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MS-HEMs: An On-line Management System for High-Energy Molecules at ADD and BMDRC in Korea

  • Lee, Sung-Kwang;Cho, Soo-Gyeong;Park, Jae-Sung;Kim, Kwang-Yeon;No, Kyoung-Tae
    • Bulletin of the Korean Chemical Society
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    • v.33 no.3
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    • pp.855-861
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    • 2012
  • A pioneering version of an on-line management system for high-energy molecules (MS-HEMs) was developed by the ADD and BMDRC in Korea. The current system can manage the physicochemical and explosive properties of virtual and existing HEMs. The on-line MS-HEMs consist of three main routines: management, calculation, and search. The management routine contains a user-friendly interface to store and manage molecular structures and other properties of the new HEMs. The calculation routine automatically calculates a number of compositional and topological molecular descriptors when a new HEM is stored in the MS-HEMs. Physical properties, such as the heat of formation and density, can also be calculated using group additivity methods. In addition, the calculation routine for the impact sensitivity can be used to obtain the safety nature of new HEMs. The impact sensitivity was estimated in a knowledge-based manner using in-house neural network code. The search routine enables general users to find an exact HEM and its properties by sketching a 2D chemical structure, or to retrieve HEMs and their properties by giving a range of properties. These on-line MS-HEMs are expected be powerful tool for deriving novel promising HEMs.

Model analysis for production and utilization of hydrogen energy from wind power and solar cell (풍력-태양전지에 의한 수소에너지 생산과 이용 모델 분석)

  • Lee, Kee Mun;Park, Chang Kwon;Jeong, Kwi Seong;Oh, Byeong Soo
    • Transactions of the Korean hydrogen and new energy society
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    • v.12 no.4
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    • pp.239-246
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    • 2001
  • Fossil fuel such as oil and natural gas has been used and will be no longer supplied enough to demand in the beginning of thisg century. The use of the fuel makes a lot of environmental pollution to threaten human being's health especially in big cities and produces a lot of $CO_{2}$ to make green house effect of the earth. It is the time to use clean fuel such as hydrogen to prevent the expected energy crisis and the pollution. A new engine such as fuel cell can be used instead of the conventional internal combustion engine with 2 to 3 times higher efficiency of the conventional engine. The fuel cell uses hydrogen and oxygen and produces electric energy and pure water, which is a calm engine without air pollution. In big cities the city buses and the taxies powered by hydrogen fuel cells are suggested to be operated for clean environment. The energy and cost analysis performed for hydrogen and electricity production from wind power and solar cell.

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Survey on residual antibiotics for beef, pork and chicken at slaughter house in Gyeongbuk province (경북지방 도축장의 지육에 대한 잔류물질 실태조사)

  • Seo Hee-Jin;Lee Yeong-Mi;Do Jae-Cheul;Park No-Chan;Lee Yang-Soo
    • Korean Journal of Veterinary Service
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    • v.29 no.3
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    • pp.331-338
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    • 2006
  • This survey was carried out to detect the residual antibiotics in beef (n = 1,071), pork (n=7,837) and chicken (n=1,536) from slaughter houses in Gyeongbuk province by EEC-4 plate method, Charm II and HPLC during 2005. Residues of antibiotic were detected from 9 beef (0.8%) and 119pork (1.52%) by EEC-4 plate method, and total positive rates were 1.23% (128). 126 samples of the 128 positive samples by the EEC-4 plate method were detected by charm II test. 128 samples were classified as tetracyclines 110 (95.5%), ${\beta}$-lactam 2 (1.6%), sulfonamide 22 (17.2%), quinolone 1 (0.8%). The highest residual concentration of oxytetracycline, tetracycline, chlor-tetracycline, penicillin, sulfamethazine, sulfadimethoxine, sulfaquinoxaline, sulfamerazine, sulfamonomethoxine and enrofloxacin were 7.57, 0.27, 0.40, 0.24, 14.24, 4.33, 8.59, 0.12, 0.09 and 1.98 ppm, respectively and 49 samples were exceeded legal admitted levels.

