• 생물정신의학
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• 제2권1호
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• pp.28-37
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• 1995

Clinical neuropsychology which belongs to the necuroscience field is concerned with relationship between human behaviors and the brain structure. Clinical neuropsychology has grown to be a specialized separate field within psychology over the last twenty years. Clinical neuropsychology offers an objective methodology to consider the mind-body interaction and evaluate the behavioral consequences and functional deficits associated with brain lesions. Clinical neuropsychological assessment is composed of cognitive, perceptual, motor and emotional function through various neuropsychological examinations such as Halsted-Reitan and Luria-Nebraska batteries, and computerized neuropsychological test such as PCIS Vienna Test System and Stim. The goals of neuropsychological evaluation are to identify of neuropsychological dysfuncitions, to develop execute and monitor treatment plans, and to make rehabilitation programs. Recently, the neuropsychiatric patients are increasing in number and 15-20% of acute psychiatric patients suffer from organic mental problems. Moreover, clinical neuropsychology has an increasingly important role in both neurobehavioral foundation and clinical application. So, psychiatrists must play a major role in the development of clinical neuropsychology in psychiatry.

• 동의신경정신과학회지
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• 제15권2호
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• pp.159-172
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• 2004

Objective : There are many treatments for Headache. We suggested the clinical effect and utilization of Rainbow Theraphy on functional headache. Methods : 1. Setting up of Groups : A Group is 29 people being used Herb remedy, acupuncture and Rainbow Theraphy, B Group is 23 people being used only Rainbow Theraphy. 2. Operation of Rainbow Theraphy : By using RP-UM103(Umax Medical, Korea), we regulated ki and stimulated important acupuncture’s spots of headache. 3. We examined improvement of headache by giving marks about symptoms - occipital pain, Pressure, dyspepsia, anxiety, fatigue, attention deficiency - through interviewing before treatment and after 3 weeks' treatments. Results and Conclusions : 1. There was a significantly effect of Rainbow Theraphy on functional headache in both A Group and B Group. 2. In subjective appraisee of groups, A group$(17.28{\pm}2.15)$ is more effective than B group$(14.74{\pm}2.38)$. 3. In doctor's last appraisee of groups, A group$(3.83{\pm}0.71)$ is more significantly improvement than B group$(2.70{\pm}0.47)$.

• 동의생리병리학회지
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• 제18권5호
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• pp.1418-1425
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• 2004

The water extract of Chongmyung-tang has been traditionally used for treatment of memory-disorder in oriental medicine. This study was designed to investigate the protective mechanisms of Chongmyung-tang on β-amyloid or H₂O₂-induced cytotoxicity in Neuro 2A cells. The water extract of Chongmyung-tang significantly reduced both β-amyloid or H₂O₂-induced cell death and apoptotic characteristics through reduction of intracellular peroxide generation. Also, it inhibited the mitochondrial dysfunction including the disruption of mitochondria membrane permeability transition(MPT) and the modulation in expression of Bcl-2 family proteins in H₂O₂-treated H9c2 cells. Furthermore, pretreatment of quercetin inhibited the activation of caspase-3, in turn, degradation of ICAD/DFF45 were completely abolished in H₂O₂-treated cells. Taken together, that data suggest that the protective effects of the water extract of Chongmyung-tang against β-amyloid induced oxidative injuries may be achieved through modulation of mitochondrial dysfunction.

• 동의생리병리학회지
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• 제18권6호
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• pp.1810-1820
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• 2004

The purpose of this study was to estimate the effects of Ramulus et Uncus Uncariae DM fraction on CT105-injuried neuronal cells. We were examined by ROS formation, neurite outgrowth assay and DPPH scravage assay. Additionally, we investigated the association between the CT105 and neurite degeneration caused by CT105-induced apoptotic response in neurone cells. We studied on the regeneratory and inhibitory effects of anti-Alzheimer disease in pCT105-induced neuroblastoma cell lines by REUD. Findings from our experiments have shown that REUD inhibits the synthesis or activities of CT105, which has neurotoxityies and apoptotic activities in cell line. In addition, treatment of REUD(>50㎍/㎖ for 12 hours) partially prevented CT105-induced cytotoxicity in SK-N-SH cell lines, and were inhibited by the treatment with its. REUD(>50㎍/㎖ for 12 hours) repaired CT105-induced neurite outgrowth when SK-N-SH cell lines was transfected with CT105. As the result of this study, In REUD group, the apoptosis in the nervous system was inhibited, the repai: against the degeneration of Neuroblastoma cells by CT105 expression was promoted. Base on these findings, REUD may be beneficial for the treatment of AD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제16권1호
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• pp.33-46
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• 2005

본고에서는 인간의 뇌 발달과 주의력, 지각, 기억, 언어 등 다양한 인지기능의 발달과의 관계를 살펴본 후, Luria의 발달 신경심리 이론 및 그에 입각하여 개발된 아동용 Luria-Nebraska신경심리검사를 간략하게 소개하였다. 마지막으로, 현재 국내, 외에서 널리 사용되는 주의력 검사, 시-지각 검사, 시각-운동 협응 능력 검사, 그리고 전두엽의 집행기능검사 등을 포함한 아동용 신경심리 평가도구에 대해 고찰해보았다.

