• Journal of Korean Public Health Nursing
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• 제7권2호
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• pp.39-52
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• 1993

The primary purpose of this study is to promote and establish the development of home health care in Korea. It focuses on identifying and classifying the nursing activities that were provided by health professionals for patients who were admitted to two hospitals with cerebral vascular disease. And also. the study was conducted for comparison of client selection criteria between health professionals, and identifying patients who needed home health care The subjects of this study were 38 patients with cerebral vascular disease who were admitted to neuro-surgery wards at 2 hospitals with more than 500 beds in Daegu from November 1. through 30. 1991. Survey instruments were questionnaires to identify nursing activities and classify patients who needed home health care. Data was collelected by 1 doctor and 2 nurses per patient independently. They checked the same patient with the questionnaire on the same day and never communicated their information about patients with each other. All the questionnaires checked by doctor and nurses completely were 90. Statistical methods for analyzing data were non-parametric tests (Kruskal Wallice test and sign test). Correlation and percentages were used for further analysis. From this study. the following summarized conclusions have been drawn. 1. 10. 2 kinds of treatment and nursing activities were provided by health professionals for patients with cerebral vascular disease in hospital. 2. The points of nursing needs were between 32-37 out of a total of 500 as a result of the assessment about the health status of patients who were admitted to neuro-surgery ward with cerebral vascular disease. The points of Barthel Index of Functional Status Assessing Devices were between 24-34. Client Selection Criteria for Home Health Care was congruent between the Health professionals because the difference were not found to be statistically significant. 3. Patients classfied as home health care clients were $70-80\%$ of all patients who were admitted in hospital. There was not significant difference in patient selection criteria for home health care between health professionals statistically. As a result. the validity of different tools used in classifying home health care client were found to be congruent. 4. $80-85\%$ patients who could be discharged and sent to their homes early were identified as home health care clients. This study using client selection criteria. for home health care contributed to tool development because the validity of tools was verified. And also, this research represented that there was congruency in patient selection criteria for home health care between different health professionals. As a result, this study represented that many patients who were admitted to hospitals could be classified as a home health care clients. On the basis of the findings. further studies are required to develop client selection criteria using universal tools for classifying home health care clients in other chronic diseases. It is also recommended that comparative studies for client selection criteria between health professionals treating in other chronic diseases are necessary.

• Advances in Traditional Medicine
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• 제6권4호
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• pp.253-263
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• 2006

The plant is used in India as well as several countries since several centuries for treating different types of ailments. The plant is an important constituent of the Ayurvedic Materia Medica and finds mention in several ancient texts including Caraka Sanhita ($6^{th}$ century A.D.) and the Bhavprakasa ($16^{th}$ century A.D.). The scientific studies on this plant have reported several activities of this plant. Though the plant has cardiotonic, vasoconstrictor, sedative, neuro-muscular blocking, and anticancer activities, it is more popular as memory enhancer. Traditionally, a poultice made of the boiled plant is placed on the chest in acute bronchitis and coughs of children. The plant contains saponins: bacosides A and B, hersaponin, sapogenins: bacogenin $A_{1}$, $A_{2}$, and $A_{3}$ stigmasterol, and flavonoids: luteolin and luteolin-7 glucoside, nicotine, brahmine, and herpestine. This review focuses on the scientific data published since 1931.

• Proceedings of the KOSOMBE Conference
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.165-166
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• 1998

A multi-parameter neuro muscular electrical simulator (NMES) system was developed to be used to find the optimal parameter condition in obtaining maximum muscle power and minimal fatigue. Since the performance of NMES is mainly determined by the characteristic of its output-stage circuit, we implemented 3 different circuits and compared output characteristics of them. Three amplifier circuits are; 1) a resonant switching converter, 2) a linear amplifier with a transformer, and 3) a step-up DC/DC converter with a high-voltage linear amplifier. Experimental results showed that the step up DC/DC converter with a high-voltage linear amplifier has the best performance.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제5권1호
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• pp.157-176
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• 2011

