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http://dx.doi.org/10.5483/BMBRep.2012.45.2.85

CopA3 peptide from Copris tripartitus induces apoptosis in human leukemia cells via a caspase-independent pathway  

Kang, Bo-Ram (Department of Life Science, College of Natural Science, Daejin University)
Kim, Ho (Department of Life Science, College of Natural Science, Daejin University)
Nam, Sung-Hee (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Yun, Eun-Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Kim, Seong-Ryul (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Ahn, Mi-Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Chang, Jong-Soo (Department of Life Science, College of Natural Science, Daejin University)
Hwang, Jae-Sam (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Publication Information
BMB Reports / v.45, no.2, 2012 , pp. 85-90 More about this Journal
Abstract
Our previous study demonstrated that CopA3, a disulfide dimer of the coprisin peptide analogue (LLCIALRKK), has antibacterial activity. In this study, we assessed whether CopA3 caused cellular toxicity in various mammalian cell lines. CopA3 selectively caused a marked decrease in cell viability in Jurkat T, U937, and AML-2 cells (human leukemia cells), but was not cytotoxic to Caki or Hela cells. Fragmentation of DNA, a marker of apoptosis, was also confirmed in the leukemia cell lines, but not in the other cells. CopA3-induced apoptosis in leukemia cells was mediated by apoptosis inducing factor (AIF), indicating induction of a caspase-independent signaling pathway.
Keywords
Anti-cancer effect; Apoptosis; Caspase-independent apoptosis pathways; Cell membrane penetration; Insect peptide; Leukemia;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
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