• 생물정신의학
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• 제4권1호
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• pp.12-18
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• 1997

In this article neuroanatomical theory and verbal developmental process were introduced, followed that disorders and assesment of language function were reviewed. Finally, the causes and assesment of developmental dyslexia as a childhood disorder related to verbal function were reviewed.

• 수면정신생리
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• 제2권2호
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• pp.105-114
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• 1995

Schiophrenia is characterized by a variety of cognitive dysfunctions. A number of research findings suggest that schizophrenic patients have global deficits in cognitive functions, such as attention, memory, executive functions, and motor functions. These cognitive deficits, once they arise, tend to become relatively stable. In spite of much efforts to search for the cognitive dysfunctions in schizophrenia, there are no specific deficits or localizations found. It is necessary that future neuropsychological research of schizophrenia should include relationships between symptoms and cognitive dysfunctions and their relationships to treatment.

• 생물정신의학
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• 제7권2호
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• pp.186-190
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• 2000

Objective : The authors experienced that cognitive behavioral therapy(CBT) could replace medication for controlling panic attacks and anticipatory anxiety symptoms. The objective of this study was finding out predicting factors of discontinuation of medication after CBT for patients with panic disorder. Method : A hundred forty-eight patients who met DSM-IV criteria for panic disorder with or without agoraphobia for at least 3 months had completed 12 weekly sessions of Panic Control Therapy(PCT ; Barlow et al). Eighty-one patients who could discontinue medication and sixty-seven patients who could not discontinue medication were measured with several scales as the pre- and post-treatment aassessment. The scales were Beck Depression Inventory(BDI), Clinical Global Impression(CGI), Spielberger State Anxiety Inventory(STAI-state), Anxiety Sensitivity Index(ASI), Body Sensation Questionnaire (BSQ), Panic Belief Questionnaire(PBQ), Agoraphobic Cognition Questionnaire(ACQ), Fear Questionnaire(FQ), Toronto Alexithymia Scale(TAS). Results : At the pre-treatment assessment, the scores of BDI, CGI, STAI-state, ACQ, BSQ were higher in the patients who could discontinue medication than in the patients who could not discontinue medication(t=-2.68, t=-4.88, t=-3.07, t=-3.68, t=-3.35, p<0.01). Conclusion : Patients with panic disorder who were less depressed, less anxious, less agoraphobic and who had less negative cognitions for the bodily sensation and who had higher scores in the therapist's assessment could discontinue their medications.

• 융합정보논문지
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• 제9권7호
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• pp.145-152
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• 2019

본 연구는 뇌졸중 환자를 대상으로 상호작용식 메트로놈 훈련이 관리기능에 미치는 효과에 대해서 알아보고자 실시하였다. 뇌졸중 환자 20명을 대상으로 실험군 10명, 대조군 10명으로 무작위 배분하였다. 실험군은 기본적인 재활치료와 상호작용식 메트로놈을 적용하였고, 대조군은 기본적 재활치료와 전통적 인지재활을 실시하였다. 훈련 전 후 관리기능을 검사하기 위하여 Kims 전두엽 관리기능 신경심리검사 II를 실시하였다. 연구 결과 실험군이 대조군에 비해 스트룹 간섭시행, 단어유창성, 지연회상, 관리기능지수에서 유의한 향상을 나타냈다. 따라서 상호작용식 메트로놈 훈련이 관리기능 향상에 효과적으로 것으로 나타났으며, 상호작용식 메트로놈 훈련이 관리기능 향상을 위한 중재방법으로 유용할 것으로 기대한다.

• 생물정신의학
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• 제4권1호
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• pp.3-11
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• 1997

Disturbances in memory are the most common problem in patients with an organic mental syndrome. Other patients with significant psychiatric disorders also often have difficulty with memory. So it is very important in the clinical practice of psychiatry to understand the biological and neurocognitive mechanisms of memory proessing, and to develop the assessment tools with which memory function can be evaluated reliably and validly. Moreover, memory researches provide an important viewpoint from which we can understand the pathophysiological mechanisms of major neuropsychiatric illnesses. This article focuses on our understanding of memory functions in clinical and neurobiological aspects. The relevant material will be presented in four parts : 1) terminologies needed in defining major stages of various types of memory processing : 2) neurochemical and neuroanatomical basis of memory processing : 3) brief bed-side screening tests and more comprehensive neuropsychological tests for the evaluation of memory function : 4) the characteristics of memory dysfunction in several major psychiatric illnesses.