• Archives of Plastic Surgery
• /
• 제32권1호
• /
• pp.124-130
• /
• 2005

In the microsurgical era, replantation with microvascular anastomosis is considered as the most superior method in aspects of texture, color, shape in case of nose amputation. There are some reported cases of replantation in nose amputation historically, but most of them are composite graft cases rather than microvascular anastomosis. Only a few cases of successful nasal replantation with microvascular anastomosis have been reported due to the reason that the size of vessels is usually very small and identifying suitable vessels for anastomosis is difficult. Microanastomosis of artery and microanastomosis of vein are ideal in replantation, but identifying suitable veins is often difficult. Without venous anastomosis, resolving the venous congestion remains to be a problem. We can carry out arteriovenous shunt if we can find two arteries in amputee. However, the smaller the size of amputee is, the more difficult it is to find two arteries. Instead of arteriovenous shunt, we can try external venous drainage(frequently swab, pin-prick, stab incision, IV or local heparin injection, dropping, apply of heparin-soaked gauze, use of medical leech). Here, we present three cases of replantation with microscopical arterial anastomosis (one angular artery, two dorsal nasal arteries) and external venous drainage (stab incision, application of medical leech and heparin-soaked gauze) even though the size of amputee may be as small as $1.5{\times}1.0cm$. In all cases, surgical outcomes were excellent in cosmetic and functional aspects. This report describes successful replantation by microvasular anastomosis in case that suitable veins are not found.

• 한방안이비인후피부과학회지
• /
• 제30권2호
• /
• pp.112-125
• /
• 2017

Objectives : The prevalence of allergic rhinitis (AR) is 10-40% worldwide and there are many demands for Traditionl Medicine (TM) treatment for AR. Pattern identification (PI) is essential process in diagnosis and treatment of TM, however, objective assessment measurement for PI of AR in TM is lacked. Methods : PI questionnaire for AR was developed in 2008 by specialists in the department of Otolaryngology of TM, based on systemic and nasal symptoms and signs. However, that questionnaire had many problems in application to clinical practice and has since been revised based on several studies and delphi method. Consequently, the PI questionnaire for AR version 3.0 has been developed. Results & Conclusions : This questionnaire classifies patients with AR as possessing lung-heat, lung-cold, or spleen qi deficiency based on nasal symptoms and general conditions of AR patients. This is first questionnaire for pattern identification of AR. We plan to conduct a validation and reliability study, and revise the questionnaire based on the results of this study.

• 대한치과교정학회지
• /
• 제15권2호
• /
• pp.211-227
• /
• 1985

The purpose of this study was to analyze the stress distribution and the displacement in the maxillary complex after the application of the three kinds of the head gear. (high pull head gear, straight pull head gear, cervical pull head gear.) Orthopedic force, 300 gram, was applied to the maxilla of the dry human skull in a high, straight and cervical direction. The stress distribution and the displacement within the maxillary complex was analyzed by a 3-dimensional finite element method. The results were as follow: 1. In won, the stress of conical pull head gear was the greatest stress and straight pull head gear was the medium stress and high pull head gear was the least stress. 2. The compressive stress was observed on the anterior portion of premaxilla, especially anterior nasal spine area, when the three kinds of head gear were applied to the dry kuman skull. 3. It appeared that the stress of the anterior portion of the zygomatic bone was greater than the posterior portion in the case of three kinds of head gear application and compressive stress was noted only at the below of the frontozygomatic suture of the zygomatic bone. 4. The backward, upward, sideward displacement of the alveolar area was observed in a high pull head gear application but in the case of straight pull head gear and cervical pull head gear application, the backward, downward, sideward displacement was observed. 5. The forward, downward, sideward displacement was observed on the midpalatine suture and premaxilla on the sagittal plane and transverse palatine suture in the case of three kinds of headgear application.

