• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.46 no.5
• /
• pp.341-347
• /
• 2020

Objectives: Oral squamous cell carcinoma (OSCC) is one of the most common types of head and neck cancer. MicroRNAs, as new biomarkers, are recommended for diagnosis and treatment of different types of cancers. Bevacizumab, sold under the trade name Avastin, is a humanized whole monoclonal antibody that targets and blocks VEGF-A (vascular endothelial growth factor A; angiogenesis) and oncogenic signaling pathways. Materials and Methods: This study comprised 50 cases suffering from OSCC and 50 healthy participants. Peripheral blood samples were collected in glass test tubes, and RNA extraction was started immediately. Expression levels of miR-155, miR-191, and miR-494 biomarkers in the peripheral blood of OSCC-affected individuals and healthy volunteers in vivo were evaluated using real-time PCR. The influence of Avastin on the expression levels of the aforementioned biomarkers in vitro and in the HN5 cell line was also investigated. Results: Expression levels of miR-155, miR-191, and miR-494 in the peripheral blood of individuals affected by OSCC were higher than in those who were healthy. Moreover, Avastin at a concentration of 400 μM caused a decrease in the expression levels of the three biomarkers and a 1.5-fold, 3.5-fold, and 4-fold increase in apoptosis in the test samples compared to the controls in the HN5 cell line after 24, 48, and 72 hours, respectively. Conclusion: The findings of this study demonstrate that overexpression of miR-155, miR-191, and miR-494 is associated with OSCC, and Avastin is able to regulate and downregulate the expression of those biomarkers and increase apoptosis in cancerous cells in the HN5 cell line.

• Management & Information Systems Review
• /
• v.37 no.3
• /
• pp.65-81
• /
• 2018

This study estimated the long-run and the short-run price and income elasticity of crude oil demand by using the ARDL model in Korea. First, the long-run cointegration relationship existed between crude oil demand and price or income in the ARDL-bounds tests. Second, the long-run own price, the cross price elasticity and the income elasticity were both statistically significant elastic and sensitive in the ARDL. Third, there was autocorrelation of the residuals, but no misspecification errors and heteroscedasticity, and then the residuals showed a normal distribution. And the CUSUM & CUSUMSQ tests showed that the coefficients were stable. Fourth, the short-run own price, the cross price elasticity and the income elasticity were both statistically significant elastic and sensitive in the ARDL-RECM. The ECM with the short-run dynamics showed rapid adjustments in the long-run equilibrium of oil demand after the economic crisis. In the short-run, the sensitivity of crude oil demand to price and income changes has moved in the same direction as the long-run case. Korea, depending too much on foreign crude oil, is vulnerable to the shocks of oil prices, so rising oil prices can certainly have a negative impact on Korea's trade balance. And the elasticity of long-run oil prices may help to control and manage Korea's oil demand. The government needs to strengthen monitoring of the country's policies and market trends related to crude oil, establish strategies to customize national policies and market conditions, and strengthen active market dominance efforts through pioneering new market and diversification.

• Journal of Korea Port Economic Association
• /
• v.28 no.1
• /
• pp.159-178
• /
• 2012

Recently, Global network expansion strategy of GTOs(Global Terminal Operator) coupled with each country's port policy, plays huge role for the evolution of modern container port. The Chinese ports can be regarded as the major markets to the GTOs. However, there are scant of researches for finding the key success factors of GTOs' strategies when they consider to invest in overseas. In this respect, the aims of this study were to draw out the evaluation variables for successful investment strategies of GTOs, and to calculate the selected target ports. The 14 variables are selected including the variable named 'development potentiality of a port' through literature reviews. Using the Factor Analysis (FA) based on selected variables, four principal factors were extracted such as 'ability for port operating and cargo generating', 'the trade route and volume', 'the calling potentiality for large vessels' and 'the possibility of utilization of existing infrastructure'. In addition, the weights of factors and variables are evaluated through Fuzzy AHP method. As a result, 'ability for port operating and cargo generating' is chosen as the most important factor among principal factors as scored 0.343, and 'the development potentiality of a port' (0.107) is represented as the most important variable among 14 detailed variables. In overall, from the Global Terminal Operator's point of view, Shanghai is ranked as most suitable port for operating new terminal among the top 5 Chinese ports.

