• Journal of Oriental Neuropsychiatry
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• v.23 no.2
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• pp.85-98
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• 2012

Objectives : The histrionic personality disorder(HPD) is characterized by a pattern of excessive emotion and attention-seeking behavior, including a seductive behavior. It is known that HPD is closely related to a somatization disorder. The somatization disorder is characterized with various physical symptoms that have no pathologic manifestation. This report is on a case of 55 years old woman with HPD, who has been suffering from various physical symptoms that are coincided with diagnostic criteria for somatization disorder by DSM-IV. Methods : The patient was treated with oriental medical treatments (acupuncture, moxibustion, cupping therapy, and herb-medication), hypnotic therapy, and emotional freedom techniques. The effects of treatment were measured by VAS. Results : Chest pain was improved by hypnotic therapy and oriental medical treatments. But the patient's pantalgia and abdominal discomfort were controlled effectively by emotional freedom techniques. Conclusions : This result suggests that EFT might be effective for the defensive and dependent somatization disorder patient with HPD.

• Journal of Oriental Neuropsychiatry
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• v.23 no.2
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• pp.67-84
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• 2012

Objectives : The purpose of this study is to evaluate the effects of Yeongkyekamjo-tang on patients with menopausal disorder. Methods : We recruited 3 patients with menopausal disorder, who have been suffering from palpitation and depression. In addition, the patients had been administrated Yeongkyekamjo-tang. The patients of menopausal disorder had been estimated with Kupperman's index, Beck's Depression Inventory, The Menopause Quiz of Argosy University, visual analogue scale and Heart rate variability. We measured the Kupperman's index, Beck's Depression Inventory and The Menopause Quiz of Argosy University for every seven days. The heart rate variability was estimated twice, before and after the treatment. Results : After the treatments, symptoms of menopausal disorder were decreased. Conclusions : This study suggests that Yeongkyekamjo-tang is significantly effective on patients with menopausal disorder as well as palpitation and depression.

• Journal of Oriental Neuropsychiatry
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• v.21 no.3
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• pp.87-93
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• 2010

Objectives : The oriental medicine Jangwonhwan originally described in the Korean medical text, DonguiBogam(amnesia chapter). Recently, a modified formula of Jangwonhwan(LMK02-Jangwonhwan), was shown to reduce $\beta$-amyloid deposition in the brain of Tg-APPswe/PS1dE9 mouse model for Alzheimer's disease. This experiment aimed to investigate the acute oral toxicity of LMK02 in SD rats by up-and-down procedure determinations. Methods : Quality control of tablet form of LMK02 was established by estimating indicative components, Ginsenoside Rg3 of Red Ginseng and Decursin of Angelicagigas Nakai. The toxicity of LMK02 was investigated in 6 week old, specific pathogen free(SPF), Sprageu-Dawley rats. 3 female rats received 5,000 mg/10 ml/kg of test substance and their death rate, clinical sings, weight changes and autopsy findings had been observed for 2 weeks. Results : Any specific symptoms or death were resulted in this experiment. No significant changes in rats' weight. No significant differences in atopsy. Conclusions : The minimum lethal dose(MLD) of LMK02 for female Sprauge-Dawley rats were more than 5,000mg/kg in this experiment.

• Journal of Oriental Neuropsychiatry
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• v.24 no.2
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• pp.145-154
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• 2013

Objectives : The purpose of this study is to examine the effects of treatment with scalp acupunctures for children with learning disorders. Methods : For this study, we evaluated Korea standard progressive matrices test (K-SPM) on 24 children with learning disorders who visited Korean medical center neuropsychiatry outpatient clinic from July 2012 to January 2013. Scalp acupuncture, cognitive enhancement therapy and speech-language therapy were applied. All children were treated 2 times a week for 4 months and we compared K-SPM test scores before treatment and 30 times after the treatment. Results : 1) After the treatment, K-SPM test scores have increased significantly (p<0.05) and the number of children in grade 5 (<5%) have decreased from 14 to 6. 2) Comparing K-SPM test scores between two groups: one with medical history and the other without medical history, the scores in both groups have increased significantly (p<0.05). 3) We also divided the children into two groups according to age: under the age of 13 and over the age of 13, and compared K-SPM test scores. Although the scores in both groups have increased respectively, it is the scores of the former group (under the age of 13) that have increased significantly (p<0.05). Conclusions : The treatments with scalp acupunctures were shown to be an effective intervention when improving K-SPM test scores of children with learning disorders.

