Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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In Vitro Evaluation of Three Positional Isomers of mono-PEGylated Salmon Calcitonin

  • Jung, J.Y. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Youn, Y.S. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Oh, S.H. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Hong, S.T. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Lee, J.E. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Lee, S.O. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Lee, K.C. (Drug Targeting Laboratory, SungKyunKwan University)
  • Published : 2003.04.01
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Abstract

Salmon calcitonin (sCT) is a therapeutic polypeptide hormone consisting of 32 amino acids (3432 Da). As with other bioactive peptide therapeutics, however, therapeutic use of sCT has been limited due to the problems of short circulating half-life and rapid proteolytic degradation. To get over this problem, the three positional isomers of mono-PEGylated sCT were prepared and among these, the best drug candiate for nasal application was chosen. (omitted)

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