• Bulletin of the Korean Chemical Society
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• v.18 no.9
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• pp.939-945
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• 1997

Several types of 4-substituted-quinoline-2-carboxylic acid derivatives possessing different substituents at C4-position such as sulfonyl, phosphonyl, carbonyl groups, or a flexible alkyl chain have been synthesized and evaluated for their in vitro antagonistic activity at the glycine site on the N-methyl-D-aspartate (NMDA) receptor. Of them, 5,7-dichloro-4-(tolylsulfonylamino)-quinoline-2-carboxylic acid 9 was found to have the best in vitro binding affinity with IC50 of 0.57 μM. On the other hand, in compounds 21 and 22 the introduction of flexible alkyl chains on C4 of the quinoline mother nuclei caused a significant decrease of the in vitro binding affinity. In addition, replacement of polar carboxylic acid group on C2 by neutral bioisosteres in compounds 23a-d also seems to be disadvantageous to in vitro activity. In the structure-activity relationship (SAR) study of the 4-substituted quinoline-2-carboxylic acid acid derivatives, it was realized that the substitution pattern on C4 significantly influences on the binding affinity for the glycine site of NMDA receptor and the binding affinity might be increased by the introduction of a suitable electron rich substituent at C4 which has the ability of H-bonding donor.

• Journal of Contemporary Eastern Asia
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• v.19 no.2
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• pp.234-263
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• 2020

This study aims to assess the quality of the EU's public diplomacy efforts through social media. Specifically, this research explores the headquarters of European public diplomacy (European External Action Service, EEAS) and its subordinate agent (EU Delegation to South Korea, EUDK). The main research question is "how coherently and effectively does the EU execute public diplomacy strategies in the third countries?'' This study employs both quantitative and qualitative approaches―the former for the results presentation and the latter for the results interpretation. The results are summarized in two points. First, both the EEAS and the EUDK maintained an objective position by posting only neutral perspectives on their social media. Second, the narratives of the main actors were the same, but the main themes were different according to their contexts. The analysis discusses the effectiveness of the EU's strategic narratives by focusing on measuring message reception. Its limited findings were that social media postings could not induce the audiences' active discussion of the EU's diplomatic performances. The conclusion suggests that the EU should identify the expectations from its global counterparts and use these to forge the Union's strategic narratives.

• Korean Journal of Soil Science and Fertilizer
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• v.22 no.4
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• pp.265-270
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• 1989

Soil properties for the limestone-derived soil were examined to relate soil formation to stratigraphy of parent materials and hillslope positions in Bangjeol Ri, Yeongweol Eup, Gangweon Do. Pyeongchang, Anmi, Yulgog and Mungyeong series were described for topographic positions such as shoulder position, footslope, terrace and local bottom associated with toposequence where the landscape consisted of gently rolling hillslopes and nearly level plains. 1. Pyeongchang, Anmi, Yulgog and Mungyeong series had the standard hue of the 2.5YR, 5YR, 10YR and 2.5Y, respectively. Thus, color sequence of soil could be related to hillslope positions on the landscape. 2. With ascending slope toward summit, the clay content increased while silt content decreased 3. Silt/Clay ratios ranged from 0.27 to 3.76 and it was increased with descending to bottom. It, also, appeared that maturity of soil was higher at summit position than at bottom. 4. Soils developed in limestone were neutral in soil reaction and very low in available $P_2O_5$. OM, available $SiO_2$, CEC, and active Fe in soils seemed to be increased with ascending to summit position.

• Korean Journal of Acupuncture
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• v.39 no.2
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• pp.23-33
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• 2022