• 한국환경보건학회지
• /
• 제39권1호
• /
• pp.48-55
• /
• 2013

Objective: The use of nanoparticle products is expected to present a potential harmful effect on consumers. Also, the lack of information regarding inhaled nanoparticles may pose a serious problem. In this study, we addressed this issue by studying pulmonary toxicity after nasal instillation of Al-NPs in SD rats. Methods: The animals were exposed to Al-NPs at 1 mg/kg body weight (low dose), 20 mg/kg body weight (medium dose) and 40 mg/kg body weight (high dose). To determine pulmonary toxicity, bronchoalveolar lavage (ts.AnBAL) fluid analysis and histopathological examination were conducted in rats. In addition, cell viability was investigated at 24 hours after the treatment with Al-NPs. Results: BAL fluid analysis showed that total cells (TC) count and total protein (TP) concentrations increased significantly in all treatment groups, approximately two to three times. Also, lactate dehydrogenase (LDH) and cytokines such as TNF-alpha and IL-6 dose-dependently increased following nasal instillation of Al-NPs. However, polymorphonuclear leukocytes (PMNs) levels showed no significant changes in a dose dependant manner in BAL fluid. In the cytotoxicity analysis, the treatment of Al-NPs significantly and dose-dependently induced cell viability loss (20 to 30%) and damage of cell membrane (5 to 10%) in rat normal lung epithelial cells (L2). Conclusions: Our results suggest that inhaled Al-NPs in the lungs may be removed quickly by alveolar macrophages with minimal inflammatory reaction, but Al-NPs have the potential to affect lung permeability. Therefore, extensive toxicity evaluations of Al-NPs are required prior to their practical application as consumer products.

• 대한소아치과학회지
• /
• 제24권3호
• /
• pp.549-555
• /
• 1997

Usage of the rubber dam has been advocated by countless number of dentists. The advantages of the rubber dam such as the following are well-known 1. Moisture control. 2. Improved field of vision. 3. Ease of approach. 4. Soft tissue retraction and Injury prevention. 5. Prevention of aspiration of materials or instruments. 6. Shortened chair time. 7. Induction of nasal breathing during administration of $N_2O-O_2$ sedation. Recent reports indicate the rubber dam can protect the dental staffs from the infection when treating HBV or HIV positive patients. Also, improved moisture control and freeing of both hands allowed by the rubber dam makes it very useful when bonding orthodontic brackets. This case study presents the various clinical application of the rubber dam on patients visiting SNUDH dept. of pediatric dentistry to emphasize the importance of its use in pediatric dentistry.

• Journal of Korean Neurosurgical Society
• /
• 제60권3호
• /
• pp.315-321
• /
• 2017

The endoscopic endonasal approach (EEA) has been popularized in adults and has been applied to an expanding range of surgical modules and indications in this population. However, its clinical application in pediatric neurosurgery has been impeded by the differences in anatomical features and the relatively low incidence of diseases to which it is applicable. In this review article, we mainly discuss the surgical indications, feasibility, and complications of EEA for suprasellar lesions in children based on a review of the literature, focusing especially on the age-related anatomical features of the nasal cavity, various pathologic entities, and the impact of EEA on long-term craniofacial growth.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
• /
• pp.300.1-300.1
• /
• 2003

Salmon calcitonin (sCT) is a therapeutic polypeptide hormone consisting of 32 amino acids (3432 Da). As with other bioactive peptide therapeutics, however, therapeutic use of sCT has been limited due to the problems of short circulating half-life and rapid proteolytic degradation. To get over this problem, the three positional isomers of mono-PEGylated sCT were prepared and among these, the best drug candiate for nasal application was chosen. (omitted)

• 대한치과교정학회지
• /
• 제54권1호
• /
• pp.69-73
• /
• 2024

Since its inception in Europe in the 1950s, alveolar molding treatment for neonates with complete cleft lip and palate has undergone significant evolution in both design and application methodology, demonstrating effectiveness in normalizing the alveolar cleft and nasal shape. However, excessively wide alveolar clefts accompanied by disproportionately wide total maxillary arch pose significant challenges when utilizing conventional alveolar molding methods involving cyclical adding and grinding of acrylic on molding plates. The current report introduces a novel alveolar molding method named Biocreative Alveolar Molding Plate Treatment (BioAMP), which can normalize the maxillary alveolar cleft and arch shape without laborious conventional acrylic procedures. BioAMP sets the target arch form and provides unrestricted space for natural growth of the maxillary alveolar bones while systematically reducing the total maxillary arch width in precise increments. Two exemplary cases are presented as proof-of-concept, showcasing the clinical innovation of BioAMP.

