• Hanyang Medical Reviews
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• v.33 no.1
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• pp.59-64
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• 2013

Cancer remains the leading cause of death worldwide despite intense efforts in developing innovative treatments. Current approaches in cancer therapy are mainly directed to a selective targeting of cancer cells to avoid potential side effects associated with conventional therapy. In this respect, Natural killer (NK) cells have gained growing attention and are now being considered as promising therapeutic tools for cancer therapy owing to their intrinsic ability to rapidly recognize and kill cancer cells, while sparing normal healthy cells. NK cells play a key role in the first line of defense against transformed and virus-infected cells. NK cells sense their target through a whole array of receptors, both activating and inhibitory. Functional outcome of NK cell against target cells is determined by the balance of signals transmitted from diverse activating and inhibiting receptors. Despite significant progress made in the role of NK cells attack as a pivotal sentinel in tumor surveillance, the molecular has been that regulate NK cell responses remain unclear, which restricts the use of NK cells as a therapeutic measure. Accordingly, current efforts for NK cell-based cancer therapy have largely relied on the strategies that are based on the manipulation of inhibitory receptor function. However, if we better understand the mechanisms governing NK cell activation, including those mediated by diverse activating receptors, this knowledge can be applied to the development of optimal design for cancer immunotherapy by targeting NK cells.

• Proceedings of the IEEK Conference
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• 1998.10a
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• pp.1259-1262
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• 1998

This paper introduced a scheme for finding the relationships between the measurements and tracks in multi-target tracking (MTT). We considered the relationships between targets and measurements as MRF and assumed a priori as a Gibbs distribution. An energy function is defined over the measurement space, as accurately as possible so that it may incorporate most of the important natural constraints. To find the minimizer of the energy function, we derived a new equation of closed form.

• Proceedings of the Korea Institute of Convergence Signal Processing
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• 2000.08a
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• pp.5-8
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• 2000

This paper introduced a scheme for finding an optimal association matrix that represents the relationships between the measurements and tracks in multi-target tracking of Radar system. We considered the relationships between targets and measurements as MRF and assumed a priori of the associations as a Gibbs distribution. Based on these assumptions, it was possible to reduce the MAP estimate of the association matrix to the energy minimization problem. After then, we defined an energy function over the measurement space, that may incorporate most of the important natural constraints.

• Journal of Integrative Natural Science
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• v.15 no.4
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• pp.187-194
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• 2022

Protein Arginine Methyltransferase 5 (PRMT5), a significant member of the PRMT family, is a promising anticancer target. In this study, novel small compounds that act against the PRMT5 target are found by combining virtual screening with ChEMBL database medicines and Density Functional Theory. The ChEMBL database compounds were screened to retrieve the hit molecules, which further subjected for DFT analysis. Finally we have evaluated that ChEMBL- approved drugs such as Lifitegrast, Abiraterone acetate and Solifenacin may be potential inhibitors for PRMT5.

• Journal of Microbiology and Biotechnology
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• v.32 no.10
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• pp.1355-1355
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• 2022

• Industrial Engineering and Management Systems
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• v.15 no.3
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• pp.231-238
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• 2016

Traditional acceptance sampling plans have focused on the proportion of nonconforming items as an attribute criterion for quality. In today's modern quality management under high quality production environments, the reduction of the deviation from a target value in a quality characteristic has become the most important purpose. In consequence, various inspection plans for the purpose of reducing the deviation from the target value in the quality characteristic have been investigated. In this case, a concept of the quality loss evaluated by the deviation from the target value has been accepted as the variable evaluation criterion of quality. Further, some quality measures based on the quality loss have been devised; e.g. the process loss and the process capability index. Then, as one of inspection plans based on the quality loss, the rigorous design procedure for the variable sampling plan having desired operating characteristics (VS-OC plan) indexed by the quality loss has been proposed by Yen and Chang in 2009. By the way, since the estimator of the quality loss obeys the non-central chi-square distribution, the rigorous design procedure for the VS-OC plan indexed by the quality loss is complicated. In particular, the rigorous design procedure for the VS-OC plan requires a large number of the repetitive and complicated numerical calculation about the non-central chi-square distribution. On the other hand, an approximate design procedure for the VS-OC plan has been proposed before the proposal of the above rigorous design procedure. The approximate design procedure for the VS-OC plan has been constructed by combining Patnaik approximation relating the non-central chi-square distribution to the central chi-square distribution and Wilson-Hilferty approximation relating the central chi-square distribution to the standard normal distribution. Then, the approximate design procedure has been devised as a convenient procedure without complicated and repetitive numerical calculations. In this study, through some comparisons between the rigorous and approximate design procedures, the applicability of the approximate design procedure has been confirmed.