Objectives : The purpose of this study is to establish a Korean medical perspective on the human body through understanding of the meridians according to the distribution of the three yin and three yang (삼음삼양) and the opening, closing and pivot (관합추) as defined in ≪Huangdi's Internal Classic≫. Methods : A total of 8 medical databases including KISS, Earticle, DBpia, RISS, OASIS, KMbase, and ScienceON were used to search studies published through July 2021, and literature was included without limitations on the publication period. The search terms were "(meridian OR acupoint OR meridian sinew) AND position" OR "Gwan-Hap-Chu" OR "Gae-Hap-Chu" OR "three yin and three yang". Two researchers independently made choices among the searched literature based on the preplanned selection/exclusion criteria. The search terms were"(meridian OR acupoint OR meridian sinew) AND position" OR "Gwan-Hap-Chu" OR "Gae-Hap-Chu" OR "three yin and three yang". Results : Of the 36 obtained from the survey, 19 (53%) followed the definitions of "internal diameter" for "three yin and three yang" and "the opening, closing and pivot," but 6 (about 16%) took a neutral position and 10 (22%) avoided mentioning. Therefore, it was judged that research was needed to end the debate on the distribution of 'three yin and three yang' and 'the opening, closing and pivot'. In order to apply the definition of ≪Huangdi's Internal Classic≫ on 'distribution of the three-yin and three-yang' and 'the opening, closing and pivot' to the upper limb and lower limb as well as the torso of the human body, this author proposed a human body model with both upper limb and lower limb attached, inspired by the posture of the fetus in the developmental stage. Conclusions : In this study, using a new human body model, it was revealed that the distribution of the three yin and three yang and the opening, closing and pivot' as defined in the ≪Huangdi's Internal Classic≫ can be applied not only to the torso of the human body, but also to the upper limb and lower limb. Based on the understanding of meridians, the selection of meridians in the clinical acupuncture should be made accurately, and continuous interest and research on this are expected.

• Korean Journal of Social Welfare
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• v.64 no.2
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• pp.325-354
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• 2012

The current research intends to analyse the construction process of gender in the biographies of migrant women. Ten autobiographical-narrative interviews with Korean female migrant workers in Germany were conducted and the following conclusions were ascertained through the analysis of Schutze's autobiographical-narrative interview: The genders in their biographies were constructed similar before their marriage, but different after their marriage according to the work-family balanced type and the family centered type. Before their migration the 'process of life' as female high school students and female workers showed that both types had partially deconstructed a sex-segregated gender. The process of life as female migrant workers after their migration showed that both types had partially constructed a sex-neutral gender. The process of life after their marriage exhibited that the former strengthened and strengthens a sex-neutral gender in a double position as female migrant workers and female marriage migrants, but the latter reconstructed a sex-segregated gender again and intensifies this in a process of time. Based on these results, some implications for the social work practice were addressed, which emerged from the understanding on the gender in the biographies of migrant women.

• Cartoon and Animation Studies
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• s.50
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• pp.1-22
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• 2018

This study investigated realism sceneries shown in animation movies of auteurism. Although animation has properties of mechanical images arranged by short cuts, it essentially starts with the images dealing with space art based on the consciousness of an author. In this aspect, sceneries of animation movies can be the most proper subject for study from the viewpoint of image. Generally, sceneries of animation movies maintain the neutral position as a stage setting for story. However, as for auteurism animation, the sceneries have subjective meaning as major media to express the work or the vision and value of the author on the world. The representative animation movies that reflect the role and meaning of realism sceneries among auteurism animations are and . The former shows Korean sceneries and the latter presents local sceneries of Japan quite well. Reviewing the characteristics of sceneries shown in two movies, the sceneries of are the discovery of internal consciousness of the author that signifies pure innocence of childhood into the voice of nature through the style of the author. Meanwhile, sceneries of adopted nature landscape surrealistically based on the internal consciousness of the author and described the forest as the absolute utopia of the author. As such, the sceneries shown in two movies were utilized as the "framework of thought" of the authors that intensify the viewpoint of the movies on the world through empirical interpretation and detailed description of neutral landscape based on internal consciousness of the authors.

• Korean Journal of Food Science and Technology
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• v.53 no.5
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• pp.570-577
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• 2021

This study elucidated the biological activities and structural characteristics of polysaccharides isolated from ginseng leaves fermented using Cordyceps sinensis (GLF). GLF comprised at least 18 glycosyl linkages, including 4-linked glucose residues (24.0%). To characterize the neutral polysaccharides in GLF, it was further fractionated by anion exchange chromatography, and the unabsorbed fraction (GLF1) was isolated. Peritoneal macrophages stimulated with GLF1 produced various cytokines in a dose-dependent manner. The properties and activities of the four subfractions (PHI, PHIA1-PHIA3) obtained after sequential enzymatic digestion were examined. PHI and PHIA3 primarily comprised glucose, whereas PHI exhibited an iodine-color reaction. Furthermore, the PHIA1-3 fractions indicated that cytokine production was completely inhibited. These results suggest at the immune activities of GLF1 may be due to the α-(1→4)-glucan branched at the C(O)6 position, which was produced by C. sinensis.

