• Journal of Animal Science and Technology
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• v.48 no.6
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• pp.847-860
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• 2006

This study investigated the effects of feeding Charolais steers on diets rich in either n-6 or n-3 polyunsaturated fatty acids (PUFA) and time on feed (TOF) on muscle fatty acid composition and content. Twenty eight steers were fed on ad libitum forage and one of two concentrates varying in the source of fat; soya (high in C18:2 n-6) or whole linseed (high in C18:3 n-3) for either 60 or 90 days in IGER (Institute of Grassland and Environmental Research, UK). The concentrates were fed at approximately 0.73 of total DM intake. TOF influenced carcass weight, conformation and fatness scores, which were higher at 90 v. 60 days (P<0.05). Diet did not affect total fatty acid content of neutral lipid in m. longissimus thoracis but feeding linseed increased total phospholipid fatty acid by approx- imately 15%(P<0.05). Linseed increased the amount and proportion of C18:3 n-3 (P<0.001) and the proportion of CLA (cis-9, trans-11 conjugated linoleic acid), while soya increased the content (P<0.05) and proportion (P<0.001) of C18:2 n-6 in muscle neutral lipid. In muscle phospholipid, linseed significantly increased the amount of CLA, C18:3 n-3 and its longer chain derivatives as well as C14:0, C16:0, C18:0. C18:1 trans and C18:2 n-6. The amount and proportion of C18:2 n-6 and its longer chain C20 derivatives were higher on feeding soya. TOF (90 v. 60 day) increased the content of C14:0, C16:0, C16:1, CLA, C18:1 n-9, C18:2 n-6 and C18:3 n-3 in muscle neutral lipid. The P:S was not affected by diet or TOF. The ratio of C18:2 n-6 : C18:3 n-3 and sum of n-6 : n-3 fatty acids were higher in muscle from animals fed on linseed v. soya (P<0.001). The study indicates that the PUFA composition of beef muscle may be significantly modified by feeding contrasting dietary lipids, soya vs. linseed. Feeding linseed produced a better balance of muscle fatty acids, more in line with current nutritional recommendations with a lower C18:2 n-6:C18:3 n-3 ratio associated with higher muscle content of C18:3 n-3 and C20:5 n-3 and CLA and lower C20:4 n-6.

• Korean Chemical Engineering Research
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• v.57 no.6
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• pp.868-873
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• 2019

In this study, the evaluation of performance of AORFB using methyl viologen and TEMPOL as organic active materials in neutral supporting electrolyte (NaCl) with various membrane types was performed. Using methyl viologen and TEMPOL as active materials in neutral electrolyte solution, the cell voltage is 1.37V which is relatively high value for AORFB. Two types of membranes were examined for performance comparison. First, when using Nafion 117 membrane which is commercial cation exchange membrane, only the charge process occurred in the first cycle and the single cell couldn't work because of its high resistance. However, when using Fumasep anion exchange membrane (FAA-3-50) instead of Nafion 117 membrane, the result was obtained as the totally different charge-discharge graphs. When current density was $40mA{\cdot}cm^{-2}$ and cut off voltage range was from 0.55 V to 1.7 V, the charge efficiency (CE) was 97% and voltage efficiency (VE) was 78%. In addition, the discharge capacity was $1.44Ah{\cdot}L^{-1}$ which was 54% of theoretical capacity ($2.68Ah{\cdot}L^{-1}$) at $10^{th}$ cycle and the capacity loss rate was $0.0015Ah{\cdot}L^{-1}$ per cycle during 50 cycles. Through cyclic voltammetry test, it seems that this difference in the performance between the full cell using Nafion 117 membrane and Fumasep anion exchange membrane came from increasing resistance due to chemical reaction between membrane and active material, not the capacity loss due to cross-over of active material through membrane.

• Corrosion Science and Technology
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• v.18 no.6
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• pp.300-311
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• 2019

The corrosion behaviors of twinning-induced plasticity (TWIP) steels with different alloying elements (Cu, Al, Si) in a neutral aqueous environment were investigated in terms of the characteristics of the corrosion products formed on the steel surface. The corrosion behavior was evaluated by measuring potentiodynamic polarization test and electrochemical impedance spectroscopy. For compositional analysis of the corrosion products formed on the steel surface, an electron probe x-ray micro analyzer was also utilized. This study showed that the addition of Cu to the steel contributed to the increase in corrosion resistance to a certain extent by the presence of metallic Cu in discontinuous form at the oxide/steel interface. Compared to the case of steel with Cu, the Al-bearing specimen exhibited much higher polarization resistance and lower corrosion current by the formation of a thin Al-enriched oxide layer. On the other hand, Si addition (3.0 wt%) to the steel led to an increase in grain size, which was twice as large as that of the other specimens, resulting in a deterioration of the corrosion resistance. This was closely associated with the localized corrosion attacks along the grain boundaries by the formation of a galvanic couple with a large cathode-small anode.

