• Archives of Pharmacal Research
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• v.26 no.7
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• pp.526-531
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• 2003

KR-31378 is a new drug candidate intended for the use in the prevention of ischemia-reperfusion damage. The objective of this preformulation study was to determine the physicochemical properties of KR-31378. The n-octanol to water partition coefficients of KR-31378 were 0.0504 at pH 3 and 0.8874 at pH 10. Accelerated stability of KR-31378 in solution and solid state was studied at 5, 40, $60^{\circ}C$. The stability testing indicated that the t90 for the drug in solid was estimated to be 2 years and 128.6 days at $25^{\circ}C$, while the that in aquesou solution was 68.6 days at $25^{\circ}C$. The KR-31378 was also found to be unstable under the relative humidity of 76%, probably because of the hygroscopic nature of the drug. In order to study compatibility of KR-31378 with typical excipients, potential change in differential scanning calorimetry spectrum was studied in 1:1 binary mixtures of KR-31378 and Aerosil, Avicel, Eudragit, lactose, PEG, talc, CMC, PVP, starch. As a result, CMC, PVP, and starch were found to be incompatible with KR-31378, indicating the addition of these excipients may complicate the manufacturing of the formulation for the drug. Particle size distribution of KR-31378 powder was in the size range of 9-93 $\mu$ m with the mean particle size of 37.9 $\mu$ m. The flowability of KR-31378 was apparently inadequate, indicating the granulation may be necessary for the processing of the drug to solid dosage forms. Crystallization of the drug with a number of organic solvents did not lead a crystalline polymorphism. In addition, dissolution of the drug from the powder was adequately rapid at $37^{\circ}C$ in water.

• International Journal of Contents
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• v.8 no.2
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• pp.67-74
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• 2012

Technological substitution is the process by which a radical technology replaces the dominant technology in an industry. The processes of diffusion and substitution have been modeled extensively (Technology & innovation, 2010). However, the formulation of classical quantitative models encompasses only part of the theoretical space. These models impose many simplified constraints to the achievement of analytical resolution. The interior design organization needs to establish a set of technical system requirements by describing the scope of the accessibility needs of the organization against current technology use. Because of complicated design resources and ongoing advances in design technologies, design systems face the challenge of prioritizing new technologies for supporting. The problem is small design organization administration often displays a lack of concern toward the evaluation of technology integration. In this paper, I will identify the influence of a design organization's technology, and predict how future technology will inform, support, and potentially hinder productivity, culture, and work satisfaction within a design organization in the industry. In addition, I will use current design organizational behavior and leadership models to support my predictions. Finally, I will examine a proven approach to assist designers with evaluating technology integration in interior design organization. The goal is to develop a high quality, professional development scorecards for the evaluation. I will conduct both the evaluation of technology integration and CRM performance evaluation is recommended to assess the effectiveness of technology integration. Therefore, the evaluation of integration technologies oriented design hold the promise of solving the organization application integration challenge. The evaluation of integration technology is a significant pattern for processing such a vision. The careful selection of an integration technology for this purpose is crucial in contributing toward the success of such an interior design organization endeavor.

• Journal of Digital Convergence
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• v.12 no.8
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• pp.271-282
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• 2014

The recent flow of broadcasting technology, HDTV and 3DTV are being followed to develop UHDTV. UHDTV has established itself as the new paradigm. In Korea, the 4K-UHDTV experimental terrestrial broadcasting and cable and satellite TV services are being carried out in the present. 4K-UHD content creation workflow to enable a systematic formulation is needed. In this study, Through expert opinion 4K-UHD production workflow to derive the important topics and Hierarchical analysis methods (AHP, Analytic Hierarchy Process) is applied to 4K-UHD content creation is important to consider the items were compared to each other. The upper layer has a content creation workflow planning side, the media file management side and operational aspects of the selection and production equipment were classified. In the lower layer, UHD STAFF roles between production and training, media management, selection and operation of the storage device was evaluated in a relatively important. In addition, real-time 4K-UHD suggested workflow for production.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.10
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• pp.1395-1403
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• 2012

The objective of the study was to quantify annual and seasonal differences in the chemical composition, in vitro gas production, in situ degradability and ruminal fermentation of grazing steers… diets. Diet samples were collected with four esophageal cannulated steers ($350{\pm}3$ kg BW); and four ruminally cannulated heifers ($342{\pm}1.5$ kg BW) were used to study the dry matter degradation and fermentation in rumen. Data were analyzed with repeated measurements split plot design. The crude protein, in vitro dry matter digestibility and metabolizable energy were higher during the first year of trial and in the summer (p<0.01). The values of calcium, phosphorus, magnesium, zinc and copper were higher in summer (p<0.05). The gas produced by the soluble and insoluble fractions, as well as the constant rate of gas production were greater in summer and fall (p<0.01). The ammonia nitrogen ($NH_3N$) and total volatile fatty acids concentrations in rumen, the soluble and degradable fractions, the constant rate of degradation and the effective degradability of DM and NDF were affected by year (p<0.05) and season (p<0.01). Our study provides new and useful knowledge for the formulation of protein, energetic and mineral supplements that grazing cattle need to improve their productive and reproductive performance.

