• Journal of the Korean Society of Radiology
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• v.17 no.7
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• pp.1165-1170
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• 2023

In this study, we aimed to develop a cost-effective neuro-modulation device for use in neuroscientific and clinical medical imaging applications. To achieve this, we designed and fabricated a brain neuro-modulation device with a material cost of less than $500, and subsequently evaluated its performance. The measured performance was found to be comparable to existing medical devices (TENS), with the developed device being compact in size, measuring less than 3 cm by 3 cm. The outcomes of this study are expected to be applicable in accelerating research and development in related fields, as well as in the rapid commercialization of neuro-modulation technology. Furthermore, it is anticipated that this work will contribute to advancements in functional radiological medical imaging technology and enhance accessibility to brain science and brain stimulation technology.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.05a
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• pp.1259-1260
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• 2005

• Journal of the Korean Society of Physical Medicine
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• v.2 no.2
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• pp.173-182
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• 2007

Purpose : The purpose of this study was carried out to review for the importance of breathing pattern training for the spinal stabilization. Methods : This is a literature study with books and thesis. Results : Breathing with normal respiratory mechanics has a potent role in neuro-musculo-skeletal system. The evaluation of respiratory mechanics should be a routine part of every physical examination. And respiratory mechanics must be intact for both normal posture and spinal stabilization to be possible. Conclusion : The spinal stabilization exercise with the breathing pattern training is more efficient therapeutic exercise program for the patient with neuro-musculo-skeletal system disorder.

• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.92-100
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• 2019

Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this study, a ginger constituent, 12-dehydrogingerdione (DHGD) was proven that has comparable anti-inflammatory activity with positive control 6-shogaol in inhibiting LPS-induced interleukin (IL)-6, tumor necrosis factor $(TNF)-{\alpha}$, prostaglandin (PG) $E_2$, nitric oxide (NO), inducible NO synthase (iNOS) and cyclooxygenase (COX)-2, without interfering with COX-1 in cultured microglial cells. Subsequent mechanistic studies indicate that 12-DHGD may inhibit neuro-inflammation through suppressing the LPS-activated $Akt/IKK/NF-{\kappa}B$ pathway. Furthermore, 12-DHGD markedly promoted the activation of NF-E2-related factor (Nrf)-2 and heme oxygenase (HO)-1, and we demonstrated that the involvement of HO-1 on the production of pro-inflammatory mediators such as NO and $TNF-{\alpha}$ by using a HO-1 inhibitor, Zinc protoporphyrin (Znpp). These results indicate that 12-DHGD may protect against neuro-inflammation by inhibiting $Akt/IKK/I{\kappa}B/NF-{\kappa}B$ pathway and promoting Nrf-2/HO-1 pathway.

• Molecules and Cells
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• v.42 no.5
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• pp.418-425
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• 2019

Multicistronic elements, such as the internal ribosome entry site (IRES) and 2A-like cleavage sequence, serve crucial roles in the eukaryotic ectopic expression of exogenous genes. For utilization of multicistronic elements, the cleavage efficiency and order of elements in multicistronic vectors have been investigated; however, the dynamics of multicistronic element-mediated expression remains unclear. Here, we investigated the dynamics of encephalomyocarditis virus (EMCV) IRES- and porcine teschovirus-1 2A (p2A)-mediated expression. By utilizing real-time fluorescent imaging at a minute-level resolution, we monitored the expression of fluorescent reporters bridged by either EMCV IRES or p2A in two independent cultured cell lines, HEK293 and Neuro2a. We observed significant correlations for the two fluorescent reporters in both multicistronic elements, with a higher correlation coefficient for p2A in HEK293 but similar coefficients for IRES-mediated expression and p2A-mediated expression in Neuro2a. We further analyzed the causal relationship of multicistronic elements by convergent cross mapping (CCM). CCM revealed that in all four conditions examined, the expression of the preceding gene causally affected the dynamics of the subsequent gene. As with the cross correlation, the predictive skill of p2A was higher than that of IRES in HEK293, while the predictive skills of the two multicistronic elements were indistinguishable in Neuro2a. To summarize, we report a significant temporal correlation in both EMCV IRES- and p2A-mediated expression based on the simple bicistronic vector and real-time fluorescent monitoring. The current system also provides a valuable platform to examine the dynamic aspects of expression mediated by diverse multicistronic elements under various physiological conditions.