• Journal of Oriental Neuropsychiatry
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• v.31 no.3
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• pp.135-147
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• 2020

Objectives: Hwa-byung is a mental illness. It is also known as a Korean culture-related syndrome. In traditional Korean medicine, Sihogayonggolmoryeo-tang is used to treat Hwa-byung related neuropsychiatric symptoms. The purpose of this research was to examine the effect of Sihogayonggolmoryeo-tang on Hwa-byung. Methods: A multicenter, randomized, double-blinded, placebo-controlled study was performed for 160 patients with Hwa-byung. Patients were divided into a Sihogayonggolmoryeo-tang group and a placebo group. Treatment period was 8 weeks. Hamilton Rating Scale for Anxiety (HAM-A), Likert scale for major symptoms of Hwa-byung, Hwa-byung Scale (HBS), Korean Beck Depression Inventory (K-BDI), Korean State-Trait Anxiety Inventory (K-STAI), Korean State-Trait Anger Expression Inventory (K-STAXI), and Korean WHO Quality of Life Scale Abbreviated Version (WHOQOL-BREF) were used to evaluate the effect of Sihogayonggolmoryeo-tang on Hwa-byung. We also used an Instrument of Pattern Identification for Hwa-Byung to evaluate different responses for six patterns of patients. Results: Scores of all the measurements improved significantly for each group, showing no significant differences between the two groups. In the case of deficiency of both Qi and blood pattern, the Sihogayonggolmoryeo-tang group showed a significant decrease in the HAM-A score compared to the placebo group. Conclusions: The effect of Sihogayonggolmoryeo-tang on Hwa-byung did not exceed that of the placebo. Further studies involving more elaborate pattern identification are needed.

• Journal of Oriental Neuropsychiatry
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• v.31 no.3
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• pp.149-156
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• 2020

Objectives: The purpose of this study was to experimentally assess the effects of Chengsimyeonjatanggagam extracts in the animal model regarding ADHD related symptoms and indicators. Methods: The experimental group was classified into the normal group (WKY rat) in 7, the control group (SHR rat) in 7, the low-concentration group of herbal medicines (SHR rat) in 7, and the high-concentration group of herbal medicines (SHR rat) in 7 by random sampling. The open field test was conducted three times on the 7th, 14th, and 21st days during the oral medication. After that, Y-maze test, intestinal permeability verification (L/M ratio), and Western blotting (CDK expression in the cerebral cortex) were performed in sequence. Results: The Chengsimyeonjatang-gagam extracts reduced the activity distance in the SHR rat at 21 days in the low and high concentration groups by the open field test. It also reduced the cross-action rate in the low and high concentration groups by the Y-maze test. And the low concentration group showed 52.3% decrease in the L/M ratio compared to the SHR group. Finally, the CDK5 protein significantly increased in the low and high concentration groups. Conclusions: This study suggests that the Chengsimyeonjatang-gagam extracts have potential to be used for the treatment of ADHD.