• Korean Journal of Agricultural Science
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• v.43 no.5
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• pp.750-760
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• 2016

The use of antibiotics in Korean swine production has been changing to a restricted use of in-feed antibiotics. These antibiotics, which are also growth promoters, are powerful for disease control. Due to this issue, the swine industry is consistently looking for any kind of alternatives to antibiotics such as new feed ingredients, feed additives, feed formulation practices, or feeding methods to improve pig health and performance. In general, dietary factors provide bioavailable nutrients and/or affect physiological activity to modify the physiological condition, immune system, or microbial population of pigs to improve their performance and health. Thus, it is suggested that dietary factors may be important components in the growth and health management of pigs. Using an alternative grain feed such as rice, barley, and oats, low protein diets or low-high energy diets can be used as solutions to manage the effect of stress factors that cause growth and health problems at specific time points during the stages of pig production. Several studies support that these alternative feeds and dietary factors may improve pig growth and health by changes in intestinal conditions, immunity, or other physiological conditions compared with typical feed ingredients and diet management in pig production. Therefore, feed ingredients, low protein levels, and different energy contents in swine diets were reviewed to better understand how these dietary factors can contribute to improved pig performance and health under different physiological conditions.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.16 no.2
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• pp.165-172
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• 2003

In this study, a new and efficient harmonic axisymmetric shell element for static and dynamic analysis Is proposed. The present element considering shear strain is based on a modified mixed variational principle in which the independent unknowns are only the Quantities prescribable at the shell edges. Unlike existing hybrid-mixed axisymmetric shell elements, the present element introduces additional nodeless degrees for displacement field Interpolation In order to enhance the numerical performance. The stress parameters are eliminated by the stationary condition and the nodeless degrees are condensed out by the Guyan reduction. Through several numerical examples, the hybrid-miked shell element with the additional nodeless degrees and the consistent stress parameters is shown to be efficient and yield very accurate results for static and vibration analysis.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.2
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• pp.123-130
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• 2015

This paper presents a new formulation for transient simulations of microwave propagation in heterogeneous unbounded domains. In particular, perfectly-matched-layers(PMLs) are introduced to allow for wave absorption at artificial boundaries used to truncate the infinite extent of the physical domains. The development of the electromagnetic PML targets the application to engineering mechanics problems such as structural health monitoring and inverse medium problems. To formulate the PML for plane electromagnetic waves, a complex coordinate transformation is introduced to Maxwell's equations in the frequency-domain. Then the PML-endowed partial differential equations(PDEs) for transient electromagnetic waves are recovered by the application of the inverse Fourier transform to the frequency-domain equations. A mixed finite element method is employed to solve the time-domain PDEs for electric and magnetic fields in the PML-truncated domain. Numerical results are presented for plane microwaves propagating through concrete structures, and the accuracy of solutions is investigated by a series of error analyses.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.41 no.2
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• pp.9-15
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• 2004

We present a new unified analytical front surface potential model, which can accurately describe the transitions between the partially-depleted (PD) and the fully-depleted (FD) regimes with an analytical expression for the critical voltage V$_{c}$ delineating the PD and the FD region. It is valid in all regions of operation (from the sub -threshold to the strong inversion) and has the shorter calculation time than the iterative procedure approach. A charge sheet model based on the above explicit surface potential formulation is used to derive a single formula for the drain current valid in all regions of operation. Most of the secondary effects can be easily included in the charge sheet model and the model accurately reproduces various numerical and experimental results. No discontinuity in the derivative of the surface potential is found even though three types of smoothing functions are used. More importantly, the newly introduced parameters used in the smoothing functions do not strongly depend on the process parameter.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4751-4756
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• 2012

Colon cancer continues to be one of the most common cancers, and the importance and necessity of new therapies needs to be stressed. The most important proto-oncogen factors for colon cancer appear to be epidermal growth factor receptor, EGFR, and c-Src with high expression and activity leading to tumor growth and ultimately to colon cancer progression. Application of c-Src and EGFR antisense agents simultaneously should theoretically therefore have major benefit. In the present study, anti-EGFR and c-Src specific antisense oligodeoxynucleotides were combined in a formulation using PAMAM dendrimers as a carrier. Nano drug entry into cells was confirmed by flow cytometry and fluorescence microscopy imaging and real time PCR showed gene expression of c-Src and EGFR, as well as downstream STAT5 and MAPK-1 with the tumor suppressor gene P53 to all be downregulated. EGFR and c-Src protein expression was also reduced when assessed by western blotting techniques. The effect of the antisense oligonucleotide on HT29 cell proliferation was determined by MTT assay, reduction beijng observed after 48 hours. In summary, nano-drug, anti-EGFR and c-Src specific antisense oligodeoxynucleotides were effectively transferred into HT-29 cells and inhibited gene expression in target cells. Based on the results of this study it appears that the use of antisense EGFR and c-Src simultaneously might have a significant effect on colon cancer growth by down regulation of EGFR and its downstream genes.

• Journal of the Korean Geosynthetics Society
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• v.18 no.4
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• pp.243-252
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• 2019

Recently, as the utilization of underground space increases, the demand for underground excavation increases. In this study, the concrete mixture with a new material was used to develop and evaluate the stability of the CS-H wall that can greatly minimize the problems of existing wall and minimize the impact of ground depression and surrounding ground that may occur in the future for excavation of over 30 m deep in urban areas. The fiber reinforcement formulation of steel fibers, synthetic fibers, and glass fibers, along with fine aggregate parts of PS-ball and ferronickel, were mixed. The Mixture ratios were determined by conducting slump test compresive strength test, modulus of elastic test, flexural strength test, splitting tensile strength test and conductivity test. As a result of the test, the steel fiber mixture showed very good results compared to other reference values in all items, and it is considered to be the most suitable for the CS-H wall to be developed.