• Biomolecules & Therapeutics
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• v.26 no.2
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• pp.101-108
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• 2018

G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are the most commonly used therapeutic target. It has been suggested that GPCRs undergo massive genetic variations such as genetic polymorphisms and DNA insertions or deletions. Among these genetic variations, non-synonymous natural variations change the amino acid sequence and could thus alter GPCR functions such as expression, localization, signaling, and ligand binding, which may be involved in disease development and altered responses to GPCR-targeting drugs. Despite the clinical importance of GPCRs, studies on the genotype-phenotype relationship of GPCR natural variants have been limited to a few GPCRs such as b-adrenergic receptors and opioid receptors. Comprehensive understanding of non-synonymous natural variations within GPCRs would help to predict the unknown genotype-phenotype relationship and yet-to-be-discovered natural variants. Here, we analyzed the non-synonymous natural variants of all non-olfactory GPCRs available from a public database, UniProt. The results suggest that non-synonymous natural variations occur extensively within the GPCR superfamily especially in the N-terminus and transmembrane domains. Within the transmembrane domains, natural variations observed more frequently in the conserved residues, which leads to disruption of the receptor function. Our analysis also suggests that only few non-synonymous natural variations have been studied in efforts to link the variations with functional consequences.

• Journal of Korean Society on Water Environment
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• v.32 no.6
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• pp.546-551
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• 2016

In this study, capping with recycled aggregate and natural zeolite in marine sediment was performed to investigate its inhibitory effect on pollutants released from sediment to seawater. An experiment was performed by capping with amendments for 60 days, and concentrations of organic matter (COD), nitrate, phosphate and metallic elements (Ni, Zn, Cu, Pb, Cd, As, and Cr) were measured. Two capping materials effectively suppressed pollutant release. Recycled aggregate showed better effectiveness for organic pollutant, nitrate and phosphate release. Meanwhile, natural zeolite was effective for metallic elements. As a result, recycled aggregate and natural zeolite can be considered as cost-effective/inexpensive capping material candidates. Also, the capping material can be selected according to the target pollutant.

• Journal of the Korean Wood Science and Technology
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• v.33 no.2 s.130
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• pp.24-28
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• 2005

Monte Carlo simulation was performed on theoretical models of plywood warp for southern yellow pine plywood originating from the United States. The objective of the investigation was to determine which plywood layers was more warp sensitive to veneers that were manufactured to an undesired thickness. This study found that for a balanced panel (a panel of equal target thickness for each of five layers) manufactured veneers of undesired thickness would experience minimal warp. The veneers of undesired thickness placed in the center of the plywood panel also provided a minimum change of plywood warp properties. The panel warp was very sensitive to surface veneers constructed with undesired thickness. Conversely, this study confirms that monitoring of veneer thickness and proper allocations within the plywood lay-up were critical.

• Smart Structures and Systems
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• v.24 no.3
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• pp.415-425
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• 2019

This study was carried out to evaluate the natural zeolite in producing green concrete as an effort to prevent global warming and environmental impact problems of cement industries. To achieve this target, two types of natural zeolites applied to study physical, chemical and compressive strength of concrete containing different percentages of zeolites. The results in comparison with control samples indicate that compressive strength of zeolites mixes increases with the 15% replacement of zeolite instead of cement in all types of samples. In the water-cement ratio of 0.6, results showed an increase in the compressive strength of all percentages of replacement. This results indicate that using natural zeolites could be produced a green concrete by a huge reduction and saving in the consumption of cement.