• Clinical and Experimental Pediatrics
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• v.64 no.12
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• pp.608-618
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• 2021

Hypoxic-ischemic encephalopathy (HIE) is the most common cause of neonatal encephalopathy with a global incidence of approximately 1 to 8 per 1,000 live births. Neonatal encephalopathy can cause neurodevelopmental and cognitive impairments in survivors of hypoxic-ischemic insults with and without functional motor deficits. Normal neurodevelopmental outcomes in early childhood do not preclude cognitive and behavioral difficulties in late childhood and adolescence because cognitive functions are not yet fully developed at this early age. Therapeutic hypothermia has been shown to significantly reduced death and severe disabilities in term newborns with HIE. However, children treated with hypothermia therapy remain at risk for cognitive impairments and follow-up is necessary throughout late childhood and adolescence. Novel adjunctive neuroprotective therapies combined with therapeutic hypothermia may enhance the survival and neurodevelopmental outcomes of infants with HIE. The extent and severity of brain injury on magnetic resonance imaging might predict neurodevelopmental outcomes and lead to targeted interven tions in children with a history of neonatal encephalopathy. We provide a summary of the long-term cognitive outcomes in late childhood and adolescence in children with a history of HIE and the association between pattern of brain injury and neurodevelopmental outcomes.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.11a
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• pp.971-974
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• 2020

Infants express their physical and emotional needs to the outside world mainly through crying. However, most of parents find it challenging to understand the reason behind their babies' cries. Failure to correctly understand the cause of a baby' cry and take appropriate actions can affect the cognitive and motor development of newborns undergoing rapid brain development. In this paper, we propose an infant cry recognition system based on deep transfer learning to help parents identify crying babies' needs the same way a specialist would. The proposed system works by transforming the waveform of the cry signal into log-mel spectrogram, then uses the VGGish model pre-trained on AudioSet to extract a 128-dimensional feature vector from the spectrogram. Finally, a softmax function is used to classify the extracted feature vector and recognize the corresponding type of cry. The experimental results show that our method achieves a good performance exceeding 0.96 in precision and recall, and f1-score.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.05a
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• pp.354-357
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• 2021

Infants communicate their feelings and needs to the outside world through non-verbal methods such as crying and displaying diverse facial expressions. However, inexperienced parents tend to decode these non-verbal messages incorrectly and take inappropriate actions, which might affect the bonding they build with their babies and the cognitive development of the newborns. In this paper, we propose an aural-visual two-stream based infant cry recognition system to help parents comprehend the feelings and needs of crying babies. The proposed system first extracts the features from the pre-processed audio and video data by using the VGGish model and 3D-CNN model respectively, fuses the extracted features using a fully connected layer, and finally applies a SoftMax function to classify the fused features and recognize the corresponding type of cry. The experimental results show that the proposed system classification exceeds 0.92 in F1-score, which is 0.08 and 0.10 higher than the single-stream aural model and single-stream visual model.

• Anatomy and Cell Biology
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• v.56 no.4
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• pp.421-427
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• 2023

Bladder exstrophy is a rare congenital condition of the pelvis, bladder, and lower abdomen that opens the bladder against the abdominal wall, produces aberrant growth, short penis, upward curvature during erection, wide penis, and undescended testes. Exstrophy affects 1/30,000 newborns. The bladder opens against the abdominal wall in bladder exstrophy, a rare genitourinary condition. This study is vital to provide appropriate therapy choices as a basis to improve patient outcomes. This study may explain bladder exstrophy and provide treatment. Epispadias, secretory placenta, cloacal exstrophy, and other embryonic abnormalities comprise the exstrophy-spades complex. The mesenchymal layer does not migrate from the ectoderm and endoderm layers in the first trimester, affecting the cloacal membrane. Embryological problems define the exstrophy-aspidistra complex, which resembles epimedium, classic bladder, cloacal exstrophy, and other diseases. Urogenital ventral body wall anomalies expose the bladder mucosa, causing bladder exstrophy. Genetic mutations in the Hedgehog cascade pathway, Wnt signal, FGF, BMP4, Alx4, Gli3, and ISL1 cause ventral body wall closure and urinary bladder failure. External factors such as high maternal age, smoking moms, and high maternal body mass index have also been associated to bladder exstrophy. Valproic acid increases bladder exstrophy risk; chemicals and pollutants during pregnancy may increase bladder exstrophy risk. Bladder exstrophy has no identified cause despite these risk factors. Exstrophy reconstruction seals the bladder, improves bowel function, reconstructs the vaginal region, and restores urination.

• Journal of The Korea Institute of Healthcare Architecture
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• v.30 no.3
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• pp.35-44
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• 2024

Purpose: The purpose of this study is to present basic data on installation location, functional connection, and arrangement to be considered when planning a neonatal intensive care unit in a certified tertiary general hospital. Method: Review the facility standards related to the neonatal intensive care unit, such as laws and guidelines, and select a Certified Tertiary General Hospital as a case hospital among the Neonatal Intensive Care Regional Centers designated by the Ministry of Health and Welfare to analyze the placement characteristics of major NICU components such as the location of the NICU installation, the connection of movement between adjacent facilities and functions, and the treatment room and accessory room. Results and Implications: NICU is a facility for critically ill babies among newborns and needs to consider more about infection and patient management compared to adult intensive care units, which not only install close to delivery-related facilities to enable immediate action after childbirth, but also divide the treatment room into open rooms and allow access to the attached rooms through dedicated corridors to minimize movement in the treatment room.

