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Antigastritic and Anti Helicobacter pylori Effects of Baicalein from Scutellaria Baicalensis  

Kang, Min-Hee (College of Pharmacy, Duksung Women's University)
Lee, Jung-Hun (College of Pharmacy, Duksung Women's University)
Lee, Yong-Soo (College of Pharmacy, Duksung Women's University)
Son, Kun-Ho (Department of Food Science and Nutrition, Andong National University)
Lee, Dong-Hwa (Department of Food Science and Nutrition, Andong National University)
Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University)
Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
Bang, Hyo-Choon (Department of chemistry, Duksung Women's University)
Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
Publication Information
YAKHAK HOEJI / v.51, no.1, 2007 , pp. 68-74 More about this Journal
Abstract
Scutellaria Radix, the dried roots of Scutellaria baicalensis Georgi (Labiatae), has been used in oriental traditional medicine for treatment of fever urine disorder, diarrhea, inflammation. Present study was carried out for the gastroprotective effect of chrysin, baicalein, baicalin, wogonin from Scutellaria baicalensis. This reports evaluated antioxidant effect, antibacterial activity against Helicobacter pylori and HCI-ethanol-induced gastric lesion in rats and showed the significant effectiveness. It may be regarded that the antigastritic effects and antibacterial activity of baicalin, baicalein from Scutellaria baicalensis are originated from acid-neutralizing capacity, free radical scavenging effects and the antibacterial activity against Helicobacter pylori.
Keywords
baicalein; Scutellaria baicalensis; antigastritic; acid-neutralizing capacity; free radical scavenging effec; H. pylori;
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1 Li, B. Q., Fu, T., Gong, W. H., Dunlop, N., Kung, H. F., Yan, Y. D., Kang, J. J. and Wang, M. : The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology 49, 295 (2000)
2 Li, B. Q., Fu, T., Yan, Y. D., Baylor, N. W., Ruscetti, F. W. and Kung, H. F. : Inhibition of HIV infection by baicalin-a flavonoid compound purified from Chinese herbal medicine. Cell Mol. Biol. Res. 39, 119 (1993)
3 Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S. F. and Huang, Y. : Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Cancer Lett. 160, 219 (2000)
4 Shieh, D. E., Liu, L. T. and Lin, C. C. : Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 20, 2861 (2000)
5 Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C. and Hsieh, M. T. : Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Planta Med. 66, 694 (2000)
6 Yoshida, T., Mori. K., Hatano, T., Okumura, T., Uehara, I., Komagoe, K., Fujita., Y. and Okura, T. : Studies in inhibition mechanism of tannins and flavonoids. V. Radical-scavenging effects of tannins and related olyphenols on 1,1-diphenyl-2- picrylhydrazyl radical. Chem. Pharm. Bull. 37, 1919 (1989)
7 한국약학대학협의회약전분과회편저 : 대한약전 제 8 개정 해설서, 문성사, 서울 p. 264 (2003)
8 Kubo, M., Matsuka, H., Kimura, Y., Okuda, H. and Arichi, S. : Scutellariae Radix. X. Inhibitory effects of various flavonoids on histamine release from rat peritoneal mast cells in vitro. Chem. Pharm. Bull. 32, 5051 (1984)
9 Hanaoka, M., Kohsu, M. and Yasuda, S. : A first and stereoselective synthesis of $(\pm)$-Raddeanamine. Chem. Pharm. Bull. 33, 4113 (1985)
10 Yoshida, N., Yoshikawa, T., Iinuma S., Arai, M., Takenaka, S., Sakamoto, K., Miyajima, T., Nakamura, Y., Yagi, N., Naito, Y., Mukai, F. and Kondo, M. : Rebamipide protects against activation of neutrophils by Helicobacter pylori. Dig Dis Sci. 41, 1139 (1996)
11 Kim, J. M., Shin, J. E., Han, M. J., Baek, N. I. and Kim, D. H. : Inhibitory effect of ginseng polyacetylenes on infection and vacuolation of Helicobacter pylori. Natural Product Science 9, 158 (2003)
12 Wu, J. A., Attele, A. S., Zhang, L. and Yuan, C. S. : Anti-HIV activity of medicinal herbs : usage and potential development. Am. J. Chinese Med. 29, 69 (2001)
13 Konoshima, T., Kokumai, M., Kozuka, M., Iinuma, M., Mizuno, M., Tanaka, T., Tokuda, H., Tokuda, H., Nishino, H. and Iwashima, A. : STUDIES ON INHIBITORS OF SKIN TUMOR PROMOTION; Inhibitory effects of flavonoids from scutellaria baicalensis on epstein-barr virus activation and their anti-tumor-promoting activities. Chem. Pharm. Bull. 40, 531 (1992)
14 Leunk, R. D., Johnson, P. T., David, B. C., Kraft, W. G. and Morgan, D. R. : Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J. Med. Microbiol. 26, 93 (1988)
15 Gao, Z. H., Huang, K. X. and Xu, H. B. : Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacol. Res. 43, 173 (2001)
16 Mizui, T. and Dodeuchi, M. : Effect of polyamines on acidified ethanol induced gastric lesion in rats. Jpn. J. Pharmacol. 33, 939 (1983)   DOI   PUBMED
17 Uchiyama, M., Suzuki, Y. and Fukuzawa, K. : Biochemical studies of physiological function of tocopherolactone. Yakugaku Zasshi 88, 678 (1968)
18 Koda, A., Watanabe, S., Yanagihara, Y., Nagai, H. and Sakamoto, K. : A comparative study of the anti-allergic effects of disodium baicalein 6-phosphate (BPS) and disodium cromoglycate (DSCG). Jpn. J. Pharmacol. 27, 31 (1977)
19 Kimura, Y., Okuda, H., Taira, Z., Shoji, N., Takemoto, T. and Arichi, S. : Studies on scutellariae radix; New component inhibiting lipid peroxidation in rat liver. Planta Med. 50, 290 (1984)
20 Shay, H., Komarov, S. A., Fels, S. S., Meranze, D., Gruenstein, M. and Siplet, H. : A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol. 4, 43 (1945)
21 Bae, E. A., Han, M. J., Baek, N. I. and Kim, D. H. : In vitro anti Helicobacter pylori activity of panaxtriol isolated from ginseng. Arch. Pharm. Res. 24, 297 (2001)   DOI   ScienceOn
22 Ikemoto, S., Sugimura, K., Yoshida, N., Yasumoto, R., Wada, S., Yamamoto, K. and Kishimoto, T. : Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Urology 55, 951 (2000)
23 Ma, S. C., Du, J., But, P. P. H., Deng, X. L., Zhang, Y. W., Ooi, V. E. C., Xu, H. X., Lee, S. H. S. and Lee, S. F. : Antiviral Chinese medicinal herbs against respiratory syncytial virus. J. Ethnopharmacol. 79, 205 (2002)