagents had no effect on the sensitivity of non-NO-producing RD-995 cells. Pretreatment of RD-995 target cells with SNAP increased the sensitivity in comparison with untreated cells. Conclusions: Sensitivity of target cells to LAK cell cytotoxicity is increased by target cell NO synthesis or exposure to NO. Further studies are needed to evaluate whether these in vitro results have relevance to in vivo phenomena.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.586-586
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• 2012

The vuv spectrometer for ITER main plasma measurement is designed as a five-channel spectral system. To develop and verify the design, a two-channel prototype system was fabricated with No. 3 (14.4-31.8 nm) and No. 4 (29.0-60.0 nm) among the five channels. For test of the prototype system, a hollow cathode lamp is used as a light source. The system is composed of a collimating mirror to collect the light from source to slit, and two holographic diffraction gratings with toroidal geometry to diffract and also to collimate the light from the common slit to detectors. The overall system performance was verified by comparing the measured spectral resolutions with the calculated spectral resolutions. And we also have developed liquid jet target system. This study is about a neutron generator, which is designed to overcome many of the limitations of traditional beam-target neutron generators by utilizing a liquid target. One of the most critical aspects of the beam-target neutron generator is the target integrity under the beam exposure. A liquid target can be a good solution to overcome damage to the target such as target erosion and depletion of hydrogen isotopes in the active layer, especially for the ones operating at high neutron fluxes and maintained relatively thin with no need for water cooling. In this study, liquid target containing hydrogen has been developed and tested.

• The Journal of Asian Finance, Economics and Business
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• v.1 no.3
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• pp.29-36
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• 2014

This paper attempts to measure the impact of non-financial factors including analyst practices and broker resources on performance of sell side research. Results reveal that these non-financial factors have a measurable impact on performance of target price forecasts. Number of pages written by an analyst (surrogate for analyst practice) is significantly and directly linked with target price accuracy indicating a more elaborate analyst produces better target price forecasts. Analyst compensation (surrogate for broker resource) is significantly and inversely linked with target price accuracy. Out performance by analysts working with lower paying firms is possibly associated with motivation to migrate to higher paying broking firms. The study finds that employing more number of analysts per research report has no significant impact on target price accuracy -negative coefficient indicates that team work may not result in better target price forecasts. Though insignificant, long term forecast horizon negatively affects target price accuracy while stock volatility improves target price accuracy.

• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.3
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• pp.397-418
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• 2019

It is very important to understand and analyze the interactive behaviour between ground and adjacent structures due to tunneling. With many technological advancement in modern society, numerous methods for analyzing the interactive behaviour are used in a wide range of civil engineering fields. Close range photogrammetry is mainly being used in the field of geotechnical engineering and research on measuring methods associated with GeoPIV has been currently increased. Originally, the close range photogrammetry using target points and aluminum rods for VMS (Vision Measurement System) program has been used. However, applying this has a problem that external errors can be occurred because the target points are artificially installed by hand, and if the grid between points is being wider or narrower, deficient data can be obtained. Therefore, in this study, MATLAB-based No-target program that can analyze displacement without using target was developed. Additionally, this study focused on comparison and verification with existing program through numerical analysis and laboratory model test. Three cases of Greenfield condition, Strip foundation, and Pile foundation were analyzed. From results of VMS program and No-target program, the error rate and reliability of the total displacement and the vertical displacement were analyzed. It was also compared and verified through the finite element numerical program, PLAXIS.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.421-422
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• 2011

The first part is about development of a liquid target for a neutron source, which is designed to overcome many of the limitations of traditional beam-target neutron generators by utilizing a liquid target neutron source. One of the most critical aspects of the beam-target neutron generator is the target integrity under the beam exposure. A liquid target can be a good solution to overcome damage to the target such as target erosion and depletion of hydrogen isotopes in the active layer, especially for the one operating at high neutron fluxes with no need for water cooling. There is no inherent target lifetime for the liquid target neutron generator when used with continuous refreshment of the target surface exposed to the energetic beam. In this work, liquid target containing hydrogen has been developed and tested in vacuum environment. Potentially, liquid targets could allow a point neutron source whose spatial extension is on the order of 1 to $10{\mu}m$. And the second is about the vacuum ultraviolet (VUV) spectrometer which is designed as a five-channel spectral system for ITER main plasma measurement. To develop and verify the design, a two-channel prototype system was fabricated with No. 3 (14.4 nm~31.8 nm) and No. 4 (29.0 nm~60.0 nm) among the five channels. For test of the prototype system, a hollow cathode lamp is used as a light source. The system is composed of a collimating mirror to collect the light from source to slit, and two holographic diffraction gratings with toroidal geometry to diffract and also to collimate the light from the common slit to detectors. The two gratings are positioned at different optical distances and heights as designed. To study the appropriate detector for ITER VUV system, two different electronic detectors of the back-illuminated charge coupled device and the micro-channel plate electron multiplier were installed and the performance has been investigated and compared in the same experimental conditions. The overall system performance was verified by measuring the spectrums.