An interest-based P2P constructs the peer connections based on similarities for efficient search of resources. A clustering technique using peer similarities as data is an effective approach to group the most relevant peers. However, the separation of groups produced from clustering lowers the scalability of a P2P network. Moreover, the interest-based approach is only concerned with user-level grouping where topology-awareness on the physical network is not considered. This paper proposes an efficient scalable search for the interest-based P2P system. A scalable multi-ring (SMR) based on fuzzy clustering handles the grouping of relevant peers and the proposed scalable search utilizes the SMR for scalability of peer queries. In forming the multi-ring, a minimized route function is used to determine the shortest route to connect peers on the physical network. Performance evaluation showed that the SMR acquired an accurate peer grouping and improved the connectivity rate of the P2P network. Also, the proposed scalable search was efficient in finding more replicated files throughout the peer network compared to other traditional P2P approaches.

• The Transactions of the Korean Institute of Electrical Engineers P
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• 제51권2호
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• pp.99-104
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• 2002

In this paper, we construct a hybrid intelligent controller based on a fusion scheme of GA(Genetic Algorithm) and FCM(Fuzzy C-Means) clustering-based ANFIS(Adaptive Neuro-Fuzzy Inference System). In the structure identification, a set of fuzzy rules are generated for a given criterion by FCM clustering algorithm. In the parameter identification, premise parameters are optimally searched by adaptive GA. On the other hand, consequent parameters are estimated by RLSE(Recursive Least Square Estimate) to reduce the search space. Finally, we applied the proposed method to the truck backer-upper control and obtained a better performance than previous works.

• Korean Journal of Food Science and Technology
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• 제6권3호
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• pp.158-162
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• 1974

The writer has undertaken a survey, against 467 urban university women students, of the fatigue due to their schoolwork and has intended to clarify the relationship between the fatigue and dietary. As a result, the following described conclusion was obtained: (1) The fatigue due to their schoolwork was found in an order of mental fatigue >physical fatigue> neuro-sensory fatigue among which their schoolwork was proved as a typical mental works. (2) It was found, in comparison of the health condition with the fatigue from schoolwork, that the frequencies of mental and neurosensory fatigue in which physical fatigue is excluded had a significant difference. (3) In an analysis of the fatigue rate in relation with the daily dietary, it was found that fatigue rate of the group which takes meat, egg, fish and milk every day showed a significantly lower rate over the group which takes these food occasionally.

• BMB Reports
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• 제49권2호
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• pp.128-133
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• 2016

Astrocytes play a critical role in normal brain functions and maintaining the brain microenvironment, and defects in astrocytogenesis during neurodevelopment could give rise to severe mental illness and psychiatric disorders. During neuro-embryogenesis, astrocytogenesis involves astrocytic differentiation of neural precursor cells (NPCs) induced by signals from ciliary neurotrophic factor (CNTF) or pituitary adenylate cyclase-activating peptide (PACAP). However, in contrast to the CNTF signaling pathway, the exact mechanism underlying astrocytic differentiation induced by PACAP is unknown. In the present study, we aimed to verify a signaling pathway specific to PACAP-induced astrocytogenesis, using exchange protein directly activated by cAMP2 (Epac2)-knockout mice. We found that PACAP could trigger astrocytic differentiation of NPCs via Epac2 activation and an increase in the intracellular calcium concentration via a calcium ion influx. Taken together, we concluded that astrocytogenesis stimulated by PACAP occurs through a novel signaling pathway independent from CNTF-JAK/STAT signaling, that is the well-known pathway of astrocytogenesis.

• Journal of Institute of Control, Robotics and Systems
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• 제5권2호
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• pp.189-199
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• 1999

This paper presents an optimization algorithm for a stable Self Dynamic Neural Network(SDNN) using genetic algorithm. Optimized SDNN is applied to a problem of controlling nonlinear dynamical systems. SDNN is dynamic mapping and is better suited for dynamical systems than static forward neural network. The real-time implementation is very important, and thus the neuro controller also needs to be designed such that it converges with a relatively small number of training cycles. SDW has considerably fewer weights than DNN. Since there is no interlink among the hidden layer. The object of proposed algorithm is that the number of self dynamic neuron node and the gradient of activation functions are simultaneously optimized by genetic algorithms. To guarantee convergence, an analytic method based on the Lyapunov function is used to find a stable learning for the SDNN. The ability and effectiveness of identifying and controlling a nonlinear dynamic system using the proposed optimized SDNN considering stability is demonstrated by case studies.

