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http://dx.doi.org/10.4062/biomolther.2012.20.2.239

Inhibitory Effects of 4-Guanidinobutyric Acid against Gastric Lesions  

Hwang, In-Young (College of Pharmacy, Duksung Women's University)
Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
Publication Information
Biomolecules & Therapeutics / v.20, no.2, 2012 , pp. 239-244 More about this Journal
Abstract
This study examined the inhibitory effects of 4-guanidinobutyric acid (4GBA), an alkaloid, against gastric lesions by assessing the inhibition of Helicobacter pylori (H. pylori) and gastric cancer cells. Acute and chronic gastritis were also observed using HCl/ethanol (EtOH) and indomethacin-induced gastric lesion models, respectively. 4GBA inhibited the growth of H. pylori in a dose dependent manner, and showed acid-neutralizing capacity. In the pylorus ligated rats, 4GBA decreased the volume of gastric secretion and gastric acid output slightly, and increased the pH. 4GBA at a dose of 100 mg/kg reduced the size of HCl/EtOH-induced gastric lesions (70.8%) and indomethacin-induced gastric lesions (38.8%). The antigastritic action of 4GBA might be associated with the acid-neutralizing capacity, anti-H. pylori action, and decreased volume of gastric secretion. These results suggest that 4GBA might be useful in the treatment and/or protection of gastritis.
Keywords
4-guanidinobutyric acid; Helicobacter pylori; Cytotoxicity; Anti-oxidant; Gastric lesion;
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1 Arend, A., Loime, L., Roosaar, P., Soom, M., Loivukene, K., Sepp, E., Aunapuu, M., Zilmer, K., Selstam, G. and Zilmer, M. (2005) Helicobacter pylori substantially increases oxidative stress in indomethacin- exposed rat gastric mucosa. Medicina (Kaunas). 41, 343-347.
2 Ashley, S. W., Sonnenschein, L. A. and Cheung, L. Y. (1985) Focal gastric mucosal blood flow at the site of aspirin-induced ulceration. Am. J. Surg. 149, 53-59.   DOI   ScienceOn
3 Choi, C. H., Cha, Y. J., An, C. S., Kim, K. J., Kim, K. C., Moon, S. P., Lee, Z. H. and Min, Y. D. (2004) Molecular mechanisms of heptaplatin effective against cisplatin-resistant cancer cell lines: less involvement of metallothionein. Cancer Cell Int. 4, 6-17.   DOI   ScienceOn
4 Correa, P. (1992) Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 52, 6735- 6740.
5 Drake, I. M., Mapstone, N. P., Schorah, C. J., White, K. L., Chalmers, D. M., Dixon, M. F. and Axon, A. T. (1998) Reactive oxygen species activity and lipid peroxidation in Helicobacter pylori associated gastritis: relation to gastric mucosal ascorbic acid concentrations and effect of H pylori eradication. Gut. 42, 768-771.   DOI   ScienceOn
6 Eliakim, R., Karmeli, F., Okon, E. and Rachmilewitz, D. (1995) Ketotifen and nitroxides decrease capsaicin-augmented ethanol-induced gastric damage in rats. Dig. Dis. Sci. 40, 1140-1146.   DOI   ScienceOn
7 Kahraman, A., Erkasap, N., Koken, T., Serteser, M., Aktepe, F. and Erkasap, S. (2003) The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. Toxicology. 183, 133-142.   DOI
8 Kasuya, Y., Urushidani, T. and Okabe, S. (1979) Effects of various drugs and vagotomy on indomethacin-induced gastric ulcers in the rat. Jpn. J. Pharmacol. 29, 670-673.   DOI
9 Kim, J. M., Shin, J. E., Han, M. J., Baek, N. I. and Kim, D. H. (2003) Inhibitory Effect of Ginseng Polyacetylenes on Infection and Vacuolation of Helicobacter pylori. Nat. Prod. Sci. 9, 158-160.
