Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway |
Zhao, Dong
(Natural Products Research Center, Korea Institute of Science and Technology)
Gu, Ming-Yao (Natural Products Research Center, Korea Institute of Science and Technology) Xu, Jiu Liang (Natural Products Research Center, Korea Institute of Science and Technology) Zhang, Li Jun (Natural Products Research Center, Korea Institute of Science and Technology) Ryu, Shi Yong (Research Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology) Yang, Hyun Ok (Natural Products Research Center, Korea Institute of Science and Technology) |
1 | Wang, L., Chen, Y., Sternberg, P., Cai, J. (2008) Essential roles of the PI3K/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE. Invest. Ophthalmol. Vis. Sci. 49, 1671-1678. DOI |
2 | Young, H. Y., Luo, Y. L., Cheng, H. Y., Hsieh, W. C., Liao, J. C. and Peng, W. H. (2005) Analgesic and anti-inflammatory activities of [6]-gingerol. J. Ethnopharmacol. 96, 207-210. DOI |
3 | Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M. and Karin, M. (1997) The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91, 243-252. DOI |
4 | Zhao, D., Kwon, S. H., Chun, Y. S., Gu, M. Y. and Yang, H. O. (2017) Anti-neuroinflammatory effects of fucoxanthin via inhibition of Akt/NF-kappaB and MAPKs/AP-1 pathways and activation of PKA/CREB pathway in lipopolysaccharide-activated BV-2 microglial cells. Neurochem. Res. 42, 667-677. DOI |
5 | Han, Y. A., Song, C. W., Koh, W. S., Yon, G. H., Kim, Y. S., Ryu, S. Y., Kwon, H. J. and Lee, K. H. (2013) Anti-inflammatory effects of the Zingiber officinale roscoe constituent 12-dehydrogingerdione in lipopolysaccharide-stimulated Raw 264.7 cells. Phytother. Res. 27, 1200-1205. DOI |
6 | Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G. M., Cooper, N. R., Eikelenboom, P., Emmerling, M., Fiebich, B. L., Finch, C. E., Frautschy, S., Griffin, W. S., Hampel, H., Hull, M., Landreth, G., Lue, L., Mrak, R., Mackenzie, I. R., McGeer, P. L., O'Banion, M. K., Pachter, J., Pasinetti, G., Plata-Salaman, C., Rogers, J., Rydel, R., Shen, Y., Streit, W., Strohmeyer, R., Tooyoma, I., Van Muiswinkel, F. L., Veerhuis, R., Walker, D., Webster, S., Wegrzyniak, B., Wenk, G. and Wyss-Coray, T. (2000) Inflammation and Alzheimer's disease. Neurobiol. Aging 21, 383-421. DOI |
7 | Baeuerle, P. A. and Henkel, T. (1994) Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12, 141-179. DOI |
8 | Bai, D., Ueno, L. and Vogt, P. K. (2009) Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt. Int. J. Cancer 125, 2863-2870. DOI |
9 | Gupta, S. C., Sundaram, C., Reuter, S. and Aggarwal, B. B. (2010) Inhibiting NF-kappaB activation by small molecules as a therapeutic strategy. Biochim. Biophys. Acta 1799, 775-787. DOI |
10 | Ha, S. K., Moon, E., Ju, M. S., Kim, D. H., Ryu, J. H., Oh, M. S. and Kim, S. Y. (2012) 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. Neuropharmacology 63, 211-223. DOI |
11 | Infante-Duarte, C., Waiczies, S., Wuerfel, J. and Zipp, F. (2008) New developments in understanding and treating neuroinflammation. J. Mol. Med. 86, 975-985. DOI |
12 | Jeong, Y. H., Park, J. S., Kim, D. H. and Kim, H. S. (2016) Lonchocarpine increases Nrf2/ARE-mediated antioxidant enzyme expression by modulating AMPK and MAPK signaling in brain astrocytes. Biomol. Ther. (Seoul) 24, 581-588. DOI |
13 | Jung, J. S., Choi, M. J., Lee, Y. Y., Moon, B. I., Park, J. S., Kim, H. S. (2017) Suppression of Lipopolysaccharide-induced Neuroinflammation by Morin via MAPK, PI3K/Akt, and PKA/HO-1 Signaling Pathway Modulation. J. Agric. Food Chem. 65, 373-382. DOI |
14 | Karin, M. and Delhase, M. (2000) The kinase (IKK) and NF-: key elements of proinflammatory signalling. Semin. Immunol. 12, 85-98. DOI |
15 | Koh, E. M., Kim, H. J., Kim, S., Choi, W. H., Choi, Y. H., Ryu, S. Y., Kim, Y. S., Koh, W. S. and Park, S. Y. (2009) Modulation of macrophage functions by compounds isolated from Zingiber officinale. Planta Med. 75, 148-151. DOI |
16 | Syapin, P. J. (2008) Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders. Br. J. Pharmacol. 155, 623-640. DOI |
17 | Park, M., Bae, J. and Lee, D. S. (2008) Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytother. Res. 22, 1446-1449. DOI |
