• BMB Reports
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• v.45 no.2
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• pp.85-90
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• 2012

Our previous study demonstrated that CopA3, a disulfide dimer of the coprisin peptide analogue (LLCIALRKK), has antibacterial activity. In this study, we assessed whether CopA3 caused cellular toxicity in various mammalian cell lines. CopA3 selectively caused a marked decrease in cell viability in Jurkat T, U937, and AML-2 cells (human leukemia cells), but was not cytotoxic to Caki or Hela cells. Fragmentation of DNA, a marker of apoptosis, was also confirmed in the leukemia cell lines, but not in the other cells. CopA3-induced apoptosis in leukemia cells was mediated by apoptosis inducing factor (AIF), indicating induction of a caspase-independent signaling pathway.

• Journal of the Korean Society of Physical Medicine
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• v.10 no.4
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• pp.91-99
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• 2015

PURPOSE: The purpose of this study was to investigate effect of the manual joint mobilization to the patients with knee osteoarthritis and to determine the effect of pain, range of motion, body function and balance after applying it. METHODS: The thirty participants who complained the knee pain were randomly assigned to control (Con) group (n=15) that received the general physical therapy and experimental (Exp) group (n=15) that received the applied the manual joint mobilization and the general physical therapy three times per week, 30 minutes per day for four weeks. It measured the visual analogue scale (VAS), the range of motion (ROM), body function (WOMAC) and balance (TUG). RESULTS: It showed the significantly different between the control group and experiment group in VAS, ROM and WOMAC. After 4 weeks, the experiment group was significantly different from other group in VAS, ROM and WOMAC. But the measurement of balance did not show the significantly difference within group and between groups. CONCLUSION: This results suggest that Manual joint mobilization was effective in pain, ROM, function in patient with knee osteoarthritis.

• Journal of Korean Dental Science
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• v.4 no.1
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• pp.14-19
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• 2011

Purpose: The aim of our study was to evaluate natural recovery of neurologic injury after minor dental surgery based on subjective neurologic evaluation. Materials and Methods: From December 2005 through July 2009, 30 patients from Seoul National University Bundang Hospital were identified as having been treated with minor dental surgery. The patients were composed of 12 men and 18 women, with a mean age of 50.6 years. The median duration of this study was 62 weeks. Results: The patients were treated by implants (17 cases), tooth extractions (6 cases), bone grafts (4 cases), inferior alveolar nerve transpositions (2 cases) and periodontal surgery (1 case) prior to the occurrence of altered sensation. Areas of altered sensation after minor surgery included the lip (36.7%), chin (30.0%) and tooth (21.7%), and at final follow-up, there was no change of ranking. Altered sensations expressed by patients included numbness (33.3%), discomfort (22.9%), relieving sense (14.6%), tingling (14.6%) and itching (14.6%). There was no change of ranking of altered sensation at the last follow-up. Patients experienced the altered sensation always (47.8%), during tactile stimulation (26.1%), when chewing food (13.0%), and talking (13.0%). Mean visual analogue scale (VAS) was $3.43{\pm}2.84$ for pain and $6.64{\pm}2.72$ for paresthesia. VAS of pain was decreased significantly between the first visit and the end of follow-up, and paresthesia also showed a significant difference. Conclusion: Altered sensations may occur at any time after minor dental surgery, but we observed that natural recovery of altered sensation occurred as time went on.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.1172-1177
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• 2009

This study is to determine the effects of BUDDEUMI(moxibustion and cupping a boli) therapy on the relief of shoulder pain among middle aged women. methods : A total of 39 middle aged women with shoulder pain are selected : 20 in the experimental group and 19 in the control group. The data was collected by using questionnaires. The BUDDEUMI(moxibustion and cupping a boli) therapy on the should and back was administered to the experimental group, and no treatment was given to the control group. All of the subjects were examined on a subjective symptom scale and on the grade of discomfort and pain in everyday life as developed by Japan's Industrial Fatigue Research Committee of the Industrial Hygienics Society(1988), Sohn, Mong Ho(1999), Visual Analogue Scale as developed by Cline (1992). SPSS/win 12.0 was used for Date analysis, General features demonstrated by frequency number and percentage. The effects of the BUDDEUMI(moxibustion and cupping a boli) therapy was analyzed by a t-test. The homogeneity testing revealed that all study variables are equally distributed between experimental and control groups. The hypothesis, 'the experimental group who received BUDDEUMI(moxibustion and cupping a boli) therapy will decrease in the grade of discomfort of shoulder', is supported. The hypothesis, 'the experimental group who received BUDDEUMI(moxibustion and cupping a boli) therapy will decrease in the Visual Analogue Scale is supported. Conclusion : As a result of this study, BUDDEUMI(moxibustion and cupping a boli) therapy will be able to be used as the self care therapy to improve the symptoms of middle aged women who has the shoulder pain.