10 Kinoshita, M., Noto, T. and Tamaki, H. (1995) Effect of a combination of ecabet sodium and cimetidine on experimentally induced gastric lesions and gastric mucosal resistance to ulcerogenic agents in rats. Biol. Pharm. Bull. 18, 223-226.   DOI   ScienceOn
11 Kusters, J. G., van Vliet, A. H. and Kuipers, E. J. (2006) Pathogenesis of Helicobacter pylori infection. Clin. Microbiol. Rev. 19, 449-490.   DOI   ScienceOn
12 Lee, E. J., Kim, K. S., Jung, H. Y., Kim, D. H. and Jang, H. D. (2005) Antioxidant activities of garlic (Allium sativum L.) with growing districts. Food Sci. Biotechnol. 14, 123-130.
13 Leirisalo-Repo, M., Paimela, L., Koskimies, S. and Repo, H. (1993) Functions of polymorphonuclear leukocytes in early rheumatoid arthritis. Inflammation. 17, 427-442.   DOI   ScienceOn
14 Leunk, R. D., Johnson, P. T., David, B. C., Kraft, W. G. and Morgan, D. R. (1988) Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J. Med. Microbiol. 26, 93-99.   DOI
15 McQuaid, K. R. and Isenberg, J. I. (1992) Medical therapy of peptic ulcer disease. Surg. Clin. North Am. 72, 285-316.
16 Schepers, E., Glorieux, G., Dou, L., Cerini, C., Gayrard, N., Louvet, L., Maugard, C., Preus, P., Rodriguez-Ortiz, M., Argiles, A., Brunet, P., Cohen, G., Jankowski, J., Jankowski, V., Massy, Z., Rodriguez, M. and Vanholder, R.; European Uremic Toxin Work Group (EUTox). (2010) Guanidino compounds as cause of cardiovascular damage in chronic kidney disease: an in vitro evaluation. Blood Purif. 30, 277-287.   DOI   ScienceOn
17 Mizui, T. and Doteuchi, M. (1983) Effect of polyamines on acidified ethanol-induced gastric lesions in rats. Jpn. J. Pharmacol. 33, 939- 945.   DOI
18 Oyaizu, M. (1986) Studied on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine. Jpn. J. Nutr. 44, 307-315.   DOI
19 Sarosiek, J., Bilski, J., Murty, V. L., Slomiany, A. and Slomiany, B. L. (1989) Colloidal bismuth subcitrate (De-Nol) inhibits degradation of gastric mucus by Campylobacter pylori protease. Am. J. Gastroenterol. 84, 506-510.
20 Seiki, M., Ueki, S., Tanaka, Y., Soeda, M., Hori, Y., Aita, H., Yoneta, T., Morita, H., Tagashira, E. and Okabe, S. (1990) Studies on antiulcer effects of a new compound, zinc L-carnosine (Z-103). Nihon Yakurigaku Zasshi. 95, 257-269.   DOI   ScienceOn
21 Shay, H., Komarov, S. A., Fels, S. E., Meraze, D., Gruenstein, M. and Siplet, H. (1945) A simple method for the uniform production of gastric ulceration in rat. Gastroenterology 5, 43-61.
22 Slomiany, B. L. and Slomiany, A. (1992) Mechanism of Helicobacter pylori pathogenesis: focus on mucus. J Clin. Gastroenterol. 14 (Suppl 1), S114-121.   DOI
23 Tachikawa, M. and Hosoya, K. (2011) Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fl uid barrier: relevance to neural disorders. Fluids. Barriers. CNS. 8, 13-24.   DOI
24 Tarnawski, A., Hollander, D., Gergely, H. and Stachura, J. (1985) Comparison of antacid, sucralfate, cimetidine, and ranitidine in protection of the gastric mucosa against ethanol injury. Am. J. Med. 79, 19-23.
25 Wallace, J. L. and Granger, D. N. (1992) Pathogenesis of NSAID gastropathy: are neutrophils the culprits? Trends Pharmacol. Sci. 13, 129-131.   DOI
26 Tarnawski, A., Tanoue, K., Santos, A. M. and Sarfeh, I. J. (1995) Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment? Scand. J. Gastroenterol. 210(Suppl), 9-14.
27 Veldhuyzen van Zanten, S. J. and Sherman, P. M. (1994) Helicobacter pylori infection as a cause of gastritis, duodenal ulcer, gastric cancer and nonulcer dyspepsia: a systematic overview. CMAJ. 150, 177-185.