• Korean Journal of Applied Biomechanics
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• v.12 no.1
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• pp.193-204
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• 2002

The purpose of this study was to investigate the effect of martial art type and target height on the ground reaction force factors during Dollyuchagi motion. Data were collected using force plate. Five Taekwondo players and five Hapkido players were tested during Dollyuchagi motion to three different target heights(0.8, 1.2, 1.6 m). After analysis of kinetics using force plate data, maximum vertical ground reaction force was 1.62~2.44 BW, and impulse was $0.66\sim1.01 BW{\cdot}s$. Even though there was no difference for maximum ground reaction forces and impulse between Hapkido and Taekwondo, as target height was higher, impulse increased. Anterior-posterior and vertical ground reaction forces at kicking foot take-off were greater with target height, although there was no difference for medio-lateral force with target height. At impact there was significant difference for anterior-posterior ground reaction force between Hapkido and Taekwondo players. Taekwondo players' force (range, -0.23~-0.26 BW) was greater than Hapkido players's force (range, -0.08~-0.14 BW).

• Journal of the military operations research society of Korea
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• v.17 no.1
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• pp.159-176
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• 1991

The probability of target survival is the most important factor in the target assignment, Most of the studies about it have assumed the case of one target and ane weapon type. Therefore, they can not be applied to the real situation. In this paper. the quantity and type of enemy assets of the friendly force are considered simultaneously. Considered defense type is the coordinated defense with no impact point prediction. The objective function is to minimize the expected total survival value of targets which are scattered in the defense area. The rules of aircraft assignment are as follows : first, classify targets into several groups, each of those has the same desired damage level secondly. select the critical group which has the least survival value in accordance with the additional aircraft assignment, and finally. assign the same number of attack assets against each target in the critical group. In this paper, the attack assets, the escort assets, and the defense assets are considered. The model is useful to not only the simple aircraft assignment problem but also the complicated wargame models.

• Journal of Information Technology Applications and Management
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• v.9 no.2
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• pp.1-16
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• 2002

Recently, neural network methods have been studied to find out more valuable information in data bases. But the supervised learning methods of neural networks have an overfitting problem, which leads to errors of target patterns. And the unsupervised learning methods can distort important information in the process of regularizing data. Thus they can't efficiently classify data, To solve the problems, this paper introduces a hybrid neural networks HACAB(Hybrid Algorithm combining a Competition learning model And BP Algorithm) combining a competition learning model and 8P algorithm. HACAB is designed for cases which there is no target patterns. HACAB makes target patterns by adopting a competition learning model and classifies input patterns using the target patterns by BP algorithm. HACAB is evaluated with random input patterns and Iris data In cases of no target patterns, HACAB can classify data more effectively than BP algorithm does.

• Journal of the Korean Institute of Telematics and Electronics
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• v.12 no.4
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• pp.15-20
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• 1975

The power overshoot is rises in the output during the transient period when the output of nuclear reactor is increased from the initial state to the desired target state and certain amount of constraint on power level is of primary importance for safety control of nuclear reactor. Therefore, the maximum principle is applied to this process control in transfering its power from the initial state(no, co) to the final target state(2no, 2co or 1.5no, 1.5co), adjusting the reactivity so that its overshoot is limited within the allowable constraint required. In this case, the switching points, switching times, optimal lima and optimal control reactivity are calculated.

• International Journal of Internet, Broadcasting and Communication
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• v.12 no.3
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• pp.1-8
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• 2020

This paper studied a method of estimating target information using a radar in wireless communication. Position information on the target can be estimated angle, distance and velocity. The velocity information can be estimated since the Doppler frequency is changed in the moving target. The signal incident on the receiving array antenna is multiplied by the delay time and the reference signal to represent the output signal. This output signal is estimated by applying FFT (Fast Fourier Transform) after calculating signal correlation through correlation integrator. Since the output signal must be calculated within the correlator, it should be processed with the Dwell time. The correlation signal of the correlation integrator outside this Dwell time is indicated by the velocity measurement error. The FFT is applied to the signal that has passed through the correlated integrator in order to estimate the distance of the signal. The Doppler resolution must be improved because the FFT estimates target information using the Doppler information. The Doppler resolution decreases with increasing the integration time. The velocity information estimation should have no spread of the velocity. As a result of the simulation, there was no spread of the target velocity in this study.