• Journal of Service Research and Studies
• /
• v.8 no.1
• /
• pp.13-26
• /
• 2018

Most product consists of various national components, and brand strategy using nationality images is prevalent in marketing field. Country of origin is meaningful consideration for decision making. The purpose is that how consumer evaluate the global brand depending on two-sided dimension of country of origin. This research aims to examine the interaction effect of two-sided country of origin and moderating effect of global identity. In study 1, two-way interaction effect of origin of brand and origin of production was significant with social prestige. In study 2, there-way ANOVA provided marginally significant main effect of origin of brand and global identity. Two-way interaction effect of origin of brand and production was significant with social prestige. Also two-way interaction effect origin of brand and global identity was significant with innovation and social responsibility. Three-way interaction of origin of brand, origin of production, and global identity was significant with social responsibility, this approved moderating effect of global identity. Results contribute to understanding global brands strategy using country of origin effect, and to adding new knowledge to the country of origin literature. Academic and practical implications, limitations, and future research directions were discussed.

• Journal of Digital Convergence
• /
• v.15 no.1
• /
• pp.143-149
• /
• 2017

The company strives constantly to prepare for the current crisis and uncertainty of the future and to strengthen its competitiveness. At times, it strives to strengthen its competitiveness through continuous innovation, as well as securing technological innovation and talented personnel. However, even if the company makes such a hard effort, the sustainable growth of the enterprise will not be guaranteed unless smooth communication and efforts among the internal resources are supported. The social responsibility of management and the attitude of labor-management relations are important factors for the smooth coordination of labor-management relations. Therefore, this study empirically analyzed the relationship between manager 's social responsibility, labor relations attitude and job performance. The results of this study showed that the social responsibility of managers affects job satisfaction and job commitment. In addition, managers' attitudes toward labor relations have an effect on job satisfaction and job commitment. Also, job satisfaction has a positive effect on job commitment. The result of this study can be used as a practical application data for establishing new labor - management relations among the managers of the enterprise in the future.

• Korean Journal of Agricultural Science
• /
• v.20 no.1
• /
• pp.88-101
• /
• 1993

This study is aimed at evaluating the present management status of the rural special production area development projects and identifying managerial problems to propose new direction of the political countermeasures for the projects. In the con text of implementing the five year's economic developent plans for the past three decades, agricultural production and farm-household income have also been grown rapidly. However the income gap between rural and urbarn laborer, as an internal problem, has widened during the decades and the UR problems concerning free trade of agricultural products, as an external problems, are now agonizing the small-holder farm economy in Korea. The internal and external farm problems could be solved through improvement of agricultural structure and provision of off-farm jobs for farm household income increase. As a part of the off-farm income sources, the rural special production area development projects have propelled by the government throughout the country. The main problems to be solved for the successful implementation of the projects are as follows : 1. Present loan amount by the financial fund was estimated at 6-7% of the total installation costs required. To expand and implement the project successfully, enough financial credit support with favorable terms and conditions have to be considered by the government. 2. The operation patterns of the special production area development project should be recommended from the view point of cooperative and private operation to maximize farm household incomes including profits, marketing charges and dividens. 3. Improvement of the marketing channel of the products and marketing information through TV program and other mass communication should be implemented strongly to promote marketsales by the financial supports of the government. 4. In connection with the off-farm income increase, the population migrating to urban area in outside Chungnam province equivalent to 10-12 thousand persons with age of 20-49 years should be taken into account politically to be employed in the projects in the province. 5. Surplus farm labors should be created by means of improvement of agricultural structure including large farm management with farm mechanization and job opportunities have also to be provided in connection with the rural special production area development projects. The two imminent subjects are the prerequisites to increase off-farm incomes for the farmers living in Chungnam province. 6. Required credit supports for investment and operation costs of the projects should be taken actions by the government.

• Proceedings of the KSR Conference
• /
• 2009.05a
• /
• pp.1498-1508
• /
• 2009

Recently, the expansion of roads are necessary because the population and vehicles have rapidly increased, but those are restricted because of the limited site. JES(Jointed Element Structure) method is the method of the new cross-structure, which is element-traction method which draws and excavates elements under the existing structure with high accuracy within a short time. Also JES(Jointed Element Structure) method has a facility of the economical execution, a small effect on the train-service during construction period and no limit of the crossing length under the trade In this study, the tractive force and settlement are compared with the upper element, side wall element and the lower element respectively in the section which the JES method is applied In the case of element located at left side wall, the tractive force measured by a guage is double or more than the tractive force calculated by a formula. It is expected that many boulder contented in the ground contrary to the site investigation data cause high tractive force. For comparison of the settlement, the settlement as excavating the upper element is the largest in all steps. It is expected that this is the same as the cause of high tractive force. Also in this study, the practical use of the JES method when some under pass structures are extended in the future is studied.

