• IMMUNE NETWORK
• /
• v.9 no.2
• /
• pp.46-52
• /
• 2009

Although tuberculosis poses a significant health threat to the global population, it is a challenge to develop new and effective therapeutic strategies. Nitric oxide (NO) and inducible NO synthase (iNOS) are important in innate immune responses to various intracellular bacterial infections, including mycobacterial infections. It is generally recognized that reactive nitrogen intermediates play an effective role in host defense mechanisms against tuberculosis. In a murine model of tuberculosis, NO plays a crucial role in antimycobacterial activity; however, it is controversial whether NO is critically involved in host defense against Mycobacterium tuberculosis in humans. Here, we review the roles of NO in host defense against murine and human tuberculosis. We also discuss the specific roles of NO in the central nervous system and lung epithelial cells during mycobacterial infection. A greater understanding of these defense mechanisms in human tuberculosis will aid in the development of new strategies for the treatment of disease.

• Bulletin of the Korean Chemical Society
• /
• v.32 no.3
• /
• pp.841-846
• /
• 2011

New green host materials, 9-phenyl-3-(4-(1-phenyl-1H-benzo[d] imidazol-2-yl)phenyl)-9H-carbazole (3a) and 9-(naphthyl-2-yl)-3-(4-(1-phenyl-1H-benzo[d]imidazol-2-yl)phenyl)-9H-carbazole (3b), have been designed and synthesized by attaching the electron transporting benzimidazole moiety to the hole transporting carbazole unit. These compounds have similar HOMO, LUMO levels and band-gap characteristics compared with CBP (4,4'-di(N-carbazolyl)biphenyl). The fabricated green phosphorescent OLED with this 3a host shows much better device performances compared to CBP-based one. The current and power efficiency is enhanced at least by 60 percent at a given constant luminance of 1000 cd/$m^2$.

• Journal of Plant Biotechnology
• /
• v.36 no.3
• /
• pp.244-254
• /
• 2009

The hypersensitive reaction (HR) is the most common plant defense reaction against pathogens. HR is produced during both host- and nonhost-incompatible interactions. Several reports suggest that similarities exist between host and nonhost resistances. We assayed the pattern of generation of reactive oxygen species (ROS) and scavenging enzyme activities during nonhost pathogen-plant interactions (Xanthomonas campestris pv. campestris/Capsicum annuum L.) and incompatible host pathogen-plant interactions (Xanthomonas campestris pv. vesicatoria race1/Capsicum annuum L.). Both ${O_2}^-\;and\;H_2O_2 $ accumulated much faster during nonhost resistance when compared to the host resistance. The scavenging enzyme activities of superoxide dismutase (SOD), catalase (CAT) and peroxidase (POX) were also different during the host- and nonhost-incompatible interactions. CAT activity was much higher during nonhost resistance, and several new isozymes of SOD and POX were detected during nonhost resistance when compared to the host resistance. Lipoxygenase (LOX) activity was higher in host resistance than nonhost resistance during the early stages of infection. Interestingly, the nitric oxide (NO) radical accumulated equal amounts during both host and nonhost resistance at early stages of infection. Further studies are needed to determine the specific pathways underlying these differences between host and nonhost resistance responses.

• Journal of Microbiology and Biotechnology
• /
• v.21 no.5
• /
• pp.449-454
• /
• 2011

The infection of pandemic influenza viruses such as swine flu (H1N1) and avian flu viruses to the host cells is related to the following two factors: First, the surface protein such as HA (hemagglutinin) and NA (neuraminidase) of the influenza virus. Second, the specific structure of the oligosaccharide [sialic acid(${\alpha}2$-6) galactose(${\beta}1$-4)glucose or sialic acid(${\alpha}2$-3)galactose(${\beta}1$-4)glucose] on the host cell. After recognizing the specific structure of the oligosaccharide on the surface of host cells by the surface protein of the influenza virus, the influenza virus can secrete sialidase and cleave the sialic acid attached on the final position of the specific structure of the oligosaccharide on the surface of host cells. Tamiflu (oseltamivir), known as a remedy of swine flu, has a saccharide analog structure, especially the sialic acid analog. Tamiflu can inhibit the invasion of influenza viruses (swine flu and avian flu viruses) into the host cells by competition with sialic acid on the terminal position of the specific oligosaccharide on the surface of the host cell. Because of the emergence of Tamiflu resistance, the development of new potent anti-influenza inhibitors is needed. The inhibitors with positive-charge groups have potential as antiviral therapeutics, and the strain specificity must also be resolved.

• The Journal of Engineering Research
• /
• v.6 no.2
• /
• pp.125-130
• /
• 2004

In the current Internet, IP addresses does not support Mobility and Multi-homming because it depend on their topological location. To resolve these problems, IETF hip WG introduces Host Identity Protocol that separates the endpoint identifier and locator roles of IP addresses. However the DNS that was presented for the HIP had only a part of the expansion design from the existing DNS function, so it was not an absolute complete method. This paper propose how the dymanic DNS has been designed so that it support the HIP completely. We added the Host Identity Namespace and the Rendezvous Server Namespace, defined the new PRs in DNS.