• Tuberculosis and Respiratory Diseases
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• v.72 no.6
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• pp.501-506
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• 2012

Congenital cystic adenomatoid malformation (CCAM) is an uncommon, nonhereditary anomaly caused by arrest of lung. Patients with CCAM may present with respiratory distress as newborns, or may remain asymptomatic until later in life. CCAM type I is rarely found in association with bronchial atresia (BA) in adults; we present such a case. Case: A 54-year-old female presented with chronic cough and blood-tinged sputum. Physical examination and laboratory tests were unremarkable. Chest radiographs and a CT scan of the chest showed multiple large air-filled cysts consistent with a CCAM in the right lower lobe, and an oval-shaped opacity in the distal right middle lobal bronchus. Based on the radiologic findings, right middle lobectomy and a medial basal segmentectomy of the right lower lobe were performed via a thoracotomy. These lesions were consistent with Stocker's Type I CCAM and BA in the different lobes.

• Korean Journal of Childcare and Education
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• v.8 no.3
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• pp.53-67
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• 2012

This study was to focus on the effect on parenting stress of children's developmental characteristics, emotionality and mother's self-efficacy, thus to set the structure equation model. Analysis data was collected from 2078 newborns to be involved Korea Children's Panel 1st year. The valuables were all measured by mothers. The main results of this study were as follows. First, children's developmental characteristics and emotionality had an effect on parenting stress directly. A lower level of children's developmental characteristics and a higher level of children's emotionality indicated a higher maternal parenting stress level. Second, mother's self-efficacy also had an effect on parenting stress level. A lower level of maternal self-efficacy demonstrated a higher level of maternal parenting stress level. Third, children's developmental characteristics and emotionality had an effect on parenting stress indirectly through mother's self-efficacy. Mother's self-efficacy which was affected by children's developmental characteristics and emotionality aggravated mother's parenting stress. The implication of these findings are also discussed.

• Korean Journal of Agricultural Science
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• v.43 no.1
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• pp.72-79
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• 2016

It has long been known that nutritional and environmental influences during the early developmental period affect the biological mechanisms which determine animal metabolism. This phenomenon, termed 'metabolic imprinting', can cause subtle but long-lasting responses to prenatal and postnatal nutrition and even be passed onto the next generation. A large amount of research data shows that nutrient availability, in terms of quantity as well as quality, during the early developing stages can decrease the number of newborn piglets and their body weight and increase their susceptibility to death before weaning. However, investigation of potential mechanisms of 'the metabolic imprinting' effect have been scant. Therefore, it remains unknown which factors are responsible for embryonic and early postnatal nutrition and which factors are major determinants of body weight and number of new born piglets. Intrauterine undernutrition, for example, was studied using a rat model providing dams 50% restricted nutrients during pregnancy and the results showed significant decreases in birth weight of newborns. This response may be a characteristic of a subset of modulations in embryonic development which is caused by the metabolic imprinting. Underlying mechanisms of intrauterine undernutrition and growth retardation can be explained in part by epigenetics. Epigenetics modulate animal phenotypes without changes in DNA sequences. Epigenetic modifications include DNA methylation, chromatin modification and small non-coding RNA-associated gene silencing. Precise mechanisms must be identified at the morphologic, cellular, and molecular levels by using interdisciplinary nutrigenomics approaches to increase pig production. Experimental approaches for explaining these potential mechanisms will be discussed in this review.

• Clinical and Experimental Pediatrics
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• v.57 no.8
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• pp.351-356
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• 2014

Purpose: Among the many factors associated with acute intestinal mucosal infection, numerous studies have proposed the usefulness of fecal calprotectin. The aim of this study was to evaluate the usefulness of fecal calprotectin in the diagnosis of necrotizing enterocolitis (NEC). Methods: We collected 154 stool samples from 16 very low birth weight and premature newborns at the Konyang University Hospital neonatal intensive care unit or neonatal nursery. The stool samples were collected using the Calprest device, and the fecal calprotectin level was measured with the $B\ddot{U}HLMANN$ Calprotectin enzyme-linked immunosorbent assay kit. Results: Fecal calprotectin levels were significantly higher in the NEC group than in the non-NEC group (P=0.02). There was a significant positive linear relationship between the fecal calprotectin level and number of days after birth (P=0.00) in the gestational age <26 weeks group. There was a significant negative linear relationship between the calprotectin level and number of days after birth (P=0.03) in the gestational age ${\geq}26$ weeks and <30 weeks group. There was no difference in the calprotectin levels according to the type and method of feeding between the NEC and non-NEC groups. Conclusion: Fecal calprotectin levels were significantly increased in premature infants with NEC. The fecal calprotectin test is a noninvasive, easy, and useful tool for the diagnosis of NEC.

• Korean Parent-Child Health Journal
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• v.12 no.1
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• pp.15-24
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• 2009

Purpose: This study was conducted to investigate the performance level of breastfeeding health behaviors and general characteristics of breastfeeding mothers related to breastfeeding health behaviors. Method: 123 breastfeeding mothers whose infants are between 5-7 months of age participated in this study. Data was collected during a Breastfeeding Infant Contest held in September 2007 in Changwon-si, Gyeongsangnam-do. Health behaviors related to breastfeeding were measured in Likert scale 5 including 20 questions developed by Park et al., and the collected data was analyzed with descriptive statistics, T-test and ANOVA using SPSS program. Result: The performance level on breastfeeding health behaviors scored $3.73{\pm}.35$ on average (5.0 in full score). The score showed that there were significant statistical differences only in the knowledge of breastfeeding between groups. The score of 'enough' knowledge group was higher than that of 'a little short' knowledge group (t=2.071, p=0.045). Conclusion: The performance level on breastfeeding health behaviors was related to the knowledge of breastfeeding in breastfeeding mothers. Therefore, it is necessary to enhance education on breastfeeding health behaviors for mothers of newborns in the hospital and to have a reevaluation process on their performance at the time of revisiting.