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http://dx.doi.org/10.7231/jon.2020.31.3.135

Effect of Sihogayonggolmoryeo-Tang on Hwa-byung: A Multicenter, Randomized, Double-Blinded, Placebo-Control Trial  

Choi, Woo-Chang (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University)
Lee, Hun-Soo (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University)
Kim, Ju-Yeon (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University)
Kang, Wee-Chang (Department of Statistics, H-LAC, Daejeon University)
Park, Yang-Chun (Department of Internal Medicine, College of Korean Medicine, Daejeon University)
Kim, Geun-Woo (Department of Neuropsychiatry, Dongguk University Bundang Oriental Hospital)
Kim, Jong-Woo (Department of Neuropsychiatry, College of Korean Medicine, Kyung Hee University)
Jung, In Chul (Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Oriental Neuropsychiatry / v.31, no.3, 2020 , pp. 135-147 More about this Journal
Abstract
Objectives: Hwa-byung is a mental illness. It is also known as a Korean culture-related syndrome. In traditional Korean medicine, Sihogayonggolmoryeo-tang is used to treat Hwa-byung related neuropsychiatric symptoms. The purpose of this research was to examine the effect of Sihogayonggolmoryeo-tang on Hwa-byung. Methods: A multicenter, randomized, double-blinded, placebo-controlled study was performed for 160 patients with Hwa-byung. Patients were divided into a Sihogayonggolmoryeo-tang group and a placebo group. Treatment period was 8 weeks. Hamilton Rating Scale for Anxiety (HAM-A), Likert scale for major symptoms of Hwa-byung, Hwa-byung Scale (HBS), Korean Beck Depression Inventory (K-BDI), Korean State-Trait Anxiety Inventory (K-STAI), Korean State-Trait Anger Expression Inventory (K-STAXI), and Korean WHO Quality of Life Scale Abbreviated Version (WHOQOL-BREF) were used to evaluate the effect of Sihogayonggolmoryeo-tang on Hwa-byung. We also used an Instrument of Pattern Identification for Hwa-Byung to evaluate different responses for six patterns of patients. Results: Scores of all the measurements improved significantly for each group, showing no significant differences between the two groups. In the case of deficiency of both Qi and blood pattern, the Sihogayonggolmoryeo-tang group showed a significant decrease in the HAM-A score compared to the placebo group. Conclusions: The effect of Sihogayonggolmoryeo-tang on Hwa-byung did not exceed that of the placebo. Further studies involving more elaborate pattern identification are needed.
Keywords
Hwa-byung; Sihogayonggolmoryeo-tang; Clinical trial; Randomized; Placebo-control study;
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Times Cited By KSCI : 5  (Citation Analysis)
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