Facial Chuna Manual Therapy and Acupuncture Treatment for the Sequelae of Peripheral Facial Nerve Palsy: Two Clinical Cases

  • Choi, Ga-Young;Park, Yu-Kyeong;Woo, Sang Ha;Lee, Jung Hee;Lee, Yun Kyu;Lee, Hyun-Jong;Kim, Jae Soo
    • Journal of Acupuncture Research
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    • v.39 no.1
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    • pp.70-75
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    • 2022
  • Two patients with sequelae of peripheral facial nerve palsy were treated with Facial Chuna Manual Therapy (FCMT) and acupuncture over 6 months. The House-Brackmann (HB) scale, facial nerve grading system 2.0 (FNGS), the scale of Peitersen, the scale of Murata, and the Numeric Rating Scale (NRS) were used to assess the effects of treatment. The HB scale, FNGS and NRS scores showed improvement for both patients (Case 1: HB scale 5 to 3, FNGS 4 to 2, NRS 10 to 5; Case 2: HB scale 5 to 3, FNGS 4 to 3, NRS 10 to 2.5) following 6 months of treatment. The scores for the Peitersen and Murata scales showed improvement over 6 months in Case 1 (Peitersen 2 to 1, Murata 10 to 7), but there was no change in Case 2 over the test period (4 months). FCMT and acupuncture may help patients with sequelae of facial palsy.

Properties of Water-based Paint mixed with Photocatalyst for Indoor Air Quality Improvement (실내 공기질 개선을 위한 광촉매를 혼입한 수성도료의 특성)

  • Choi, Byung-Cheol;Park, Chae-Wool;Kyoung, In-Su;Lee, Sang-Soo
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2020.06a
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    • pp.29-30
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    • 2020
  • As the modern society enters, the building becomes sealed and the public's interest in the environment increases, so the interest in indoor air pollution increases and the environmental pollution is raised as an important issue not only outdoors but also indoors. In addition, the emergence of sick house syndrome (SHS) has increased the interest in formaldehyde and is a cause of deteriorating indoor air quality. Accordingly, this study prepared a functional paint by incorporating a photocatalyst in an aqueous paint, and conducted formaldehyde adsorption experiments and functional evaluation. As a result of the experiment, as the photocatalyst was added, the formaldehyde adsorption performance tended to increase. In addition, as a result of measuring the impact resistance and alkali resistance according to the KS standard, there is no difference in residual cracks and cracks between the water-based paint without the photocatalyst and the water-based paint with the photocatalyst added. Therefore, it is considered that the water-based paint added with a photocatalyst can improve the indoor air quality by adsorbing formaldehyde and can be used as a functional paint because the functionality is not different from that of a general water-based paint.

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A Survey on Egg Laying Performance and Distribution Status of Animal Welfare Certified Farms for Laying Hens (산란계 동물복지 인증 농가의 사육 및 유통 현황 조사)

