Antigastritic and Anti Helicobacter pylori Effects of Baicalein from Scutellaria Baicalensis

황금 Baicalein의 위염 및 H. pylori균에 미치는 효과

  • Kang, Min-Hee (College of Pharmacy, Duksung Women's University) ;
  • Lee, Jung-Hun (College of Pharmacy, Duksung Women's University) ;
  • Lee, Yong-Soo (College of Pharmacy, Duksung Women's University) ;
  • Son, Kun-Ho (Department of Food Science and Nutrition, Andong National University) ;
  • Lee, Dong-Hwa (Department of Food Science and Nutrition, Andong National University) ;
  • Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University) ;
  • Bang, Hyo-Choon (Department of chemistry, Duksung Women's University) ;
  • Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
  • 강민희 (덕성여자대학교 약학대학) ;
  • 이정헌 (덕성여자대학교 약학대학) ;
  • 이용수 (덕성여자대학교 약학대학) ;
  • 손건호 (안동대학교 식품영양학과) ;
  • 이동화 (안동대학교 식품영양학과) ;
  • 김영식 (서울대학교 약학대학) ;
  • 강삼식 (서울대학교 약학대학) ;
  • 방효춘 (덕성여자대학 자연과학대학 화학과) ;
  • 정춘식 (덕성여자대학교 약학대학)
  • Published : 2007.02.28


Scutellaria Radix, the dried roots of Scutellaria baicalensis Georgi (Labiatae), has been used in oriental traditional medicine for treatment of fever urine disorder, diarrhea, inflammation. Present study was carried out for the gastroprotective effect of chrysin, baicalein, baicalin, wogonin from Scutellaria baicalensis. This reports evaluated antioxidant effect, antibacterial activity against Helicobacter pylori and HCI-ethanol-induced gastric lesion in rats and showed the significant effectiveness. It may be regarded that the antigastritic effects and antibacterial activity of baicalin, baicalein from Scutellaria baicalensis are originated from acid-neutralizing capacity, free radical scavenging effects and the antibacterial activity against Helicobacter pylori.



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