• Journal of Digital Convergence
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• v.12 no.4
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• pp.443-454
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• 2014

This study designed to know subjective structure about clinical experience of adaptation of new nursing staffs in a general hospital and using Q-methodology. Using Q-methodology, 40 new nursing staffs sorted working a general hospital through personal interview. The statement positions on the sorting continuum were scored from +4(representing the highest level of agreement) through 0(at the neutral position on the continuum) through to -4(representing the highest level of disagreement). Factor analysis of the data was undertaken using PC QUANL program to determine if any patterns were discernible. The five types extracted all had eigenvalues greater than 1.0 and explained 62.38% of the variation in responses.: (1) New workload type, (2) Interest and responsibility type, (3) Improve the situation type, (4) Lack of knowledge and technology type, and (5) Excessive workload type. The significant differences found in the subjective structure of clinical experience of adaptation of new nursing staffs in ad general hospital. The findings of this study could contribute to the development of an effective programmes of education and personnel clinical practice strategies.

• Structural Engineering and Mechanics
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• v.58 no.3
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• pp.515-532
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• 2016

The elastoplastic response of functionally graded material (FGM) beams resting on a nonlinear elastic foundation to an eccentric axial load is investigated by using the finite element method. The FGM is assumed to be formed from ceramic and metal phases with their volume fraction vary in the thickness direction by a power-law function. A bilinear elastoplastic behavior is assumed for the metallic phase, and the effective elastoplastic properties of the FGM are evaluated by Tamura-Tomota-Ozawa (TTO) model. Based on the classical beam theory, a nonlinear finite beam element taking the shift in the neutral axis position into account is formulated and employed in the investigation. An incremental-iterative procedure in combination with the arc-length control method is employed in computing the equilibrium paths of the beams. The validation of the formulated element is confirmed by comparing the equilibrium paths obtained by using the present element and the one available in the literature. The numerical results show that the elastoplastic post-buckling of the FGM beams is unstable, and the post-buckling strength is higher for the beams associated with a higher ceramic content. Different from homogeneous beams, yielding in the FGM beam occurs in the layer near the ceramic layer before in the layer near metal surface. A parametric study is carried out to highlight the effect of the material distribution, foundation support and eccentric ratio on the elastoplastic response of the beams.

• Korean Journal of Applied Biomechanics
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• v.25 no.2
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• pp.141-147
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• 2015

Objective : This study aimed to understand how increased heart rates at the time of drop landing during a step test would affect biomechanical variables of the lower extremity limbs. Background : Ballet performers do more than 200 landings in a daily training. This training raises the heart rate and the fatigability of the lower extremity limbs. Ballet performance high heart rate can trigger lower extremity limb injury. Method : We instructed eight female ballet dancers with no instability in their ankle joints(mean ${\pm}$ SD: age, $20.7{\pm}0.7yr$; body mass index, $19.5{\pm}1.2kg/m^2$, career duration, $8.7{\pm}2.0yr$) to perform the drop landing under the following conditions: rest, 60% heart rate reserve (HRR) and 80% HRR. Results : First, the study confirmed that the increased heart rates of the female ballet dancers did not affect the working ranges of the knee joints during drop landing but only increased angular speeds, which was considered a negative shock-absorption strategy. Second, 80% HRR, which was increased through the step tests, led to severe fatigue among the female ballet dancers, which made them unable to perform a lower extremity limb-neutral position. Hence, their drop landing was unstable, with increased introversion and extroversion moments. Third, we observed that the increasing 80% HRR failed to help the dancers effectively control ground reaction forces but improved the muscular activities of the rectus femoris and vastus medialis oblique muscles. Fourth, the increasing heart rates were positively related to the muscular activities of the vastus medialis oblique and rectus femoris muscles, and the extroversion and introversion moments. Conclusion/Application : Our results prove that increased HRR during a step test negatively affects the biomechanical variables of the lower extremity limbs at the time of drop landing.