• Journal of Energy Engineering
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• v.11 no.4
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• pp.370-379
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• 2002

In the Korean electricity supply structure, the role of nuclear power generation is essential. But, the delaying of radioactive waste management program induces negative impact to the stable electricity supply. Despite the continuing endeavors of Korean Government and nuclear power industry, radioactive waste management program of Korea is experiencing a continuing setback. In this background, the study examined the past and current policy and recommends that; Long term safety assurance should be the prime objective of radioactive waste management; Siting process should be transparent and opened to the public with the involvement of safety regulatory authority; A new neutral organization which has no conflicts of interest with any other existing organizations should be established to coordinate and manage the R&D programs.

• Journal of Life Science
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• v.28 no.6
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• pp.753-763
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• 2018

Cysteine cathepsins are lysosomal enzymes that belong to the papain family and can induce the degradation of damaged proteins through the endo-lysosomal pathway. It is highly upregulated in many cancers by regulating gene amplification and transcriptional, translational, and post-transcriptional modifications. Cathepsin S is part of the cysteine cathepsin family. Many studies have demonstrated that cathepsin S not only plays a specific role in MHC class II antigen presentation but also plays a crucial role in cancers. Cathepsin S is more stable at a neutral pH compared to other cysteine cathepsins, which supports the importance of cathepsin S in disease microenvironments. Therefore, the dysregulation of cathepsin S has participated in a variety of pathological processes, including cancer, arthritis, and cardiovascular disease. Furthermore, a decrease or depletion in the expression of cathepsin S has been implicated in the processes of tumor growth, invasion, metastasis, and angiogenesis. Taken together, cathepsin S has been suggested as an attractive therapeutic target for cancer therapy. In this review, the known involvement of cathepsin S in diseases, particularly with respect to recent work indicating its role in cancer therapy, is examined. An overview of current literature on the inhibitors of cathepsin S as a therapeutic target for cancer is also provided.

• Journal of Environmental Science International
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• v.4 no.2
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• pp.121-139
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• 1995

Based on the Results of Marine Meteorological and Oceanographical Observations (1966 -1987), the phenomenon of chimney is found as a candidate for the formation of the Japan Sea Proper Water (JSPW). The chimney phenomenon occurs twelve times Inuring 1966∼ 1987. The water types in the chimney denoting the deep convection are similar to those of the JSPW 0∼ 1℃ in potential temperature, 34.0∼34.1 ‰ in salinity and 68∼80 cl/t in potential thermosteric anomaly from the sea surface to the deep layer. The static stabilities in the chimney stations are unstable or neutral. This indicates that the winter time convection occurs. The JSPW sunken from the surface layer of chimney in winter spreads out under the Tsushima Warm Current area, following the isosteric surface of about 76 cl/t in Potential thermosteric anomaly. The formation of the deep water of the JSPW is mainly affected by the cooling of the sea surface than the evaporation of winds because the temperature and the salinity on the isoteric surface of about 76 cl/t in potential thermosteric anomaly ate cold and low The phenomenon of chimney occurred in here and there of the area in the north of 40" 30'N, west of 138" E. This suggests that the deep water of the JSPW is formed not in a limited area but probably in the overall region of the northern open ocean.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.3
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• pp.431-436
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• 2009

As the telecommunication lines bring into widespread use, one of the most important aspects related to power distribution systems is effectively to evaluate the effect on the telecommunication lines from power lines. One of the efficient methods to evaluate the effect is to measure the induced voltage of a telecommunication line as a result of a ground-loop. If the power lines cause high induced voltage, the ground reference in the telecommunication lines is no longer a stable potential, so signals may ride on the noise. A ground loop is common wiring conditions where a ground current may take more than one path to return to the grounding electrode at the arrangement between the power lines and telecommunication lines. When a multi-path connection between the power lines and telecommunication line circuits exists, the resulting arrangement is known as a ground loop. Whenever a ground loop exists, there are potential for damages or abnormal operations of the telecommunication lines. The power lines can induce the voltage on the communication line. The effects can be calculated by considering the inductances and capacitances. However, if we assume that there are only power lines, it doesn't have a practical meaning because there are conductors with other purpose in the neighborhood of the lines. If we consider that case, we need more complex system. Therefore we suggest more complex system considering the conductors with other purpose in the neighborhood of the lines. The neutral wires and the overhead ground wires are considered for calculating the induced voltage. We assume that there are the messenger wires beside the power line as a result of increased use of them. The main purpose of this paper is a study on a shielding effect of messenger wires in the distribution lines. EMTP(Electro-Magnetic Transients Program) program is used for the induced voltage calculation.