• The Plant Pathology Journal
• /
• v.21 no.4
• /
• pp.310-316
• /
• 2005

The objectives of this study were to identify the aecial host ranges of four Korean Gymnosporangium species, G. asiaticum, G. cornutum, Gjaponicum and Gyamadae, and to verify the morphological characteristics of telia as diagnostic keys to the species. Thirteen Korean Rosaceous woody species were artificially inoculated with teliospores obtained from Juniperus species. There was high specificity between telial and aecial hosts and the fungal species, providing the first experimental proof on host alternation of these rust fungi in Korea. Telia on the witches' broom and on the small galls were identified as new telial characteristics in G asiaticum and in G. yamadae, respectively. Aecial hosts of G. asiaticum and G. yamadae showed varying responses in their susceptibility and in the days required for formation and duration of spermogonia and aecia after inoculation. Four telial host species in Juniperus were confirmed for the first time in Korea, which include J. chinensis var. kaizuka, J. chinensis var. horizontalis and J. chinensis var. globosa for G. asiaticum; and J. chinensis var. kaizuka for G. yamadae.

• Journal of Information Processing Systems
• /
• v.17 no.4
• /
• pp.851-865
• /
• 2021

Enterprise networks in the PyeongChang Winter Olympics were hacked in February 2018. According to a domestic security company's analysis report, attackers destroyed approximately 300 hosts with the aim of interfering with the Olympics. Enterprise have no choice but to rely on digital vaccines since it is overwhelming to analyze all programs executed in the host used by ordinary users. However, traditional vaccines cannot protect the host against variant or new malware because they cannot detect intrusions without signatures for malwares. To overcome this limitation of signature-based detection, there has been much research conducted on the behavior analysis of malwares. However, since most of them rely on a sandbox where only analysis target program is running, we cannot detect malwares intruding the host where many normal programs are running. Therefore, this study proposes a method to detect malware variants in the host through logs rather than the sandbox. The proposed method extracts common behaviors from variants group and finds characteristic behaviors optimized for querying. Through experimentation on 1,584,363 logs, generated by executing 6,430 malware samples, we prove that there exist the common behaviors that variants share and we demonstrate that these behaviors can be used to detect variants.

• Journal of Microbiology and Biotechnology
• /
• v.29 no.8
• /
• pp.1184-1192
• /
• 2019

The influenza A virus is a highly infectious respiratory pathogen that sickens many people with respiratory disease annually. To prevent outbreaks of this viral infection, an understanding of the characteristics of virus-host interaction and development of an anti-viral agent is urgently needed. The influenza A virus can infect mammalian species including humans, pigs, horses and seals. Furthermore, this virus can switch hosts and form a novel lineage. This so-called zoonotic infection provides an opportunity for virus adaptation to the new host and leads to pandemics. Most influenza A viruses express proteins that antagonize the antiviral defense of the host cell. The non-structural protein 1 (NS1) of the influenza A virus is the most important viral regulatory factor controlling cellular processes to modulate host cell gene expression and double-stranded RNA (dsRNA)-mediated antiviral response. This review focuses on the influenza A virus NS1 protein and outlines current issues including the life cycle of the influenza A virus, structural characterization of the influenza A virus NS1, interaction between NS1 and host immune response factor, and design of inhibitors resistant to the influenza A virus.

• International journal of advanced smart convergence
• /
• v.10 no.1
• /
• pp.142-150
• /
• 2021

Open-channel SSD is a new type of Solid-State Disk (SSD) that improves the garbage collection overhead and write amplification due to physical constraints of NAND flash memory by exposing the internal structure of the SSD to the host. However, the host-level Flash Translation Layer (FTL) provided for open-channel SSDs in the current Linux kernel consumes host memory excessively because it use page-level mapping table to translate logical address to physical address. Therefore, in this paper, we implemente a selective mapping table loading scheme that loads only a currently required part of the mapping table to the mapping table cache from SSD instead of entire mapping table. In addition, to increase the hit ratio of the mapping table cache, filesystem information and mapping table access history are utilized for cache replacement policy. The proposed scheme is implemented in the host-level FTL of the Linux kernel and evaluated using open-channel SSD emulator. According to the evaluation results, we can achieve 80% of I/O performance using the only 32% of memory usage compared to the previous host-level FTL.

• Biomolecules & Therapeutics
• /
• v.29 no.3
• /
• pp.263-267
• /
• 2021

Periodontal disease is primarily associated with bacterial infection such as dental plaque. Dental plaque, an oral biofilm harboring a complex microbial community, can cause various inflammatory reactions in periodontal tissue. In many cases, the local bacterial invasion and host-mediated immune responses lead to severe alveolar bone destruction. To date, plaque control, non-surgical, and surgical interventions have been the conventional periodontal treatment modalities. Although adjuvant therapies including antibiotics or supplements have accompanied these procedures, their usage has been limited by antibiotic resistance, as well as their partial effectiveness. Therefore, new strategies are needed to control local inflammation in the periodontium and host immune responses. In recent years, target molecules that modulate microbial signaling mechanisms, host inflammatory substances, and bone immune responses have received considerable attention by researchers. In this review, we introduce three approaches that suggest a way forward for the development of new treatments for periodontal disease; (1) quorum quenching using quorum sensing inhibitors, (2) inflammasome targeting, and (3) use of FDA-approved anabolic agents, including Teriparatide and sclerostin antibody.