  • Hong, Eui-Chul;Kang, Hwan-Ku;Park, Ki-Tae;Jeon, Jin-Joo;Kim, Hyun-Soo;Kim, Chan-Ho;Kim, Sang-Ho
    • Korean Journal of Poultry Science
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    • v.46 no.2
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    • pp.55-63
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    • 2019
  • This study was conducted to evaluate animal welfare approved farms in three housing systems (open, windowless, and free-range). The survey was conducted in 25 animal welfare approved farms, and 10 farms were surveyed for distribution status. The main breed in all animal welfare approved farms of laying hens was Hy-Line Brown variety. In the case of open house, laying hens were bred in traditional and panel houses simultaneously; however, the ratio of panel house was 58.3%, which was higher than that of the traditional house. All the windowless houses were made of panels and more than 15,000 laying hens were housed in a single windowless house. In the case of free-range house, it was maintained on a small scale of less than 12,000 birds. Fifty-six percent of the surveyed farms were breeding at $7{\sim}8birds/m^2$. In terms of male and female ratios, most farms maintained 1 male:15 females, but there was a farmhouse that switched 17 or 20 females to 1 male. The daily dietary allowance was 110~170 g, and 32% of the surveyed farms provided feed of more than 150 g/day, which showed that forage feed was important. The age of at the first egg was 123 days, 122 days, and 120 days, and the peak percent was 91.8%, 94.9%, and 86.5% in open, windowless and free-range houses, respectively. The average egg production rate was 74.0%, 84.6%, and 72.7% in open, windowless, and free-range houses respectively, thus, there was no correlation between feed intake and hen-housed eggs. Distribution of welfare certified eggs was mainly a direct deal with the consumer or through contract production. The ratio of direct transactions between large-scale marts and eco-friendly specialty stores of welfare approved eggs was higher than that of conventional eggs. The rate of contract sales of eggs in both the barn and free-range systems was high, and the percentage of courier sales farms was also high. Excluding courier services, price of eggs in the barn system rose to more than 30 won/egg in the second half of 2017 (after AI). Price of eggs in the free-range system rose to more than 50 won/egg in the second half of 2017 (after AI). In the case of courier sales, the same price of 500 won was maintained before and after AI. In conclusion, the results of this study can be used as basic data for improving the animal welfare certification system for laying hens in Korea.

Comparison of Temperature-dependent Development Model of Aphis gossypii (Hemiptera: Aphididae) under Constant Temperature and Fluctuating Temperature (실내 항온과 온실 변온조건에서 목화진딧물의 온도 발육비교)

  • Kim, Do-Ik;Ko, Suk-Ju;Choi, Duck-Soo;Kang, Beom-Ryong;Park, Chang-Gyu;Kim, Seon-Gon;Park, Jong-Dae;Kim, Sang-Soo
    • Korean journal of applied entomology
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    • v.51 no.4
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    • pp.421-429
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    • 2012
  • The developmental time period of Aphis gossypii was studied in laboratory (six constant temperatures from 15 to $30^{\circ}C$ with 50~60% RH, and a photoperiod of 14L:10D) and in a cucumber plastic house. The mortality of A. gossypii in the laboratory was high in the 2nd (20.0%) and 3rd stage(13.3%) at low temperature but high in the 3rd (26.7%) and 4th stage (33.3%) at high temperatures. Mortality in the plastic house was high in the 1st and 2nd stage but there was no mortality in the 4th stage at low temperature. The total developmental period was longest at $15^{\circ}C$ (12.2 days) in the laboratory and shortest at $28.5^{\circ}C$ (4.09 days) in the plastic house. The lower threshold temperature at the total nymphal stage was $6.8^{\circ}C$ in laboratory. The thermal constant required to reach the total nymphal stage was 111.1DD. The relationship between the developmental rate and temperature fit the nonlinear model of Logan-6 which has the lowest value for the Akaike information criterion(AIC) and Bayesian information criterion(BIC). The distribution of completion of each development stage was well described by the 3-parameter Weibull function ($r^2=0.89{\sim}0.96$). This model accurately described the predicted and observed outcomes. Thus it is considered that the model can be used for predicting the optimal spray time for Aphis gossypii.

HISTOMORPHOMETRIC STUDY ON THE INFLUENCE OF STEROID TOPICAL IRRIGATION AND IMPLANT SURFACE ON BONE HEALING IN THE IRRADIATED RABBIT TIBIA (방사선 조사 후 매식한 임프란트의 표면 종류와 스테로이드 관주에 따른 골 치유 효과에 대한 조직 형태학적 연구)

