• Advances in Traditional Medicine
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• v.7 no.4
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• pp.441-443
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• 2007

A preliminary in vitro acid neutralizing capacity test of twelve traditional Ayurvedic antacids were performed in this study. Five traditional preparations of ash of conch shell, ash of oyster, ash of pearl, limestone, and ash of cowrie showed high acid neutralizing capacity similar to standard antacid combination of $Al(OH)_3\;and\;Mg(OH)_2$. Among these the ash of conch shell found the highest acid neutralizing capacity. The ash of tamarind and ash of Achyranthus aspera showed moderate acid neutralizing capacity. The acid neutralizing capacity of red ochre; ash of iron; mixture of niter, alum and ammonium chloride; saltpeter; and ash of mica found below the USP 23 limit.

• Journal of the korean academy of Pediatric Dentistry
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• v.40 no.3
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• pp.168-176
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• 2013

The aim of this study was to evaluate the acid neutralizing capacity and to observe surface changes of giomer in comparison with composite resin, when it comes in contact with an acidic solution. A packable giomer(Beautifil II) and a flowable giomer(Beautifil Flow F02) were used as experimental groups, while a packable composite resin($Filtek^{TM}$ Z-250) was used as control group. pH values were measured after mixing the specimens of the disc and powder types with a pH 2.0 hydrochloric acid solution, respectively. Also, in the case of powder type giomers used in the earlier experiment, their pH values were measured again after mixing them with a fresh acid solution. Moreover, surface structure changes of disc type specimens were observed by using a scanning electron microscopy(SEM). In the disc type test, the pH values of packable giomer were significantly increased after 24 hours(p < 0.05). In contrast, in the powder type test, the pH values of packable and flowable giomers were dramatically increased within 30 minutes. The pH value of packable giomer, in particular, was higer than that of flowable giomer(p < 0.05). In the repeated neutralizing test, the degree of pH variation was lower than that of the previous neutralizing test(p < 0.05). Erosive changes on the surface of packable giomer were observed to be more than those on composite resin and flowable giomer as well. In conclusion, giomer has a acid neutralizing capacity, when it comes in contact with an acidic solution. Especially, packable giomer with high filler content has a greater acid neutralizing capacity than flowable giomer.

• Journal of Pharmaceutical Investigation
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• v.23 no.4
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• pp.217-223
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• 1993

The combined products of antacid and anti-ulcer agent were prepared with antacid composed of aluminium hydroxide dried gel, magnesium hydroxide and simethicone with a ratio of 1:1:0.1 (M) and anti-ulcer agent, aceglutamide aluminium (AGA). The efficacy of antacid was evaluated in vitro with Fuchs, Johnson-Duncan and Rosset-Rice methods and in vivo using an aspiration method in rat. The addition of anti-ulcer agent did not affect the neutralizing capacity of M significantly. The combined products with the M/AGA ratios of 2.3:1 and 3.4:1 produced the maximum pH of $4.0{\sim}5.8$ and the duration time of $64{\sim}137$ min in vitro test. The in vivo neutralizing test in rats showed the rapid increase of gastric pH up to 3.5 within 30 min and the gastric pH of $4{\sim}6$ was kept for 5 hr.

• Korean Journal of Soil Science and Fertilizer
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• v.37 no.6
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• pp.378-382
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• 2004

Soil pH is an important indicator for soil reactions and crop growth. pH buffer capacity and lime requirements are necessary to comprehend and manage soils well. The characteristics related with soil pH were analyzed and 5 field trials were conducted to elucidate pH buffer capacity of soil and lime requirements and liming factor for Korean acid soils. Soil minerals were analyzed for the soil of 2 years after treating $CaCO_3$ using X-ray diffraction. The amount of neutralized $H^+$ was regarded as the exchangeable aluminium overcoming ${\Delta}pH$, because pH buffer capacity of soil depended on exchangeable aluminium. Lime requirement was somewhat similar to the KCl exchangeable aluminium and it was also affected by the exchangeable cation by added lime. X-ray diffraction analyses revealed that an aluminium dissociation from Korean acid soils was equilibrated with kaolin minerals and changed into anorthite ($CaAl_2Si_2O_8$) by neutralizing with $CaCO_3$. Neutralizing process was composed of changing process of $Al^{3+}$ into $H^+$ and $Al(OH)_4{^-}$ ionic species and of neutralizing $H^+$ by, the amount of which was lime requirement. The fact that anorthite dissociates an aluminium ion higher than kaolinite does enabled to consider a liming factor (LF) the content of exchangeable cation and ${\Delta}pH$, $LF=1.5+0.2{\times}{\sum} Cations{\times}{\Delta}pH$.

• Biomolecules & Therapeutics
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• v.20 no.2
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• pp.239-244
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• 2012

This study examined the inhibitory effects of 4-guanidinobutyric acid (4GBA), an alkaloid, against gastric lesions by assessing the inhibition of Helicobacter pylori (H. pylori) and gastric cancer cells. Acute and chronic gastritis were also observed using HCl/ethanol (EtOH) and indomethacin-induced gastric lesion models, respectively. 4GBA inhibited the growth of H. pylori in a dose dependent manner, and showed acid-neutralizing capacity. In the pylorus ligated rats, 4GBA decreased the volume of gastric secretion and gastric acid output slightly, and increased the pH. 4GBA at a dose of 100 mg/kg reduced the size of HCl/EtOH-induced gastric lesions (70.8%) and indomethacin-induced gastric lesions (38.8%). The antigastritic action of 4GBA might be associated with the acid-neutralizing capacity, anti-H. pylori action, and decreased volume of gastric secretion. These results suggest that 4GBA might be useful in the treatment and/or protection of gastritis.