• Journal of Arbitration Studies
• /
• v.18 no.1
• /
• pp.121-145
• /
• 2008

Northeast Asia is increasingly making a transition to distinctive and crucial region in the 21st Century and growing into one of world's top three economic spheres along with the EU and NAFTA. In 2003, Korean government announced the Northeast Asian economic hub country plan as an important agenda. As a means of coping with the changing global environment, Korean government designated Incheon in 2003 as the country's first Free Economic Zone ahead of Busan and Gwangyang Bay in the south of the country because Incheon has a geographical advantage linking North America and Europe with Incheon International Airport and Incheon Seaport. The purpose of this paper is to make research on establishment and operation of an arbitral body entitled ${\ulcorner}International Arbitration Center{\lrcorner}$ (IAC) within Incheon Free Economic Zone(IFEZ). For the purpose of this, the writer in this paper, reviewed the necessity of the IAC's establishment and its legal basis as well as the role and function of the Center. Also, the writer presented plans for how to operate the IAC and how to cooperate with the key arbitral organizations of foreign countries for the settlement promotion of commercial disputes including trade and investment. With development of the IFEZ, world-renowned enterprises will invest in the Incheon economic bloc and conduct economic activities, business operation, marketing, logistics, financing, etc. In this connection, diverse types of commercial disputes are expected to occur between foreign companies entering the IFEZ and Korean firms. In this connection, the Korean Commercial Arbitration Board(KCAB) has been operating its liaison office in the IFEZ since 2004. However, in view of the increasing arbitration demand, the IAC should be set up in the IFEZ in the near future by the positive support of the government in the respect of both administration and finance because the free economic zone-related law provides for the installation of arbitration organization. For the success of the IAC, the Center will have to provide not only good quality of arbitral services that can satisfy arbitration parties but also need to conduct researches and make efforts so that arbitration can be utilized well in the IFEZ. If the IFEZ can provide advantageous business environments to those multinational enterprises intending to the Incheon economic bloc, the IAC will also contribute to the settlement of commercial disputes arising from the Gaeseong Industrial Complex in North Korea in view of the geographical advantage and logistic benefit of the IFEZ. Finally, this paper also suggests a new model for a joint dispute resolution system by the initiative of Korean government and Korean arbitral organizations for the settlement of commercial disputes within Northeast Asia, for which the CAMCA(Commercial Arbitration and Mediation Center for the Americas) of NAFTA can be a good example.

• Korean Business Review
• /
• v.14
• /
• pp.77-93
• /
• 2001

The ISO issued the first standard for environmental management standard(EMS) in 1993. This standard provide for elements of an effective environmental management system and can also help companies ingrain effective environmental management practice into their overall business operations. ISO 14001 is predicted to become the leading voluntary environmental management system standard. Companies selling products and services internationally and domestically will also be affected by publication of this standard. Especially, this new environmental management standards are fast becoming a condition for doing global business because it can be acted with trade barriers. Actually, an automobile companies of America including Ford and GM require their subcontracting companies to gain the recognition of ISO 14001. The purpose of this paper is to investigate the ISO 14000 and its application of Korean firms focusing on environmental management system(EMS). This paper proceeds to present the effective alternatives through analysing the existing Korean firms which has established EMS. Korean firms should adopt EMS not for the enhancement of corporate image but for the purpose of strategic competitive advantage.

• Journal of the Institute of Electronics Engineers of Korea CI
• /
• v.41 no.3
• /
• pp.1-10
• /
• 2004

Quite many papers about moving objects database (MOD) have been Published. Most of them are concerning of improving efficiency of updating policy, but none of them talks about verification of system's requirements. No matter how efficient updating policy is employed, a system designer still has to verify if the MOD satisfies user's requirement at the beginning of system lifestyle. For example, if a MOD serves n moving objects, then the designer must verity if it can update information for n moving objects and provide new information to moving objects within specified time limit. For the purpose of requirement analysis of MODs, we build a Petri net model for MOD using Design/CPN, and then we show how to verify whether the MOD satisfies user's requirements by simulation. The contribution of this paper is providing a simulation model for requirement analysis of MOD for the first time. The model is expansion of our previous fuzzy-timing Petri net model. The distance-based updating policy, and distributed database management system are reflected in this model and system analysis for moving objects is considered. It is built in Design/CPN so that the simulation can be automatically performed. The application of our model is not limited to requirement analysis, it is useful to study other MOD design issues, such as the trade-offs between update cost and information accuracy, and between the tim interval needed for updating database and MOD system resources, etc.