• Journal of Pharmaceutical Investigation
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• 제41권1호
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• pp.31-36
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• 2011

$5HT_{2C}$ receptor among fourteen 5-HT subtypes plays important roles in several disorders such as depression, anxiety, epilepsy, schizophrenia and sleep disorders. The purpose of the study is to investigate pharmacokinetic parameters and bioavailability of a newly synthesized selective agonist of $5-HT_{2C}$ receptor, KOPC-20010 (KP10) in rats after intravenous and oral administration for the development of therapeutic anti-obesity agents. KP10 was administered orally (40 mg/kg) or intravenously (20 mg/kg), blood was collected via a catheter, and analyzed by GC/MSD. The calibration curve of KP10 in plasma and urine showed high linearity ($r^2$ >0.999). The retention times of KP10 in plasma and urine were 8.7 and 9.7 min, respectively. After oral administration of 40 mg/kg, pharmacokinetic parameters were calculated as follows; $C_{max}$ value was $1242.9{\pm}1195.5$ ng/mL at $1.1{\pm}0.6$ hr ($T_{max}$). $AUC_{0->24hr}$ and $AUC_{0>{\infty}}$ were $8034.2{\pm}960.7$ and $10464.1{\pm}681.5\;ng{\cdot}hr/mL$, respectively. The terminal half-life was $21.9{\pm}7.6$ hr. $AUC_{0->24hr}$ and $AUC_{0>{\infty}}$ were $4292.4{\pm}523.0$ and $6111.2{\pm}756.2\;ng{\cdot}hr/mL$, respectively, after 20 mg/kg of intravenous administration. The terminal half-life after intravenous administration was $25.1{\pm}9.4$ hr. Bioavailability of KP10 was determined to 86%. The excretion amount into the urine within 48 hr was approximately 4.7 to 6.7% of the dose administered. These data may be beneficial to the anti-obesity drug development of KP10.

• The Korea Journal of Herbology
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• 제38권1호
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• pp.11-19
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• 2023

Objectives : Neuroinflammation is a common pathological mechanism of neurodegenerative diseases, and the development of therapeutic agents is urgently needed. Red ginseng has been known to be good for the immune stimulation in Eastern Asia. Although the immuno-stimulatory activity of red ginseng are already known, the neuro-protective effects of cultivated red ginseng with fermented complex mushroom-cereal mycelium (RGFM) have not been conducted. Thus, in this study, we tried to investigate the anti-neuroinflammatory effect of RGFM water extract on lipopolysaccharide (LPS) stimulated BV2 cells. Methods : BV2 cells were pretreated with RGFM 1 h prior to LPS exposure. To determine the neuro-protective effects of RGFM water extract, we measured the expression of inflammatory mediators including inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and nitric oxide (NO) and pro-inflammatory cytokines such as interleukin (IL)-1𝛽, IL-6 and tumor necrosis factor (TNF)-𝛼 in LPS-stimulated BV2 cells. In addition, to find out the regulatory mechanism of RGFM water extract, we assessed the protein levels of mitogen-activated protein kinases (MAPKs) and inhibitory 𝜅B𝛼 (I𝜅B𝛼) by western blotting. Results : In our study, treatment of RGFM reduced the mRNA expression of iNOS and COX-2 and suppressed NO production in LPS-stimulated BV2 cells. Additionally, the secretion of IL-1𝛽 and TNF-𝛼 but not IL-6 was significantly inhibited by RGFM. Furthermore, RGFM water extract inhibited the phosphorylation of c-Jun N-terminal kinase (JNK). Conclusions : Taken together, these findings suggest that RGFM water extract has a protective effect on neuroinflammation through inhibition of JNK.