• YAKHAK HOEJI
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• v.5 no.1
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• pp.37-40
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• 1960

Sixteen Antacid preparations in Korea were evaluated their acid-neutralizing capacity by Rossett and Rice Method in comparison with U.S.P. and K.P. method.

• Journal of Environmental Health Sciences
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• v.23 no.1
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• pp.50-54
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• 1997

The removal efficiency of nutrient was investicated by using Glycine max Meer seedling. After budding, Glycine max Merr was raised at darkness for 4 days. During cultivation, the removal efficiency of $NO_2-N+NO_3-N$ was up to 90% with initial concentration of 20-100 ppm. The removal efficiency of PO$_4$-P was up to 80% with initial concentration at 30 ppm, but it was down to 22% and 27% at 40 ppm and 50 ppm. When the removal efficiency of nutrient was compared with alternating 12 hours' light and darkness, the removal efficiency of NO$_2$-N + NO$_3$-N was up to 90% at below 60 ppm. It was not different from each other. But it was particularly low about 62% and 34% at 80 ppm and 100 ppm in alternating 12 hours' light. The removal efficiency of PO$_4$-P was low at alternating 12 hours' light between 10-50 ppm on the whole range. The neutralizing capacity of pH was shown in acidity and alkalinity except strong acidity(below pH 3). The initial pH was neutralized at 6.0-7.7 of pH after 4 days. Particularly, Glycine max Meer seedling that was difference from other water plants, was shown the neutralizing capacity in strong alkalinity.

• YAKHAK HOEJI
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• v.51 no.1
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• pp.68-74
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• 2007

Scutellaria Radix, the dried roots of Scutellaria baicalensis Georgi (Labiatae), has been used in oriental traditional medicine for treatment of fever urine disorder, diarrhea, inflammation. Present study was carried out for the gastroprotective effect of chrysin, baicalein, baicalin, wogonin from Scutellaria baicalensis. This reports evaluated antioxidant effect, antibacterial activity against Helicobacter pylori and HCI-ethanol-induced gastric lesion in rats and showed the significant effectiveness. It may be regarded that the antigastritic effects and antibacterial activity of baicalin, baicalein from Scutellaria baicalensis are originated from acid-neutralizing capacity, free radical scavenging effects and the antibacterial activity against Helicobacter pylori.

• Journal of Veterinary Science
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• v.21 no.1
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• pp.5.1-5.12
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• 2020

The major glycoproteins of bovine gammaherpesvirus 4 (BoHV-4) are gB, gH, gM, gL, and gp180 with gB, gH, and gp180 being the most glycosylated. These glycoproteins participate in cell binding while some act as neutralization targets. Glycosylation of these envelope proteins may be involved in virion protection against neutralization by antibodies. In infected cattle, BoHV-4 induces an immune response characterized by low neutralizing antibody levels or an absence of such antibodies. Therefore, virus seroneutralization in vitro cannot always be easily demonstrated. The aim of this study was to evaluate the neutralizing capacity of 2 Argentine BoHV-4 strains and to associate those findings with the gene expression profiles of the major envelope glycoproteins. Expression of genes coding for the envelope glycoproteins occurred earlier in cells infected with isolate 10/154 than in cells infected with strain 07/435, demonstrating a distinct difference between the strains. Differences in serological response can be attributed to differences in the expression of antigenic proteins or to post-translational modifications that mask neutralizing epitopes. Strain 07/435 induced significantly high titers of neutralizing antibodies in several animal species in addition to bovines. The most relevant serological differences were observed in adult animals. This is the first comprehensive analysis of the expression kinetics of genes coding for BoHV-4 glycoproteins in 2 Argentine strains (genotypes 1 and 2). The results further elucidate the BoHV-4 life cycle and may also help determine the genetic variability of the strains circulating in Argentina.

• Journal of Korean Society of Forest Science
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• v.86 no.3
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• pp.342-351
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• 1997

The objective of this study was to compare acid-neutralizing and buffering capacity of four tree species against soil acidification by acid rain. About 30-year-old forests composed of Pinus rigida, Alnus hirsuta, Quercus mongolica, and Liriodendron tulipifera in a provincial experimental forest located 15km east from Banwol Industrial Complex in Kyonggido were used in this study. Incident precipitation, throughfall and stemflow, and soil samples were collected from May to September, 1996 to analyze their pH and canon concentrations. Internal leaf pH, external acid neutralizing capacity(ENC), and buffering capacity index(BCI) of leaves were also determined. The incident precipitation showed an average pH of 4.56, with the percentage of acid rain incidents being 74%. The average soil pH of the study area was 4.15. The pH of throughfall and stemflow in all four species was higher than that of precipitation except that of the stemflow of Pinus rigida which showed a pH of 3.73. The throughfall of Liriodendron tulipifera showed the highest pH of 5.38. The pH of throughfall and stemflow showed a positive correlation and no correlation, respectively, with precipitations. The most abundant cation in precipitation was Ca. The canon concentraions in throughfall and stemflow decreased in the following order of K, Na, Ca, and Mg. Cation concentrations in stemflow were highest in Lirioendron tulipifera and lowest in Pines rigida. Nutrient leaching from above ground increased with decreasing pH of precipitation. The pH of stemflow showed a positive correlation with ENC and BCI. The highest values in ENC, BCI, soil pH, and soil cation concentrations were observed in Liriodendron tulipifera, while the lowest values were obtained in Pinus rigida, It was concluded that Liriodendron tulipifera had highest neutralizing capacity against acid rain, while Pinus rigida had the lowest capacity and even promoted acidification of soil.