18 | Piirainen, S., Youssef, A., Song, C., Kalueff, A. V., Landreth, G. E., Malm, T. and Tian, L. (2017) Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia? Neurosci. Biobehav. Rev. 77, 148-164. DOI |
19 | Rahmani, A. H., Shabrmi, F. M. and Aly, S. M. (2014) Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. Int. J. Physiol. Pathophysiol. Pharmacol. 6, 125-136. |
20 | Sizemore, N., Leung, S. and Stark, G. R. (1999) Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol. Cell. Biol. 19, 4798-4805. DOI |
21 | Tak, P. P. and Firestein, G. S. (2001) NF-kappaB: a key role in inflammatory diseases. J. Clin. Invest. 107, 7-11. DOI |
22 | Tan, B. S., Kang, O., Mai, C. W., Tiong, K. H., Khoo, A. S., Pichika, M. R., Bradshaw, T. D. and Leong, C. O. (2013) 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor gamma (PPARgamma). Cancer Lett. 336, 127-139. DOI |
23 | Teismann, P., Tieu, K., Cohen, O., Choi, D. K., Wu, D. C., Marks, D., Vila, M., Jackson-Lewis, V. and Przedborski, S. (2003) Pathogenic role of glial cells in Parkinson's disease. Mov. Disord. 18, 121-129. DOI |
24 | Villarino, A. V., Kanno, Y. and O'Shea, J. J. (2017) Mechanisms and consequences of Jak-STAT signaling in the immune system. Nat. Immunol. 18, 374-384. DOI |
25 | Mattson, M. P. and Meffert, M. K. (2006) Roles for NF- in nerve cell survival, plasticity, and disease. Cell Death Differ. 13, 852-860. DOI |
26 | Kwon, D. H., Cha, H. J., Choi, E. O., Leem, S. H., Kim, G. Y., Moon, S. K., Chang, Y. C., Yun, S. J., Hwang, H. J., Kim, B. W., Kim, W. J., Choi, Y. H. (2018) Schisandrin A suppresses lipopolysaccharide-indcued inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-B, MAPKs and PI3K/Akt pathways and activating Nrf2/HO-1 signaling. Int. J. Mol. Med. 41, 264-274. DOI |
27 | Lee, H. Y., Park, S. H., Lee, M., Kim, H. J., Ryu, S. Y., Kim, N. D., Hwang, B. Y., Hong, J. T., Han, S. B. and Kim, Y. (2012) 1-Dehydro-[10]-gingerdione from ginger inhibits IKKbeta activity for NF-kappaB activation and suppresses NF-kappaB-regulated expression of inflammatory genes. Br. J. Pharmacol. 167, 128-140. DOI |
28 | Li, F., Nitteranon, V., Tang, X., Liang, J., Zhang, G., Parkin, K. L. and Hu, Q. (2012) In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. Food Chem. 135, 332-337. DOI |
29 | Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J., Young, D. B., Barbosa, M., Mann, M., Manning, A. and Rao, A. (1997) IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278, 860-866. DOI |
30 | Ozes, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M. and Donner, D. B. (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401, 82-85. DOI |
31 | Pan, M. H., Hsieh, M. C., Hsu, P. C., Ho, S. Y., Lai, C. S., Wu, H., Sang, S. and Ho, C. T. (2008) 6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. Mol. Nutr. Food Res. 52, 1467-1477. DOI |
32 | Dendorfer, U., Oettgen, P. and Libermann, T. A. (1994) Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol. Cell. Biol. 14, 4443-4454. DOI |
33 | Choi, D. K., Koppula, S. and Suk, K. (2011) Inhibitors of microglial neurotoxicity: focus on natural products. Molecules 16, 1021-1043. DOI |
34 | Cianciulli, A., Calvello, R., Porro, C., Trotta, T., Salvatore, R. and Panaro, M. A. (2016) PI3K/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-acivated microglia. Int. Immunopharmacol. 36, 282-290 DOI |
35 | Cuadrado, A., Martin-Moldes, Z., Ye, J. and Lastres-Becker, I. (2014) Transcription factors NRF2 and NF-kappaB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation. J. Biol. Chem. 289, 15244-15258. DOI |
36 | Dugasani, S., Pichika, M. R., Nadarajah, V. D., Balijepalli, M. K., Tandra, S. and Korlakunta, J. N. (2010) Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J. Ethnopharmacol. 127, 515-520. DOI |
37 | El-Ashmawy, N. E., Khedr, N. F., El-Bahrawy, H. A. and Abo Mansour, H. E. (2017) Ginger extract adjuvant to doxorubicin in mammary carcinoma: study of some molecular mechanisms. Eur. J. Nutr. 57, 981-989. |
38 | Giulian, D. and Baker, T. J. (1986) Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6, 2163-2178 DOI |
39 | Grzanna, R., Lindmark, L. and Frondoza, C. G. (2005) Ginger--an herbal medicinal product with broad anti-inflammatory actions. J. Med. Food 8, 125-132. DOI |
40 | Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C. and Gage, F. H. (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140, 918-934. DOI |