Determination of Novel Synthetic 5HT2C Agonist KOPC20010 by Gas-Chromatography/Mass Spectrometry and its Bioavailability in Sprague-Dawley Rats |
Im, Hye-Yeon
(Doping Control Center, Korea Institute of Science and Technology (KIST))
Pae, Ae-Nim (Neuro-Medicine Center, Korea Institute of Science and Technology (KIST)) Yang, Ha-Yun (Neuro-Medicine Center, Korea Institute of Science and Technology (KIST)) Park, Woo-Kyu (Pharmacology Research Center, Korea Research Institute of Chemical Technology) Seo, Ji-Eun (Doping Control Center, Korea Institute of Science and Technology (KIST)) Haque, Md. Mamunul (Doping Control Center, Korea Institute of Science and Technology (KIST)) Kwon, Oh-Seung (Doping Control Center, Korea Institute of Science and Technology (KIST)) |
1 |
Issac, M., 2005. Serotonergic |
2 | Halford, J.C.G., Harrold, J.A., Boyland, EJ., Lawton, C.L., Blundell, J.E., 2007. Serotonergic drugs effects on appetite expression and use for the treatment of obesity. Adis Data Information BV. 67, 27-55. |
3 |
Millan, M.J., 2005. Serotonin |
4 | Tecott, L.H., Sun, L.M., Akana, S.F., Strack, A.M., Lowenstein, D.H., Dallman, M.F., Julius, D., 1995. Eating disorders and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature, 374 (6522), 542-546. DOI |
5 |
Tecott, L.H., Abdallah, L., 2003. Mouse genetic approaches to feeding regulation: serotonin |
6 |
Thomsen, W.J., Grottick, A.J., Menzaghi, F., Reyes-Saldana, H., Espitia, S., Yuskin, D., Whelan, K., Martin, M., Morgan, M., Chen, W., Al-Shamma, H., Smith, B., Chalmers, D., Behan, D., 2008. Lorcaserin, a novel selective human |
7 | DiPiro, J.T., Spruill, W.J., Wade, W.E., Blouin, R.A., Pruemer, J.M., 2005. Half-life, elimination rate and AUC: In Concept in Clinical Pharmacokinetics (4th Ed.), American Society of Health-System Pharmacists, pp. 29-44. |
8 | Giovanni, G. Di, Matteo, V., Pierucci, M., Benigno, A., Espoito, E., 2006. Central serotoinin 2C receptor: from physiology to pathology. Curr. Top. Med. Chem. 6, 1909-1925. DOI |
9 |
Dunlop, J., Marquis, K.L., Lim, H.K., Leung, L., Kao, J., Cheesman, C., Rosenzweig-Lipson S., 2006. Pharmacological Profile of the |
10 |
Frank, M.G., Stryker, M.P., Tecott, L.H., 2002. Sleep and sleep homeostasis in mice lacking the |
11 | Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, P.R., Martin, G.R., Mylecharrane E.J., Saxena P.R., Humphrey P.P.A., 1994. Internation Union of Pharmacology classification of receptors for hydroxytryptamine (serotonin). Pharmacol. Rev. 46, 157-204. |
12 | Hoyer, D., Martin, G.R., 1997. 5-HT receptor classification and nomenclature: towards a harmonization with the human genome. Neuropharmacology. 36, 419-428. DOI |
13 |
Im, H.Y., Choo, H.A., Pae, A.N., Kwon, O.S., 2009. Pharmacokinetics and bioavailability of new synthetic |
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