• Anxiety and mood
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• v.8 no.2
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• pp.113-119
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• 2012

Objective : The purpose of this study is to assess the utility of clinician administered posttraumatic stress disorder scale (CAPS) to diagnose combat related posttraumatic stress disorder (PTSD) in Korean veterans of the Vietnam War. Methods : Sixty-one Korean male veterans of the Vietnam war participated in this study. We compared the diagnostic values of CAPS, Korean version of mini international neuropsychiatric interview (MINI) against the Structured Clinical Interview for DSM-IV (SCID) in diagnosing PTSD. Results : The overall internal consistency of CAPS was 0.93. Compared to the SCID, total severity 45 (TSEV45) showed the best results among 5 CAPS scoring rules. In detail, sensitivity was 71.4%, specificity was 85.1, positive predictive value was 58.8%, negative predictive value was 90.9%, and accuracy was 82.0. Conclusion : CAPS was demonstrated as a reliable tool to diagnose combat related PTSD in the elderly. The optimum CAPS scoring was TSEV45.

• Anxiety and mood
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• v.8 no.2
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• pp.106-112
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• 2012

Objective : In posttraumatic stress disorder (PTSD), it is essential to evaluate the severity of trauma with a reliable instrument. The combat exposure scale (CES) is one of the most widely used measures for the combat-related trauma. The present study was conducted to test the reliability and validity of the Korean version of CES (CES-K). Methods : One hundred and forty-five male Korean veterans of the Vietnam War participated in this study. CES-K, the structured clinical interview for DSM-III-R (SCID), clinician administered PTSD scale (CAPS), and the Korean version life events checklist (LEC-K) were administered. Results : Cronbach's coefficient of CES-K was .85, and the test-retest reliability was .94. The mean [standard deviation (SD)] scores of CES-K were 20.4 (9.0) in the PTSD group and 12.0 (8.6) in the non-PTSD group (p<.001). CES-K showed a significant correlation with LEC-K (r=.31, p<.001) and CAPS (r=.52, p<.001). Only one factor was revealed by the factor analysis. Conclusion : CES-K showed good reliability and validity for assessing the severity of combat exposure. Further, it demonstrated comparable psychometric properties to the previous study. It is expected that CES-K will be a useful tool for evaluating the severity of combat exposure in Korea.

• Journal of Oriental Neuropsychiatry
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• v.16 no.1
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• pp.129-142
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• 2005

Objectives : This study was to investigate MMPI profile on clinical scales and personality scales of Panic Disorder patients. Methods : Thirty eight Panic Disorder patients and twenty eight normal control were administered the MMPI. Experimental design was done by nonequivalent control group and statistics were crosstabs, chi-square test, ANOVA, t-test and cluster analysis Results and Conclusions : 1. The MMPI clinical scales profile of Panic Disorder patients was neurotic profile of 2-7 type. Panic Disorder patients was elevated the other scales except L, K, Mf and Ma scales for control group. 2. A result of grouping MMPI in Panic Disorder patients, we could classify into 3 different groups. Group 1 is a profile of conversional neurosis. Group 2 is a normal proflie. Group 3 is a proflie of $'{\Lambda}'$ type neurosis. 3. Personality characteristics in Panic Disorder patients was lowed scores in HST, NAR scales, elevated the other scales except ANT scale. Specially in PAG, AVD scales showed high scores.

• Journal of Oriental Neuropsychiatry
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• v.22 no.4
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• pp.125-134
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• 2011

Objectives : This study was designed to report the effect of Jawon(Ziuan)'s purgative action for insomnia. Methods : A 60 year-old male patient has been suffered from insomnia for 2 years and has been on taking sleeping tablets during about a year and a half. We administered Sihogayonggolmoryeo-tang because we thougt that the disease was So-Yang-Bing Li Jeung. And Jawon was added for quick improvement. Results : 1. The score of PSQI(Pittsburgh Sleep Quality Index) decreased from 18 to 16 after the patient tooks Sihogayonggolmoryeo-tang. 2. After 23 days, the patient tooks Sihogayonggolmoryeo-tang with Jawon at the same time. With the purgative action with Jawon appearing, the score of PSQI decreased from 16 to 4 extremely and accompanying symptoms were also improved. Conclusions : In this case, for the patient taking Sihogayonggolmoryeo-tang with Jawon at the same time is far more effective than only doing Sihogayonggolmoryeo-tang. The result was more improved with appearing the effect of purgative action.