• Journal of the Korean Applied Science and Technology
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• v.25 no.4
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• pp.438-445
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• 2008

For recipe prediction of colorant proportion showing nonlinear behavior, we modeled the effects of colorant proportion of basic colors on the target colors and predicted colorant proportion necessary for making target colors. First, colorant proportion of basic colors and color information indicated by the instrument was applied by a linear model and a multi-layer perceptrons model with back-propagation learning method. However, satisfactory results were not obtained because of nonlinear property of colors. Thus, in this study the neuro-fuzzy model with merit of artificial neural networks and fuzzy systems was presented. The proposed model was trained with test data and colorant proportion was predicted. The effectiveness of the proposed model was verified by evaluation of color difference(${\Delta}E$).

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.871-877
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• 2002

현재 공작기계의 상당부분에서 자동화 및 무인화가 이루어지고 있는 추세이며, 이러한 대부분의 산업시설들과 기계류에는 회전체 부품들을 가지고 있다. 이들 부품들에서 베어링(Bearing)은 절대적으로 매우 중요한 부분을 차지하고 있으며, 만일 회전축시스템(Rotor System)에 베어링의심각한 이상은 시스템이 정지되는 사태를 불러일으킬 수도 있다. 따라서 이상에 대한 조기 감지의 역할은 전체 시스템의 향상뿐만 아니라, 비용이나 시간적인 측면에서도 크나큰 이익을 가져다 줄 수 있다. 지금까지 이러한 회전축시스템에 대한 다양한 이상진단을 시도하여 왔으며 앞으로도 많은 종류의 이상진단이 이루어지리라 생각한다. 이런 다양한 형태의 이상진단은 시스템에서 추출되는 데이터를 여러 가지 기법과 추출하는 센서의 특징을 파악하여 이상진단 알고리즘을 수립하는 과정을 망라하게 된다. 특히 이상진단 알고리즘에는 측정된 데이터의 불확실성을 감안한 이론이 적용되어야 한다. 본 연구에서는 회전축시스템의 베어링에 대한 이상진단을 통계적 기법, Fuzzy Clustering, Neural network과 Neuro-fuzzy를 이용한 기법과의 상호비교를 통해서 여러 종류의 이상을 구분하는 작업수행을 연구하고자 한다.

• International journal of advanced smart convergence
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• v.12 no.1
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• pp.199-207
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• 2023

Trend Impact Analysis is a prominent hybrid method has been used in future studies with a modified surprise- free forecast. It considers experts' perceptions about how future events may change the surprise-free forecast. It is an advanced forecasting tool used in futures studies for identifying, understanding and analyzing the consequences of unprecedented events on future trends. In this paper, we propose an advanced mechanism to generate more justifiable estimates to the probability of occurrence of an unprecedented event as a function of time with different degrees of severity using adaptive neuro-fuzzy inference system (ANFIS). The key idea of the paper is to enhance the generic process of reasoning with fuzzy logic and neural network by adding the additional step of attributes simulation, as unprecedented events do not occur all of a sudden but rather their occurrence is affected by change in the values of a set of attributes. An ANFIS approach is used to identify the occurrence and severity of an event, depending on the values of its trigger attributes.

• Molecules and Cells
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• v.45 no.2
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• pp.76-83
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• 2022

Neurons-on-a-Chip technology has been developed to provide diverse in vitro neuro-tools to study neuritogenesis, synaptogensis, axon guidance, and network dynamics. The two core enabling technologies are soft-lithography and microelectrode array technology. Soft lithography technology made it possible to fabricate microstamps and microfluidic channel devices with a simple replica molding method in a biological laboratory and innovatively reduced the turn-around time from assay design to chip fabrication, facilitating various experimental designs. To control nerve cell behaviors at the single cell level via chemical cues, surface biofunctionalization methods and micropatterning techniques were developed. Microelectrode chip technology, which provides a functional readout by measuring the electrophysiological signals from individual neurons, has become a popular platform to investigate neural information processing in networks. Due to these key advances, it is possible to study the relationship between the network structure and functions, and they have opened a new era of neurobiology and will become standard tools in the near future.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2004.11a
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• pp.95-99
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• 2004