  • Shin, Sung-Soo;Park, Yang-Ho;Park, Jun-Woo;Rhee, Gun-Joo;Kim, Hyun-Man;Ko, Jae-Seung
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.30 no.6
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    • pp.455-464
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    • 2004
  • The purpose of this study was to evaluate and compare the influence of Steroid topical irrigation and implant surface on bone healing in the irradiated rabbit tibia. Implant to bone contact surface ratio and the pattern of bone healing around hydroxyapatite(HA) coated implant and pure titanium (Ti) implant which were inserted into the irradiated rabbit tibia were compared. 16 Korean house mature male rabbits were used as experimental animal. Each rabbit received 15 Gy of irradiation. 4 weeks after the irradiation, two holes were prepared in the irradiated tibia of each rabbits, where two surface type of implants were inserted :1) HA coated type and 2) pure Ti type. Right before placing implants, one group of rabbit received steroid irrigation and the other group did saline. After the irrigation, two implants of HA coated type and pure Ti type were inserted into the tibia of each rabbits. Each rabbit were sacrificed at 2nd, 4th, and 8th week after the implantation and the specimens were observed by the light microscope. The pattern of bone healing and histomorphometric analysis of the implant-bone interface were done. The results were as follows. 1. All implants inserted into the irradiated tibia of rabbit did not show any sign of clinical mobility and the bone around implants inserted into the irradiated tibia of rabbit did not show any resorption. 2. The bone to implant contact surface ratio around HA coated implants that received steroid irrigation got more bone to implant contact surface ratio than that of the saline irrigation. This result showed statistically significant(p<0.05). There was no statistically significant difference in 8th week group. 3. Though there was no statistically significant difference HA coated implants had more bone to implant contact surface ratio than pure Ti implant in 2nd and 4th groups, and there was no difference in 8th week group. 4. All implants inserted into the irradiated tibia of rabbit had exhibited successful osseointegraion.

Assessment of Owner Organization's Business Function for Successful Application of CM (발주자 유형별 CM 업무기능 특성 분석)

  • Kang Seung-Hee;Jung Young-Soo;Woo Sung-Kwon;Park Ji-Ho;Lee Young-Hwan;Lee Bok-Nam
    • Proceedings of the Korean Institute Of Construction Engineering and Management
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    • autumn
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    • pp.388-393
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    • 2003
  • Since the Construction Management(CM) was introduced into the Korea construction industry, the efforts for acceleration of CM adaption have been continued. The fact that an owner organization has the essential key to successful application of CM delivery method is true, but there has been no study on owner's organization. An owner should decide their organization type and measure their current needs of each CM business functions for successful application of CM. After the needs of CM business functions are measured, the owner should reinforce their required business functions through strengthening their in-house capability or outsourcing. Thus, this paper defines four kinds of owner organization type and suggest the form for evaluation of owner's CM ability and analyze about needs of each type's CM ability through making up question.

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Evaluation of the Current Regimen of Tacrolimus in Patients with Hematopoietic Stem Cell Transplantation (조혈모세포 이식환자에서의 현행 tacrolimus 치료방법 평가)

  • Yeo, Mi-Jin;Park, Soo-Jin;Bang, Joon-Seok;La, Hyen-Oh
    • Korean Journal of Clinical Pharmacy
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    • v.20 no.3
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    • pp.193-199
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    • 2010
  • Tacrolimus, an immunosuppressant prescribed against graft-versus-host disease (GVHD) in patients with allogeneichematopoietic stem cell transplantation (HSCT), is affected to change its pharmacokinetic properties by various factors. For this reason, it is needed a close monitoring to adjust dosage amount in order to optimize the blood concentration of tacrolimus is located within the effective range. According to our in-house study, 62% of HSCT-patients were needed dosage-adjustment and it is necessary to optimize the current immunosuppressive regimen in clinical settings. A retrospective study was designed to evaluate the dosing regimen (converting ratio of IV:PO=1:4) of tacrolimus in HSCT patients (n=62). After collecting data from patient's profile and medical record, pharmacokinetic parameters were calculate and compared between the estimated and the actual values in the selected subjects (n=58). It was found that the bioavailabilty (BA) of oral tacrolimus was 40.5% very much different from that is known as 25%. It implies that the current protocol has a potent risk causes dose-related toxicities to the patients. Furthermore, analyses among factors demonstrated that there was no statistical significance between BA of tacrolimus and the variable factors. In the clinical perspectives, the current converting ratio of tacrolimus in patients with HSCT to be re-considered and an appropriate and optimal alternative regimen should be adopted to prevent GVHD and to increase the quality of life of patients.