• Tuberculosis and Respiratory Diseases
• /
• 제51권1호
• /
• pp.44-52
• /
• 2001

배 경 : 만성호흡부전증 환자에게 산소농축기는 간편하면서도 경제적인 의료장비이나 국내에서는 생산되지 않아 수입한 값 비싼 외국산산소농축기를 사용하고 있는 실정이다. 서강대학교에서 개발한 국산 산소농축기를 임상에 사용하기 전에 성능을 검증하고자, 외국산 산소농축기와 임상시험을 통하여 비교 분석함으로써 국산 산소농축기의 효능 및 안전성을 측정하였다. 대상 및 방법 : 임상시험은 1999년 4월부터 1999년 8월까지 36명의 다한증환자를 대상으로 시행되었다. 동일한 환자에게 국산 산소농축기와 외국산 산소농축기를 nasal prong을 사용하여 60분동안 분당 3리터의 양으로 교대 사용하였다 어떤 기계를 먼저 적용할 것인 지는 무작위배정방법을 이용하였다. 산소농축기 적용전후의 동맥혈 산소압, 동맥혈 COHb, 동맥혈 pH, 동맥혈 이산화탄소압, 맥박수, 혈압, 호흡수 등을 각각 측정하여 그 변화량을 비교 검증하였다. 결 과 : 효능면에서 볼 때 동맥혈 산소압의 변화량은 통계적으로 유의한 차이가 없었고, 안전성면에서도 동맥혈 pH, 동맥혈 이산화탄소압, 맥박수, 혈압, 호흡수, 혈중 COHb 등의 변화 차이를 발견할 수 없었다. 결 론 : 현재 개발중인 국산 산소 농축기의 시제품의 성능을 임상시험한 결과 외국산 산소 농축기와 비교하여 동등한 만족스러운 성능을 보였다.

• 대한핵의학회지
• /
• 제33권6호
• /
• pp.484-492
• /
• 1999

목적: 안구제거술 후 삽입한 hydroxyapatite 안구보충물 내로의 혈관 신생 여부의 평가에 $^{99m}Tc$-MDP 골신티그라피의 임상적 유용성에 대해 알아보고자 하였다. 대상 및 방법: 안구적출술이나 안구내용물 제거술의 방법을 이용하여 안구 제거 후 hydroxyapatite 보충물을 삽입한 24명의 환자를 대상으로 하였다(여자 7명, 남자 17명, 연령 분포 $12{\sim}78$세, 평균 연령 36세, 안구적출술 12명, 안구내용물 제거술12명) Hydroxyapatite 보충물 삽입 후 $3{\sim}33$주($3{\sim}10$주 사이에 4명, $11{\sim}20$주 사이에 10명, $21{\sim}33$주 사이에 10명) 사이에 $^{99m}Tc$-MDP 골신티그라피를 시행하였다. 방사능 섭취 정도는 육안적으로 안구보충물과 비교(nasal bridge) 및 반대측 안구와 비교하여 안구 보충물이 비교보다 강할 경우 등급 4, 같을 경우 등급 3, 비교와 반대측 안구 사이일 경우 등급 2, 그 이하일 경우 등급 1로 하였다. 또한 골신티그라피 정면 영상에서 관심영역을 안구 보충물과 반대측 안구에 같은 크기로 설정하여 방사능 계수 비(H/N ratio)를 구하였다. 검사 시기와 방사능 섭취의 등급 분류, 방사능 계수 비와 안구 고정술 후 성공여부와의 관계를 분석하였다. 결과: 등급 2 이상, 방사능 계수 비가 1.56 이상인 환자 중 추적 관찰할 수 없었던 2명을 제외한 19명 모두에서 천공 시 출혈을 확인하였고, 의안과 연결하여 안구 고정술을 시행하였다. 방사능 섭취 정도를 육안적 분류 방법과 정량적 측정 방법에 의한 결과는 두 방법 모두 통계적으로 유의하였고 검사 시기와 방사능 계수 비 사이에 각각 유의한 상관관계가 있었으나 수술 방법에 따른 차이는 보이지 않았다. 결론: $^{99m}Tc$-MDP 골신티그라피의 방사능 섭취 등급 분류와 방사능 계수 비는 안구고정술의 시기 결정에 도움을 주었다. 안구적출술과 안구내용물제거술의 수술 방법 차이에 관계없이 안구고정술을 위한 첫 검사 시기는 안구보충물삽입 후 $11{\sim}20$주 사이가 좋을 것으로 생각되며, 등급 2, 방사능 계수 비 1.56 이상인 경우에는 안구 고정술을 시행하여 좋은 결과를 기대할 수 있을 것으로 생각된다.