• Journal of the Korean Mathematical Society
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• v.51 no.5
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• pp.1045-1073
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• 2014

The study of the identities of symmetry for the Bernoulli polynomials arises from the study of Gauss's multiplication formula for the gamma function. There are many works in this direction. In the sense of p-adic analysis, the q-Bernoulli polynomials are natural extensions of the Bernoulli and Apostol-Bernoulli polynomials (see the introduction of this paper). By using the N-fold iterated Volkenborn integral, we derive serval identities of symmetry related to the q-extension power sums and the higher order q-Bernoulli polynomials. Many previous results are special cases of the results presented in this paper, including Tuenter's classical results on the symmetry relation between the power sum polynomials and the Bernoulli numbers in [A symmetry of power sum polynomials and Bernoulli numbers, Amer. Math. Monthly 108 (2001), no. 3, 258-261] and D. S. Kim's eight basic identities of symmetry in three variables related to the q-analogue power sums and the q-Bernoulli polynomials in [Identities of symmetry for q-Bernoulli polynomials, Comput. Math. Appl. 60 (2010), no. 8, 2350-2359].

• Journal of the Korean Mathematical Society
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• v.54 no.1
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• pp.35-57
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• 2017

In this paper, we study the natural star-operation defined by the set of associated primes of principal ideals of an integral domain, which is called the g-operation. We are mainly concerned with the ideal-theoretic properties of this star-operation. In particular, we investigate DG-domains (i.e., integral domains in which each ideal is a g-ideal), which form a proper subclass of the DW-domains. In order to provide some original examples, we examine the transfer of the DG-property to pullbacks. As an application of the g-operation, it is shown that w-divisorial Mori domains can be seen as a Gorenstein analogue of Krull domains.

• YAKHAK HOEJI
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• v.48 no.1
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• pp.88-92
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• 2004

In this study; a series of 2',4'-doubly branched carbocyclic nucleosides (8,9,10) were synthesized from simple acyclic ketone derivative as starting material. The installation of the 4'-quaternary carbon needed was carried out using a 〔3,3〕-sigmatropic rearrangement. In addition, the introduction of a methyl group in the 2'-position was accomplished by Grig-nard reaction. Bis-vinyl was successfully cyclized using a Grubbs' catalyst II. The natural bases (adenine, cytosine, uracil) were efficiently coupled with the use of a Pd(0) catalyst. Although all the synthesized compounds were assayed against several viruses, only cytosine analogue 9 showed weak antiviral viral activity (EC$_{50}$=45.4 $\mu$M) against CoxB3 virus.s.

• Bulletin of the Korean Chemical Society
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• v.25 no.12
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• pp.1812-1816
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• 2004

The stereoselective synthesis 4′,6′-dually branched carbocyclic nucleosides was accomplished in this study. The introduction of a methyl group in the 6′$({\alpha})$-position was accomplished by Felkin-Anh controlled alkylation. The construction of the required 4′$({\alpha})$-quaternary carbon was carried out using a [3,3]-sigmatropic rearrangement. Bis-vinyl 6 was successfully cyclized using a Grubbs' catalyst II. The natural bases (adenine, cytosine) were efficiently coupled using a Pd(0) catalyst. When the synthesized compounds were examined for their activity against several viruses such as the HIV-1, HSV-1, HSV-2 and HCMV, the cytosine analogue 13 exhibited good antiviral activity against the HCMV.

• YAKHAK HOEJI
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• v.49 no.1
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• pp.20-24
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• 2005

The synthesis of 4',5'-doubly branched carbocyclic nucleosides was accomplished in this study. The selective methylation in the 5'-position was made by Felkin-Anh controlled Grignard addition. The construction of the required 4'-quaternary carbon was carried out by using a [3,3]-sigmatropic rearrangement. Bis-vinyl 6 was successfully cyclized using a Grubbs' catalyst II. The natural pyrimidine bases (cytosine, uracil, thymine) were efficiently coupled using a Pd(0) catalyst. When the synthesized compounds were examined for their activity against several viruses such as the HIV-1, HSV-1, HSV-2 and HCMV, the cytosine analogue 13 exhibited weak antiviral activity against the HCMV.

• Journal of Korean Academy of Nursing
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• v.34 no.7
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• pp.1343-1350
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• 2004

Purpose: The purpose of this study was to identify effects of the SP-6 acupressure on dysmenorrhea, the skin temperature of the CV2 acupoint and oral temperatures in the college students. Method: Data was collected from May 1 to August 31, 2002. A total of 58 students from two universities ticipated in the study. Both groups were pretested before the intervention for three variables', the intensity of dysmenorrhea, skin temperature of the CV2 acupoint and oral temperature. Then, SP-6 acupressure was provided for 20 minutes for students in the experimental group. The instruments used in this study included the Visual Analogue Scale developed by Johnson & Rice(1974), Menstrual Attitudes Questionnaire Scale developed by Brooks-Gunn & Ruble(l980), and a Stress scale developed by Cheun and Kim(l991). Result: There were statistically significant differences in the intensity of dysmenorrhea 30minutes after the intervention. The experimental group had a lower intensity than the control group. There were not statistically significant differences in skin temperature of the CV2 acupoint and oral temperature 30minutes after the intervention with the experimental group. Conclusion: SP-6 acupressure reduced the subjective perception of dysmenorrhea.