• Journal of Microbiology and Biotechnology
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• v.24 no.6
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• pp.781-787
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• 2014

2-Ketogluconic acid production by Klebsiella pneumoniae is a pH-dependent process, strictly proceeding under acidic conditions. Unfortunately, cell growth is inhibited by acidic conditions, resulting in low productivity of 2-ketogluconic acid. To overcome this deficiency, a two-stage fermentation strategy was exploited in the current study. During the first stage, the culture was maintained at neutral pH, favoring cell growth. During the second stage, the culture pH was switched to acidic conditions favoring 2-ketogluconic acid accumulation. Culture parameters, including switching time, dissolved oxygen levels, pH, and temperature were optimized for the fed-batch fermentation. Characteristics of glucose dehydrogenase and gluconate dehydrogenase were revealed in vitro, and the optimal pHs of the two enzymes coincided with the optimum culture pH. Under optimum conditions, a total of 186 g/l 2-ketogluconic acid was produced at 26 h, and the conversion ratio was 0.98 mol/mol. This fermentation strategy has successfully overcome the mismatch between optimum parameters required for cell growth and 2-ketogluconic acid accumulation, and this result has the highest productivity and conversion ratio of 2-ketogluconic and produced by microorganism.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.199-203
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• 2014

Background: Rosuvastatine, doxazosin, repaglinide and oxcarbazepin are therapeutic drugs available in the market for the treatment of different diseases. Potential to display antitumor activities has also been suggested. The aim of the current study was to evaluate their in vitro effects on some human transformed cell lines. Materials and Methods: Cytotoxicity of the four drugs was tested in MCF-7, HeLa and HepG2 cells by the neutral red assay method and also the effect of rosuvastatine and doxazosin against Ehrlich Ascities Carcinoma Cells (EACC) by trypan blue assay. Results: Rosuvastatine exerted the greatest cytotoxic effect against HepG2 cells with an $IC_{50}$ value of $58.7{\pm}69.3$; in contrast doxazosin showed least activity with $IC_{50}=104.4{\pm}115.7$. Repaglinide inhibited the growth of both HepG2 and HeLa cells with $IC_{50}$ values of $87.6{\pm}117.5$ and $89.3{\pm}119.5$, respectively. Oxcarbazepine showed a potent cytotoxicity against both HeLa ($IC_{50}=19.4{\pm}43.9$) and MCF7 cancer cells (($IC_{50}=22{\pm}35.7$).On the other hand the growth of EACC was completely inhibited by doxazosine (100% inhibition) while rosuvastatine had weak inhibitory activity (11.6%). Conclusions: The four tested drugs may have cytotoxic effects against hepatic, breast and cervical carcinoma cells; also doxazosine may inhibit the growth of endometrial cancer cells. Further investigations in animals are needed to confirm these results.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.50 no.8
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• pp.387-393
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• 2001

This paper describes an advanced measuring method and precise evaluation of the ground resistance for the grounding system of energized substations and power equipments. A grounding system of substations consists of all interconnected grounding connections of grounded conductors, neutral ground wires, underground conductors of distribution lines, cable shields, grounding terminals of equipments, and etc. It is very difficult to measure the accurate ground resistance of the grounding terminals of equipments, and etc. It is very difficult to measure the accurate ground resistance of the grounding system of high voltage energized substations because of harmonic components caused by switched power supplies or overloads. The conventional fall-of-potential method may be subject to big error if stray ground currents and potentials are present. In this work, to improve the precision in measurements of the ground resistance by eliminating the effects of harmonic components and stray currents and potentials, the investigations of the ground resistance measurement by using a low pass filter in a model energized grounding system were conducted. The accuracy of ground resistance mesurements was evaluated as a function of the ratio of the test signal to noise (S/N). The errors due to the proposed ground resistance measurement method were decreased with increasing S/N and were less than 5[%] as S/N is 10. The proposed ground resistance measurement method appears to be considerably more accurate than the conventional fall-of -potential method. It is allows cancellation of the parasitic resistance of energized grounding systems, to employ the measurement method that allows cancellation of the parasitic effects due to other circulating ground currents and ground potential rises in practical situations.